Kinetics of photosensitivity in bath-PUVA photochemotherapy.

Abstract:

BACKGROUND:Bath-PUVA is used to treat a variety of dermatoses. However, the kinetics of 8-methoxypsoralen during treatment are not completely clarified. OBJECTIVE:The purpose of this study was to investigate the intensity of the phototoxic response and the persistence of phototoxicity after bath-PUVA. METHODS:Twelve volunteers were exposed to UVA doses ranging from 0.5 to 40 J/cm2 from 10 to 240 minutes after bath-PUVA treatment. The resulting phototoxic response of the skin was determined. RESULTS:Irradiation 10 minutes after the psoralen bath led to the lowest assessed minimal phototoxic dose (MPD) of 1.42 J/cm2 (mean, SD +/- 0.29). Thereafter, the MPD increased significantly and sharply every hour. At 4 hours after the psoralen bath, UVA doses up to 40 J/cm2 failed to induce any phototoxic erythema (MPD). CONCLUSION:For optimal effects, UVA irradiation has to be administered immediately after the psoralen bath; no restrictive behavior is necessary after bath-PUVA treatment.

journal_name

J Am Acad Dermatol

authors

Gruss C,Behrens S,Reuther T,Husebo L,Neumann N,Altmeyer P,Lehmann P,Kerscher M

doi

10.1016/s0190-9622(98)70322-6

subject

Has Abstract

pub_date

1998-09-01 00:00:00

pages

443-6

issue

3

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(98)70322-6

journal_volume

39

pub_type

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