Abstract:
:A family of phosphoinositide-3 kinase (PI3K) isoenzymes catalyzes the production of second messengers that recruit critical regulators of cell growth, survival, proliferation and motility. Conversely, 3'-(phosphatase and tensin homolog) and 5'-inositol polyphosphatases (SH2-containing inositol phosphatases 1/2, SHIP1/2) are recruited to sites of PI3K signaling at the plasma membrane to oppose or, in some cases, to modify and enhance PI3K signaling. A substantial and growing body of literature demonstrates that these enzymes which mediate interchange of phosphates on inositol phospholipid species at the plasma membrane have prominent roles in natural killer cell biology, including development, effector functions and trafficking. Here, we review the salient points of these recent papers with a special emphasis on the role of p110δ and SHIP1 in natural killer cells.
journal_name
J Innate Immunjournal_title
Journal of innate immunityauthors
Kerr WG,Colucci Fdoi
10.1159/000323920subject
Has Abstractpub_date
2011-01-01 00:00:00pages
249-57issue
3eissn
1662-811Xissn
1662-8128pii
000323920journal_volume
3pub_type
杂志文章,评审abstract::Activation of complement leads to generation of the 3 anaphylatoxins C3a, C4a, and C5a. Although all 3 peptides are structurally similar, only C3a and C5a share a similar functional profile that includes the classic inflammatory activities and, more recently, developmental homing and regenerative properties among othe...
journal_title:Journal of innate immunity
pub_type: 杂志文章,评审
doi:10.1159/000371423
更新日期:2015-01-01 00:00:00
abstract::Toll-like receptors (TLRs) are key molecules in innate immunity that recognize a variety of pathogen-associated molecular patterns. Activation of TLRs by their agonists initiates several signaling cascades, which eventually result in the expression of immune modifiers. Despite the fact that MCPIP1 is reported as an im...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000339826
更新日期:2013-01-01 00:00:00
abstract::Glucocorticoid-induced leucine zipper (GILZ) is a potent anti-inflammatory protein, the expression of which is mainly induced by glucocorticoids (GCs) in haematopoietic cells. GILZ regulates signal transduction pathways of inflammation and plays a role in cell survival. The objective of this study was to evaluate the ...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000439052
更新日期:2016-01-01 00:00:00
abstract::There is incomplete mechanistic understanding of the mobilization of neutrophils in the systemic and local compartment in smokers with chronic obstructive pulmonary disease (COPD). In this pilot study, we characterized how the adhesion molecules CD11b and CD62L, surface markers indicative of priming, are altered as ne...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000509715
更新日期:2020-01-01 00:00:00
abstract::Infections with highly pathogenic avian influenza viruses (HPAIV) in humans lead to systemic disease associated with cytokine storm and multiorgan failure. In this study we aimed to identify the role of monocytes for the host response to HPAIV infection. Using genome-wide microarray analysis, we surprisingly demonstra...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000346706
更新日期:2013-01-01 00:00:00
abstract::The phagocyte NADPH oxidase, crucial for innate immunity, is dormant in resting cells, but becomes activated during phagocytosis to produce superoxide, a precursor of microbicidal oxidants. In activation of the oxidase, the multidomain protein p67(phox)plays a central role: it translocates to the membrane as a ternary...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000235656
更新日期:2009-01-01 00:00:00
abstract::We demonstrated recently that Francisella tularensis profoundly impairs human neutrophil apoptosis, but how this is achieved is largely unknown. Herein we used human oligonucleotide microarrays to test the hypothesis that changes in neutrophil gene expression contribute to this phenotype, and now demonstrate that F. t...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000342430
更新日期:2013-01-01 00:00:00
abstract::Melanoma differentiation-associated gene 5 (MDA5) is a pattern recognition receptor that recognizes cytoplasmic viral double-stranded RNA (dsRNA) and initiates rapid innate antiviral responses. MDA5 forms a filament-like multimer along the dsRNA leading to oligomerization, which in turn activates the adaptor protein m...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000480740
更新日期:2018-01-01 00:00:00
abstract::Streptococcus pyogenes is an important human pathogen that causes a variety of diseases including life-threatening invasive diseases, such as toxic shock and deep tissue infections. Although S. pyogenes are classically considered extracellular pathogens, a clinical significance of an intracellular source has been emph...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000317635
更新日期:2010-01-01 00:00:00
abstract::To protect against viral infection, the immune response is critically dependent on innate sensing mechanisms to provide rapid detection of pathogens and allow for the development of an appropriate adaptive immune response. Mounting evidence suggests that mechanistic differences in the sensing of viruses by the innate ...
journal_title:Journal of innate immunity
pub_type: 杂志文章,评审
doi:10.1159/000226247
更新日期:2009-01-01 00:00:00
abstract::Early interactions between natural killer (NK) and dendritic cells (DC) shape the immune response at the frontier of innate and adaptive immunity. Activated NK cells participate in maturation or deletion of DCs that remain immature. We previously demonstrated that infection with a high virulence (HV) population of the...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000350242
更新日期:2013-01-01 00:00:00
abstract::There is increasing evidence that the immune system is regulated by circadian rhythms. A wide range of immune parameters, such as the number of red blood cells and peripheral blood mononuclear cells as well as the level of critical immune mediators, such as cytokines, undergo daily fluctuations. Current experimental d...
journal_title:Journal of innate immunity
pub_type: 杂志文章,评审
doi:10.1159/000342427
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Chronic inflammation and oxidative stress are hallmarks of chagasic cardiomyopathy (CCM). In this study, we determined if microparticles (MPs) generated during Trypanosoma cruzi (Tc) infection carry the host's signature of the inflammatory/oxidative state and provide information regarding the progression of ...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000451055
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:We have previously identified the upregulation of the innate immune response, neutrophil activation, and apoptosis during anaphylaxis using a microarray approach. This study aimed to validate the differential gene expression and investigate protein concentrations of "hub genes" and upstream regulators during...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000492301
更新日期:2019-01-01 00:00:00
abstract::Psoriasis is one of the most common immune-mediated disorders. There is evidence that it is mediated by Th1 and, more recently, Th17 cells. The cytokine pattern, particularly the dominance of TNF-α, implicates the innate immune system in psoriasis pathogenesis. Of the many components of the innate immune system known ...
journal_title:Journal of innate immunity
pub_type: 杂志文章,评审
doi:10.1159/000328011
更新日期:2011-01-01 00:00:00
abstract::In in vitro experiments, Chlamydia pneumoniae has been shown to infect macrophages and to accelerate foam cell formation. It has been hypothesized that the C. pneumoniae infection affects foam cell formation by suppressing the expression of liver X receptors (LXR), but whether such an event occurs in human atheroscler...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000327522
更新日期:2011-01-01 00:00:00
abstract::Klebsiella pneumoniae is a common cause of hospital-acquired pneumonia. Granzymes (gzms), mainly found in cytotoxic lymphocytes, have been implicated as mediators of infection and inflammation. We here sought to investigate the role of gzmA and gzmB in the host response to K. pneumoniae-induced airway infection and se...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000443401
更新日期:2016-01-01 00:00:00
abstract::Listeria monocytogenes is a facultative intracellular pathogen which can infect Drosophila melanogaster. Upon infection, Drosophila mounts an immune response including antimicrobial peptide production and autophagy activation. A set of previously published results prompted us to study the role of the deubiquitinating ...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000360293
更新日期:2014-01-01 00:00:00
abstract::Neutrophils are the most abundant cell type involved in the innate immune response. They are rapidly recruited to sites of injury or infection where they engulf and kill invading microorganisms. Neutrophil apoptosis, the process of programmed cell death that prevents the release of neutrophil histotoxic contents, is t...
journal_title:Journal of innate immunity
pub_type: 杂志文章,评审
doi:10.1159/000284367
更新日期:2010-01-01 00:00:00
abstract::Unwarranted overproduction of cytokines, such as interleukin (IL)-1β, can cause moderate to severe pathological complications, and thus elaborate mechanisms are needed to regulate its onset and termination. One such, well-known, mechanism is endotoxin tolerance, generally described as controlling lipopolysaccharide To...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000371517
更新日期:2015-01-01 00:00:00
abstract::The host innate immune response, including the production of type-I IFN, represents the primary line of defense against invading viral pathogens. Of the hundreds of IFN-stimulated genes (ISGs) discovered to date, ISG15 was one of the first identified and shown to encode a ubiquitin-like protein that functions, in part...
journal_title:Journal of innate immunity
pub_type: 杂志文章,评审
doi:10.1159/000226245
更新日期:2009-01-01 00:00:00
abstract::After phagocytosis by macrophages, Staphylococcus aureus evades killing in an α-toxin-dependent manner, and then prevents apoptosis of infected cells by upregulating expression of antiapoptotic genes like MCL-1 (myeloid cell leukemia-1). Here, using purified α-toxin and a set of hla-deficient strains, we show that α-t...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000368048
更新日期:2015-01-01 00:00:00
abstract::Particulate systems in the form of liposomes, polymeric micelles, polymeric nano- and microparticles, and many others offer a rational approach for selective delivery of therapeutic agents to the macrophage from different physiological portals of entry. Particulate targeting of macrophages and intracellular drug relea...
journal_title:Journal of innate immunity
pub_type: 杂志文章,评审
doi:10.1159/000339153
更新日期:2012-01-01 00:00:00
abstract::Atherosclerosis is a chronic inflammatory disease characterized by dyslipidemia and accumulation of lipids in the arterial intima, with activation of both innate and adaptive immunity. Reciprocally, dyslipidemia associated with atherosclerosis can perturb normal immune function. Natural killer T (NKT) cells are a spec...
journal_title:Journal of innate immunity
pub_type: 杂志文章,评审
doi:10.1159/000296915
更新日期:2010-01-01 00:00:00
abstract::The formation of neutrophil extracellular traps (NETs) is a host defence mechanism, known to facilitate the entrapment and growth inhibition of many bacterial pathogens. It has been implicated that the translocation of myeloperoxidase (MPO) from neutrophilic granules to the nucleus is crucial to this process. Under di...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000480386
更新日期:2018-01-01 00:00:00
abstract::Mucosal surfaces line our body cavities and provide the interaction surface between commensal and pathogenic microbiota and the host. The barrier function of the mucosal layer is largely maintained by gel-forming mucin proteins that are secreted by goblet cells. In addition, mucosal epithelial cells express cell-bound...
journal_title:Journal of innate immunity
pub_type: 杂志文章,评审
doi:10.1159/000453594
更新日期:2017-01-01 00:00:00
abstract::The Drosophila larval cellular immune response involves cells (haemocytes) that can be recruited from a haematopoietic organ known as the lymph gland, as well as a sessile population of cells found just underneath the larval cuticle arranged in a segmental pattern. Overexpression of the Drosophila c-src homologue Src6...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000191216
更新日期:2009-01-01 00:00:00
abstract::We characterized the dual oxidase (Duox) gene in the major Indian malaria vector Anopheles stephensi, which regulates the generation of reactive oxygen species. The AsDuox gene encodes for a 1,475-amino-acid transmembrane protein that contains an N-terminal noncytoplasmic heme peroxidase domain, a calcium-binding doma...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000497417
更新日期:2019-01-01 00:00:00
abstract::Mannose-binding lectin (MBL) is an innate immune system pattern recognition protein that kills a wide range of pathogenic microbes through complement activation. A substantial proportion of all human populations studied to date have MBL deficiency due to MBL2 polymorphisms, which potentially increases susceptibility t...
journal_title:Journal of innate immunity
pub_type: 杂志文章,评审
doi:10.1159/000228159
更新日期:2010-01-01 00:00:00
abstract::Calcium-independent phospholipase A2 (iPLA2) has been suggested to play an important role in the activation of caspase-1 induced by lipopolysaccharides (LPS). Here, we used pharmacological and genetic approaches to study the role of iPLA 2 in the activation of caspase-1. Bromoenol lactone (BEL), an inhibitor that was ...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000227263
更新日期:2009-01-01 00:00:00