Treatment of resistant severe psoriasis with systemic cyclosporine.

Abstract:

:Four patients with severe psoriasis have been treated with oral cyclosporine for 6 months. Two had generalized erythroderma and two had extensive plaque-type psoriasis; all had either become unresponsive to or were unable to use other accepted treatments. All four patients responded rapidly and were completely clear of psoriasis within 3 weeks of beginning therapy. Initial doses ranged from 7.5 to 8.5 mg/kg/day. Mild reversible nephrotoxicity occurred in the one patient whose cyclosporine trough level briefly exceeded 200 ng/ml. Cyclosporine may offer an alternative therapeutic modality in the management of erythrodermic or severe resistant plaque-type psoriasis. The effectiveness of cyclosporine in psoriasis underscores the putative role of cell-mediated immune factors in the pathogenesis of psoriasis.

journal_name

J Am Acad Dermatol

authors

Picascia DD,Garden JM,Freinkel RK,Roenigk HH Jr

doi

10.1016/s0190-9622(87)70221-7

subject

Has Abstract

pub_date

1987-09-01 00:00:00

pages

408-14

issue

3

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(87)70221-7

journal_volume

17

pub_type

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