Particulate systems for targeting of macrophages: basic and therapeutic concepts.

abstract：:Elevated inflammation and altered immune responses are features found in atopic asthmatic airways. Recent studies indicate γ-tocopherol (GT) supplementation can suppress airway inflammation in allergic asthma. We studied the effects of in vitro GT supplementation on receptor-mediated phagocytosis and expression of cel...

journal_title：Journal of innate immunity

authors： Geiser M,Lay JC,Bennett WD,Zhou H,Wang X,Peden DB,Alexis NE

更新日期：2013-01-01 00:00:00

abstract：:We characterized the dual oxidase (Duox) gene in the major Indian malaria vector Anopheles stephensi, which regulates the generation of reactive oxygen species. The AsDuox gene encodes for a 1,475-amino-acid transmembrane protein that contains an N-terminal noncytoplasmic heme peroxidase domain, a calcium-binding doma...

journal_title：Journal of innate immunity

authors： Kakani P,Kajla M,Choudhury TP,Gupta L,Kumar S

更新日期：2019-01-01 00:00:00

abstract：:Psoriasis is one of the most common immune-mediated disorders. There is evidence that it is mediated by Th1 and, more recently, Th17 cells. The cytokine pattern, particularly the dominance of TNF-α, implicates the innate immune system in psoriasis pathogenesis. Of the many components of the innate immune system known ...

journal_title：Journal of innate immunity

authors： Tobin AM,Lynch L,Kirby B,O'Farrelly C

更新日期：2011-01-01 00:00:00

abstract：:The host innate immune response, including the production of type-I IFN, represents the primary line of defense against invading viral pathogens. Of the hundreds of IFN-stimulated genes (ISGs) discovered to date, ISG15 was one of the first identified and shown to encode a ubiquitin-like protein that functions, in part...

journal_title：Journal of innate immunity

authors： Harty RN,Pitha PM,Okumura A

更新日期：2009-01-01 00:00:00

abstract：:Killer immunoglobulin-like receptors (KIRs) recognize class I major histocompatibility complex molecules and participate in the calibration of activation thresholds during human natural killer (NK) cell development. The stochastic expression pattern of the KIR repertoire follows the product rule, meaning that the prob...

journal_title：Journal of innate immunity

authors： Cichocki F,Miller JS,Anderson SK

更新日期：2011-01-01 00:00:00

abstract：:Neutrophil-derived antimicrobial peptides and proteins (AMPs) play an important role in the defense against microbes. Absence of defense is illustrated by neutropenic patients with frequent bacterial and fungal infections. However, the specificity of the antimicrobial effects has not been adequately described. We set ...

journal_title：Journal of innate immunity

authors： Cederlund A,Agerberth B,Bergman P

更新日期：2010-01-01 00:00:00

abstract：:Melanoma differentiation-associated gene 5 (MDA5) is a pattern recognition receptor that recognizes cytoplasmic viral double-stranded RNA (dsRNA) and initiates rapid innate antiviral responses. MDA5 forms a filament-like multimer along the dsRNA leading to oligomerization, which in turn activates the adaptor protein m...

journal_title：Journal of innate immunity

authors： Takashima K,Oshiumi H,Matsumoto M,Seya T

更新日期：2018-01-01 00:00:00

abstract：:Atherosclerosis is a chronic inflammatory disease characterized by dyslipidemia and accumulation of lipids in the arterial intima, with activation of both innate and adaptive immunity. Reciprocally, dyslipidemia associated with atherosclerosis can perturb normal immune function. Natural killer T (NKT) cells are a spec...

journal_title：Journal of innate immunity

authors： Braun NA,Covarrubias R,Major AS

更新日期：2010-01-01 00:00:00

abstract：:Infections with highly pathogenic avian influenza viruses (HPAIV) in humans lead to systemic disease associated with cytokine storm and multiorgan failure. In this study we aimed to identify the role of monocytes for the host response to HPAIV infection. Using genome-wide microarray analysis, we surprisingly demonstra...

journal_title：Journal of innate immunity

authors： Friesenhagen J,Viemann D,Börgeling Y,Schmolke M,Spiekermann C,Kirschnek S,Ludwig S,Roth J

更新日期：2013-01-01 00:00:00

abstract：:Neutrophils are the most abundant cell type involved in the innate immune response. They are rapidly recruited to sites of injury or infection where they engulf and kill invading microorganisms. Neutrophil apoptosis, the process of programmed cell death that prevents the release of neutrophil histotoxic contents, is t...

journal_title：Journal of innate immunity

authors： Fox S,Leitch AE,Duffin R,Haslett C,Rossi AG

更新日期：2010-01-01 00:00:00

abstract：:Urinary tract infection (UTI) is a prominent global health care burden. Although UTI is readily treated with antibiotics in healthy adults, complicated cases in immune-compromised individuals and the emerging antibiotic resistance of several uropathogens have accelerated the need for new treatment strategies. Here, we...

journal_title：Journal of innate immunity

authors： Patras KA,Ha AD,Rooholfada E,Olson J,Ramachandra Rao SP,Lin AE,Nizet V

更新日期：2019-01-01 00:00:00

abstract：:There is increasing evidence that the immune system is regulated by circadian rhythms. A wide range of immune parameters, such as the number of red blood cells and peripheral blood mononuclear cells as well as the level of critical immune mediators, such as cytokines, undergo daily fluctuations. Current experimental d...

journal_title：Journal of innate immunity

authors： Mavroudis PD,Scheff JD,Calvano SE,Androulakis IP

更新日期：2013-01-01 00:00:00

abstract：:Despite the extensive efforts that have been made to combat acquired immune deficiency syndrome (AIDS), the number of people infected each year with human immunodeficiency virus type 1 (HIV-1) is still increasing worldwide, and a safe and effective vaccine to control HIV infection is urgently needed. Recently, the nat...

journal_title：Journal of innate immunity

authors： Chang MO,Suzuki T,Suzuki H,Takaku H

更新日期：2012-01-01 00:00:00

abstract：:Withdrawal of iron from serum (hypoferraemia) is a conserved innate immune antimicrobial strategy that can withhold this critical nutrient from invading pathogens, impairing their growth. Hepcidin (Hamp1) is the master regulator of iron and its expression is induced by inflammation. Mice lacking Hamp1 from birth rapid...

journal_title：Journal of innate immunity

authors： Armitage AE,Lim PJ,Frost JN,Pasricha SR,Soilleux EJ,Evans E,Morovat A,Santos A,Diaz R,Biggs D,Davies B,Gileadi U,Robbins PA,Lakhal-Littleton S,Drakesmith H

更新日期：2016-01-01 00:00:00

abstract：:Monocytes (Mos) play an important role in the pathogenesis of intestinal mucosal inflammation. This study aims to investigate the mechanism by which the intestinal epithelial cell-derived thrombospondin 1 (TSP1) modulates Mo properties and regulates intestinal inflammatory responses. In this study, the production of T...

journal_title：Journal of innate immunity

authors： Fang LL,Yu HQ,Wu RJ,He C,Li M,Yan H,Li JJ,Wang S,Liu ZG,Liu ZJ,Yang PC

更新日期：2015-01-01 00:00:00

abstract：:Mucosal surfaces line our body cavities and provide the interaction surface between commensal and pathogenic microbiota and the host. The barrier function of the mucosal layer is largely maintained by gel-forming mucin proteins that are secreted by goblet cells. In addition, mucosal epithelial cells express cell-bound...

journal_title：Journal of innate immunity

authors： van Putten JPM,Strijbis K

更新日期：2017-01-01 00:00:00

abstract：:Streptococcus pyogenes is an important human pathogen that causes a variety of diseases including life-threatening invasive diseases, such as toxic shock and deep tissue infections. Although S. pyogenes are classically considered extracellular pathogens, a clinical significance of an intracellular source has been emph...

journal_title：Journal of innate immunity

authors： Hertzén E,Johansson L,Wallin R,Schmidt H,Kroll M,Rehn AP,Kotb M,Mörgelin M,Norrby-Teglund A

更新日期：2010-01-01 00:00:00

abstract：:Activation of complement leads to generation of the 3 anaphylatoxins C3a, C4a, and C5a. Although all 3 peptides are structurally similar, only C3a and C5a share a similar functional profile that includes the classic inflammatory activities and, more recently, developmental homing and regenerative properties among othe...

journal_title：Journal of innate immunity

authors： Barnum SR

更新日期：2015-01-01 00:00:00

abstract：:Listeria monocytogenes is a facultative intracellular pathogen which can infect Drosophila melanogaster. Upon infection, Drosophila mounts an immune response including antimicrobial peptide production and autophagy activation. A set of previously published results prompted us to study the role of the deubiquitinating ...

journal_title：Journal of innate immunity

authors： Taillebourg E,Schneider DS,Fauvarque MO

更新日期：2014-01-01 00:00:00

abstract：:Immunoglobulin A nephropathy (IgAN) is the most common form of glomerulonephritis throughout the world. A majority (approx. 60%) of patients with IgAN experience disease exacerbations associated with an acute respiratory or gastrointestinal illness that appears to represent a viral infection. However, the exact mechan...

journal_title：Journal of innate immunity

authors： Yamashita M,Millward CA,Inoshita H,Saikia P,Chattopadhyay S,Sen GC,Emancipator SN

更新日期：2013-01-01 00:00:00

abstract：:Calcium-independent phospholipase A2 (iPLA2) has been suggested to play an important role in the activation of caspase-1 induced by lipopolysaccharides (LPS). Here, we used pharmacological and genetic approaches to study the role of iPLA 2 in the activation of caspase-1. Bromoenol lactone (BEL), an inhibitor that was ...

journal_title：Journal of innate immunity

authors： Franchi L,Chen G,Marina-Garcia N,Abe A,Qu Y,Bao S,Shayman JA,Turk J,Dubyak GR,Núñez G

更新日期：2009-01-01 00:00:00

abstract：:Human immunodeficiency virus-1 (HIV-1) infection and the acquired immune deficiency syndrome (AIDS) pandemic remain global threats in the absence of a protective or a therapeutic vaccine. HIV-1 replication is reportedly inhibited by some cellular factors, including APOBEC3G (A3G) and APOBEC3F (A3F), which are well kno...

journal_title：Journal of innate immunity

authors： Chang MO,Suzuki T,Yamamoto N,Watanabe M,Takaku H

更新日期：2012-01-01 00:00:00

abstract：:In in vitro experiments, Chlamydia pneumoniae has been shown to infect macrophages and to accelerate foam cell formation. It has been hypothesized that the C. pneumoniae infection affects foam cell formation by suppressing the expression of liver X receptors (LXR), but whether such an event occurs in human atheroscler...

journal_title：Journal of innate immunity

authors： Bobryshev YV,Orekhov AN,Killingsworth MC,Lu J

更新日期：2011-01-01 00:00:00

abstract：:Ficolins are a group of oligomeric lectins with subunits consisting of both collagen-like and fibrinogen-like domains. The majority of ficolins identified in vertebrates and invertebrates to date recognize N-acetylglucosamine (GlcNAc). X-ray crystallographic analysis of human ficolins has shown that the fibrinogen-lik...

journal_title：Journal of innate immunity

authors： Matsushita M

更新日期：2010-01-01 00:00:00

abstract：:The concept that macrophages play an active role in inflammatory responses began its development in the late 1800s with the now iconic studies by Elie Metchnikoff using starfish larvae and Daphnia [reviewed in Kaufmann SHE: Nat Immunol 2008;9:705-712 and Cavaillon JM: J Leukoc Biol 2011;90:413-424]. Based on his obser...

journal_title：Journal of innate immunity

authors： Dasgupta P,Keegan AD

更新日期：2012-01-01 00:00:00

abstract：:NK cells play a central role in innate immunity, acting directly through cell-mediated cytotoxicity and by secreting cytokines. TNFα activation of TNFR2 enhances NK cell cytotoxicity, but its effects on the other essential function of NK cells - cytokine production, for which IFNγ is paramount - are poorly defined. We...

journal_title：Journal of innate immunity

authors： Almishri W,Santodomingo-Garzon T,Le T,Stack D,Mody CH,Swain MG

更新日期：2016-01-01 00:00:00

abstract：:Early interactions between natural killer (NK) and dendritic cells (DC) shape the immune response at the frontier of innate and adaptive immunity. Activated NK cells participate in maturation or deletion of DCs that remain immature. We previously demonstrated that infection with a high virulence (HV) population of the...

journal_title：Journal of innate immunity

authors： Batalla EI,Pino Martínez AM,Poncini CV,Duffy T,Schijman AG,González Cappa SM,Alba Soto CD

更新日期：2013-01-01 00:00:00

abstract：:Hemolytic uremic syndrome (HUS), a vascular disease characterized by hemolytic anemia, thrombocytopenia, and acute renal failure, is caused by enterohemorrhagic Shiga toxin (Stx)-producing bacteria, which mainly affect children. Besides Stx, the inflammatory response mediated by neutrophils (PMN) is essential to HUS e...

journal_title：Journal of innate immunity

authors： Ramos MV,Mejias MP,Sabbione F,Fernandez-Brando RJ,Santiago AP,Amaral MM,Exeni R,Trevani AS,Palermo MS

更新日期：2016-01-01 00:00:00

abstract：:Klebsiella pneumoniae is a common cause of hospital-acquired pneumonia. Granzymes (gzms), mainly found in cytotoxic lymphocytes, have been implicated as mediators of infection and inflammation. We here sought to investigate the role of gzmA and gzmB in the host response to K. pneumoniae-induced airway infection and se...

journal_title：Journal of innate immunity

authors： García-Laorden MI,Stroo I,Blok DC,Florquin S,Medema JP,de Vos AF,van der Poll T

更新日期：2016-01-01 00:00:00

abstract：:We demonstrated recently that Francisella tularensis profoundly impairs human neutrophil apoptosis, but how this is achieved is largely unknown. Herein we used human oligonucleotide microarrays to test the hypothesis that changes in neutrophil gene expression contribute to this phenotype, and now demonstrate that F. t...

journal_title：Journal of innate immunity

authors： Schwartz JT,Bandyopadhyay S,Kobayashi SD,McCracken J,Whitney AR,Deleo FR,Allen LA

更新日期：2013-01-01 00:00:00