Abstract:
:To determine whether systemic hydrocortisone can elicit allergic skin reactions in patients with contact hypersensitivity to hydrocortisone, we studied four patients with contact hypersensitivity to hydrocortisone and hydrocortisone-17-butyrate and two patients with contact hypersensitivity to hydrocortisone-17-butyrate but not to hydrocortisone. Open oral provocation with 100 or 250 mg hydrocortisone in patients with hydrocortisone contact hypersensitivity elicited cutaneous reactions at sites of previous allergic dermatitis caused by hydrocortisone in two patients and at sites of earlier allergic patch test reactions caused by hydrocortisone in the other two patients. Provocations in two patients with contact hypersensitivity to hydrocortisone-17-butyrate but not to hydrocortisone remained negative. To determine whether the adrenal cortical hormone cortisol, which is identical to hydrocortisone, could induce similar skin reactions, one patient with hydrocortisone contact hypersensitivity underwent adrenocorticotropic hormone stimulation tests; as a control, one hydrocortisone-sensitive patient underwent analogous provocations with placebo. After an 8-hour infusion with the adrenocorticotropic hormone analog tetracosactide, a similar skin reaction to that seen with oral hydrocortisone was observed, whereas provocations with placebo remained negative. We conclude that both oral hydrocortisone and intrinsic cortisol are able to induce allergic skin reactions in presensitized subjects.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Lauerma AI,Reitamo S,Maibach HIdoi
10.1016/0190-9622(91)70024-vsubject
Has Abstractpub_date
1991-02-01 00:00:00pages
182-5issue
2 Pt 1eissn
0190-9622issn
1097-6787pii
0190-9622(91)70024-Vjournal_volume
24pub_type
杂志文章abstract:BACKGROUND:In several studies, delays in malignant melanoma (MM) diagnosis have been correlated with increased tumor thickness, increased morbidity, and increased mortality. OBJECTIVE:We sought to assess how MM is detected in British Columbia, Canada, and to understand the role of patient education and other factors o...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2004.04.031
更新日期:2005-01-01 00:00:00
abstract::A tumor is reported that had remarkable pathologic changes showing with light microscopy a pattern in some portions consistent with tubular apocrine adenoma, while other areas were suggestive of syringoid eccrine carcinoma. Perineural invasion, commonly seen in syringoid eccrine carcinoma and never before reported in ...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(84)70221-0
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abstract::A 2 1/2-year-old white girl with citrullinemia accompanied by neurologic symptoms presented with 2- to 3-week loss of scalp hair. Examination of the scalp revealed 90% of the hairs to be broken off, leaving a stubble of hairs less than 1 mm in length. Microscopically, plucked hairs demonstrated flattening, twisting th...
journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
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更新日期:1988-10-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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更新日期:1983-03-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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doi:
更新日期:1997-08-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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doi:10.1016/s0190-9622(87)70216-3
更新日期:1987-08-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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更新日期:2009-12-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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更新日期:1992-02-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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更新日期:2017-08-01 00:00:00