The HtrA2 Drosophila model of Parkinson's disease is suppressed by the pro-survival Bcl-2 Buffy.

Abstract:

:Mutations in High temperature requirement A2 (HtrA2), also designated PARK13, which lead to the loss of its protease activity, have been associated with Parkinson's disease (PD). HtrA2 is a mitochondrial protease that translocates to the cytosol upon the initiation of apoptosis where it participates in the abrogation of inhibitors of apoptosis (IAP) inhibition of caspases. Here, we demonstrate that the loss of the HtrA2 function in the dopaminergic neurons of Drosophila melanogaster results in PD-like phenotypes, and we attempt to restore the age-dependent loss in locomotor ability by co-expressing the sole pro-survival Bcl-2 homologue Buffy. The inhibition of HtrA2 in the dopaminergic neurons of Drosophila resulted in shortened lifespan and impaired climbing ability, and the overexpression of Buffy rescued the reduction in lifespan and the age-dependent loss of locomotor ability. In supportive experiments, the inhibition of HtrA2 in the Drosophila eye results in eye defects, marked by reduction in ommatidia number and increased disruption of the ommatidial array; phenotypes that are suppressed by the overexpression of Buffy.

journal_name

Genome

journal_title

Genome

authors

M'Angale PG,Staveley BE

doi

10.1139/gen-2016-0069

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

1-7

issue

1

eissn

0831-2796

issn

1480-3321

journal_volume

60

pub_type

杂志文章

相关文献

GENOME文献大全
  • Genetic diversity within the species Arachis duranensis Krapov. &W.C. Gregory, a possible progenitor of cultivated peanut.

    abstract::Eighteen accessions of a diploid wild peanut species (Arachis duranensis) were analyzed using morphological, intercrossing, cytological, and RFLP data. Abundant variation was found for morphological characters and for RFLP patterns both between and within accessions, and each accession could be uniquely identified by ...

    journal_title:Genome

    pub_type: 杂志文章

    doi:10.1139/g95-158

    authors: Stalker HT,Dhesi JS,Kochert G

    更新日期:1995-12-01 00:00:00

  • Potential of trispecies bridge crosses and random amplified polymorphic DNA markers for introgression of Medicago daghestanica and M. pironae germplasm into alfalfa (M. sativa).

    abstract::This report describes the production and cytology of the first interspecific hybrids between cultivated alfalfa (Medicago sativa L.) at the diploid level (2n = x = 16) and the diploid (2n = 2x = 16) perennial species M. daghestanica and M. pironae. An ovule-embryo culture technique was required to rescue hybrid embryo...

    journal_title:Genome

    pub_type: 杂志文章

    doi:10.1139/g93-080

    authors: McCoy TJ,Echt CS

    更新日期:1993-06-01 00:00:00

  • Genetic diversity analysis in blackgram (Vigna mungo (L.) Hepper) using AFLP and transferable microsatellite markers from azuki bean (Vigna angularis (Willd.) Ohwi & Ohashi).

    abstract::Genetic diversity in 20 elite blackgram (Vigna mungo (L.) Hepper) genotypes was studied using microsatellite and AFLP markers. Thirty-six microsatellite markers from azuki bean (Vigna angularis (Willd.) Ohwi & Ohashi) were successfully amplified across the 20 blackgram genotypes and 33 microsatellite markers showed po...

    journal_title:Genome

    pub_type: 杂志文章

    doi:10.1139/g08-107

    authors: Gupta SK,Gopalakrishna T

    更新日期:2009-02-01 00:00:00

  • Phaseolin nucleotide sequence diversity in Phaseolus. I. Intraspecific diversity in Phaseolus vulgaris.

    abstract::Most information about the molecular biology of phaseolin, the major seed storage protein in Phaseolus vulgaris, has been obtained from the T-type phaseolin, which is characteristic of the Andean gene pool of the species. In the work reported here, two cDNA clones for the S-type phaseolin representing the other major,...

    journal_title:Genome

    pub_type: 杂志文章

    doi:10.1139/g94-107

    authors: Kami JA,Gepts P

    更新日期:1994-10-01 00:00:00

  • Chloroplast microsatellite polymorphisms in Vitis species.

    abstract::The use of consensus chloroplast microsatellites primers for dicotyledonous chloroplast genomes revealed the existence of intra and interspecific length variation within the genus Vitis. Three chloroplast microsatellite loci were found to be polymorphic in samples of Vitis vinifera, Vitis berlandieri, Vitis riparia, a...

    journal_title:Genome

    pub_type: 杂志文章

    doi:10.1139/g02-087

    authors: Arroyo-García R,Lefort F,de Andrés MT,Ibáñaez J,Borrego J,Jouve N,Cabello F,Martínez-Zapater JM

    更新日期:2002-12-01 00:00:00

  • Fast-GBS v2.0: an analysis toolkit for genotyping-by-sequencing data.

    abstract::Genotyping-by-sequencing (GBS) is a rapid, flexible, low-cost, and robust genotyping method that simultaneously discovers variants and calls genotypes within a broad range of samples. These characteristics make GBS an excellent tool for many applications and research questions from conservation biology to functional g...

    journal_title:Genome

    pub_type: 杂志文章

    doi:10.1139/gen-2020-0077

    authors: Torkamaneh D,Laroche J,Belzile F

    更新日期:2020-11-01 00:00:00

  • Reference transcriptome assembly and annotation for perennial ryegrass.

    abstract::RNA-Seq methodology has been used to generate a comprehensive transcriptome sequence resource for perennial ryegrass, an important temperate pasture grass species. A total of 931 547 255 reads were obtained from libraries corresponding to 19 distinct tissue samples, including both vegetative and reproductive stages of...

    journal_title:Genome

    pub_type: 杂志文章

    doi:10.1139/gen-2017-0077

    authors: Shinozuka H,Cogan NOI,Spangenberg GC,Forster JW

    更新日期:2017-12-01 00:00:00

  • Genetic diversity and structure in the northern populations of European hazelnut (Corylus avellana L.).

    abstract::European hazelnut (Corylus avellana L.) is a strictly cross-pollinated diploid tree species, which has its northernmost populations in Fennoscandia, and it was one of the first species to recolonize northern Europe after the last ice age. Hazelnut produces edible nuts in Finland but nowadays they are underutilized as ...

    journal_title:Genome

    pub_type: 杂志文章

    doi:10.1139/gen-2018-0193

    authors: Tanhuanpää P,Heinonen M,Bitz L,Rokka VM

    更新日期:2019-08-01 00:00:00

  • The effect of gamma radiation on recombination frequency in Caenorhabditis elegans.

    abstract::We have studied the effect of gamma radiation on recombination frequency for intervals across the cluster of linkage group I in Caenorhabditis elegans. Recombination frequency increased approximately twofold across the dpy-5-unc-13 interval after treatment with 2000 rads (1 rad = 10 mGy) of cobalt 60 gamma radiation. ...

    journal_title:Genome

    pub_type: 杂志文章

    doi:10.1139/g87-079

    authors: Kim JS,Rose AM

    更新日期:1987-06-01 00:00:00

  • Development of PCR-based SCAR and CAPS markers linked to beta-glucan and protein content QTL regions in oat.

    abstract::A key breeding objective in oat (Avena sativa L.) is cultivars with high and low beta-glucan content. In a targeted strategy to develop PCR-based markers linked to published beta-glucan content quantitative trait loci (QTLs) regions, 15 random amplified polymorphic DNA (RAPD) fragments were cloned and their sequences ...

    journal_title:Genome

    pub_type: 杂志文章

    doi:10.1139/G08-026

    authors: Orr W,Molnar SJ

    更新日期:2008-06-01 00:00:00

  • An RFLP species-specific DNA sequence for the A genome of rice.

    abstract::A DNA sequence, pOs6.20, was cloned from the nuclear genome of cultivated rice (Oryza sativa L.) by hybridization with a human minisatellite sequence. At high hybridization stringency, a subfragment of the rice sequence, pOs6.20.3, detected low-copy restriction fragment length polymorphisms (RFLPs), which behaved as M...

    journal_title:Genome

    pub_type: 杂志文章

    doi:10.1139/g93-061

    authors: Dallas JF,McIntyre CL,Gustafson JP

    更新日期:1993-06-01 00:00:00

  • Genome and transcriptome analysis of the latent pathogen Lasiodiplodia theobromae, an emerging threat to the cacao industry.

    abstract::Lasiodiplodia theobromae (Pat.) Griffon & Maubl., a member of the family Botryosphaeriaceae, is becoming a significant threat to crops and woody plants in many parts of the world, including the major cacao growing areas. While attempting to isolate Ceratobasidium theobromae, a causal agent of vascular streak dieback (...

    journal_title:Genome

    pub_type: 杂志文章

    doi:10.1139/gen-2019-0112

    authors: Ali SS,Asman A,Shao J,Balidion JF,Strem MD,Puig AS,Meinhardt LW,Bailey BA

    更新日期:2020-01-01 00:00:00

  • AFLP targeting of the 1-cM region conferring the vrs1 gene for six-rowed spike in barley, Hordeum vulgare L.

    abstract::Spike morphology is a key characteristic in the study of barley domestication, yield, and use. Multiple alleles at the vrs1 locus control the development and fertility of the lateral spikelets of barley. We developed five amplified fragment length polymorphism (AFLP) markers tightly linked to the vrs1 locus using well...

    journal_title:Genome

    pub_type: 杂志文章

    doi:10.1139/g04-073

    authors: He C,Sayed-Tabatabaei BE,Komatsuda T

    更新日期:2004-12-01 00:00:00

  • Substitution pattern of the CArG element in human and mouse genomes.

    abstract::cis-Elements CArG bound by serum response factor (SRF) are presently being intensively studied, but little is known about the substitution pattern of functional CArG elements. Here, we have performed the first evolutionary analysis of CArGome in the human and mouse genome through bioinformatic methods and statistical ...

    journal_title:Genome

    pub_type: 杂志文章

    doi:10.1139/G10-105

    authors: Shen X,Mao H,Miao S

    更新日期:2011-02-01 00:00:00

  • FISH of a maize sh2-selected sorghum BAC to chromosomes of Sorghum bicolor.

    abstract::Fluorescence in situ hybridization (FISH) of a 205 kb Sorghum bicolor bacterial artificial chromosome (BAC) containing a sequence complementary to maize sh2 cDNA produced a large pair of FISH signals at one end of a midsize metacentric chromosome of S. bicolor. Three pairs of signals were observed in metaphase spreads...

    journal_title:Genome

    pub_type: 杂志文章

    doi:10.1139/g97-063

    authors: Gómez MI,Islam-Faridi MN,Woo SS,Czeschin D Jr,Zwick MS,Stelly DM,Price HJ,Schertz KF,Wing RA

    更新日期:1997-08-01 00:00:00

  • Recombination nodule mapping and chiasma distribution in spermatocytes of the pigeon, Columba livia.

    abstract::Pigeon spermatocytes were processed with a drying-down technique and their synaptonemal complex (SC) complements were analyzed by electron microscopy. The synaptonemal complex karyotype of the macrobivalents shows an excellent correspondence with the mitotic karyotype. The number and distribution of recombination nodu...

    journal_title:Genome

    pub_type: 杂志文章

    doi:10.1139/g98-138

    authors: Pigozzi MI,Solari AJ

    更新日期:1999-04-01 00:00:00

  • QTL mapping of seed-quality traits in sunflower recombinant inbred lines under different water regimes.

    abstract::The objectives of the present research were to determine the effects of water stress on seed-quality traits and to map QTLs controlling the studied traits under two different water treatments in a population of sunflower recombinant inbred lines (RILs). Two experiments were conducted in greenhouse and field conditions...

    journal_title:Genome

    pub_type: 杂志文章

    doi:10.1139/G08-038

    authors: Ebrahimi A,Maury P,Berger M,Kiani SP,Nabipour A,Shariati F,Grieu P,Sarrafi A

    更新日期:2008-08-01 00:00:00

  • Alterations in subtelomeric tandem repeats during early stages of allopolyploidy in wheat.

    abstract::The genomic content of the subtelomeric repeated sequences Spelt1 and Spelt52 was studied by dot, Southern, and in situ hybridization in 11 newly synthesized amphiploids of Aegilops and Triticum, and data were compared with the parental plants. Spelt1 had reduced copy numbers in the first generation of three synthetic...

    journal_title:Genome

    pub_type: 杂志文章

    doi:10.1139/g04-044

    authors: Salina EA,Numerova OM,Ozkan H,Feldman M

    更新日期:2004-10-01 00:00:00

  • Identification of a new class of recombinant prolamin genes in wheat.

    abstract::A novel storage protein gene with obvious [corrected] chimeric structure was isolated from an immature kernel-specific cDNA library prepared from the old Hungarian wheat [corrected] variety, Bánkúti 1201. This clone contains gamma-gliadin sequences in the 5' region and LMW-glutenin sequences on the 3' end. A frameshif...

    journal_title:Genome

    pub_type: 杂志文章

    doi:10.1139/g05-042

    authors: Nagy IJ,Takács I,Juhász A,Tamás L,Bedo Z

    更新日期:2005-10-01 00:00:00

  • Structure of Aegilops ventricosa chromosome 6Nv, the donor of wheat genes Yr17, Lr37, Sr38, and Cre5.

    abstract::An Aegilops ventricosa Tausch (2n = 28, DvDvNvNv) subtelocentric chromosome added to wheat (Triticum aestivum L.) in a disomic addition line was found to carry the genes for resistance Yr17, Lr37, Sr38, and Cre5 already transferred onto chromosome 2AS of the wheat line VPM1. Previous works demonstrated that this Ae. v...

    journal_title:Genome

    pub_type: 杂志文章

    doi:10.1139/g05-001

    authors: Tanguy AM,Coriton O,Abélard P,Dedryver F,Jahier J

    更新日期:2005-06-01 00:00:00

  • Segmental chromosomal duplications harbouring group IV CONSTANS-like genes in cereals.

    abstract::Comparative mapping is an important component of map-based cloning in large-genome cereal species. We describe evidence of a segmental chromosomal duplication harbouring CONSTANS-like genes in barley that predates the divergence of the Oryzoideae (rice) and Pooideae (brachypodium, barley, wheat) clades, and discuss th...

    journal_title:Genome

    pub_type: 杂志文章

    doi:10.1139/g09-101

    authors: Cockram J,Howells RM,O'Sullivan DM

    更新日期:2010-03-01 00:00:00

  • Genome flux in tomato cell clones cultured in vitro in different physiological equilibria. II. A RAPD analysis of variability.

    abstract::An analysis of the effect of changing physiological conditions on genome evolution in tomato cell populations has been carried out on long-term in vitro cultured clones grown on different auxin-cytokinin equilibria or selected for low-high competence for active defense against Fusarium oxysporum f.sp. lycopersici. RAP...

    journal_title:Genome

    pub_type: 杂志文章

    doi:10.1139/g96-107

    authors: Bogani P,Simoni A,Lio' P,Scialpi A,Buiatti M

    更新日期:1996-10-01 00:00:00

  • Genetic diversity of different apricot geographical groups determined by SSR markers.

    abstract::Forty apricot cultivars with different geographic origins belonging to the germplasm collections of St. Istvan University (Budapest, Hungary) and the Instituto Valenciano de Investigaciones Agrarias (IVIA) (Valencia, Spain) were studied by means of SSR markers. The aim of the study was to determine the genetic relatio...

    journal_title:Genome

    pub_type: 杂志文章

    doi:10.1139/g02-128

    authors: Romero C,Pedryc A,Muñoz V,Llácer G,Badenes ML

    更新日期:2003-04-01 00:00:00

  • Post-glacial recolonization of insular Newfoundland across the Strait of Belle Isle gave rise to an endemic subspecies of woodland caribou, Rangifer tarandus terranovae (Bangs, 1896): evidence from mtDNA haplotypes.

    abstract::Post-glacial origins of woodland caribou (Rangifer tarandus subsp.) on the island of Newfoundland and their relationship to mainland populations have been uncertain. Sequence analysis of 2223 bp of the mitochondrial DNA control region and cytochrome b gene from 233 Newfoundland caribou identified 32 haplotypes in four...

    journal_title:Genome

    pub_type: 杂志文章

    doi:10.1139/gen-2017-0199

    authors: Wilkerson CD,Mahoney SP,Carr SM

    更新日期:2018-08-01 00:00:00

  • The mitochondrial genome of Anopheles quadrimaculatus species A: complete nucleotide sequence and gene organization.

    abstract::The complete sequence (15,455 bp) of the mitochondrial DNA of the mosquito Anopheles quadrimaculatus species A is reported. This genome is compact and very A+T rich (77.4% A+T). It contains genes for 2 ribosomal RNAs (rRNAs), 22 transfer RNAs (tRNAs), and 13 subunits of the mitochondrial inner membrane respiratory com...

    journal_title:Genome

    pub_type: 杂志文章

    doi:10.1139/g93-141

    authors: Mitchell SE,Cockburn AF,Seawright JA

    更新日期:1993-12-01 00:00:00

  • Size matters in Triticeae polyploids: larger genomes have higher remodeling.

    abstract::Polyploidization is one of the major driving forces in plant evolution and is extremely relevant to speciation and diversity creation. Polyploidization leads to a myriad of genetic and epigenetic alterations that ultimately generate plants and species with increased genome plasticity. Polyploids are the result of the ...

    journal_title:Genome

    pub_type: 杂志文章,评审

    doi:10.1139/G10-107

    authors: Bento M,Gustafson JP,Viegas W,Silva M

    更新日期:2011-03-01 00:00:00

  • Genetic control of chromosome synapsis in yeast meiosis.

    abstract::Both meiosis-specific and general recombination functions, recruited from the mitotic cell cycle, are required for elevated levels of recombination and for chromosome synapsis (assembly of the synaptonemal complex) during yeast meiosis. The meiosis-specific SPO11 gene (previously shown to be required for meiotic recom...

    journal_title:Genome

    pub_type: 杂志文章

    doi:10.1139/g89-017

    authors: Giroux CN,Dresser ME,Tiano HF

    更新日期:1989-01-01 00:00:00

  • Development of microsatellite markers in Fragaria, their use in genetic diversity analysis, and their potential for genetic linkage mapping.

    abstract::We have developed 21 new microsatellites in the model diploid perennial species Fragaria vesca from an enriched genomic library developed using F. vesca 'Ruegen'. The transferability of the primer pairs to other Fragaria species was high; all 31 primer pairs produced amplicons in 3 accessions of the octoploid strawber...

    journal_title:Genome

    pub_type: 杂志文章

    doi:10.1139/g03-142

    authors: Hadonou AM,Sargent DJ,Wilson F,James CM,Simpson DW

    更新日期:2004-06-01 00:00:00

  • Linkage and mapping analyses of the densonucleosis non-susceptible gene nsd-Z in the silkworm Bombyx mori using SSR markers.

    abstract::In the silkworm Bombyx mori, non-susceptibility to the Zhenjiang (China) strain of the densonucleosis virus (DNV-Z) is controlled by the recessive gene nsd-Z (non-susceptible to DNV-Z), which is located on chromosome 15. Owing to a lack of crossing over in females, reciprocal backcrossed F1 (BC1) progeny were used for...

    journal_title:Genome

    pub_type: 杂志文章

    doi:10.1139/g05-125

    authors: Li M,Guo Q,Hou C,Miao X,Xu A,Guo X,Huang Y

    更新日期:2006-04-01 00:00:00

  • Karyotype variation in the albino rainbow trout (Oncorhynchus mykiss (Walbaum)).

    abstract::A Robertsonian polymorphism resulting in diploid chromosome number ranging from 59 to 61 and constant chromosome arm number (fundamental number = 104) was observed in the albino rainbow trout (Oncorhynchus mykiss (Walbaum)) from the yellow color strain. In one individual, 90 mitotic chromosomes and 156 chromosome arms...

    journal_title:Genome

    pub_type: 杂志文章

    doi:10.1139/g09-009

    authors: Ocalewicz K,Dobosz S

    更新日期:2009-04-01 00:00:00