Clofazimine: a review of its medical uses and mechanisms of action.

abstract：:The presence of immunoglobulin and complement deposits in the skin of three patients with papular urticaria suggests that these lesions may be due to a cutaneous vasculitis. These deposits were most frequently found in biopsy specimens taken from lesions within 24 hours of their development. The presence of granular d...

journal_title：Journal of the American Academy of Dermatology

authors： Heng MC,Kloss SG,Haberfelde GC

更新日期：1984-06-01 00:00:00

abstract：BACKGROUND:The Patient-Reported Outcomes Measurement Information System (PROMIS) Itch Questionnaire (PIQ) was recently developed. OBJECTIVE:To validate PIQ short forms in adults with AD. METHODS:Self-administered questionnaires and skin examinations were performed in 239 adults with atopic dermatitis (AD) in a dermat...

journal_title：Journal of the American Academy of Dermatology

authors： Silverberg JI,Lai JS,Vakharia PP,Patel K,Singam V,Chopra R,Sacotte R,Patel N,Rastogi S,Kantor R,Hsu DY,Cella D

更新日期：2020-05-01 00:00:00

abstract：:Aquagenic urticaria is a rare disorder characterized by the occurrence of pruritus and wheals after temporary contact with water. The familial occurrence of aquagenic urticaria over 3 generations is reported here in association with familial lactose intolerance, a condition in which the enzyme lactase encoded on chrom...

journal_title：Journal of the American Academy of Dermatology

authors： Treudler R,Tebbe B,Steinhoff M,Orfanos CE

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Isotretinoin is a very effective drug for treating severe recalcitrant nodular acne. A new micronized formulation of isotretinoin has been shown to be clinically equivalent to standard isotretinoin with improved bioavailability and minimal food effect. The safety profile of the micronized formulation has not...

journal_title：Journal of the American Academy of Dermatology

authors： Strauss JS,Leyden JJ,Lucky AW,Lookingbill DP,Drake LA,Hanifin JM,Lowe NJ,Jones TM,Stewart DM,Jarratt MT,Katz I,Pariser DM,Pariser RJ,Tschen E,Chalker DK,Rafal ES,Savin RP,Roth HL,Chang LK,Baginski DJ,Kempers S,M

更新日期：2001-08-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs have been shown to inhibit inflammation, an integral part of the wound-healing process. Compromised wound repair has been demonstrated in laboratory animals administered high-dose nonsteroidal anti-inflammatory drugs, a phenomenon we speculate could occur in humans undergoing surge...

journal_title：Journal of the American Academy of Dermatology

authors： Proper SA,Fenske NA,Burnett SM,Luria LW

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND:Surgical procedures used to remove genital warts (cryotherapy, electrodesiccation) are painful. Attempts to reduce the discomfort of surgery by prior lidocaine infiltration anesthesia are compromised by the pain of the infiltration. OBJECTIVE:Our purpose was to determine the efficacy of topically applied li...

journal_title：Journal of the American Academy of Dermatology

authors： Menter A,Black-Noller G,Riendeau LA,Monti KL

更新日期：1997-07-01 00:00:00

abstract：:We studied the effects of two retinoids, naturally occurring all-trans-retinoic acid (retinoic acid) and the synthetic 4-hydroxyphenylretinamide (4-OH-PRT) on monolayer cultures of rabbit synovial fibroblasts and on explants of rabbit articular cartilage. Treatment of fibroblasts with phorbol myristate acetate (PMA; 1...

journal_title：Journal of the American Academy of Dermatology

authors： Brinckerhoff CE,Nagase H,Nagel JE,Harris ED Jr

更新日期：1982-04-01 00:00:00

abstract：:In this article we focus on updates in select etiologies of retiform purpura. These causes of retiform purpura, in addition to bacterial or fungal sepsis, disseminated intravascular coagulation, purpura fulminans, and catastrophic antiphospholipid syndrome, are important diagnoses with potential for morbidity and mort...

journal_title：Journal of the American Academy of Dermatology

authors： Georgesen C,Fox LP,Harp J

更新日期：2020-04-01 00:00:00

abstract：:Reflections from instruments in the surgical field involving the CO2 laser beam present a serious ocular hazard. In addition to the use of plastic or glass protective eyewear, this hazard can be minimized by utilizing anodized instruments and recognizing the specific distances at which various reflections are no longe...

journal_title：Journal of the American Academy of Dermatology

authors： Friedman NR,Saleeby ER,Rubin MG,Sandu T,Krull EA

更新日期：1987-11-01 00:00:00

abstract：:We are reporting the third case of the Olmsted syndrome, an entity that has received little attention in the medical literature. The syndrome consists of congenital diffuse, sharply marginated keratoderma of the palms and soles, onychodystrophy , constrictions of digits, and periorificial keratoses. Our patient, in ad...

journal_title：Journal of the American Academy of Dermatology

authors： Poulin Y,Perry HO,Muller SA

更新日期：1984-04-01 00:00:00

abstract：:A locally invasive tumor developed in a 71-year-old woman on the right retroauricular skin, involving cartilage and parotid glands. Histologically, the tumor displayed characteristic features of basal cell epithelioma accompanied by stromal fibrosis. Histochemically, an apocrine pattern in enzyme reactions was detecte...

journal_title：Journal of the American Academy of Dermatology

authors： Sakamoto F,Ito M,Sato S,Sato Y

更新日期：1985-08-01 00:00:00

abstract：BACKGROUND:Actinic keratosis is a skin lesion that can progress to squamous cell carcinoma but cannot always be clinically distinguished from a squamous cell carcinoma. OBJECTIVE:The purpose of this article is to describe the clinical presentation of actinic keratoses and squamous cell carcinoma. METHODS:The author's...

journal_title：Journal of the American Academy of Dermatology

authors： Moy RL

更新日期：2000-01-01 00:00:00

abstract：:Pyoderma gangrenosum is a rare and often painful skin disease that can be unpredictable in its response to treatment. There is currently no gold standard of treatment or published algorithm for choice of therapy. The majority of data comes from case studies that lack a standard protocol not only for treatment administ...

journal_title：Journal of the American Academy of Dermatology

authors： Miller J,Yentzer BA,Clark A,Jorizzo JL,Feldman SR

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:A new anticancer therapy, electrochemotherapy (ECT), has been introduced that entails exposing cancerous tissues to short pulses of electricity during chemotherapy. This enhances cell membrane permeability and has been shown to have potent antitumor effects in vitro in animal models and in several clinical t...

journal_title：Journal of the American Academy of Dermatology

authors： Glass LF,Jaroszeski M,Gilbert R,Reintgen DS,Heller R

更新日期：1997-10-01 00:00:00

abstract：:An unusual American epidemic consisting of twenty cases of granuloma inguinale is chronicled. Evidence from this series supports the venereal transmission of the disorder. Trimethoprim/sulfamethoxazole proved to be a safe and effective therapy. ...

journal_title：Journal of the American Academy of Dermatology

authors： Rosen T,Tschen JA,Ramsdell W,Moore J,Markham B

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND:Keratoacanthomas usually occur spontaneously as a single rapidly growing tumor on sun-exposed skin. Multiple keratoacanthomas are rarely seen. Keratoacanthomas may also develop after trauma, laser resurfacing, radiation therapy, and at the donor site after skin grafting. OBJECTIVE:We report 6 cases of kerat...

journal_title：Journal of the American Academy of Dermatology

authors： Goldberg LH,Silapunt S,Beyrau KK,Peterson SR,Friedman PM,Alam M

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Spironolactone is used off-label for androgenic alopecia because of its ability to arrest hair loss progression and long-term safety profile. However, little is known about the safety of spironolactone in breast cancer (BC) survivors. Because spironolactone has estrogenic effects, there is a theoretical risk...

journal_title：Journal of the American Academy of Dermatology

authors： Wei C,Bovonratwet P,Gu A,Moawad G,Silverberg JI,Friedman AJ

更新日期：2020-10-01 00:00:00

abstract：:The case presented here involves a 32-year-old homosexual man with human immunodeficiency virus (HIV) seropositivity and unusual manifestations of secondary syphilis. The patient presented with syphilitic keratoderma and chorioretinitis, and his appearance superficially resembled that of a patient with Reiter's syndro...

journal_title：Journal of the American Academy of Dermatology

authors： Radolf JD,Kaplan RP

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND:Despite recommendations to limit the use of oral antibiotics and increasing support for hormonal agents in the treatment of acne, it is unclear whether there have been any significant changes in practice patterns. OBJECTIVE:To characterize changes in prescribing behavior for systemic agents in the treatment...

journal_title：Journal of the American Academy of Dermatology

authors： Barbieri JS,James WD,Margolis DJ

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Many patients who give a history of a dermatitis reaction to jewelry or metal contact with skin are negative to metals on standard patch testing. Some may be showing false-negative reactions. OBJECTIVE:Our purpose was to determine whether patients with a history of jewelry reactions but whose standard patch...

journal_title：Journal of the American Academy of Dermatology

authors： Gawkrodger DJ,Lewis FM,Shah M

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Psoralen plus ultraviolet A (PUVA) for the treatment of psoriasis has never been evaluated using the Psoriasis Area Severity Index (PASI) in a randomized, double-blind, placebo-controlled trial. The lack of such data limits our capacity to estimate PUVA's efficacy relative to other treatment options that are...

journal_title：Journal of the American Academy of Dermatology

authors： Sivanesan SP,Gattu S,Hong J,Chavez-Frazier A,Bandow GD,Malick F,Kricorian G,Koo J

更新日期：2009-11-01 00:00:00

abstract：:This study compares the histopathologic characteristics of photodistributed and nonphotodistributed lichenoid drug eruptions in 13 patients. Both types have been said to be, in an unknown proportion, different from idiopathic lichen planus in that they can involve the deep as well as the superficial plexus, can contai...

journal_title：Journal of the American Academy of Dermatology

authors： West AJ,Berger TG,LeBoit PE

更新日期：1990-10-01 00:00:00

abstract：:Erythropoietic protoporphyria is an inherited disorder characterized biochemically by a deficiency of ferrochelatase, the enzyme that catalyzes the incorporation of ferrous iron into protoporphyrin to form heme. We describe a patient who illustrates the unpredictability of the course of liver disease in erythropoietic...

journal_title：Journal of the American Academy of Dermatology

authors： Mercurio MG,Prince G,Weber FL Jr,Jacobs G,Zaim MT,Bickers DR

更新日期：1993-11-01 00:00:00

abstract：:Five patients with the yellow nail syndrome triad are described; all five had yellow nails, primary lymphedema, and respiratory tract involvement. Four of the patients noted the onset of the syndrome after an episode of pneumonia. Four patients had a chronic productive cough, two had bronchiectasis, two had chronic si...

journal_title：Journal of the American Academy of Dermatology

authors： Venencie PY,Dicken CH

更新日期：1984-02-01 00:00:00

abstract：BACKGROUND:Incontinentia pigmenti (IP) is a multisystem disorder, in which cutaneous symptoms can be accompanied by dental, ocular, and central nervous system defects. In adults, the clinical diagnosis of IP is based principally on the late onset of stage 4 lesions and their association with dental, nail, ocular, or ce...

journal_title：Journal of the American Academy of Dermatology

authors： Hadj-Rabia S,Rimella A,Smahi A,Fraitag S,Hamel-Teillac D,Bonnefont JP,de Prost Y,Bodemer C

更新日期：2011-03-01 00:00:00

abstract：:Malignant melanoma presenting as an inflammatory skin metastasis has been described but is an exceedingly rare phenomenon. We report an unusual case of a patient who developed right leg lesions that were initially thought to be infectious in origin. There was no resolution of these lesions with antibiotic therapy, and...

journal_title：Journal of the American Academy of Dermatology

authors： Cotton J,Armstrong DJ,Wedig R,Hood AF

更新日期：1998-11-01 00:00:00

abstract：:A 2 1/2-year-old white girl with citrullinemia accompanied by neurologic symptoms presented with 2- to 3-week loss of scalp hair. Examination of the scalp revealed 90% of the hairs to be broken off, leaving a stubble of hairs less than 1 mm in length. Microscopically, plucked hairs demonstrated flattening, twisting th...

journal_title：Journal of the American Academy of Dermatology

authors： Patel HP,Unis ME

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:A radiofrequency-controlled electrosurgical device (ESD) has been adapted for skin peeling. A high-voltage, low-amperage current converts an irrigant into an ionized vapor, causing molecular dissociation and superficial damage in adjacent tissue. OBJECTIVE:We compared the clinical and histologic effects of ...

journal_title：Journal of the American Academy of Dermatology

authors： Acland KM,Calonje E,Seed PT,Stat C,Barlow RJ

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Secukinumab is a first-in-class interleukin 17A monoclonal antibody that has demonstrated an excellent safety and efficacy profile in phase 3 studies. OBJECTIVE:To evaluate the effectiveness of secukinumab in daily clinical practice and to understand the clinical and epidemiologic characteristics of patient...

journal_title：Journal of the American Academy of Dermatology

authors： Ortiz-Salvador JM,Saneleuterio-Temporal M,Magdaleno-Tapial J,Velasco-Pastor M,Pujol-Marco C,Sahuquillo-Torralba A,Mateu-Puchades A,Pitarch-Bort G,Marí-Ruiz JI,Mataix-Díaz J,Montesinos-Villaescusa E,Miralles-Botella J,García-Ferná

更新日期：2019-08-01 00:00:00

abstract：:This is the second reported case of minocycline-induced Sweet's syndrome (and the first such case to appear in the American literature). The syndrome developed in a 32-year-old man 10 days after minocycline therapy for acne was begun and resolved rapidly after discontinuation of the medication and start of oral predni...

journal_title：Journal of the American Academy of Dermatology

authors： Thibault MJ,Billick RC,Srolovitz H

更新日期：1992-11-01 00:00:00