当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY期刊下所有文献 > Markedly elevated serum levels of calcium-binding S100A8/A9 proteins in psoriatic arthritis are due to activated monocytes/macrophages.

Markedly elevated serum levels of calcium-binding S100A8/A9 proteins in psoriatic arthritis are due to activated monocytes/macrophages.

Abstract：

BACKGROUND:Serum levels of S100A8/A9 may correlate with disease activity in psoriasis. OBJECTIVE:We sought to elucidate the association of serum levels of S100A8/A9 heterodimers with the clinical subtypes of psoriasis and the major cell source. METHODS:Serum samples were collected from patients with psoriasis vulgaris (n = 30), psoriatic arthritis (PA) (n = 16), pustular psoriasis (n = 24), and atopic dermatitis (n = 14) and from healthy control subjects (n = 21). Serum concentrations of S100A8/A9 were measured, and the expression levels were examined in psoriatic lesions. The messenger RNA levels were quantified in circulating monocytes and neutrophils. RESULTS:Serum levels of S100A8/A9 were significantly increased in all subtypes of psoriasis as compared with healthy controls and atopic dermatitis. Among the psoriatic subtypes, PA and pustular psoriasis showed remarkably high concentrations of S100A8/A9 heterodimers. The higher serum levels were associated with the presence of articular symptoms, but not significantly correlated with body surface areas of psoriatic lesions. S100A8 was expressed by both keratinocytes and infiltrating mononuclear cells, whereas S100A9 was predominantly expressed by neutrophils. The expression levels of S100A8 and S100A9 messenger RNA in monocytes were increased by approximately 2.25- and 1.91-fold in PA, respectively, whereas no significant increase was observed in psoriasis vulgaris and pustular psoriasis. LIMITATIONS:Difficulty in acquisition of clinical and laboratory samples in untreated patients, and of a sufficient number of subjects, were limitations. CONCLUSIONS:Although serum levels of S100A8/A9 were increased in all types of psoriasis examined, patients with PA had higher levels of S100A8/A9, probably because of an activated monocyte/macrophage system.

journal_name

J Am Acad Dermatol

journal_title

Journal of the American Academy of Dermatology

authors

Aochi S,Tsuji K,Sakaguchi M,Huh N,Tsuda T,Yamanishi K,Komine M,Iwatsuki K

doi

10.1016/j.jaad.2010.02.049

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

879-87

issue

5

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(10)00322-1

journal_volume

64

pub_type

杂志文章

相关文献

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY文献大全
  • Acrokeratoelastoidosis.

    abstract：:Acrokeratoelastoidosis is a genodermatosis characterized by firm papules or plaques on the sides of the hands and feet. Although poorly understood, the lesions may result from an abnormality in the secretion or excretion of elastic material by fibroblasts in the dermis. In this report, we will present a patient with t...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1067/mjd.2002.112928

    authors： Bogle MA,Hwang LY,Tschen JA

    更新日期：2002-09-01 00:00:00

  • Indoleamine 2,3-dioxygenase-expressing myeloid dendritic cells and macrophages in infectious and noninfectious cutaneous granulomas.

    abstract：BACKGROUND:The enzyme indoleamine 2,3-dioxygenase (IDO) degrades the essential amino acid tryptophan, and this degradation is an immunosuppressive mechanism that is mainly used by antigen-presenting cells. IDO-expressing dendritic cells and macrophages have previously been identified as components of lymph node granulo...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2010.07.050

    authors： von Bubnoff D,Scheler M,Wilms H,Wenzel J,von Bubnoff N,Häcker G,Schultze J,Popov A,Racz P,Bieber T,Wickenhauser C

    更新日期：2011-10-01 00:00:00

  • Skin cancer awareness in suburban employees: a Hispanic perspective.

    abstract：:Skin cancer is the most common form of cancer in the United States and accounts for an estimated 1 million new cases per year. In the white population, the rate of new melanomas diagnosed yearly has more than doubled from 5/100,000 in 1973 to 12/100,000 in 1990. The current lifetime risks for white persons are estimat...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1067/mjd.2002.120450

    authors： Pipitone M,Robinson JK,Camara C,Chittineni B,Fisher SG

    更新日期：2002-07-01 00:00:00

  • Primary tuberculous chancre caused by Mycobacterium bovis after goring with a bull's horn.

    abstract：:A 14-year-old boy was gored by a bull during festival celebrations. The horn of the bull caused a wound on his left hand and after 3 months it was a accompanied by an ulcerated nodule on the left upper arm and an axillary adenopathy. The tuberculin test was positive and a culture of the aspiration biopsy specimen of t...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1067/mjd.2000.108019

    authors： Ara M,Seral C,Baselga C,Navarro M,del Pilar Grasa M,Carapeto FJ

    更新日期：2000-09-01 00:00:00

  • Patterns of distribution of giant congenital melanocytic nevi (GCMN): The 6B rule.

    abstract：BACKGROUND:Garment-related terms have been used to describe the pattern of distribution of giant congenital melanocytic nevi (GCMN). OBJECTIVE:We sought to describe patterns of distribution of GCMN and propose a classification scheme. METHODS:Photographic records of patients with GCMN from the Hospital Clinic of Barc...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2016.05.042

    authors： Martins da Silva VP,Marghoob A,Pigem R,Carrera C,Aguilera P,Puig-Butillé JA,Puig S,Malvehy J

    更新日期：2017-04-01 00:00:00

  • Cutaneous findings in HIV-1-positive patients: a 42-month prospective study. Military Medical Consortium for the Advancement of Retroviral Research (MMCARR).

    abstract：BACKGROUND:Cutaneous disease is common in patients infected with HIV-1. OBJECTIVE:The aim of our study was to identify cutaneous markers associated with HIV-1 infection and disease progression as measured by Walter Reed (WR) stage. METHODS:For 42 months we have observed 912 HIV-1-positive patients in all WR stages. A...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(94)70236-5

    authors： Smith KJ,Skelton HG,Yeager J,Ledsky R,McCarthy W,Baxter D,Turiansky GW,Wagner KF,Turianski G

    更新日期：1994-11-01 00:00:00

  • Two decades of using the combination of tetracycline derivatives and niacinamide as steroid-sparing agents in the management of pemphigus: defining a niche for these low toxicity agents.

    abstract：BACKGROUND:The twin goals of long-term disease control and minimizing toxicities related to immunosuppression necessitate efforts to find effective steroid-sparing agents in the management of patients with autoimmune bullous diseases. Pemphigus especially requires a long view, because the disease can persist throughout...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2014.04.040

    authors： McCarty M,Fivenson D

    更新日期：2014-09-01 00:00:00

  • Removal of dermal edema with class I and II compression stockings in patients with lipodermatosclerosis.

    abstract：BACKGROUND:Lipodermatosclerosis is a sequela of deep venous insufficiency and a risk factor for the occurrence of venous leg ulceration. Medical compression stockings facilitate leg ulcer healing and prevent occurrence of ulcers resulting from removal of edema. Although the exact level of compression necessary for remo...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0190-9622(98)70271-3

    authors： Gniadecka M,Karlsmark T,Bertram A

    更新日期：1998-12-01 00:00:00

  • Ulcerative vulvitis in atypical Reiter's syndrome.

    abstract：:We report a case of atypical Reiter's syndrome occurring in a female patient who had severe, ulcerative vulvar disease develop in association with conjunctivitis, low back pain, stomatitis, and psoriasiform skin lesions. Vulvar lesions have rarely been described in Reiter's syndrome and are not well characterized. ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1067/mjd.2003.225

    authors： Lotery HE,Galask RP,Stone MS,Sontheimer RD

    更新日期：2003-04-01 00:00:00

  • Usefulness of dermoscopy to improve the clinical and histopathologic diagnosis of skin cancers.

    abstract：:Multiple studies have shown that dermoscopy increases the sensitivity and specificity for the detection of skin cancers compared with examination by the naked eye. Dermoscopy can also lead to the detection of thinner and smaller cancers. In addition, dermoscopy leads to the more precise selection of lesions requiring ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaad.2018.07.072

    authors： Yélamos O,Braun RP,Liopyris K,Wolner ZJ,Kerl K,Gerami P,Marghoob AA

    更新日期：2019-02-01 00:00:00

  • Analysis of patients with suspected photosensitivity referred for investigation to an Australian photodermatology clinic.

    abstract：BACKGROUND:Australia's first dedicated photodermatology clinic was established at St Vincent's Hospital Melbourne in 1993. OBJECTIVE:We sought to review clinical diagnoses and results of investigations performed on patients seen at this institution. METHODS:A database was created to enable a retrospective and prospec...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1067/mjd.2003.219

    authors： Crouch RB,Foley PA,Baker CS

    更新日期：2003-05-01 00:00:00

  • Contact urticaria and allergic contact dermatitis to benzocaine gel.

    abstract：:A 39-year-ole man developed edema and vesiculation of the oral mucosa following the application of benzocaine (Hurricaine) gel. Open testing demonstrated an immediate urticarial reaction. Closed patch tests were positive after 48 hours. The contact dermatitis was consistent with a delayed-type hypersensitivity. It app...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(80)80009-0

    authors： Ryan ME,Davis BM,Marks JG Jr

    更新日期：1980-03-01 00:00:00

  • Pruritus as a presenting sign of acquired immunodeficiency syndrome.

    abstract：:A 65-year-old man with insulin-dependent diabetes developed intractable pruritus preceding weight loss and increasing fatiguability. Esophagogastroduodenoscopy revealed infection with Candida, cytomegalovirus, and Cryptosporidium. His T cell helper/suppressor ratio was inverted, and the serum human immunodeficiency vi...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(87)70145-5

    authors： Shapiro RS,Samorodin C,Hood AF

    更新日期：1987-05-01 00:00:00

  • Laser transmission through transparent membranes used in cutaneous laser treatment.

    abstract：BACKGROUND:Some clinicians perform cutaneous laser treatments through transparent membranes to protect themselves and the surroundings from contamination by ejected tissue particles. Transmissibility of these membranes influences the tissue irradiance. OBJECTIVE:We compared the optical transmissibility of 8 membranes....

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1067/mjd.2001.116221

    authors： Chen C,Diven DG,Lockhart S,Bell B

    更新日期：2001-12-01 00:00:00

  • Use of Burow's wedge principle for repair of wounds in or near the eyebrow.

    abstract：:Burow's wedge flap provides an excellent method for repair of wounds in or near the eyebrow. Advantages afforded by this technic in this context include ample flap elasticity and vascularization, versatility in dealing with wounds of varying dimension and location, and fewer incisions in comparison with the number nec...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(85)80050-5

    authors： Gormley DE

    更新日期：1985-02-01 00:00:00

  • Rosacea subtype-directed therapy.

    abstract：:Dialogues in Dermatology, a monthly audio program from the American Academy of Dermatology, contains discussions between dermatologists on timely dermatologic topics. Commentaries from the Dialogues Editor-in-Chief, Warren R. Heymann, MD, are provided after each discussion as a topic summary. These highlights are prov...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2004.03.012

    authors： Heymann WR

    更新日期：2004-07-01 00:00:00

  • Benzoyl peroxide: percutaneous penetration and metabolic disposition. II. Effect of concentration.

    abstract：:The effect of drug concentrations of 2.5%, 5%, and 10% upon the transepidermal penetration of 14C-benzoyl peroxide in a lotion vehicle was assessed in excised human skin and in vivo in the rhesus monkey. In vitro, penetration of benzoyl peroxide was concentration-dependent, both as to rate and to amount, as measured b...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(83)70209-4

    authors： Yeung D,Nacht S,Bucks D,Maibach HI

    更新日期：1983-12-01 00:00:00

  • Lack of difference in the rates of hypopigmentation with 90-microsecond pulsed and longer dwell time carbon-dioxide laser resurfacing.

    abstract：BACKGROUND:Hypopigmentation is an adverse outcome associated with carbon-dioxide (CO(2)) laser resurfacing. A 90-microsecond pulse produces a more favorable postoperative course of healing, erythema, and pain compared with a 900-microsecond dwell time. The rate of hypopigmentation after 90-microsecond pulsed CO(2) resu...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jaad.2003.07.008

    authors： Lewis KG,Nahm WK,Schmidt AN,Moy RL

    更新日期：2004-02-01 00:00:00

  • Dermatitis in treated maple syrup urine disease.

    abstract：:Two children who had classic maple syrup urine disease developed an eruptive dermatitis when plasma isoleucine levels, leucine levels, or both fell below normal during periods of protein restriction. The dermatitis was resistant to topical corticosteroid therapy. Rapid resolution occurred after treatment with isoleuci...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/0190-9622(93)70036-s

    authors： Koch SE,Packman S,Koch TK,Williams ML

    更新日期：1993-02-01 00:00:00

  • Trichoadenoma of Nikolowski is a distinct neoplasm within the spectrum of follicular tumors.

    abstract：BACKGROUND:Trichoadenoma is a rare benign follicular tumor first described by Nikolowski 50 years ago. Both trichoadenoma and desmoplastic trichoepithelioma are composed of cords of epithelial cells and cornifying cysts embedded in sclerotic stroma. In trichoadenoma the cystic component predominates, while desmoplastic...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2009.06.086

    authors： Shimanovich I,Krahl D,Rose C

    更新日期：2010-02-01 00:00:00

  • Pilomatricoma: treatment by incision and curettement.

    abstract：:The usual method of treatment of pilomatricoma (calcifying epitheliona of Malherbe) is excision. We present a review of eight patients with ten tumors treated by incision and curettement. Follow-up ranged from 1 to 10 years, and there have been no recurrences. An alternative method of therapy with excellent results is...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(80)80291-x

    authors： Morales A,McGoey J

    更新日期：1980-01-01 00:00:00

  • Simplifying contraception requirements for iPLEDGE: A decision analysis.

    abstract：BACKGROUND:For persons of childbearing potential prescribed isotretinoin, the iPLEDGE program requires use of 2 simultaneous methods of contraception or commitment to abstinence. OBJECTIVE:To model the relative effectiveness of a variety of contraception strategies for patients taking isotretinoin, including those tha...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2020.02.022

    authors： Barbieri JS,Roe AH,Mostaghimi A

    更新日期：2020-07-01 00:00:00

  • Ex vivo evaluation of radical sun protection factor in popular sunscreens with antioxidants.

    abstract：BACKGROUND:UVA induces tissue damage via the production of radical oxygen species. Adding antioxidants to UV filters in sunscreens is a novel photoprotective strategy. The topical application of antioxidants in sunscreen can potentially neutralize the UVA-induced free radicals. OBJECTIVES:We sought to assess the degre...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/j.jaad.2010.07.009

    authors： Wang SQ,Osterwalder U,Jung K

    更新日期：2011-09-01 00:00:00

  • Sclerotic fibromas of the skin.

    abstract：:Eleven cases of a peculiar, hyalinized, hypocellular dermal fibroma are reported. The lesions are characterized by epidermal atrophy, a whorled appearance of sclerotic collagen bundles separated by clefts containing mucin, and sharp demarcation of the lesions from the surrounding normal skin. They are small white or f...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(89)70033-5

    authors： Rapini RP,Golitz LE

    更新日期：1989-02-01 00:00:00

  • The ABCD rule of dermatoscopy. High prospective value in the diagnosis of doubtful melanocytic skin lesions.

    abstract：BACKGROUND:The difficulties in accurately assessing pigmented skin lesions are ever present in practice. The recently described ABCD rule of dermatoscopy (skin surface microscopy at x10 magnification), based on the criteria asymmetry (A), border (B), color (C), and differential structure (D), improved diagnostic accura...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(94)70061-3

    authors： Nachbar F,Stolz W,Merkle T,Cognetta AB,Vogt T,Landthaler M,Bilek P,Braun-Falco O,Plewig G

    更新日期：1994-04-01 00:00:00

  • Hyperkeratosis of the nipple and areola.

    abstract：:Hyperkeratosis of the nipple and areola is a rare condition. We report two cases of hyperkeratosis of the nipple and areola occurring in men with no underlying endocrinopathy or synthetic estrogenic drug therapy. Both patients demonstrated prompt resolution of the hyperkeratosis of the nipples with a keratolytic gel. ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(85)70203-4

    authors： Kuhlman DS,Hodge SJ,Owen LG

    更新日期：1985-10-01 00:00:00

  • Bath-5-methoxypsoralen-UVA therapy for psoriasis.

    abstract：BACKGROUND:After oral intake, 5-methoxypsoralen (5-MOP) is as effective as 8-MOP for PUVA therapy for psoriasis, with a lower incidence of acute cutaneous side effects. OBJECTIVE:We compared bath-water delivery of 5-MOP and 8-MOP for photochemotherapy of psoriasis. METHODS:Twenty-two patients underwent phototesting w...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(97)80278-2

    authors： Calzavara-Pinton PG,Zane C,Carlino A,De Panfilis G

    更新日期：1997-06-01 00:00:00

  • Atypical facial scarring after isotretinoin therapy in a patient with previous dermabrasion.

    abstract：:The increased use of isotretinoin therapy for severe cystic acne has posed new problems for dermatologic surgeons. There have been recent reports in the literature of unexpected "atypical" scarring after dermabrasion in patients who have previously taken isotretinoin. This scarring was considered atypical because it o...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/s0190-9622(94)70096-6

    authors： Katz BE,Mac Farlane DF

    更新日期：1994-05-01 00:00:00

  • Malignant melanoma in xeroderma pigmentosum: search for a precursor lesion.

    abstract：BACKGROUND:Malignant melanomas occur with increased frequency and at an early age in patients with xeroderma pigmentosum (XP). OBJECTIVE:The purpose of this study was to describe the histologic features of malignant melanomas in patients with XP and to search for a possible precursor lesion. METHODS:Clinical records ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章

    doi：10.1016/0190-9622(93)70079-9

    authors： Stern JB,Peck GL,Haupt HM,Hollingsworth HC,Beckerman T

    更新日期：1993-04-01 00:00:00

  • Juvenile chronic granulocytic leukemia, juvenile xanthogranulomas, and neurofibromatosis. Case report and review of the literature.

    abstract：:A 22-month-old boy had xanthomatous skin lesions, neurofibromatosis, and chronic granulocytic leukemia. Histologic examination of the xanthomatous skin lesions disclosed juvenile xanthogranulomas. Twenty-three previously published cases of this association are reviewed. ...

    journal_title：Journal of the American Academy of Dermatology

    pub_type： 杂志文章,评审

    doi：10.1016/0190-9622(90)70136-6

    authors： Morier P,Mérot Y,Paccaud D,Beck D,Frenk E

    更新日期：1990-05-01 00:00:00