当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY期刊下所有文献 > Distinctive cutaneous and systemic features associated with antitranscriptional intermediary factor-1γ antibodies in adults with dermatomyositis.

Distinctive cutaneous and systemic features associated with antitranscriptional intermediary factor-1γ antibodies in adults with dermatomyositis.

Abstract：

BACKGROUND:Antibodies against transcriptional intermediary factor (TIF)-1γ are associated with malignancy in dermatomyositis (DM). Identification of clinical findings associated with anti-TIF-1γ antibodies in DM is a high priority for both patient diagnosis and risk assessment. OBJECTIVE:We sought to define the clinical phenotype of patients with anti-TIF-1γ DM. METHODS:Using a novel, sensitive, and specific assay for anti-TIF-1γ antibodies, we retrospectively tested plasma from 134 adult patients with DM and examined associations between anti-TIF-1γ antibodies and particular clinical and laboratory features. RESULTS:In all, 55 (41%) patients had autoantibodies to TIF-1γ. Anti-TIF-1γ positive patients were less likely to have systemic features including interstitial lung disease, Raynaud phenomenon, and arthritis/arthralgia. Patients with TIF-1γ autoantibodies had more extensive skin involvement, and some patients manifested characteristic findings including palmar hyperkeratotic papules, psoriasis-like lesions and a novel finding of hypopigmented and telangiectatic ("red on white") patches. LIMITATIONS:This was a retrospective study from a single tertiary referral center. CONCLUSION:TIF-1γ is the most commonly targeted DM-specific autoantigen in adults in a large US cohort. Although these patients tend to have less systemic involvement, their skin disease is often extensive and characteristic. Recognition of cutaneous findings in anti-TIF-1γ positive patients may allow more accurate and timely diagnosis and effective treatment of patients with DM.

journal_name

J Am Acad Dermatol

journal_title

Journal of the American Academy of Dermatology

authors

Fiorentino DF,Kuo K,Chung L,Zaba L,Li S,Casciola-Rosen L

doi

10.1016/j.jaad.2014.12.009

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

449-55

issue

3

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(14)02269-5

journal_volume

72

pub_type

杂志文章

相关文献

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY文献大全
  • Epidermodysplasia verruciformis in the setting of graft-versus-host disease.

    abstract：:We report a case of epidermodysplasia verruciformis (EV)-like lesions in a patient with graft-versus-host disease after peripheral blood stem cell transplantation from his HLA-matched brother. The patient presented with a diffuse papular eruption that was clinically consistent with graft-versus-host disease; however, ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2006.04.035

    authors： Kunishige JH,Hymes SR,Madkan V,Wyatt AJ,Uptmore D,Lazar AJ,Giralt S,Rady P,Tyring S

    更新日期：2007-11-01 00:00:00

  • Vesiculobullous lesions caused by cytomegalovirus infection in an immunocompromised adult.

    abstract：:Skin involvement in cytomegalovirus (CMV) infection is very rare. Reported cutaneous manifestations are nonspecific and include petechial, purpuric, and morbilliform rashes. We describe an immunocompromised patient who developed a vesiculobullous eruption. A simple Tzanck preparation from the base of a blister reveale...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(84)70234-9

    authors： Bhawan J,Gellis S,Ucci A,Chang TW

    更新日期：1984-10-01 00:00:00

  • A five-year study of cosmetic reactions.

    abstract：:During 64 months (1977 to 1983), twelve dermatologists from various sections of the United States studied a total of 713 patients with cosmetic dermatitis out of an estimated total of 13,216 patients with contact dermatitis. The number of patients seen for all causes during this period was 281,100. An important findin...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(85)70258-7

    authors： Adams RM,Maibach HI

    更新日期：1985-12-01 00:00:00

  • Graftskin therapy in epidermolysis bullosa.

    abstract：BACKGROUND:Epidermolysis bullosa (EB) is a family of 23 genetic skin disorders for which treatments are mainly supportive. Graftskin is a bilayered living human skin construct characterized by a normal expression profile of all the genes reported as mutant in EB. OBJECTIVE:The objective of this study was to evaluate t...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1067/mjd.2003.502

    authors： Fivenson DP,Scherschun L,Choucair M,Kukuruga D,Young J,Shwayder T

    更新日期：2003-06-01 00:00:00

  • A quantitative systematic review of the efficacy of imiquimod monotherapy for lentigo maligna and an analysis of factors that affect tumor clearance.

    abstract：BACKGROUND:The reported efficacy of imiquimod for lentigo maligna varies widely, without consensus on tumor or treatment factors that can impact tumor clearance. OBJECTIVE:We sought to provide a more precise estimate of clearance rates in patients with lentigo maligna who are treated with imiquimod and to analyze fact...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaad.2015.05.022

    authors： Mora AN,Karia PS,Nguyen BM

    更新日期：2015-08-01 00:00:00

  • Apoptosis and cutaneous biology.

    abstract：:Apoptosis, a genetically encoded program that results in cell death, represents a fundamental biologic concept that has relevance to a wide range of dermatologic processes. This review discusses the basic biology of apoptosis and its relevance to cutaneous disease. ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/s0190-9622(97)80266-6

    authors： Raskin CA

    更新日期：1997-06-01 00:00:00

  • Oral dexamethasone pulse treatment for vitiligo.

    abstract：BACKGROUND:Oral corticosteroid pulse therapy has provided inconsistent results in the treatment of Indian patients with vitiligo. OBJECTIVE:We wanted to evaluate the efficacy, safety, and tolerability of oral dexamethasone pulse therapy in a cohort of Austrian patients with vitiligo. METHODS:Twenty-nine patients with...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1067/mjd.2001.113475

    authors： Radakovic-Fijan S,Fürnsinn-Friedl AM,Hönigsmann H,Tanew A

    更新日期：2001-05-01 00:00:00

  • Carney complex: a clinicopathologic and molecular biological study of a sporadic case, including extracutaneous and cutaneous lesions and a novel mutation of the PRKAR1A gene.

    abstract：BACKGROUND:Carney complex (CNC) is an autosomal dominant disorder associated with multiple neoplasms. OBJECTIVE:We report a case of a 40-year-old Caucasian man with a sporadic form of CNC. METHODS:This is a clinicopathologic description and molecular biological study with an emphasis on histopathologic findings. RES...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2008.11.015

    authors： Kacerovska D,Sima R,Michal M,Hes O,Roucka P,Zarybnicka M,Hora M,Chudacek Z,Kazakov DV

    更新日期：2009-07-01 00:00:00

  • Monoclonal gammopathies and associated skin disorders.

    abstract：:The monoclonal gammopathies are characterized by clonal proliferation of plasma cells and other clonally related cells in the B-cell lineage. These disorders include monoclonal gammopathy of undetermined significance, multiple myeloma, Waldenström macroglobulinemia, heavy chain diseases, plasmacytoma, and primary amyl...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/s0190-9622(99)70434-2

    authors： Daoud MS,Lust JA,Kyle RA,Pittelkow MR

    更新日期：1999-04-01 00:00:00

  • Histologic and clinical cross-sectional study of chronic hair loss in patients with cutaneous chronic graft-versus-host disease.

    abstract：BACKGROUND:While scalp alopecia represents a distinctive feature of chronic graft-versus-host disease (cGVHD), little is known about the clinical and histologic presentation of hair loss. OBJECTIVES:We sought to classify the clinical presentations and histologic findings of chronic hair loss in patients with cutaneous...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2019.03.031

    authors： Marks DH,Naftulin JS,Penzi LR,Manatis-Lornell A,Yasuda MR,Chapman CM,Rao SR,Saavedra A,Senna MM

    更新日期：2019-11-01 00:00:00

  • Spectrum of primary cutaneous CD30 (Ki-1)-positive lymphoproliferative disorders. A proposal for classification and guidelines for management and treatment.

    abstract：:Primary cutaneous CD30 (Ki-1)-positive, large cell lymphomas (LCLs) represent a recently recognized group of cutaneous T-cell lymphomas with a favorable prognosis. The characteristic features of this cutaneous lymphoma are reviewed, differences with primary noncutaneous CD30+ LCLs emphasized, and its relation with oth...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/0190-9622(93)70140-o

    authors： Willemze R,Beljaards RC

    更新日期：1993-06-01 00:00:00

  • Papillon-Lefèvre syndrome with acroosteolysis.

    abstract：:The Papillon-Lefèvre syndrome is characterized by palmoplantar hyperkeratosis and juvenile periodontitis that results in the precocious loss of both the deciduous and permanent teeth. We report a patient with Papillon-Lefèvre syndrome associated with acroosteolysis, an association that has not been previously describe...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/0190-9622(91)70127-n

    authors： Trattner A,David M,Sandbank M

    更新日期：1991-05-01 00:00:00

  • Thymoma-associated multiorgan autoimmunity: a graft-versus-host-like disease.

    abstract：:Graft-versus-host disease (GVHD) is a T cell-mediated disease seen most commonly after hematopoietic stem cell transplantation. Rarely, a GVHD-like disease can be seen in patients with malignant thymoma. We describe a 50-year-old man with malignant thymoma who developed skin, liver, and intestinal manifestations simil...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2007.02.027

    authors： Wadhera A,Maverakis E,Mitsiades N,Lara PN,Fung MA,Lynch PJ

    更新日期：2007-10-01 00:00:00

  • Cutaneous findings in a 51-year-old man with phenylketonuria.

    abstract：:A man with phenylketonuria who was reported to have lichen sclerosus et atrophicus at age 16 years presented to our institution 35 years later with large confluent areas of atrophy. Although sclerodermatous changes have been described in children with phenylketonuria, this case offers a longitudinal view of the progre...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1067/mjd.2003.261

    authors： Belloso LM,Lowitt MH

    更新日期：2003-08-01 00:00:00

  • Hypomelanosis of Ito. Report of a case and review of the literature.

    abstract：:A 5-month-old boy with hypomelanosis of Ito was studied. Lesions presented as bizarre, hypopigmented whorls and streaks. Histologic studies showed that the hypopigmented areas contained normal melanocytes with decreased content of intracellular melanin. A review of the literature revealed the disease to be a discrete ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(81)70023-9

    authors： Buzas JW,Sina B,Burnett JW

    更新日期：1981-02-01 00:00:00

  • Lichen sclerosus.

    abstract：:Dialogues in Dermatology, a monthly audio program from the American Academy of Dermatology, contains discussions between dermatologists on timely topics. Commentaries from Dialogues Editor-in-Chief Warren R. Heymann, MD, are provided after each discussion as a topic summary and are provided here as a special service t...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2006.11.031

    authors： Heymann WR

    更新日期：2007-04-01 00:00:00

  • Dermatopathology workforce in the United States: a survey.

    abstract：BACKGROUND:Although several studies have documented an undersupply of dermatologic services in the United States, little is known about the dermatopathology workforce. OBJECTIVE:Objectives included the following: (1) describe the dermatopathology workforce in the United States; (2) identify characteristics associated ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2010.09.733

    authors： Suwattee P,Cham PM,Abdollahi M,Warshaw EM

    更新日期：2011-12-01 00:00:00

  • Vesicular pemphigoid vs dermatitis herpetiformis.

    abstract：:We describe a patient with clinical features of dermatitis herpetiformis (DH) and histopathologic features suggestive of both DH and bullous pemphigoid (BP). Immunofluorescent (IF) studies of skin biopsy revealed IgG and C3 deposits along the basement membrane zone (BMZ) in a linear pattern and circulating BMZ antibod...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(84)80441-7

    authors： Jawitz J,Kumar V,Nigra TP,Beutner EH

    更新日期：1984-05-01 00:00:00

  • Hutchinson's sign: a reappraisal.

    abstract：:Hutchinson's sign, periungual extension of brown-black pigmentation from longitudinal melanonychia onto the proximal and lateral nailfolds, is an important indicator of subungual melanoma. However, experience has demonstrated that Hutchinson's sign, although valuable, is not an infallible predictor of melanoma. Periun...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/s0190-9622(96)90839-7

    authors： Baran R,Kechijian P

    更新日期：1996-01-01 00:00:00

  • Psoriasis and comorbid diseases: Implications for management.

    abstract：:As summarized in the first article in this continuing medical education series, the currently available epidemiologic data suggest that psoriasis may be a risk factor for cardiometabolic disease. Emerging data also suggest associations between psoriasis and other comorbidities beyond psoriatic arthritis, including chr...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaad.2016.07.065

    authors： Takeshita J,Grewal S,Langan SM,Mehta NN,Ogdie A,Van Voorhees AS,Gelfand JM

    更新日期：2017-03-01 00:00:00

  • Pruritus and nonspecific nodules preceding myelomonocytic leukemia.

    abstract：:Subacute myelomonocytic leukemia is typically preceded by a preleukemic phase lasting 1 to 10 years. We describe a case of subacute myelomonocytic leukemia preceded by pruritus for 7 years and by the intermittent appearance of nonspecific necrotic dermal nodules for 4 years. ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(80)80150-2

    authors： Peterson AO Jr,Jarratt M

    更新日期：1980-06-01 00:00:00

  • Long-term effectiveness and safety of treatment with dupilumab in patients with atopic dermatitis: Results of the TREAT NL (TREatment of ATopic eczema, the Netherlands) registry.

    abstract：BACKGROUND:Evidence on long-term dupilumab treatment for atopic dermatitis in daily practice is lacking. OBJECTIVE:To investigate patient characteristics, treatment aspects, effectiveness, and safety of up to 84 weeks of dupilumab treatment. METHODS:An observational prospective cohort study was conducted of patients ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2020.05.128

    authors： Bosma AL,de Wijs LEM,Hof MH,van Nieuwenhuizen BR,Gerbens LAA,Middelkamp-Hup MA,Hijnen D,Spuls PI

    更新日期：2020-11-01 00:00:00

  • Developing an international standard for the classification of surface anatomic location for use in clinical practice and epidemiologic research.

    abstract：BACKGROUND:There is currently no universally adopted terminology for defining human surface anatomic location. The lack of precision, accuracy, and reliability of terms used by health care providers, in particular dermatologic surgeons, is unsatisfactory both for epidemiologic research and for high-quality patient care...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2018.08.035

    authors： Kenneweg KA,Halpern AC,Chalmers RJG,Soyer HP,Weichenthal M,Molenda MA

    更新日期：2019-06-01 00:00:00

  • Intermittent short courses of cyclosporine microemulsion for the long-term management of psoriasis: a 2-year cohort study.

    abstract：BACKGROUND:Cyclosporine is effective in psoriasis, but long-term continuous therapy may be limited by renal impairment and hypertension. Intermittent short courses of treatment should minimize side effects and improve the risk-benefit ratio. OBJECTIVE:Our purpose was to assess the long-term efficacy and safety of inte...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1067/mjd.2001.112400

    authors： Ho VC,Griffiths CE,Berth-Jones J,Papp KA,Vanaclocha F,Dauden E,Beard A,Puvanarajan L,Paul C

    更新日期：2001-04-01 00:00:00

  • Histologic, pharmacologic, and immunocytochemical effects of injection of bleomycin into viral warts.

    abstract：BACKGROUND:The plasma concentration of bleomycin after injection of bleomycin into warts is unknown, as is the long-term stability of bleomycin solution. OBJECTIVE:Our purpose was to measure plasma bleomycin concentration after injection of bleomycin into warts, to relate histologic and immunocytochemical changes in w...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/0190-9622(93)70133-e

    authors： James MP,Collier PM,Aherne W,Hardcastle A,Lovegrove S

    更新日期：1993-06-01 00:00:00

  • Hereditary epidermolytic palmoplantar keratoderma (Vörner type). Report of a familial case and review of the literature.

    abstract：:A recent familial case of hereditary epidermolytic palmoplantar keratoderma (Vörner type) that was treated with orally administered etretinate is reported herein. A review of the literature with regard to the clinical, genetic, and laboratory features of this rare genodermatosis is also presented. ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/s0190-9622(87)70222-9

    authors： Kanitakis J,Tsoitis G,Kanitakis C

    更新日期：1987-09-01 00:00:00

  • The mast cell in health and disease.

    abstract：:The presence of mast cells, often in an activated state or increased numbers, has been noted in various cutaneous disorders. Recent studies suggest that mast cells are of primary importance in these conditions and their presence does not merely represent a secondary event. This review focuses on atopic dermatitis, con...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/0190-9622(90)70264-i

    authors： Rothe MJ,Nowak M,Kerdel FA

    更新日期：1990-10-01 00:00:00

  • Compromised wound repair caused by perioperative use of ibuprofen.

    abstract：:Nonsteroidal anti-inflammatory drugs have been shown to inhibit inflammation, an integral part of the wound-healing process. Compromised wound repair has been demonstrated in laboratory animals administered high-dose nonsteroidal anti-inflammatory drugs, a phenomenon we speculate could occur in humans undergoing surge...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(88)70119-x

    authors： Proper SA,Fenske NA,Burnett SM,Luria LW

    更新日期：1988-05-01 00:00:00

  • Remission of refractory pyoderma gangrenosum, severe acne, and hidradenitis suppurativa (PASH) syndrome using targeted antibiotic therapy in 4 patients.

    abstract：:Pyoderma gangrenosum, severe acne, and suppurative hidradenitis (PASH) syndrome can prove refractory to treatment and is characterized by relapses and recurrences. The combination of antibiotic therapy and surgery can produce success in the management of the syndrome. Acute treatment is required, but maintenance thera...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2015.07.040

    authors： Join-Lambert O,Duchatelet S,Delage M,Miskinyte S,Coignard H,Lemarchand N,Alemy-Carreau M,Lortholary O,Nassif X,Hovnanian A,Nassif A

    更新日期：2015-11-01 00:00:00

  • Computerized axial tomography in the early diagnosis of tuberous sclerosis.

    abstract：:Tuberous sclerosis is characterized by epilepsy, mental retardation, and adenoma sebaceum. Computerized axial tomography (CAT) is a noninvasive laboratory test that can assist in the diagnosis of this syndrome radiologically. A positive CAT scan is often present before the calcifications are noted on skull x-rays and ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(81)70009-4

    authors： Burkhart CG,El-Shaar A

    更新日期：1981-01-01 00:00:00