Safety of a new micronized formulation of isotretinoin in patients with severe recalcitrant nodular acne: A randomized trial comparing micronized isotretinoin with standard isotretinoin.

abstract：BACKGROUND:Multiple myeloma (MM) is a plasma cell dyscrasia characterized by a clonal proliferation of plasma cells that produces a monoclonal protein. There are dermatologic disorders that have been associated with MM, such as amyloidosis, cryoglobulinemia, POEMS syndrome, normolipemic plane xanthoma, and plasmacytoma...

journal_title：Journal of the American Academy of Dermatology

authors： Bayer-Garner IB,Smoller BR

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Some studies have purported to link isotretinoin prescribed for acne with the development of inflammatory bowel disease (IBD). OBJECTIVE:We sought to identify existence of disproportionate attorney-initiated reporting of isotretinoin-associated IBD in the Food and Drug Administration Adverse Event Reporting...

journal_title：Journal of the American Academy of Dermatology

authors： Stobaugh DJ,Deepak P,Ehrenpreis ED

更新日期：2013-09-01 00:00:00

abstract：:Forty cases of lentigo maligna (LM) and lentigo maligna melanoma (LMM) treated by conventional fractionated radiotherapy are reviewed. Fourteen of seventeen LM patients are alive and well 4 months to 5 years following irradiation, one patient died of intercurrent disease without recurrence, and two had residual or rec...

journal_title：Journal of the American Academy of Dermatology

authors： Harwood AR

更新日期：1982-03-01 00:00:00

abstract：BACKGROUND:Acral lentiginous melanomas compose a higher proportion of melanomas and have a higher mortality in ethnic minorities than in whites. Early detection by acral surface inspection during skin examinations may lead to improved acral lentiginous melanoma outcomes. OBJECTIVE:This study compared patient-reported ...

journal_title：Journal of the American Academy of Dermatology

authors： Tsai MS,Chiu MW

更新日期：2014-08-01 00:00:00

abstract：:We describe a patient with clinical features of dermatitis herpetiformis (DH) and histopathologic features suggestive of both DH and bullous pemphigoid (BP). Immunofluorescent (IF) studies of skin biopsy revealed IgG and C3 deposits along the basement membrane zone (BMZ) in a linear pattern and circulating BMZ antibod...

journal_title：Journal of the American Academy of Dermatology

authors： Jawitz J,Kumar V,Nigra TP,Beutner EH

更新日期：1984-05-01 00:00:00

abstract：BACKGROUND:Antibodies against transcriptional intermediary factor (TIF)-1γ are associated with malignancy in dermatomyositis (DM). Identification of clinical findings associated with anti-TIF-1γ antibodies in DM is a high priority for both patient diagnosis and risk assessment. OBJECTIVE:We sought to define the clinic...

journal_title：Journal of the American Academy of Dermatology

authors： Fiorentino DF,Kuo K,Chung L,Zaba L,Li S,Casciola-Rosen L

更新日期：2015-03-01 00:00:00

abstract：:We present further evidence that granuloma annulare and autoimmune thyroiditis may be associated. Only 11 cases have been previously reported with this association as far as we know. It may be advantageous to consider checking the thyroid-stimulating hormone and/or antithyroid antibodies before administering medicatio...

journal_title：Journal of the American Academy of Dermatology

authors： Vázquez-López F,González-López MA,Raya-Aguado C,Pérez-Oliva N

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Patients with cutaneous melanoma metastases have experienced excellent responses to intralesional interleukin (IL)-2. This has led to its recent inclusion into the US National Comprehensive Cancer Network guidelines for management of cutaneous melanoma metastases. Despite this, intralesional IL-2 has not bee...

journal_title：Journal of the American Academy of Dermatology

authors： Shi VY,Tran K,Patel F,Leventhal J,Konia T,Fung MA,Wilken R,Garcia MS,Fitzmaurice SD,Joo J,Monjazeb AM,Burrall BA,King B,Martinez S,Christensen SD,Maverakis E

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Several studies have found that the microbiota of psoriatic lesions is different from that of healthy skin. OBJECTIVE:To characterize the microbiota of lesional and unaffected skin in patients with psoriasis and controls and investigate the correlation between cutaneous microbiota and clinical features of p...

journal_title：Journal of the American Academy of Dermatology

authors： Quan C,Chen XY,Li X,Xue F,Chen LH,Liu N,Wang B,Wang LQ,Wang XP,Yang H,Zheng J

更新日期：2020-04-01 00:00:00

abstract：:Hydrogen peroxide (H2O2) is an endogenous reactive oxygen species that contributes to oxidative stress directly as a molecular oxidant and indirectly through free radical generation. Topically applied 1% to 45% H2O2 can be used for a range of clinical purposes, which will be reviewed here in addition to its safety. In...

journal_title：Journal of the American Academy of Dermatology

authors： Murphy EC,Friedman AJ

更新日期：2019-12-01 00:00:00

abstract：:Isotretinoin is most effective for patients with acne who fail to respond to other forms of treatment; virtually all patients respond to isotretinoin, 0.5 to 1.0 mg/kg/day. As many as 61% of patients are cured after one course, but 39% require further isotretinoin (16%) or oral antibiotics (23%). The relapse rate can ...

journal_title：Journal of the American Academy of Dermatology

authors： Layton AM,Cunliffe WJ

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:The Nikolskiy sign is a well-known mechanical symptom that can be helpful in the diagnosis of pemphigus. The reports about associations with other than pemphigus cause confusion concerning the diagnostic importance of the Nikolskiy sign in pemphigus. OBJECTIVE:Our purpose was to examine the significance and...

journal_title：Journal of the American Academy of Dermatology

authors： Uzun S,Durdu M

更新日期：2006-03-01 00:00:00

abstract：:Onycholysis (ONY) of the fingernails is a common disorder that is diagnosed with ease but often managed with great difficulty. The full spectrum of causes is broad and not always readily apparent. In this review, an approach to the evaluation and management of ONY is offered. ...

journal_title：Journal of the American Academy of Dermatology

authors： Kechijian P

更新日期：1985-03-01 00:00:00

abstract：:The usual method of treatment of pilomatricoma (calcifying epitheliona of Malherbe) is excision. We present a review of eight patients with ten tumors treated by incision and curettement. Follow-up ranged from 1 to 10 years, and there have been no recurrences. An alternative method of therapy with excellent results is...

journal_title：Journal of the American Academy of Dermatology

authors： Morales A,McGoey J

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:The enzyme indoleamine 2,3-dioxygenase (IDO) degrades the essential amino acid tryptophan, and this degradation is an immunosuppressive mechanism that is mainly used by antigen-presenting cells. IDO-expressing dendritic cells and macrophages have previously been identified as components of lymph node granulo...

journal_title：Journal of the American Academy of Dermatology

authors： von Bubnoff D,Scheler M,Wilms H,Wenzel J,von Bubnoff N,Häcker G,Schultze J,Popov A,Racz P,Bieber T,Wickenhauser C

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:The current standard tool for diagnosing allergic contact dermatitis (ACD) in the United States is the T.R.U.E. test panels, which consist of 23 allergens. Previous studies have raised concern regarding the adequacy of these panels in fully assessing patients with possible ACD. OBJECTIVE:We sought to examin...

journal_title：Journal of the American Academy of Dermatology

authors： Saripalli YV,Achen F,Belsito DV

更新日期：2003-07-01 00:00:00

abstract：:The acute complications that may result in failure of the surgical procedure are discussed. These include bleeding, hematoma, infection, dehiscence, and necrosis. The background of each is covered in detail and an attempt is made to show the interrelationships among them. The purpose of this communication is to aid in...

journal_title：Journal of the American Academy of Dermatology

authors： Salasche SJ

更新日期：1986-12-01 00:00:00

abstract：BACKGROUND:Excess cathelicidin and kallikrein 5 (KLK5) have been hypothesized to play a role in the pathophysiology of rosacea. OBJECTIVE:We sought to evaluate the effects of azelaic acid (AzA) on these elements of the innate immune system. METHODS:Gene expression and protease activity were measured in laboratory mod...

journal_title：Journal of the American Academy of Dermatology

authors： Coda AB,Hata T,Miller J,Audish D,Kotol P,Two A,Shafiq F,Yamasaki K,Harper JC,Del Rosso JQ,Gallo RL

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Granuloma annulare is a common skin disorder that usually presents with smooth papules arranged as annular plaques. Variants, such as disseminated, subcutaneous, and perforating granuloma annulare, have been described. OBJECTIVE:The purpose of this study is to describe the clinical and histologic features o...

journal_title：Journal of the American Academy of Dermatology

authors： Mutasim DF,Bridges AG

更新日期：2000-03-01 00:00:00

abstract：:The clinical and histologic features of 26 cases of erythema induratum are reviewed. The characteristic cutaneous lesions on the legs of middle-aged women were violaceous, indurated nodules, 1 to 2 cm in diameter, which were painful, occasionally ulcerated, and could heal with scarring. The diagnosis was confirmed in ...

journal_title：Journal of the American Academy of Dermatology

authors： Rademaker M,Lowe DG,Munro DD

更新日期：1989-10-01 00:00:00

abstract：:Chemotherapy-induced alopecia is a distressing side effect common to certain treatment regimens in oncology. Unfortunately, chemotherapy-induced alopecia is an often overlooked or minor factor among our current research priorities and thus advances in amelioration have been minimal. This review offers a comprehensive ...

journal_title：Journal of the American Academy of Dermatology

authors： Chon SY,Champion RW,Geddes ER,Rashid RM

更新日期：2012-07-01 00:00:00

abstract：:The diagnostic value of parakeratosis is reviewed, with special emphasis on associated inflammatory tissue reaction patterns and the geometric pattern of the scale. Parakeratosis may also occur in disorders not primarily inflammatory in nature and those associations are addressed. Topics are divided into 6 categories:...

journal_title：Journal of the American Academy of Dermatology

authors： Brady SP

更新日期：2004-01-01 00:00:00

abstract：:Pruritus is a common and often times difficult to treat symptom in many dermatologic and systemic diseases. For pruritus with an inflammatory or autoimmune origin, therapies such as topical corticosteroids and antihistamines are often initiated. However, in the case that these and additional systemic therapies are ine...

journal_title：Journal of the American Academy of Dermatology

authors： Sharma D,Kwatra SG

更新日期：2016-02-01 00:00:00

abstract：:Keratoacanthomas infrequently are treated by radiotherapy. However, keratoacanthomas that are recurrent after surgical excision or whose resection would result in cosmetic deformity may benefit from radiotherapy. Between January 1970 and June 1988, 29 such keratoacanthomas in 18 patients were irradiated. Doses ranged ...

journal_title：Journal of the American Academy of Dermatology

authors： Donahue B,Cooper JS,Rush S

更新日期：1990-09-01 00:00:00

abstract：:Epithelioid hemangioendothelioma (EHE) is a unique tumor, mainly of adults, which is characterized by epithelioid or histiocytoid endothelial cells. It is a low-grade malignant vascular tumor first described as a distinctive entity in 1982 by Weiss and Enzinger. An 8-year-old girl presented with an approximately 3-yea...

journal_title：Journal of the American Academy of Dermatology

authors： Roh HS,Kim YS,Suhr KB,Yoon TY,Lee JH,Park JK

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:The hazards of acute radiation exposure are well known. Bone marrow failure from total body gamma or neutron irradiation is the most clinically relevant aspect of acute radiation disease. With nonhomogeneous exposure, as is characteristic in accidents, other organ systems, such as the skin, may be more impor...

journal_title：Journal of the American Academy of Dermatology

authors： Peter RU,Braun-Falco O,Birioukov A,Hacker N,Kerscher M,Peterseim U,Ruzicka T,Konz B,Plewig G

更新日期：1994-05-01 00:00:00

abstract：:Two babies were found to have large hemangiomas. Histologically there were many islands of compactly packed mesenchymal cells in the deep dermis and subcutaneous tissue. Electron microscopically there was proliferation of immature endothelial cells and pericytes. Characteristic crystalline lamellae were in the endothe...

journal_title：Journal of the American Academy of Dermatology

authors： Kumakiri M,Muramoto F,Tsukinaga I,Yoshida T,Ohura T,Miura Y

更新日期：1983-01-01 00:00:00

abstract：:Most cutaneous squamous cell carcinomas (SCCs) of the trunk and extremities are small enough to be cured by simple surgical excision. Because the risk of metastasis of SCCs of the head and neck arising from mucosal surfaces is higher than the risk of metastasis of SCCs arising from cutaneous surfaces, it may be more a...

journal_title：Journal of the American Academy of Dermatology

authors： Geohas J,Roholt NS,Robinson JK

更新日期：1994-04-01 00:00:00

abstract：:Twenty undifferentiated skin tumors were examined by immunostaining in an attempt to achieve more precise identification. Light microscopy yielded only a differential diagnosis, whereas immunostaining of formalin-fixed, paraffin-embedded tissue sections with a panel of antibodies to intermediate filaments and other ce...

journal_title：Journal of the American Academy of Dermatology

authors： Kahn H,Baumal R,From L

更新日期：1986-06-01 00:00:00

abstract：:The large stellate and polygonal cells observed in eleven fibrous papules and two angiofibromas were examined immunohistochemically for alpha 1-antitrypsin and lysozyme. The positive findings suggest that these cells are related to histiocytes rather than nevomelanocytes. ...

journal_title：Journal of the American Academy of Dermatology

authors： Kwan TH,Smoller BR,Schneider DR

更新日期：1985-01-01 00:00:00