Dark pigmented lesions: diagnostic accuracy of dermatoscopy and reflectance confocal microscopy in a tertiary referral center for skin cancer diagnosis.

Abstract:

BACKGROUND:There is lack of studies on the diagnostic accuracy of dermatoscopy and reflectance confocal microscopy (RCM) for dark pigmented lesions. OBJECTIVE:To assess the diagnostic accuracy of dermatoscopy plus confocal microscopy for melanoma diagnosis of dark pigmented lesions in real life. METHODS:Prospective analysis of difficult dark lesions with clinical-dermatoscopic suspicion of melanoma referred to RCM for further analysis. Outcome of lesions could be: excision or dermatoscopic digital follow up. RESULTS:We included 370 clinically dark lesions from 350 patients (median age, 45 years). Due to the clinical-dermatoscopic-RCM approach, we saved 129/213 unnecessary biopsies (specificity of 60.6%) with a sensitivity of 98.1% (154/157). Number needed to excise with the addition of RCM was 1.5 for melanoma diagnosis. LIMITATIONS:Single institution based; Italian population only. CONCLUSIONS:This study demonstrated that RCM coupled with dermatoscopy increase the specificity for diagnosing melanoma and it helps to correctly identify benign lesions. Our findings provide the basis for subsequent prospective studies on melanocytic neoplasms belonging to patients in different countries.

journal_name

J Am Acad Dermatol

authors

Longo C,Mazzeo M,Raucci M,Cornacchia L,Lai M,Bianchi L,Peris K,Pampena R,Pellacani G

doi

10.1016/j.jaad.2020.07.084

subject

Has Abstract

pub_date

2020-07-27 00:00:00

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(20)32285-4

pub_type

杂志文章
  • New discoveries in the pathogenesis and classification of vitiligo.

    abstract::Vitiligo is a common autoimmune disease that progressively destroys melanocytes in the skin, resulting in the appearance of patchy depigmentation. This disfiguring condition frequently affects the face and other visible areas of the body, which can be psychologically devastating. The onset of vitiligo often occurs in ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaad.2016.10.048

    authors: Rodrigues M,Ezzedine K,Hamzavi I,Pandya AG,Harris JE,Vitiligo Working Group.

    更新日期:2017-07-01 00:00:00

  • Forensics in dermatology: part II.

    abstract::The evaluation of skin findings is critical in identifying many types of injury, whether self- inflicted or accidentally or intentionally inflicted. Specific causes of injury include homicide, abuse, neglect, assault, self-inflicted injury, suicide, torture, poisoning, and bioterrorism. Forensic findings in hair and n...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2010.06.066

    authors: Reddy K,Lowenstein EJ

    更新日期:2011-05-01 00:00:00

  • Role of immunohistochemistry in the diagnosis of undifferentiated tumors involving the skin.

    abstract::Twenty undifferentiated skin tumors were examined by immunostaining in an attempt to achieve more precise identification. Light microscopy yielded only a differential diagnosis, whereas immunostaining of formalin-fixed, paraffin-embedded tissue sections with a panel of antibodies to intermediate filaments and other ce...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(86)70133-3

    authors: Kahn H,Baumal R,From L

    更新日期:1986-06-01 00:00:00

  • Surgical technique for optimal outcomes: Part II. Repairing tissue: suturing.

    abstract::Sound surgical technique is necessary to achieve excellent surgical outcomes. Despite the fact that dermatologists perform more office-based cutaneous surgery than any other specialty, few dermatologists have opportunities for practical instruction to improve surgical technique after residency and fellowship. This 2-p...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaad.2014.08.006

    authors: Miller CJ,Antunes MB,Sobanko JF

    更新日期:2015-03-01 00:00:00

  • Spironolactone use does not increase the risk of female breast cancer recurrence: A retrospective analysis.

    abstract:BACKGROUND:Spironolactone is used off-label for androgenic alopecia because of its ability to arrest hair loss progression and long-term safety profile. However, little is known about the safety of spironolactone in breast cancer (BC) survivors. Because spironolactone has estrogenic effects, there is a theoretical risk...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2020.05.081

    authors: Wei C,Bovonratwet P,Gu A,Moawad G,Silverberg JI,Friedman AJ

    更新日期:2020-10-01 00:00:00

  • Role of topical tretinoin in melanoma and dysplastic nevi.

    abstract::The retinoids have been investigated extensively as chemopreventive and therapeutic agents in a variety of neoplasms. They have been shown to inhibit the proliferation of transformed cell lines in vitro and transplanted tumors in vivo. In cultured murine melanoma cells, retinoids inhibit proliferation and induce diffe...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0190-9622(86)70239-9

    authors: Meyskens FL Jr,Edwards L,Levine NS

    更新日期:1986-10-01 00:00:00

  • Follicular mucinosis as a presenting sign of acute myeloblastic leukemia.

    abstract::Follicular mucinosis is often associated with mycosis fungoides and has been rarely observed to occur with other neoplastic and inflammatory conditions. We describe a 60-year-old patient with follicular mucinosis who later developed acute myelogenous leukemia. This is the first reported case of follicular mucinosis as...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(98)70462-1

    authors: Sumner WT,Grichnik JM,Shea CR,Moore JO,Miller WS,Burton CS

    更新日期:1998-05-01 00:00:00

  • Pachyonychia congenita tarda.

    abstract::Pachyonychia congenita is a rare genetic disorder classified in clinical subtypes. Late onset of the disease has recently been described and designated as pachyonychia congenita tarda. A patient in whom typical manifestations of pachyonychia congenita appeared at the age of 39 years is described. This report substanti...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(96)90663-5

    authors: Mouaci-Midoun N,Cambiaghi S,Abimelec P

    更新日期:1996-08-01 00:00:00

  • A novel connexin 26 gene mutation associated with features of the keratitis-ichthyosis-deafness syndrome and the follicular occlusion triad.

    abstract::We report the case of a congenitally deaf white male with mild palmoplantar keratoderma, ichthyosiform scaling, follicular hyperkeratosis, and mild keratitis, features consistent with keratitis-ichthyosis-deafness syndrome. His major problem was severe, disfiguring, inflammatory dissecting folliculitis of the scalp, h...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2003.12.042

    authors: Montgomery JR,White TW,Martin BL,Turner ML,Holland SM

    更新日期:2004-09-01 00:00:00

  • Lower Socioeconomic Status is Associated with Delayed Access to Care for Infantile Hemangioma, a Cohort Study.

    abstract:BACKGROUND:Early specialist evaluation during rapid proliferative growth of complicated infantile hemangiomas (IH) is crucial. Health disparities and barriers of access-to-care for children with IH have not been examined. OBJECTIVE:Investigate whether socioeconomic status (SES) is associated with age at subspecialist ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2018.09.041

    authors: Lie E,Psoter KJ,Püttgen KB

    更新日期:2018-10-01 00:00:00

  • Cross-sectional study of blood biomarkers of patients with moderate to severe alopecia areata reveals systemic immune and cardiovascular biomarker dysregulation.

    abstract:BACKGROUND:Although there is increased understanding of the alopecia areata (AA) pathogenesis based on studies in scalp tissues, little is known about its systemic profile. OBJECTIVE:To evaluate the blood proteomic signature of AA and determine biomarkers associated with increased disease severity. METHODS:In a cross...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2020.04.138

    authors: Glickman JW,Dubin C,Renert-Yuval Y,Dahabreh D,Kimmel GW,Auyeung K,Estrada YD,Singer G,Krueger JG,Pavel AB,Guttman-Yassky E

    更新日期:2021-02-01 00:00:00

  • Eradication of scabies with a single treatment schedule.

    abstract::A single application (16 to 20 hours) of 1% gamma benzene hexachloride (GBH) lotion, when applied to a total island population of 178 persons in which seventy-four clinically had scabies, resulted in a cure rate of over 98%. Re-examination of the population at 10 and 21 weeks revealed only one remaining individual sti...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0190-9622(83)70167-2

    authors: Taplin D,Arrue C,Walker JG,Roth WI,Rivera A

    更新日期:1983-10-01 00:00:00

  • Oncogenic mutations in melanomas and benign melanocytic nevi of the female genital tract.

    abstract:BACKGROUND:The genetic heterogeneity of melanomas and melanocytic nevi of the female genital tract is poorly understood. OBJECTIVE:We aim to characterize the frequency of mutations of the following genes: BRAF, NRAS, KIT, GNA11, and GNAQ in female genital tract melanomas. We also characterize the frequency of BRAF mut...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2014.03.033

    authors: Tseng D,Kim J,Warrick A,Nelson D,Pukay M,Beadling C,Heinrich M,Selim MA,Corless CL,Nelson K

    更新日期:2014-08-01 00:00:00

  • Pulmonary disease in idiopathic urticarial vasculitis.

    abstract::A 45-year-old woman developed chronic urticaria clinically and cutaneous necrotizing vasculitis histologically, with arthralgias, abdominal pain, angioedema, hemoptysis, and pleuritic chest pain. An open lung biopsy revealed a leukocytoclastic vasculitis of the pulmonary venules, which may be etiologically associated ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(84)70170-8

    authors: Falk DK

    更新日期:1984-08-01 00:00:00

  • Assessing the role of race in quantitative measures of skin pigmentation and clinical assessments of photosensitivity.

    abstract:BACKGROUND:Given the increasing demographic diversity in the United States, clarifying relationships between race, color, ethnicity, and disease processes is critical. OBJECTIVES:We sought to examine the correlation between objective measures of skin pigmentation, racial identification, and physician-diagnosed and sel...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2004.03.051

    authors: Chan JL,Ehrlich A,Lawrence RC,Moshell AN,Turner ML,Kimball AB

    更新日期:2005-04-01 00:00:00

  • Prevalence of psoriatic arthritis in patients with psoriasis: A systematic review and meta-analysis of observational and clinical studies.

    abstract:BACKGROUND:Wide-ranging prevalence estimates of psoriatic arthritis (PsA) in patients with psoriasis have been reported. OBJECTIVES:To assess the prevalence and incidence of PsA in patients with psoriasis. METHODS:Two authors independently searched 3 databases for studies reporting on the prevalence or incidence of P...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.jaad.2018.06.027

    authors: Alinaghi F,Calov M,Kristensen LE,Gladman DD,Coates LC,Jullien D,Gottlieb AB,Gisondi P,Wu JJ,Thyssen JP,Egeberg A

    更新日期:2019-01-01 00:00:00

  • Vesiculobullous lesions caused by cytomegalovirus infection in an immunocompromised adult.

    abstract::Skin involvement in cytomegalovirus (CMV) infection is very rare. Reported cutaneous manifestations are nonspecific and include petechial, purpuric, and morbilliform rashes. We describe an immunocompromised patient who developed a vesiculobullous eruption. A simple Tzanck preparation from the base of a blister reveale...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(84)70234-9

    authors: Bhawan J,Gellis S,Ucci A,Chang TW

    更新日期:1984-10-01 00:00:00

  • Increasing supplies of dermatologists and family physicians are associated with earlier stage of melanoma detection.

    abstract:BACKGROUND:Physicians are important in the early detection of melanoma. We investigated whether primary care physician supply and the supply of dermatologists were related to stage at diagnosis for malignant melanoma. METHODS:From the state tumor registry in Florida in 1994, we identified incident cases of malignant m...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1067/mjd.2000.106242

    authors: Roetzheim RG,Pal N,van Durme DJ,Wathington D,Ferrante JM,Gonzalez EC,Krischer JP

    更新日期:2000-08-01 00:00:00

  • Skin type, minimal erythema dose (MED), and sunlight acclimatization.

    abstract::Minimal erythema doses (MEDs) of individuals with different skin types were compared. Each skin type was shown to be statistically different from each other skin type in terms of sunburn sensitivity. Individuals of each skin type who primarily stayed indoors were compared with those who attempted to be outdoors. In th...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(81)70106-3

    authors: Sayre RM,Desrochers DL,Wilson CJ,Marlowe E

    更新日期:1981-10-01 00:00:00

  • Lipedematous scalp and lipedematous alopecia: a clinical and histologic analysis of 3 cases.

    abstract:BACKGROUND:Lipedematous alopecia and lipedematous scalp are two similar unusual conditions mostly affecting healthy black women. OBJECTIVE:The purpose of our study was to report three cases of this condition with emphasis on clinical and histologic findings, and to review the literature on the subject. METHODS:The st...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaad.2004.05.016

    authors: Martín JM,Monteagudo C,Montesinos E,Guijarro J,Llombart B,Jordá E

    更新日期:2005-01-01 00:00:00

  • Acral localized acquired cutis laxa.

    abstract::We report the first case of acral localized acquired cutis laxa. The skin laxity was preceded by swelling of the fingers and toes and by the appearance of papular urticaria. Dapsone therapy was effective in controlling the swelling. Examination of skin biopsy specimens showed fragmentation and almost total loss of ela...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(89)70145-6

    authors: Fisher BK,Page E,Hanna W

    更新日期:1989-07-01 00:00:00

  • Cicatricial pemphigoid-induced phimosis.

    abstract::Cicatricial pemphigoid is an autoimmune bullous disease that has a predilection for mucous membranes and often results in scarring. We describe a case of cicatricial pemphigoid with severe involvement of the glans penis, which, despite systemic therapy, led to phimosis. ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1067/mjd.2002.107967

    authors: Fueston JC,Adams BB,Mutasim DF

    更新日期:2002-05-01 00:00:00

  • Local anesthesia in dermatologic surgery.

    abstract::With the growth of dermatologic surgery the appropriate use of local anesthesia is becoming an important issue. Thoughtful use of local anesthesia can improve the patient's experience and facilitate the surgical procedure. In this review we discuss historical and pharmacologic aspects of local anesthetic agents. Empha...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0190-9622(88)70213-3

    authors: Grekin RC,Auletta MJ

    更新日期:1988-10-01 00:00:00

  • The impact of dupilumab on patch testing and the prevalence of comorbid allergic contact dermatitis in recalcitrant atopic dermatitis: A retrospective chart review.

    abstract:BACKGROUND:It is unclear whether the type 2 T helper cell-specific immunosuppressive action of dupilumab interferes with patch testing. OBJECTIVES:We sought to evaluate the reliability of patch testing on dupilumab and the contribution of allergic contact dermatitis (ACD) to complex dermatitis in patients with residua...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2019.09.028

    authors: Raffi J,Suresh R,Botto N,Murase JE

    更新日期:2020-01-01 00:00:00

  • Future considerations for clinical dermatology in the setting of 21st century American policy reform: The Medicare Access and Children's Health Insurance Program Reauthorization Act and Alternative Payment Models in dermatology.

    abstract::With the introduction of the Medicare Access and Children's Health Insurance Program Reauthorization Act, clinicians who are not eligible for an exemption must choose to participate in 1 of 2 new reimbursement models: the Merit-based Incentive Payment System or Alternative Payment Models (APMs). Although most dermatol...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2017.01.031

    authors: Barbieri JS,Miller JJ,Nguyen HP,Forman HP,Bolognia JL,VanBeek MJ,Group for Research of Policy Dynamics in Dermatology.

    更新日期:2017-06-01 00:00:00

  • Synthetic membranes and cultured keratinocyte grafts.

    abstract::Significant progress has been made in skin replacement options in the past several decades. Although initially various materials have been used mainly for burn coverage, their application to dermatologic practice has increased significantly. We review the research, progress, and other aspects of wound coverage with sy...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/0190-9622(90)70279-q

    authors: Límová M,Grekin RC

    更新日期:1990-10-01 00:00:00

  • Immunosuppression is an independent prognostic factor associated with aggressive tumor behavior in cutaneous melanoma.

    abstract:BACKGROUND:A number of factors other than those identified by the American Joint Committee on Cancer (AJCC) may have prognostic significance in the evaluation of melanoma. OBJECTIVE:We sought to evaluate commonly recorded clinical features potentially associated with aggressive melanoma. METHODS:We conducted a retros...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2015.06.052

    authors: Donahue T,Lee CY,Sanghvi A,Obregon R,Sidiropoulos M,Cooper C,Merkel EA,Yélamos O,Ferris L,Gerami P

    更新日期:2015-09-01 00:00:00

  • Cutaneous melanoma and bilateral retinoblastoma.

    abstract::We report the case of an otherwise healthy 37-year-old man who had had bilateral enucleation during early childhood for bilateral retinoblastomas, in addition to two cutaneous melanomas (the first appearing at age 27 years). He also had dysplastic melanocytic nevi and a history of cutaneous melanoma in his mother. Ret...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/0190-9622(90)70322-9

    authors: Albert LS,Sober AJ,Rhodes AR

    更新日期:1990-11-01 00:00:00

  • Kyrle's disease.

    abstract::Kyrle's disease is a chronic, genetically determined, hyperkeratotic disorder occurring in the middle forties. We report fourteen cases of this disorder in a population of 1.5 million over a period of 15 years. We observed a female/male ratio of 6:1. Straw-colored keratotic plugs and flat scale show a marked predispos...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(87)70011-5

    authors: Cunningham SR,Walsh M,Matthews R,Fulton R,Burrows D

    更新日期:1987-01-01 00:00:00

  • Transillumination blisters in a neonate.

    abstract::Transillumination with a high-intensity fiberoptic light source is an effective means of diagnosing pneumothoraces and localizing arteries and veins for blood sampling. It has been used for these purposes in neonatal intensive care units since the 1970s. Thermal burns were reported in association with the technique in...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(99)70060-5

    authors: Sajben FP,Gibbs NF,Friedlander SF

    更新日期:1999-08-01 00:00:00