B-RAF and melanocytic neoplasia.

abstract：:Clofazimine has been in clinical use for almost 40 years, but little is known of its mechanism of action. The primary indication for clofazimine is multibacillary leprosy, but it is useful in several infectious and noninfectious diseases, such as typical myocobacterial infections, rhinoscleroma, pyoderma gangrenosum, ...

journal_title：Journal of the American Academy of Dermatology

authors： Arbiser JL,Moschella SL

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:Patients with cutaneous melanoma metastases have experienced excellent responses to intralesional interleukin (IL)-2. This has led to its recent inclusion into the US National Comprehensive Cancer Network guidelines for management of cutaneous melanoma metastases. Despite this, intralesional IL-2 has not bee...

journal_title：Journal of the American Academy of Dermatology

authors： Shi VY,Tran K,Patel F,Leventhal J,Konia T,Fung MA,Wilken R,Garcia MS,Fitzmaurice SD,Joo J,Monjazeb AM,Burrall BA,King B,Martinez S,Christensen SD,Maverakis E

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Previous studies have indicated that cutaneous bacteria, particularly coagulase-negative staphylococci, play a role in the pathogenesis of miliaria. An accumulation of periodic acid-Schiff (PAS)-positive material has been described as blocking the sweat duct in miliaria. Furthermore, a PAS-positive extracell...

journal_title：Journal of the American Academy of Dermatology

authors： Mowad CM,McGinley KJ,Foglia A,Leyden JJ

更新日期：1995-11-01 00:00:00

abstract：:Retiform hemangioendothelioma is a rare low-grade angiosarcoma of the skin. It shares some clinical characteristics with Kaposi's sarcoma, a tumor with known human herpesvirus 8 (HHV-8) association. We report a case of retiform hemangioendothelioma in which we detected HHV-8 DNA sequences. ...

journal_title：Journal of the American Academy of Dermatology

authors： Schommer M,Herbst RA,Brodersen JP,Kiehl P,Katenkamp D,Kapp A,Weiss J

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:Physicians are important in the early detection of melanoma. We investigated whether primary care physician supply and the supply of dermatologists were related to stage at diagnosis for malignant melanoma. METHODS:From the state tumor registry in Florida in 1994, we identified incident cases of malignant m...

journal_title：Journal of the American Academy of Dermatology

authors： Roetzheim RG,Pal N,van Durme DJ,Wathington D,Ferrante JM,Gonzalez EC,Krischer JP

更新日期：2000-08-01 00:00:00

abstract：:UVB irradiation is known to produce DNA damage at mutation hotspots in the p53 tumor suppressor gene, leading to the development of skin cancers. Mutations in the PTCH tumor suppressor gene, which is known to be responsible for the development of nevoid basal cell carcinoma syndrome, have also been identified in spora...

journal_title：Journal of the American Academy of Dermatology

authors： Ratner D,Peacocke M,Zhang H,Ping XL,Tsou HC

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:Desonide, a class 6 nonfluorinated topical corticosteroid, has been available for more than two decades. Hydrocortisone is widely used in the treatment of dermatoses in children. OBJECTIVE:Our purpose was to compare the safety and efficacy of desonide ointment and 1.0% hydrocortisone ointment in children wi...

journal_title：Journal of the American Academy of Dermatology

authors： Jorizzo J,Levy M,Lucky A,Shavin J,Goldberg G,Dunlap F,Hinds A,Strelka L,Baker M,Tuley M

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:Small open studies of patients at high risk for squamous cell carcinoma (SCC) of the skin suggest that oral retinoid use reduces the risk of these tumors. Among patients at lower risk, randomized trials of low doses of retinoids did not demonstrate significant chemopreventive effects. Patients with psoriasis...

journal_title：Journal of the American Academy of Dermatology

authors： Nijsten TE,Stern RS

更新日期：2003-10-01 00:00:00

abstract：:A large variety of underlying conditions and diseases have been associated with zygomycosis. The most common ones include leukemia or lymphoma, burns, renal failure, septicemia, malnutrition, diabetes, cancer, chemotherapy, organ transplantation, and corticosteroid administration. While being ubiquitous in the environ...

journal_title：Journal of the American Academy of Dermatology

authors： Bateman CP,Umland ET,Becker LE

更新日期：1983-06-01 00:00:00

abstract：:The use of fingerprints for personal identification became widespread early in this century. How the fingerprints slowly became standardized involves many persons, including Nathaniel Grew, Johannes Purkinje, William Herschel, Henry Faulds, Charles Darwin, Francis Galton, Mark Twain, Juan Vucetich, Edward Henry, and J...

journal_title：Journal of the American Academy of Dermatology

authors： Caplan RM

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:Bath-PUVA is used to treat a variety of dermatoses. However, the kinetics of 8-methoxypsoralen during treatment are not completely clarified. OBJECTIVE:The purpose of this study was to investigate the intensity of the phototoxic response and the persistence of phototoxicity after bath-PUVA. METHODS:Twelve ...

journal_title：Journal of the American Academy of Dermatology

authors： Gruss C,Behrens S,Reuther T,Husebo L,Neumann N,Altmeyer P,Lehmann P,Kerscher M

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Junctional nevi are traditionally associated with children and younger patients. We noticed that these lesions are also often found in elderly patients. OBJECTIVE:We sought to determine if junctional nevi are found in all age groups. METHODS:All biopsy reports for junctional nevi for the year 2001 at the P...

journal_title：Journal of the American Academy of Dermatology

authors： Westhafer J,Gildea J,Klepeiss S,Clarke L,Helm K

更新日期：2007-05-01 00:00:00

abstract：:Significant progress has been made in skin replacement options in the past several decades. Although initially various materials have been used mainly for burn coverage, their application to dermatologic practice has increased significantly. We review the research, progress, and other aspects of wound coverage with sy...

journal_title：Journal of the American Academy of Dermatology

authors： Límová M,Grekin RC

更新日期：1990-10-01 00:00:00

abstract：:Acrokeratoelastoidosis is a genodermatosis characterized by firm papules or plaques on the sides of the hands and feet. Although poorly understood, the lesions may result from an abnormality in the secretion or excretion of elastic material by fibroblasts in the dermis. In this report, we will present a patient with t...

journal_title：Journal of the American Academy of Dermatology

authors： Bogle MA,Hwang LY,Tschen JA

更新日期：2002-09-01 00:00:00

abstract：:The incidence of malignant melanoma is increasing faster than that of any other cancer. It is important to identify subsets of the population at high risk of its development so that they can be observed more closely to identify early melanomas when they are curable. It has been reported worldwide that persons with the...

journal_title：Journal of the American Academy of Dermatology

authors： Slade J,Marghoob AA,Salopek TG,Rigel DS,Kopf AW,Bart RS

更新日期：1995-03-01 00:00:00

abstract：:To determine whether systemic hydrocortisone can elicit allergic skin reactions in patients with contact hypersensitivity to hydrocortisone, we studied four patients with contact hypersensitivity to hydrocortisone and hydrocortisone-17-butyrate and two patients with contact hypersensitivity to hydrocortisone-17-butyra...

journal_title：Journal of the American Academy of Dermatology

authors： Lauerma AI,Reitamo S,Maibach HI

更新日期：1991-02-01 00:00:00

abstract：:The occurrence of Langerhans cell histiocytosis (LCH) and malignancy in the same patient is rare. When LCH occurs concomitantly with acute leukemia, distinct temporal patterns often exist; acute myelogenous leukemia (AML) typically succeeds LCH, whereas acute lymphocytic leukemia (ALL) usually precedes it. We report a...

journal_title：Journal of the American Academy of Dermatology

authors： Chiles LR,Christian MM,McCoy DK,Hawkins HK,Yen AH,Raimer SS

更新日期：2001-12-01 00:00:00

abstract：:We describe a 21-year-old male patient with linear extragenital lichen sclerosus. The lesions are confined to the left side of his body and consist of 3 long bands running along the left leg and several patchy and linear lesions on the left side of his trunk. An associated finding is a smaller diameter of the distal p...

journal_title：Journal of the American Academy of Dermatology

authors： Pavlović MD

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Topical antibiotics are not indicated for routine postoperative care in clean dermatologic procedures, but may be widely used. OBJECTIVE:We sought to describe topical antibiotic use in clean dermatologic surgical procedures in the United States. METHODS:The 1993 to 2007 National Ambulatory Medical Care Sur...

journal_title：Journal of the American Academy of Dermatology

authors： Levender MM,Davis SA,Kwatra SG,Williford PM,Feldman SR

更新日期：2012-03-01 00:00:00

abstract：:The role of estrogens in the development of skin cancer is controversial. Sex steroids have a profound effect on the epidermis and epidermal appendages. Estradiol in pharmacologic doses has been reported to stimulate basal cell carcinoma in an animal model. Sex hormones act by means of a specific protein receptor. In ...

journal_title：Journal of the American Academy of Dermatology

authors： Rogers GS,Flowers JL,Pollack SV,McCarty KS Jr

更新日期：1988-05-01 00:00:00

abstract：:Removal of Norplant contraceptive implants may be rendered difficult by the size of the capsules and variations in insertion technique. In the standard removal technique, a single transverse incision is made close to and below the distal ends of the capsules, and a mosquito forceps is used for extraction. Described,...

journal_title：Journal of the American Academy of Dermatology

authors： Lam M,Tope WD

更新日期：1997-11-01 00:00:00

abstract：:We report the coexistence of pemphigus vulgaris and Paget's disease of the nipple in a patient with a documented history of pemphigus and a 2-year complaint of an eczematous breast lesion. A biopsy taken from the lesion showed the characteristic histologic features of both pemphigus and Paget's disease of the nipple. ...

journal_title：Journal of the American Academy of Dermatology

authors： Rae V,Gould E,Ibe MJ,Penneys NS

更新日期：1987-01-01 00:00:00

abstract：:Molecular and cellular understanding of psoriasis pathogenesis has evolved considerably over the last 30 years beginning in the early 1980s when psoriasis was thought to be a skin disease driven by keratinocyte hyperproliferation. During the next 20 years, the role of the immune system and T-helper (Th) cells in psori...

journal_title：Journal of the American Academy of Dermatology

authors： Lynde CW,Poulin Y,Vender R,Bourcier M,Khalil S

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Needle puncture and infiltrational anesthesia is generally required for minor cutaneous surgical procedures and may be associated with anxiety, fear, discomfort, and pain. The use of topical anesthetics such as eutectic lidocaine/prilocaine 5% cream may provide an alternative means of delivering anesthesia. ...

journal_title：Journal of the American Academy of Dermatology

authors： Gupta AK,Sibbald RG

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Amelanotic acral melanoma (AAM) is very rare and difficult to diagnose both clinically and pathologically. Complete-type AAM shows no black to brown pigmentation in the lesion, whereas incomplete-type AAM shows focal or subtle pigmentation. AAM has been the subject of few investigations. OBJECTIVES:We analy...

journal_title：Journal of the American Academy of Dermatology

authors： Choi YD,Chun SM,Jin SA,Lee JB,Yun SJ

更新日期：2013-11-01 00:00:00

abstract：:Pyoderma gangrenosum is a neutrophilic dermatosis that may be associated with myeloid malignancies. Less information is available about the association of pyoderma gangrenosum with lymphoid malignancies. We present, to our knowledge, the first case of pyoderma gangrenosum associated with biphenotypic acute leukemia wh...

journal_title：Journal of the American Academy of Dermatology

authors： Asai M,Aragane Y,Kawada A,Shimada T,Kanamaru A,Yamada H,Tezukam T

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Acne is a multifactorial disease in which androgens appear to play an important role. A low-dose oral contraceptive containing 20 microg of ethinyl estradiol and 100 microg of levonorgestrel (EE/LNG) has been shown to improve biochemical markers of androgenicity. Lowering bioavailable androgens may improve a...

journal_title：Journal of the American Academy of Dermatology

authors： Leyden J,Shalita A,Hordinsky M,Swinyer L,Stanczyk FZ,Weber ME

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:The association of nonparaneoplastic pemphigus with comorbid hematologic malignancies has yet to be established. OBJECTIVE:To estimate the association between pemphigus and the common types of hematologic malignancies. METHODS:A cross-sectional study was conducted comparing pemphigus patients with age-, se...

journal_title：Journal of the American Academy of Dermatology

authors： Kridin K,Zelber-Sagi S,Comaneshter D,Batat E,Cohen AD

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Cutaneous leishmaniasis (CL) is caused by different species of Leishmania and transmitted by the bite of infected sand flies. It is a health problem in many countries. OBJECTIVE:This study was performed to assess the evidence for the efficacy of different therapeutic modalities for acute Old World CL, which...

journal_title：Journal of the American Academy of Dermatology

authors： Khatami A,Firooz A,Gorouhi F,Dowlati Y

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Clinical and histopathologic assessment of pigmented skin lesions remains challenging even for experts. Differentiated and accurate noninvasive diagnostic modalities are highly desirable. OBJECTIVE:We sought to provide clinicians with such a tool. METHODS:A 2-gene classification method based on LINC00518 a...

journal_title：Journal of the American Academy of Dermatology

authors： Gerami P,Yao Z,Polsky D,Jansen B,Busam K,Ho J,Martini M,Ferris LK

更新日期：2017-01-01 00:00:00