Abstract:
BACKGROUND:Necrolytic migratory erythema (NME) is an uncommon inflammatory dermatosis with a distinct clinical and histologic appearance. NME is usually associated with glucagonoma. Only a few cases of NME in the absence of glucagonoma have been previously reported. OBJECTIVE:We sought to understand further the pathogenesis of NME by analyzing data from three patients. METHODS:Three patients were examined both clinically and histopathologically. RESULTS:Each patient had an extensive erythematous scaling eruption in intertriginous, perioral, and acral areas, and a markedly red, smooth tongue. Skin biopsy specimens showed confluent parakeratosis, epidermal pallor, papillary edema, and a lymphohistiocytic infiltrate. Two patients had alcoholic liver disease and one had liver dysfunction as a result of hemochromatosis. Serum albumin level was depressed, and liver enzyme values were increased in all three patients. Glucagonoma was undetectable in these patients. CONCLUSION:In the absence of glucagonoma, hepatocellular dysfunction and hypoalbuminemia appear to be the most common factors associated with NME.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Marinkovich MP,Botella R,Datloff J,Sangueza OPdoi
10.1016/0190-9622(95)90345-3subject
Has Abstractpub_date
1995-04-01 00:00:00pages
604-9issue
4eissn
0190-9622issn
1097-6787pii
0190-9622(95)90345-3journal_volume
32pub_type
杂志文章abstract::Retinoids, synthetic vitamin A analogs, stimulate mucous metaplasia and gap-junction proliferation in embryonic and neoplastic epidermis. Such effects demonstrate that vitamin A has potent effects on epidermal differentiation. Oddly, however, retinoid action in normal postnatal tissues, where these drugs are used clin...
journal_title:Journal of the American Academy of Dermatology
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更新日期:1986-10-01 00:00:00
abstract::The standard definition of itching (as "an unpleasant sensation that provokes the desire to scratch") takes no account of recent advances in knowledge about itch physiology. Always imprecise, this definition is also out-of-date. Its defects are discussed in this article, and some modifications are proposed. ...
journal_title:Journal of the American Academy of Dermatology
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abstract:BACKGROUND:Hypopigmented macules have been described infrequently as a presenting form of mycosis fungoides (MF). OBJECTIVE:This study was designed to clarify general characteristics of a hypopigmented MF variant. METHODS:Seven new cases were investigated with the use of descriptive epidemiology techniques. Demograph...
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journal_title:Journal of the American Academy of Dermatology
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更新日期:2005-07-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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更新日期:2008-05-01 00:00:00
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更新日期:2019-11-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
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更新日期:1998-03-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,meta分析,评审
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更新日期:2017-07-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
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更新日期:2003-06-01 00:00:00