当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY期刊下所有文献 > Histologic, pharmacologic, and immunocytochemical effects of injection of bleomycin into viral warts.

Histologic, pharmacologic, and immunocytochemical effects of injection of bleomycin into viral warts.

Abstract：

BACKGROUND:The plasma concentration of bleomycin after injection of bleomycin into warts is unknown, as is the long-term stability of bleomycin solution. OBJECTIVE:Our purpose was to measure plasma bleomycin concentration after injection of bleomycin into warts, to relate histologic and immunocytochemical changes in warts to possible mechanisms of action of bleomycin, and to asses the long-term stability of stored frozen bleomycin solution. METHODS:One milligram of bleomycin was injected into warts on the hands of seven men. Blood samples were taken 15 to 120 minutes after injection, and plasma bleomycin was measured by radioimmunoassay. Warts were removed 2 hours and 48 hours after treatment and studied histologically by light microscopy and for the presence of bleomycin by immunocytochemistry. The bleomycin concentration in 8 aliquots of solution stored at -20 degrees C for varying periods was measured by radioimmunoassay. RESULTS:Peak levels of bleomycin of 7 to 113 ng/ml were reached by 45 minutes after injection. Plasma bleomycin exposure ranged from 515 to 5137 ng/ml/min between 15 and 120 minutes after injection. The most pronounced histologic changes at 48 hours were individual keratinocyte apoptosis throughout the epidermis merging into areas of complete epidermal necrosis, diffuse neutrophil accumulation, and microabscess formation at the granular layer. Immunocytochemistry demonstrated tissue-fixed bleomycin in all levels of the epidermis except the basal layer and most prominently in the granular layer. Bleomycin in solution stored for up to 27 months at -20 degrees C in glass showed no significant loss of immunoreactivity. CONCLUSION:The use of bleomycin for the treatment of warts results in significant systemic drug exposure; thus it would be prudent to exclude pregnancy before treating women of child-bearing age. Bleomycin probably has a direct toxic effect on keratinocytes. Dilute bleomycin solution stored at -20 degrees C in glass is stable.

journal_name

J Am Acad Dermatol

journal_title

Journal of the American Academy of Dermatology

authors

James MP,Collier PM,Aherne W,Hardcastle A,Lovegrove S

doi

10.1016/0190-9622(93)70133-e

subject

Has Abstract

pub_date

1993-06-01 00:00:00

pages

933-7

issue

6

eissn

0190-9622

issn

1097-6787

pii

0190-9622(93)70133-E

journal_volume

28

pub_type

杂志文章

相关文献

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY文献大全
  • Cutaneous reactive angiomatoses: patterns and classification of reactive vascular proliferation.

    abstract：:New and relatively old types of vascular (capillary) proliferations in the skin have been described or better categorized in the last few years. They include reactive angioendotheliomatosis, acroangiodermatitis (pseudo-Kaposi sarcoma), diffuse dermal angiomatosis, intravascular histocytosis, glomeruloid angioendotheli...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/s0190-9622(03)02100-5

    authors： Rongioletti F,Rebora A

    更新日期：2003-11-01 00:00:00

  • Erythema induratum (Bazin's disease).

    abstract：:The clinical and histologic features of 26 cases of erythema induratum are reviewed. The characteristic cutaneous lesions on the legs of middle-aged women were violaceous, indurated nodules, 1 to 2 cm in diameter, which were painful, occasionally ulcerated, and could heal with scarring. The diagnosis was confirmed in ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(89)70248-6

    authors： Rademaker M,Lowe DG,Munro DD

    更新日期：1989-10-01 00:00:00

  • Hereditary polymorphic light eruption of American Indians: occurrence in non-Indians with polymorphic light eruption.

    abstract：BACKGROUND:Hereditary polymorphic light eruption (HPLE) occurs unique ly in the American Indian and Inuit and exhibits autosomal dominant transmission. Because the cutaneous expression of HPLE resembles that of polymorphic light eruption (PLE) and because many non-Indians in the United States have American Indian herit...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(96)80060-0

    authors： Fusaro RM,Johnson JA

    更新日期：1996-04-01 00:00:00

  • A randomized pilot comparative study of topical methyl aminolevulinate photodynamic therapy versus imiquimod 5% versus sequential application of both therapies in immunocompetent patients with actinic keratosis: clinical and histologic outcomes.

    abstract：BACKGROUND:Photodynamic therapy (PDT) and imiquimod are the treatments of choice for actinic keratosis (AK). As they have different mechanisms of action, it seems reasonable to assume that applying both treatments sequentially would be efficacious. OBJECTIVES:We sought to determine which of these therapeutic modalitie...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jaad.2011.11.933

    authors： Serra-Guillén C,Nagore E,Hueso L,Traves V,Messeguer F,Sanmartín O,Llombart B,Requena C,Botella-Estrada R,Guillén C

    更新日期：2012-04-01 00:00:00

  • Collodion baby: an update with a focus on practical management.

    abstract：:Collodion baby is an uncommon clinical presentation of several genetic conditions, primarily disorders of cornification. The severely compromised epidermal barrier presents the greatest challenge during the newborn period and advances in neonatal care have significantly improved the prognosis. This review summarizes t...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaad.2012.05.036

    authors： Prado R,Ellis LZ,Gamble R,Funk T,Arbuckle HA,Bruckner AL

    更新日期：2012-12-01 00:00:00

  • The detection of clinically relevant contact allergens using a standard screening tray of twenty-three allergens.

    abstract：BACKGROUND:The current standard tool for diagnosing allergic contact dermatitis (ACD) in the United States is the T.R.U.E. test panels, which consist of 23 allergens. Previous studies have raised concern regarding the adequacy of these panels in fully assessing patients with possible ACD. OBJECTIVE:We sought to examin...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1067/mjd.2003.489

    authors： Saripalli YV,Achen F,Belsito DV

    更新日期：2003-07-01 00:00:00

  • Mycophenolate mofetil in autoimmune and inflammatory skin disorders.

    abstract：:Mycophenolate mofetil (MMF) has been widely used as an immunosuppressant in organ transplantation. MMF has recently been added to therapeutic regimens for skin disorders. Expanding the use of MMF in dermatology, we describe additional patients with autoimmune and inflammatory skin diseases, including 4 cases of pemphi...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(99)70203-3

    authors： Nousari HC,Sragovich A,Kimyai-Asadi A,Orlinsky D,Anhalt GJ

    更新日期：1999-02-01 00:00:00

  • Minocycline-related lupus erythematosus with associated liver disease.

    abstract：:A young woman developed minocycline-related lupus erythematosus with associated autoimmune hepatitis. All clinical and laboratory abnormalities returned to normal when the drug was stopped. The symptoms worsened dramatically upon rechallenge, strongly suggesting the reaction was related to the minocycline. ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(97)70043-4

    authors： Crosson J,Stillman MT

    更新日期：1997-05-01 00:00:00

  • Cellular and immunologic mechanisms in atopic dermatitis.

    abstract：:Atopic dermatitis is a chronic inflammatory skin disease that is frequently associated with respiratory allergies. Atopic dermatitis develops as a result of a complex interrelationship of environmental, immunologic, genetic, and pharmacologic factors. Efforts to understand the relative contributions of these factors h...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1067/mjd.2001.109815

    authors： Leung DY,Soter NA

    更新日期：2001-01-01 00:00:00

  • Losing touch with the healing art: dermatology and the decline of pastoral doctoring.

    abstract：:Technological advance in society and medicine has brought tremendous improvements and convenience but also a degree of depersonalization. The personal and pastoral aspects of medical practice, which are probably more important in helping patients toward health than we realize, are becoming increasingly stifled by heal...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1067/mjd.2000.109290

    authors： Gibbs S

    更新日期：2000-11-01 00:00:00

  • Loose anagen syndrome.

    abstract：:A distinctive new hair condition, the loose anagen syndrome, features anagen hairs that are loosely anchored and easily pulled from the scalp. The children studied had sparse hair that did not grow long and that pulled easily from the scalp. The majority of patients were blond girls, aged 2 to 5 years, but both sexes ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(89)70030-x

    authors： Price VH,Gummer CL

    更新日期：1989-02-01 00:00:00

  • Photoprotection: part II. Sunscreen: development, efficacy, and controversies.

    abstract：:In addition to the naturally occurring, physical, and systemic photoprotective agents reviewed in part I, topical ultraviolet radiation filters are an important cornerstone of photoprotection. Sunscreen development, efficacy, testing, and controversies are reviewed in part II of this continuing medical education artic...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2013.08.022

    authors： Jansen R,Osterwalder U,Wang SQ,Burnett M,Lim HW

    更新日期：2013-12-01 00:00:00

  • Treatment of resistant severe psoriasis with systemic cyclosporine.

    abstract：:Four patients with severe psoriasis have been treated with oral cyclosporine for 6 months. Two had generalized erythroderma and two had extensive plaque-type psoriasis; all had either become unresponsive to or were unable to use other accepted treatments. All four patients responded rapidly and were completely clear o...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(87)70221-7

    authors： Picascia DD,Garden JM,Freinkel RK,Roenigk HH Jr

    更新日期：1987-09-01 00:00:00

  • Mental health impairment among children with atopic dermatitis: A United States population-based cross-sectional study of the 2013-2017 National Health Interview Survey.

    abstract：BACKGROUND:Atopic dermatitis (AD) is associated with mental health disorders, but its impact on global mental health symptoms is less clear. OBJECTIVE:To determine the association between pediatric AD and mental health impairment. METHODS:In a cross-sectional study using 2013-2017 United States National Health Interv...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2019.10.019

    authors： Wan J,Takeshita J,Shin DB,Gelfand JM

    更新日期：2020-06-01 00:00:00

  • Unilateral dermatomal superficial telangiectasia. Nine new cases and a review of unilateral dermatomal superficial telangiectasia.

    abstract：:Unilateral dermatomal superficial telangiectasia (UDST) may be congenital or acquired. Acquired UDST may occur coincident with physiologic states of estrogen increase, including puberty and pregnancy in women and adrenarche in men. Acquired UDST may also occur in estrogenized pathologic states such as chronic hepatic ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(83)70051-4

    authors： Wilkin JK,Smith JG Jr,Cullison DA,Peters GE,Rodriquez-Rigau LJ,Feucht CL

    更新日期：1983-04-01 00:00:00

  • Topical and intralesional cidofovir: a review of pharmacology and therapeutic effects.

    abstract：BACKGROUND:Cidofovir is a potent nucleoside analog antiviral drug approved for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It is currently available only for intravenous infusion. Several small studies and case reports describe the successful use of cidofovir applied either topically or intr...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/s0190-9622(98)70046-5

    authors： Zabawski EJ Jr,Cockerell CJ

    更新日期：1998-11-01 00:00:00

  • Elevation of fasting serum lipids in patients treated with low-dose cyclosporine for severe plaque-type psoriasis. An assessment of clinical significance when viewed as a risk factor for cardiovascular disease.

    abstract：BACKGROUND:Hyperlipidemia has received little attention as a side effect of cyclosporine therapy for severe psoriasis. OBJECTIVE:We report changes in fasting serum lipids in patients treated with low-dose oral cyclosporine for psoriasis and discuss their significance. METHODS:Twenty-two patients with severe, recalcit...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/0190-9622(92)70213-y

    authors： Stiller MJ,Pak GH,Kenny C,Jondreau L,Davis I,Wachsman S,Shupack JL

    更新日期：1992-09-01 00:00:00

  • Nonbullous pemphigoid: A systematic review.

    abstract：BACKGROUND:Bullous pemphigoid is an autoimmune disease that typically presents with tense bullae and severe pruritus. However, bullae can be lacking, a subtype termed nonbullous pemphigoid. OBJECTIVE:To summarize the reported characteristics of nonbullous pemphigoid. METHODS:The EMBASE and MEDLINE databases were sear...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaad.2017.10.035

    authors： Lamberts A,Meijer JM,Jonkman MF

    更新日期：2018-05-01 00:00:00

  • Venous thromboembolic and bleeding complications among pregnant women with Klippel-Trenaunay syndrome.

    abstract：BACKGROUND:Klippel-Trenaunay syndrome (KTS) is a vascular malformation overgrowth syndrome characterized by capillary malformation, venous malformation, and limb overgrowth, with or without lymphatic malformation. Patients are at an increased risk of hemorrhage and venous thromboembolism (VTE). Consequently, women with...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2019.04.018

    authors： Marvin EK,Schoch JJ,Nguyen H,Anderson KR,Driscoll DJ,Rose CH,Bendel EC,Tollefson MM

    更新日期：2019-12-01 00:00:00

  • Measurement properties of the Patient-Reported Outcomes Measurement Information System Itch Questionnaire item banks in adults with atopic dermatitis.

    abstract：BACKGROUND:The Patient-Reported Outcomes Measurement Information System (PROMIS) Itch Questionnaire (PIQ) was recently developed. OBJECTIVE:To validate PIQ short forms in adults with AD. METHODS:Self-administered questionnaires and skin examinations were performed in 239 adults with atopic dermatitis (AD) in a dermat...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2019.11.057

    authors： Silverberg JI,Lai JS,Vakharia PP,Patel K,Singam V,Chopra R,Sacotte R,Patel N,Rastogi S,Kantor R,Hsu DY,Cella D

    更新日期：2020-05-01 00:00:00

  • Narrowband ultraviolet B and medium-dose ultraviolet A1 are equally effective in the treatment of moderate to severe atopic dermatitis.

    abstract：BACKGROUND:Phototherapy may be effective in atopic dermatitis (AD). Medium-dose (MD) ultraviolet (UV) A1 was introduced for the treatment of AD. Few immunohistochemical data are available pertaining to phototherapy in AD. Regulatory T cells may play a role in clearing AD. OBJECTIVES:We sought to compare the clinical a...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jaad.2008.08.048

    authors： Majoie IM,Oldhoff JM,van Weelden H,Laaper-Ertmann M,Bousema MT,Sigurdsson V,Knol EF,Bruijnzeel-Koomen CA,de Bruin-Weller MS

    更新日期：2009-01-01 00:00:00

  • Widespread cutaneous vascular papules associated with peripheral blood eosinophilia and prominent inguinal lymphadenopathy.

    abstract：:A new section entitled "Dermatology Grand Rounds at the NIH" appears this month. The idea behind it is to provide a unique look at instructive dermatologic cases being presented at the weekly Dermatology Branch Grand Rounds at the National Cancer Institute, National Institutes of Health (NIH), Bethesda, Maryland. Pati...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1067/mjd.2000.108372

    authors： Blauvelt A,Cobb MW,Turner ML

    更新日期：2000-10-01 00:00:00

  • A quantitative systematic review of the efficacy of imiquimod monotherapy for lentigo maligna and an analysis of factors that affect tumor clearance.

    abstract：BACKGROUND:The reported efficacy of imiquimod for lentigo maligna varies widely, without consensus on tumor or treatment factors that can impact tumor clearance. OBJECTIVE:We sought to provide a more precise estimate of clearance rates in patients with lentigo maligna who are treated with imiquimod and to analyze fact...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaad.2015.05.022

    authors： Mora AN,Karia PS,Nguyen BM

    更新日期：2015-08-01 00:00:00

  • Nonscarring inflammatory epidermolysis bullosa acquisita with esophageal involvement and linear IgG deposits.

    abstract：:A 24-year-old woman with autoimmune thrombocytopenia and hypothyroidism had an inflammatory bullous eruption in the mouth, face, and trunk that left no milia or scars after healing. Histologic examination revealed a subepidermal bulla and a neutrophil infiltration. Direct immunofluorescence examination showed depositi...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(97)80408-2

    authors： Taniuchi K,Inaoki M,Nishimura Y,Mori T,Takehara K

    更新日期：1997-02-01 00:00:00

  • Obsessive-compulsive disorder in patients with chronic pruritic conditions: case studies and discussion.

    abstract：BACKGROUND:Relatively few persons with obsessive-compulsive disorder (OCD) come to psychiatric clinics for treatment. Our hypothesis was that patients with a form of OCD that involves compulsive hand and body washing might initially seek treatment from a dermatologist. OBJECTIVE:Our purpose was to screen patients atte...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/0190-9622(92)70078-t

    authors： Hatch ML,Paradis C,Friedman S,Popkin M,Shalita AR

    更新日期：1992-04-01 00:00:00

  • A randomized, open-label trial of continuous versus interrupted etanercept therapy in the treatment of psoriasis.

    abstract：BACKGROUND:Although etanercept is used as a continuous therapy for moderate to severe plaque psoriasis, intermittent use may be necessary in some instances. OBJECTIVE:In this randomized, open-label study, we evaluated the effectiveness and safety of continuous versus interrupted etanercept therapy. METHODS:All patien...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jaad.2006.09.002

    authors： Moore A,Gordon KB,Kang S,Gottlieb A,Freundlich B,Xia HA,Stevens SR

    更新日期：2007-04-01 00:00:00

  • Cultivation of Borrelia burgdorferi from human tick bite sites: a guide to the risk of infection.

    abstract：BACKGROUND:The risk of acquiring Lyme disease has been evaluated by xenodiagnostic procedures with laboratory strains of Borrelia burgdorferi and laboratory-reared Ixodes ticks, or by clinical trials in which diagnosis was based on clinical findings, culture, or serologic tests. OBJECTIVE:Our purpose was to determine ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/0190-9622(95)90123-x

    authors： Berger BW,Johnson RC,Kodner C,Coleman L

    更新日期：1995-02-01 00:00:00

  • Immune checkpoint inhibitor therapy in solid organ transplant recipients: A patient-centered systematic review.

    abstract：BACKGROUND:The use of immunotherapies in the treatment of metastatic cancers has significantly advanced oncology. However, due to safety concerns, solid organ transplant recipients (SOTRs) are routinely excluded from immunotherapy trials; thus, there is limited data for these agents in this population. METHODS:A syste...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2019.07.005

    authors： Fisher J,Zeitouni N,Fan W,Samie FH

    更新日期：2020-06-01 00:00:00

  • Necrolytic migratory erythema as the only presenting sign of a glucagonoma.

    abstract：:We describe a 39-year-old man with a 3-year history of a recalcitrant psoriasiform eruption that was accentuated in the intertriginous areas. Hsitopathology was consistent with psoriasis. A glucagon level was 744 pg/mL with the upper limit of normal being 130 pg/mL. Computed tomographic scan of the abdomen revealed a ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1067/s0190-9622(02)61774-8

    authors： Johnson SM,Smoller BR,Lamps LW,Horn TD

    更新日期：2003-08-01 00:00:00

  • Risk of lymphoma in patients with atopic dermatitis and the role of topical treatment: A systematic review and meta-analysis.

    abstract：BACKGROUND:There is controversy regarding a potential increased risk of lymphoma in patients with atopic dermatitis (AD). OBJECTIVE:To assess the risk of lymphoma and the role of topical treatments in patients with AD. METHODS:A systematic literature search and a separate meta-analysis were performed on case control ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.jaad.2015.02.1116

    authors： Legendre L,Barnetche T,Mazereeuw-Hautier J,Meyer N,Murrell D,Paul C

    更新日期：2015-06-01 00:00:00