Abstract：
BACKGROUND:Small open studies of patients at high risk for squamous cell carcinoma (SCC) of the skin suggest that oral retinoid use reduces the risk of these tumors. Among patients at lower risk, randomized trials of low doses of retinoids did not demonstrate significant chemopreventive effects. Patients with psoriasis treated with oral psoralen-UVA have a high risk of SCC development. Oral retinoids are used to treat psoriasis. We performed a nested cohort study to assess whether oral retinoids reduce skin cancer risk among patients with psoriasis exposed to psoralen-UVA. METHODS:From 1985 to 2000, 135 patients (11.3% of surviving patients in our cohort) used retinoids for at least 26 weeks in 1 year or more. For these 135 patients, we compared each person's SCC and basal cell carcinoma incidence during years of substantial oral retinoid use and other years. We used Poisson regression models to adjust for potential confounders. RESULTS:In a paired analysis, which compared each patient's own tumor experience while using and not using retinoids, retinoid use was associated with a 30% reduction in SCC incidence (196 SCCs/1000 and 302 SCCs/1000 years of use and no use, respectively; P =.002). After adjusting for other factors associated with SCC risk, the incidence of SCC was significantly decreased during years of substantial retinoid use (incidence rate ratio = 0.79; 95% confidence interval = 0.65, 0.95). Oral retinoid use and basal cell carcinoma incidence were not significantly associated. CONCLUSION:In patients with psoriasis treated with psoralen-UVA, systemic retinoid use reduced SCC risk but did not significantly alter basal cell carcinoma incidence.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Nijsten TE,Stern RSdoi
10.1067/s0190-9622(03)01587-1subject
Has Abstractpub_date
2003-10-01 00:00:00pages
644-50issue
4eissn
0190-9622issn
1097-6787pii
S0190962203015871journal_volume
49pub_type
杂志文章abstract：BACKGROUND:Biologic agents may predispose patients to skin and soft tissue infections (SSTIs). Guidelines recommend discontinuing the agent pre-operatively; the true risk of infection is unclear. OBJECTIVES:To assess the incidence of SSTIs in patients on biologic agents for all clinical indications. A secondary aim is...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
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abstract：:Cannabis arteritis is a serious peripheral vascular disease affecting young adults consuming cannabis. An increasing number of cases have been recently reported in Europe. The risk of amputation is high. Cannabis arteritis is often confused with atherosclerosis. We present a new case in which complete arterial revascu...
journal_title：Journal of the American Academy of Dermatology
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doi：10.1016/j.jaad.2007.04.024
更新日期：2008-05-01 00:00:00
abstract：:Both etretinate and its principal metabolite, acitretin, are efficacious in the treatment of psoriasis. Because patients with severe psoriasis often require chronic therapy, this study was undertaken to determine the efficacy, tolerability, and safety of acitretin in patients on continuous treatment for 12 months. The...
journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/0190-9622(91)70091-f
更新日期：1991-04-01 00:00:00
abstract：BACKGROUND:We have used a schedule for soft x-ray therapy of epithelial malignancies that takes into account the clinically diagnosed tumor involution under treatment. OBJECTIVE:We sought to evaluate the effectiveness of this schedule in terms of cure rate and late ulcerations. METHODS:Patients with 1267 consecutivel...
journal_title：Journal of the American Academy of Dermatology
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doi：10.1016/j.jaad.2005.07.045
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2006.04.035
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abstract：BACKGROUND:Methotrexate has been used both as monotherapy and as an adjunct to corticosteroids in the treatment of alopecia areata (AA), though there exists a paucity of definitive evidence and guidelines in this setting. OBJECTIVES:To 1) determine the efficacy and risks associated with methotrexate therapy for AA, 2)...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,meta分析
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abstract：:Angiolymphoid hyperplasia with eosinophilia developed in a 13-year-old boy. The immune phenotype of infiltrating cells and the distribution of adhesion molecules of the integrin, immunoglobulin, and selectin families were analyzed with monoclonal antibodies. The infiltrate consisted mainly of helper lymphocytes, monoc...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
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abstract：BACKGROUND:The histopathological and clinical overlapping features between condyloma acuminata and bowenoid papulosis can present a diagnostic challenge and we sought to determine if immunochemistry can be helpful in this setting. OBJECTIVE:In this study, we evaluate the specificity and sensitivity of p16 immunohistoc...
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/s0190-9622(96)90730-6
更新日期：1996-11-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2009.01.038
更新日期：2009-08-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1067/mjd.2002.105475
更新日期：2002-02-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
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更新日期：2006-12-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
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更新日期：2014-12-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(98)70076-3
更新日期：1998-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.jaad.2020.07.084
更新日期：2020-07-27 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
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更新日期：2012-06-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
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更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:Methyldibromoglutaronitrile (MDGN) is a component of Euxyl K400, a preservative used in many skin care products in Europe. MDGN has been used in skin care products in the United States for the last 5 years. Contact allergy from MDGN has been reported from Europe. OBJECTIVE:The purpose of this study was to d...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(98)70589-4
更新日期：1998-06-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/0190-9622(93)70079-9
更新日期：1993-04-01 00:00:00
abstract：:Thimerosal, a mercuric derivative of thiosalicylic acid, is a preservative used in several types of consumer products, including cosmetics, ophthalmic and otolaryngologic medications, and vaccines. As a result of allergic reactions and environmental concerns, its use has declined significantly during the past 2 decade...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1067/mjd.2001.113473
更新日期：2001-07-01 00:00:00
abstract：BACKGROUND:Although cutaneous Crohn's disease is well recognized in adults, in children it is extremely rare. OBJECTIVE:Our purpose was to describe five children with cutaneous Crohn's disease and to review the literature. METHODS:The medical records of five children with cutaneous Crohn's disease were retrospectivel...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
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更新日期：1997-05-01 00:00:00
abstract：:Pyoderma gangrenosum, severe acne, and suppurative hidradenitis (PASH) syndrome can prove refractory to treatment and is characterized by relapses and recurrences. The combination of antibiotic therapy and surgery can produce success in the management of the syndrome. Acute treatment is required, but maintenance thera...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2015.07.040
更新日期：2015-11-01 00:00:00
