Drug-induced pemphigus related to angiotensin-converting enzyme inhibitors.

Abstract:

:We report a case of drug-induced pemphigus caused by an angiotensin-converting enzyme inhibitor, captopril. The cutaneous reaction remitted after withdrawal of captopril therapy. Unique to this case, however, was the substitution of another angiotensin-converting enzyme inhibitor, enalapril, without exacerbation of the pemphigus. To the best of our knowledge, this is the first reported patient with captopril-induced pemphigus in whom no new lesions developed after subsequent treatment with enalapril. A difference in chemical structure between these two drugs, particularly of a sulfur moiety, may help explain why the drug-induced disease did not recur.

journal_name

J Am Acad Dermatol

authors

Kaplan RP,Potter TS,Fox JN

doi

10.1016/0190-9622(92)70057-m

subject

Has Abstract

pub_date

1992-02-01 00:00:00

pages

364-6

issue

2 Pt 2

eissn

0190-9622

issn

1097-6787

pii

0190-9622(92)70057-M

journal_volume

26

pub_type

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