Abstract:
BACKGROUND:Novel picosecond lasers have been available for various pigmentary disorders. However, there are limited data directly comparing picosecond lasers and Q-switched lasers for treatment of nevus of Ota. OBJECTIVE:To compare the efficacy and safety of a picosecond alexandrite laser (PSAL) with a Q-switched alexandrite laser (QSAL) for the treatment of nevus of Ota. METHODS:Each lesion of 56 enrolled participants was split into 2 parts and randomly assigned to either the PSAL or QSAL treatment arm. Each lesion was treated in up to 6 sessions in 12-week intervals. Efficacy and safety were determined using blinded visual evaluation and self-report at each follow-up visit. RESULTS:The PSAL arm achieved a significantly better clearance (5-point scale, PSAL 4.53 vs QSAL 4.0) with fewer sessions (PSAL 5.26 vs QSAL 5.87) and less severe pain (Visual Analog Scale, PSAL 5.61 vs QSAL 6.40). Patients were more satisfied with PSAL than QSAL (Likert scale, 4.5 vs 4.0). Occurrences of postinflammatory hyperpigmentation (PSAL 26% vs QSAL 34%) and hypopigmentation (PSAL 21% vs QSAL 47%) were also lower in PSAL than QSAL arm. LIMITATIONS:Lack of objective assessments and outcome measures. CONCLUSION:PSAL demonstrated better clinical results and fewer adverse events than QSAL for the treatment of nevus of Ota.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Ge Y,Yang Y,Guo L,Zhang M,Wu Q,Zeng R,Rong H,Jia G,Shi H,Fang J,Lin Tdoi
10.1016/j.jaad.2019.03.016subject
Has Abstractpub_date
2020-08-01 00:00:00pages
397-403issue
2eissn
0190-9622issn
1097-6787pii
S0190-9622(19)30430-Xjournal_volume
83pub_type
杂志文章abstract::The Norwegian-Russian border area is polluted because of emissions from two local Russian nickel refineries. We patch tested the general adult population on both sides of the border. Only 7.2% of the Russian women were sensitized to nickel, compared with 27.5% of the Norwegian women. We suggest that long-term exposure...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1067/mjd.2002.120443
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abstract:BACKGROUND:Primary closure of surgical defects after excision of cutaneous malignancies has been traditionally accomplished with layered closure. OBJECTIVE:We sought to compare the cosmetic outcome of cheek defects repaired with layered closure versus buried sutures and adhesive strips. METHODS:In all, 38 patients un...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,随机对照试验
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abstract::Pathologic T-cell activation is implicated in psoriasis progression. CD80, a costimulatory molecule involved in T-cell activation, likely plays a key role. IDEC-114, an IgG(1) anti-CD80 antibody, was evaluated for safety, pharmacokinetics, and preliminary clinical activity in this open-label, single-dose, dose-escalat...
journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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abstract::Longitudinal pigmentation of the nail is very common. The differential diagnosis varies from subungual hematoma, to a fungal infection, to a melanocytic lesion (lentigo, nevus melanoma, etc.) to others. Often, dermatologists do not feel at ease with these pathologies and management is often not clear. In many cases, a...
journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
pub_type: 共识发展会议,杂志文章,评审
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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doi:10.1016/s0190-9622(81)70053-7
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doi:10.1016/j.jaad.2007.08.027
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
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abstract::The Publisher regrets that this article is an accidental duplication of an article that has already been published, https://doi.org/10.1016/j.jaad.2020.09.005. The duplicate article has therefore been withdrawn. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
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更新日期:2020-09-11 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
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更新日期:2019-12-01 00:00:00