Actinic reticuloid. A clinical photobiologic, histopathologic, and follow-u study of 16 patients.

Abstract:

:We report a detailed clinical, histopathologic, and photobiologic study of 16 Dutch patients with actinic reticuloid. All were middle-aged or elderly men who had persistent plaques on light-exposed skin only (two patients), extension of lesions to nonexposed areas (four patients), or prolonged or persistent episodes of erythroderma (10 patients). They were sensitive to UVB, UVA, and visible light. In 10 of 13 patients tested, the dermal infiltrate contained predominantly suppressor T cells. Many also had a reversed helper-suppressor T cell ratio. Circulating lymphocytes with deeply indented nuclei were present in all but were most pronounced in the most photosensitive erythrodermic patients. Tolerance induction therapy with UVB irradiation produced an excellent or good response in 13 of 15 patients. One patient responded to cyclosporine therapy.

journal_name

J Am Acad Dermatol

authors

Toonstra J,Henquet CJ,van Weelden H,van der Putte SC,van Vloten WA

subject

Has Abstract

pub_date

1989-08-01 00:00:00

pages

205-14

issue

2 Pt 1

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(89)70162-6

journal_volume

21

pub_type

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