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Hereditary melanoma: Update on syndromes and management: Genetics of familial atypical multiple mole melanoma syndrome.

Abstract：

:Malignant melanoma is considered the most lethal skin cancer if it is not detected and treated during its early stages. About 10% of melanoma patients report a family history of melanoma; however, individuals with features of true hereditary melanoma (ie, unilateral lineage, multigenerational, multiple primary lesions, and early onset of disease) are in fact quite rare. Although many new loci have been implicated in hereditary melanoma, CDKN2A mutations remain the most common. Familial melanoma in the presence of multiple atypical nevi should raise suspicion for a germline CDKN2A mutation. These patients have a high risk of developing multiple primary melanomas and internal organ malignancies, especially pancreatic cancer; therefore, a multidisciplinary approach is necessary in many cases. The value of dermoscopic examination and total body photography performed at regular intervals has been suggested by a number of studies, and should therefore be considered for these patients and their first-degree relatives. In addition, genetic counseling with the possibility of testing can be a valuable adjunct for familial melanoma patients. This must be performed with care, however, and only by qualified individuals trained in cancer risk analysis.

journal_name

J Am Acad Dermatol

journal_title

Journal of the American Academy of Dermatology

authors

Soura E,Eliades PJ,Shannon K,Stratigos AJ,Tsao H

doi

10.1016/j.jaad.2015.08.038

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

395-407; quiz 408-10

issue

3

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(15)02108-8

journal_volume

74

pub_type

杂志文章,评审

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