Abstract:
BACKGROUND:Bath-PUVA is used to treat a variety of dermatoses. However, the kinetics of 8-methoxypsoralen during treatment are not completely clarified. OBJECTIVE:The purpose of this study was to investigate the intensity of the phototoxic response and the persistence of phototoxicity after bath-PUVA. METHODS:Twelve volunteers were exposed to UVA doses ranging from 0.5 to 40 J/cm2 from 10 to 240 minutes after bath-PUVA treatment. The resulting phototoxic response of the skin was determined. RESULTS:Irradiation 10 minutes after the psoralen bath led to the lowest assessed minimal phototoxic dose (MPD) of 1.42 J/cm2 (mean, SD +/- 0.29). Thereafter, the MPD increased significantly and sharply every hour. At 4 hours after the psoralen bath, UVA doses up to 40 J/cm2 failed to induce any phototoxic erythema (MPD). CONCLUSION:For optimal effects, UVA irradiation has to be administered immediately after the psoralen bath; no restrictive behavior is necessary after bath-PUVA treatment.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Gruss C,Behrens S,Reuther T,Husebo L,Neumann N,Altmeyer P,Lehmann P,Kerscher Mdoi
10.1016/s0190-9622(98)70322-6subject
Has Abstractpub_date
1998-09-01 00:00:00pages
443-6issue
3eissn
0190-9622issn
1097-6787pii
S0190-9622(98)70322-6journal_volume
39pub_type
杂志文章abstract:BACKGROUND:Glomangiomas are benign tumors arising from neuromyoarterial cells surrounding cutaneous arteriovenous anastomoses that serve as temperature regulators. They exist as solitary or multiple types, occurring sporadically or in a familial pattern, the latter of which is rare. OBJECTIVE:We describe a 4-generatio...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:The dysplastic melanocytic nevus (DMN) is a putative precursor for malignant melanoma in persons with a family history of melanoma and multiple large atypical moles. Furthermore, the concept that DMN confers increased risk for melanoma has been extended to those without a family history of melanoma. Some inv...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/0190-9622(93)70221-e
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:Novel picosecond lasers have been available for various pigmentary disorders. However, there are limited data directly comparing picosecond lasers and Q-switched lasers for treatment of nevus of Ota. OBJECTIVE:To compare the efficacy and safety of a picosecond alexandrite laser (PSAL) with a Q-switched alex...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2019.03.016
更新日期:2020-08-01 00:00:00
abstract::Sexually transmitted diseases are a persistent problem in the United States and throughout the world. Many of these infections involve the skin and may be encountered in the field of dermatology. This 3-part review highlights the cutaneous features, diagnosis, and treatment of 11 of the most commonly encountered sexua...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:
更新日期:1999-10-01 00:00:00
abstract::Mycobacterium avium complex, a common opportunistic pathogen among patients with AIDS, usually manifests as disseminated disease involving the lung, lymph nodes, and gastrointestinal tract. Primary cutaneous infections with M avium complex are extremely rare, and most cutaneous lesions are caused by dissemination. Cut...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1067/mjd.2002.108486
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:Current treatments for vitiligo, a common pigmentary disorder affecting around 1% of the world's population, are largely unsatisfactory. OBJECTIVE:We sought to report a Cochrane review of all interventions for the treatment of vitiligo. METHODS:We systematically searched a range of databases for randomized...
journal_title:Journal of the American Academy of Dermatology
pub_type: 社论,评审
doi:10.1016/j.jaad.2008.06.023
更新日期:2008-10-01 00:00:00
abstract::Kathon CG, a cosmetics preservative containing, as active ingredients, 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one, appears to be a frequent cause of contact dermatitis in Europe. In the United States, where Kathon CG was introduced some 5 years later, the use of this preservative system f...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1016/s0190-9622(88)70051-1
更新日期:1988-02-01 00:00:00
abstract::A man with phenylketonuria who was reported to have lichen sclerosus et atrophicus at age 16 years presented to our institution 35 years later with large confluent areas of atrophy. Although sclerodermatous changes have been described in children with phenylketonuria, this case offers a longitudinal view of the progre...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1067/mjd.2003.261
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:Annular lichen planus (ALP) is a long-recognized clinical variant of lichen planus, but is often considered uncommon in occurrence. The typical distribution and presentation of this variant have not been well described. OBJECTIVE:We sought to better define the sites affected and clinical characteristics of ...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2003.08.011
更新日期:2004-04-01 00:00:00
abstract::A 46-year-old albino woman is described with a melanoma on the leg from which a punch biopsy specimen was inadvertently taken. In the reexcision specimen, two biopsy wounds were recognized that were filled with tumor. The initial level III lesion had to be subsequently reported as a deep level IV amelanotic melanoma w...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(85)70238-1
更新日期:1985-11-01 00:00:00
abstract:BACKGROUND:Few data exist on the relationship between psoriasis and melanocytic lesions. OBJECTIVES:We sought to investigate number of melanocytic nevi in psoriatic patients compared with control subjects and its relationship with disease severity and treatment. METHODS:We performed a prospective study in 189 psoriat...
journal_title:Journal of the American Academy of Dermatology
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doi:10.1016/j.jaad.2013.08.017
更新日期:2013-12-01 00:00:00
abstract::The use of fingerprints for personal identification became widespread early in this century. How the fingerprints slowly became standardized involves many persons, including Nathaniel Grew, Johannes Purkinje, William Herschel, Henry Faulds, Charles Darwin, Francis Galton, Mark Twain, Juan Vucetich, Edward Henry, and J...
journal_title:Journal of the American Academy of Dermatology
pub_type: 传,历史文章,杂志文章
doi:10.1016/0190-9622(90)70194-m
更新日期:1990-07-01 00:00:00
abstract::This report relates how a normal variation of the eccrine secretory coil was mistaken for pathologic change. Electron microscopic studies of this variation, which to the best of our knowledge have not previously been reported, are presented. ...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(85)70193-4
更新日期:1985-09-01 00:00:00
abstract:BACKGROUND:Digital dermoscopic image analysis of pigmented skin lesions (PSLs) has become increasingly popular, despite its unclear clinical utility. Unbiased, high-powered studies investigating the efficacy of commercially available systems are limited. OBJECTIVE:To investigate the diagnostic performance of the FotoF...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2017.01.049
更新日期:2018-05-01 00:00:00
abstract::The retinoids have been investigated extensively as chemopreventive and therapeutic agents in a variety of neoplasms. They have been shown to inhibit the proliferation of transformed cell lines in vitro and transplanted tumors in vivo. In cultured murine melanoma cells, retinoids inhibit proliferation and induce diffe...
journal_title:Journal of the American Academy of Dermatology
pub_type: 临床试验,杂志文章
doi:10.1016/s0190-9622(86)70239-9
更新日期:1986-10-01 00:00:00
abstract::In two double-blind, parallel-group, multicenter trials, 0.05% halobetasol propionate cream was compared with 0.05% clobetasol 17-propionate cream and 0.05% betamethasone dipropionate cream in 264 patients with acute, severe exacerbations of atopic dermatitis. The efficacy of halobetasol propionate cream and betametha...
journal_title:Journal of the American Academy of Dermatology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/0190-9622(91)70318-v
更新日期:1991-12-01 00:00:00
abstract:BACKGROUND:B-cell chronic lymphocytic leukemia (B-CLL) is a low-grade lymphoproliferative disorder with characteristic histomorphologic features and an identifiable immunophenotype. The skin can be involved in the context of known disease, but cutaneous signs are rarely the presenting findings. OBJECTIVE:Evaluation of...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2008.12.047
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Ultraviolet B phototherapy is underused because of costs and inconvenience. Home phototherapy may alleviate these issues, but training is spotty, and many physicians are not comfortable prescribing home phototherapy. OBJECTIVE:The purpose of this review is to provide a practical guide for recognizing approp...
journal_title:Journal of the American Academy of Dermatology
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更新日期:2015-05-01 00:00:00
abstract::A patient is described who developed sore throat, palpable purpura, and a distinctive panniculitis. The pathologic alterations in the subcutis were similar to what Wells described in the dermis as eosinophilic cellulitis. In our experience the presence of such a picture primarily in the subcutis is unique. Streptococc...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(85)80007-4
更新日期:1985-01-01 00:00:00
abstract::We used an avidin-biotin complex immunoperoxidase technique with various monoclonal antibodies to determine Langerhans cell densities, class II antigen expression on keratinocytes, and phenotypes of other infiltrating cells in several malignant and benign epithelial tumors of the skin. Our observations indicate (1) th...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(89)70125-0
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND:Rosacea is a chronic inflammatory skin disease. Inflammation plays a prominent role in atherosclerosis and its complications. OBJECTIVE:We sought to investigate the associations of rosacea with cardiovascular disease risk factors and cardiovascular diseases from a nationwide population-based database. METH...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2015.04.028
更新日期:2015-08-01 00:00:00
abstract::Lupus erythematosus (LE) is a multisystem disease. Genetic predisposition, altered immunity, hormones, drugs, viruses, and ultraviolet light all may play a role in etiology. A wide range of cutaneous lesions occur, and variants such as subacute cutaneous LE, complement-deficient LE, and neonatal LE have recently been ...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1016/s0190-9622(81)70016-1
更新日期:1981-02-01 00:00:00
abstract::We report the case of a congenitally deaf white male with mild palmoplantar keratoderma, ichthyosiform scaling, follicular hyperkeratosis, and mild keratitis, features consistent with keratitis-ichthyosis-deafness syndrome. His major problem was severe, disfiguring, inflammatory dissecting folliculitis of the scalp, h...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2003.12.042
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:Some studies have shown that switching patients from one tumor necrosis factor (TNF)-alfa inhibitor to another may be beneficial when they have an inadequate response or an adverse event. OBJECTIVE:We sought to assess the variables predicting the efficacy of the second TNF-alfa inhibitor in patients discont...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2013.10.019
更新日期:2014-02-01 00:00:00
abstract::Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin disease of unknown origin that is characterized clinically by annular patches with erythematous borders and hypopigmented centers and histologically by loss of elastic fibers and elastophagocytosis. We report a case of AEGCG in an 8-month-ol...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2005.02.013
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND:Recent developments in molecular genetics may lead to re-examination of the histopathology of inherited palmoplantar keratodermas (PPKs) based on more precise groupings of the various entities and syndromes. OBJECTIVE:We sought to characterize the histopathological findings in PPKs associated with mutations...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2009.05.016
更新日期:2010-01-01 00:00:00
abstract::Palpable purpura in a follicular localization developed in association with acute epididymitis in a white man who was seropositive for the human immunodeficiency virus (HIV). Biopsy specimens revealed a leukocytoclastic vasculitis with follicular accentuation. With antibiotic therapy the vasculitis resolved, but it re...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1016/0190-9622(91)70143-p
更新日期:1991-05-01 00:00:00
abstract::Blue-brown macules of the face occurring on both sides of the forehead, temple, eyelids, malar area, alae of the nose, and root of the nose are often observed in middle-aged Japanese women. These lesions histologically are a form of dermal melanocytosis as shown by electron microscopic examination. They differ clinica...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(84)80313-8
更新日期:1984-06-01 00:00:00
abstract::Cutaneous metastases present themselves in a variety of clinical patterns and tend to be manifested as indurated papules/nodules/tumors. Some of those clinical expressions are unique for certain types of metastases. This report describes an entirely different phenomenon of clinically incognito cutaneous metastases tha...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2006.05.011
更新日期:2006-12-01 00:00:00
abstract::Hyperkeratinization is a primary or fundamental event in a majority of today's skin disorders. Hyperkeratinization is usually the result of decreased desquamation due to increased corneocyte cohesion. Strength of corneocyte cohesion is determined by strength of intercellular bonding. Intercellular bonding is weakened ...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(84)80466-1
更新日期:1984-11-01 00:00:00