Markedly elevated serum levels of calcium-binding S100A8/A9 proteins in psoriatic arthritis are due to activated monocytes/macrophages.

Abstract:

BACKGROUND:Serum levels of S100A8/A9 may correlate with disease activity in psoriasis. OBJECTIVE:We sought to elucidate the association of serum levels of S100A8/A9 heterodimers with the clinical subtypes of psoriasis and the major cell source. METHODS:Serum samples were collected from patients with psoriasis vulgaris (n = 30), psoriatic arthritis (PA) (n = 16), pustular psoriasis (n = 24), and atopic dermatitis (n = 14) and from healthy control subjects (n = 21). Serum concentrations of S100A8/A9 were measured, and the expression levels were examined in psoriatic lesions. The messenger RNA levels were quantified in circulating monocytes and neutrophils. RESULTS:Serum levels of S100A8/A9 were significantly increased in all subtypes of psoriasis as compared with healthy controls and atopic dermatitis. Among the psoriatic subtypes, PA and pustular psoriasis showed remarkably high concentrations of S100A8/A9 heterodimers. The higher serum levels were associated with the presence of articular symptoms, but not significantly correlated with body surface areas of psoriatic lesions. S100A8 was expressed by both keratinocytes and infiltrating mononuclear cells, whereas S100A9 was predominantly expressed by neutrophils. The expression levels of S100A8 and S100A9 messenger RNA in monocytes were increased by approximately 2.25- and 1.91-fold in PA, respectively, whereas no significant increase was observed in psoriasis vulgaris and pustular psoriasis. LIMITATIONS:Difficulty in acquisition of clinical and laboratory samples in untreated patients, and of a sufficient number of subjects, were limitations. CONCLUSIONS:Although serum levels of S100A8/A9 were increased in all types of psoriasis examined, patients with PA had higher levels of S100A8/A9, probably because of an activated monocyte/macrophage system.

journal_name

J Am Acad Dermatol

authors

Aochi S,Tsuji K,Sakaguchi M,Huh N,Tsuda T,Yamanishi K,Komine M,Iwatsuki K

doi

10.1016/j.jaad.2010.02.049

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

879-87

issue

5

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(10)00322-1

journal_volume

64

pub_type

杂志文章
  • Sox10 is expressed in primary melanocytic neoplasms of various histologies but not in fibrohistiocytic proliferations and histiocytoses.

    abstract:BACKGROUND:Sox10 is a transcription factor associated with neural crest development. Its expression has been reported in melanocytes and peripheral nerve sheath cells and their associated tumors. OBJECTIVE:To assess Sox10 sensitivity in benign and malignant melanocytic neoplasms of various histologic subtypes and to d...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2011.12.035

    authors: Shin J,Vincent JG,Cuda JD,Xu H,Kang S,Kim J,Taube JM

    更新日期:2012-10-01 00:00:00

  • Minocycline-related lupus erythematosus with associated liver disease.

    abstract::A young woman developed minocycline-related lupus erythematosus with associated autoimmune hepatitis. All clinical and laboratory abnormalities returned to normal when the drug was stopped. The symptoms worsened dramatically upon rechallenge, strongly suggesting the reaction was related to the minocycline. ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(97)70043-4

    authors: Crosson J,Stillman MT

    更新日期:1997-05-01 00:00:00

  • Long-term sequelae of drug reaction with eosinophilia and systemic symptoms: a retrospective cohort study from Taiwan.

    abstract:BACKGROUND:The development of autoimmune sequelae is one of the characteristic features of drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome; however, the incidence of sequelae and prognosis of patients with DRESS are unknown. OBJECTIVE:We sought to investigate the...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2012.08.009

    authors: Chen YC,Chang CY,Cho YT,Chiu HC,Chu CY

    更新日期:2013-03-01 00:00:00

  • Seborrheic keratosis: reflectance confocal microscopy features and correlation with dermoscopy.

    abstract:BACKGROUND:Differentiation between seborrheic keratosis (SK) and skin cancers may be difficult. Reflectance confocal microscopy (RCM) enables noninvasive assessment of skin neoplasms at cellular-level resolution. OBJECTIVE:We sought to describe RCM features of SK and to correlate these RCM findings with dermoscopic st...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2012.12.969

    authors: Ahlgrimm-Siess V,Cao T,Oliviero M,Laimer M,Hofmann-Wellenhof R,Rabinovitz HS,Scope A

    更新日期:2013-07-01 00:00:00

  • In vivo percutaneous absorption of hydrocortisone in psoriatic patients and normal volunteers.

    abstract::Our objective was to determine the percutaneous absorption of hydrocortisone in psoriatic skin. [14C]-Hydrocortisone formulated as a 0.5% cream was applied to sharply defined erythematous plaques with silvery scales on the dorsal forearm of four hospitalized psoriatic patients. An average 2.32 +/- 1.4 (SD) percent of ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(83)70072-1

    authors: Wester RC,Bucks DA,Maibach HI

    更新日期:1983-05-01 00:00:00

  • Use of complementary and alternative medicine among adults with skin disease: updated results from a national survey.

    abstract:BACKGROUND:In the United States, complementary and alternative medicine (CAM) is used for a variety of diseases, including those of the skin. An estimate of the prevalence of CAM use among adults with skin disease using the alternative health supplement of the 2002 National Health Interview Survey (NHIS) has been publi...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2009.12.009

    authors: Fuhrmann T,Smith N,Tausk F

    更新日期:2010-12-01 00:00:00

  • A case of childhood epithelioid hemangioendothelioma.

    abstract::Epithelioid hemangioendothelioma (EHE) is a unique tumor, mainly of adults, which is characterized by epithelioid or histiocytoid endothelial cells. It is a low-grade malignant vascular tumor first described as a distinctive entity in 1982 by Weiss and Enzinger. An 8-year-old girl presented with an approximately 3-yea...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(00)90267-6

    authors: Roh HS,Kim YS,Suhr KB,Yoon TY,Lee JH,Park JK

    更新日期:2000-05-01 00:00:00

  • Lichen planopilaris: a clinicopathologic study.

    abstract::Three clinicopathologic variants of lichen planopilaris are described. The first is characterized clinically by individual keratotic follicular papules and histologically by a lichenoid inflammatory cell infiltrate confined to the follicular epithelium. The second variant consists of erythematous to violaceous plaques...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/0190-9622(90)70078-v

    authors: Matta M,Kibbi AG,Khattar J,Salman SM,Zaynoun ST

    更新日期:1990-04-01 00:00:00

  • Unusual cutaneous manifestations of B-cell chronic lymphocytic leukemia.

    abstract:BACKGROUND:B-cell chronic lymphocytic leukemia (B-CLL) is a low-grade lymphoproliferative disorder with characteristic histomorphologic features and an identifiable immunophenotype. The skin can be involved in the context of known disease, but cutaneous signs are rarely the presenting findings. OBJECTIVE:Evaluation of...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2008.12.047

    authors: Plaza JA,Comfere NI,Gibson LE,Colgan M,Davis DM,Pittelkow MR,Colgan JP

    更新日期:2009-05-01 00:00:00

  • Unilateral dermatomal superficial telangiectasia. Nine new cases and a review of unilateral dermatomal superficial telangiectasia.

    abstract::Unilateral dermatomal superficial telangiectasia (UDST) may be congenital or acquired. Acquired UDST may occur coincident with physiologic states of estrogen increase, including puberty and pregnancy in women and adrenarche in men. Acquired UDST may also occur in estrogenized pathologic states such as chronic hepatic ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(83)70051-4

    authors: Wilkin JK,Smith JG Jr,Cullison DA,Peters GE,Rodriquez-Rigau LJ,Feucht CL

    更新日期:1983-04-01 00:00:00

  • Compliance with sunscreen advice in a survey of adults engaged in outdoor winter recreation at high-elevation ski areas.

    abstract:BACKGROUND:Adults are advised to wear sunscreen with a sun protection factor (SPF) of 15 or higher, apply it up to 30 minutes before sun exposure, and reapply it after 2 hours to reduce exposure to ultraviolet radiation in sunlight for the prevention of skin cancer. OBJECTIVE:This study investigated the extent to whic...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2010.11.044

    authors: Buller DB,Andersen PA,Walkosz BJ,Scott MD,Maloy JA,Dignan MB,Cutter GR

    更新日期:2012-01-01 00:00:00

  • Cutaneous lentiginosis with atrial myxomas.

    abstract::This report describes a 25-year-old white woman with lentigines, cutaneous myxomas, bilateral atrial myxomas, and cerebral artery aneurysms. We believe this case to be the fifth reported case of this unusual association in the medical literature, with the additional finding of a central nervous system aneurysm. In the...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(86)70188-6

    authors: Reed OM,Mellette JR Jr,Fitzpatrick JE

    更新日期:1986-08-01 00:00:00

  • Oral dexamethasone pulse treatment for vitiligo.

    abstract:BACKGROUND:Oral corticosteroid pulse therapy has provided inconsistent results in the treatment of Indian patients with vitiligo. OBJECTIVE:We wanted to evaluate the efficacy, safety, and tolerability of oral dexamethasone pulse therapy in a cohort of Austrian patients with vitiligo. METHODS:Twenty-nine patients with...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1067/mjd.2001.113475

    authors: Radakovic-Fijan S,Fürnsinn-Friedl AM,Hönigsmann H,Tanew A

    更新日期:2001-05-01 00:00:00

  • Cellulitis-like cutaneous metastasis of uterine cervical carcinoma.

    abstract::Metastasis to the skin from cervical carcinoma is relatively uncommon. Herein we present a 41-year-old woman with a history of cervical carcinoma with severe facial erythematous swelling and telangiectasia. She was initially treated for cellulitis without improvement. A skin biopsy specimen revealed widespread intrava...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2006.03.028

    authors: Yang HI,Lee MC,Kuo TT,Hong HS

    更新日期:2007-02-01 00:00:00

  • Proliferation marker Ki-S5 as a diagnostic tool in melanocytic lesions.

    abstract:BACKGROUND:A discrimination between benign and malignant melanocytic lesions is not always possible by conventional histology. OBJECTIVE:Our purpose was to determine the proliferative activity in various types of melanocytic neoplasms and to appraise its value as a diagnostic adjunct. METHODS:The growth fraction was ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(97)80121-1

    authors: Rudolph P,Schubert C,Schubert B,Parwaresch R

    更新日期:1997-08-01 00:00:00

  • Extraparotid Warthin's tumor.

    abstract::Warthin's tumor (papillary cystadenoma lymphomatosum) is a well-known benign tumor of the parotid gland. Extraparotid tumors occasionally arise in the cervical region, where they may well be seen by the dermatologist. The following is a case report of an extraparotid Warthin's tumor encountered in a dermatology practi...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(99)70499-8

    authors: Patterson JW,Wright ED,Camden S

    更新日期:1999-03-01 00:00:00

  • Use of monoclonal antibodies (UCHL1, Ki-B3) against T and B cell antigens in routine paraffin-embedded skin biopsy specimens.

    abstract::Diagnosis and classification of cutaneous lymphoid infiltrates are often hampered by lack of frozen tissue to allow detailed immunophenotyping. Therefore antibodies that recognize antigens resistant to routine tissue processing would be of value. In this study we present a detailed analysis of two such antibodies agai...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(89)70155-9

    authors: Sterry W,Hauschild A

    更新日期:1989-07-01 00:00:00

  • Fractional carbon-dioxide (CO2) laser-assisted topical therapy for the treatment of onychomycosis.

    abstract:BACKGROUND:Inability of topical medications to penetrate via nail plate brings a great challenge to clinicians in treating onychomycosis. Furthermore, oral medications are not appropriate for all patients because of drug interactions, adverse effects, and contraindications. OBJECTIVE:We sought to evaluate the clinical...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2015.12.002

    authors: Bhatta AK,Keyal U,Huang X,Zhao JJ

    更新日期:2016-05-01 00:00:00

  • Familial multiple lipomatosis. Report of a case and a review of the literature.

    abstract::Familial multiple lipomatosis is a hereditary syndrome of multiple lipomas occurring in a particular distribution. It is clinically distinct from multiple symmetric lipomatosis with which it is frequently confused in the dermatologic literature. A case of familial multiple lipomatosis is reported and a review of this ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:

    authors: Leffell DJ,Braverman IM

    更新日期:1986-08-01 00:00:00

  • Cutaneous multilobated T-cell lymphoma with aggressive course.

    abstract::Cutaneous multilobated T-cell lymphoma is an uncommon variant of skin-based peripheral T-cell lymphoma typically characterized by cutaneous nodules in elderly patients and a chronic clinical course. We report a case of the disease that led to the patient's death within 2 years after onset. This disease may be associat...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/0190-9622(91)70201-c

    authors: Goldman BD,Bari M,Kantor GR,Kadin ME,Micaily B,Vonderheid EC

    更新日期:1991-08-01 00:00:00

  • Simultaneous development of two cases of eosinophilia-myalgia syndrome with the same lot of L-tryptophan in Japan.

    abstract::A newly recognized and well-described connective tissue disease, eosinophilia-myalgia syndrome, is thought to relate to L-tryptophan ingestion. The suspect L-tryptophan made in Japan has been distributed in Japan and in the United States. Different from many case reports of eosinophilia-myalgia syndrome in the United ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/0190-9622(91)70232-q

    authors: Mizutani T,Mizutani H,Hashimoto K,Nakamura Y,Kishida M,Taniguchi H,Murata M,Kuzuhara S,Shimizu M

    更新日期:1991-09-01 00:00:00

  • Therapeutic use of cytokines in dermatology.

    abstract::Cytokines are glycoproteins produced by many different cells. Via binding to specific receptors on target cells they regulate the activation, differentiation, and proliferation of immune and nonimmune cells. After injury keratinocytes synthesize and release cytokines such as interleukins, colony stimulating factors, a...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/0190-9622(91)70147-t

    authors: Luger TA,Schwarz T

    更新日期:1991-06-01 00:00:00

  • Ex vivo evaluation of radical sun protection factor in popular sunscreens with antioxidants.

    abstract:BACKGROUND:UVA induces tissue damage via the production of radical oxygen species. Adding antioxidants to UV filters in sunscreens is a novel photoprotective strategy. The topical application of antioxidants in sunscreen can potentially neutralize the UVA-induced free radicals. OBJECTIVES:We sought to assess the degre...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2010.07.009

    authors: Wang SQ,Osterwalder U,Jung K

    更新日期:2011-09-01 00:00:00

  • Outpatient dermatology consultation impacts the diagnosis and management of pediatric oncology patients: A retrospective study.

    abstract:BACKGROUND:The impact of dermatology consultation on the care of children with oncologic conditions is unknown. OBJECTIVE:To review outpatient dermatology visits and the resulting impact on diagnosis and management of pediatric oncology patients. METHOD:Retrospective review of pediatric oncology patients with outpati...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2017.06.005

    authors: Song H,Robinson SN,Huang JT

    更新日期:2017-11-01 00:00:00

  • A phase 2, randomized dose-finding study of tapinarof (GSK2894512 cream) for the treatment of atopic dermatitis.

    abstract:BACKGROUND:Safe and efficacious topical treatments are needed for atopic dermatitis (AD). OBJECTIVE:We assessed the safety and efficacy of tapinarof cream (2 concentrations and 2 application frequencies) in patients with AD. METHODS:A double-blind, vehicle-controlled, randomized, 6-arm trial (1:1:1:1:1:1) in patients...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jaad.2018.06.047

    authors: Peppers J,Paller AS,Maeda-Chubachi T,Wu S,Robbins K,Gallagher K,Kraus JE

    更新日期:2019-01-01 00:00:00

  • Atypical mole syndrome: risk factor for cutaneous malignant melanoma and implications for management.

    abstract::The incidence of malignant melanoma is increasing faster than that of any other cancer. It is important to identify subsets of the population at high risk of its development so that they can be observed more closely to identify early melanomas when they are curable. It has been reported worldwide that persons with the...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/0190-9622(95)90073-x

    authors: Slade J,Marghoob AA,Salopek TG,Rigel DS,Kopf AW,Bart RS

    更新日期:1995-03-01 00:00:00

  • Pediatric allergic contact dermatitis. Part I: Clinical features and common contact allergens in children.

    abstract::Allergic contact dermatitis (ACD), a delayed hypersensitivity skin reaction to environmental allergens, has a prevalence that is similar in children and adults. However, diagnostic testing for ACD in pediatric populations accounts for less than one tenth of all patch tests. The relative infrequency of pediatric patch ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaad.2020.11.002

    authors: Neale H,Garza-Mayers AC,Tam I,Yu J

    更新日期:2021-02-01 00:00:00

  • Hereditary palmoplantar keratoderma, type papulosa, in Croatia.

    abstract:BACKGROUND:Hereditary palmoplantar keratoderma (HPPK), type papulosa, is rare, and epidemiologic data are sporadic and inconsistent. An epidemiologic population study of this disease has not been performed previously. OBJECTIVE:We performed a large population study on prevalence of HPPK, type papulosa, in Croatia. ME...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/0190-9622(93)70207-a

    authors: Stanimirović A,Kansky A,Basta-Juzbasić A,Skerlev M,Beck T

    更新日期:1993-09-01 00:00:00

  • Bullosis diabeticorum. Report of a case with a review of the literature.

    abstract::The case of a male diabetic patient with recurrent bullous lesions restricted to the hands is reported. Areas of spongiosis in the epidermis, as well as subepidermal blister formation, were observed in repeated biopsies. On electron microscopy, separation was seen at the level of the lamina lucida. No immunopathology ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:

    authors: Toonstra J

    更新日期:1985-11-01 00:00:00

  • Pyoderma gangrenosum of the breasts precipitated by breast surgery.

    abstract::Pyoderma gangrenosum may occur in unusual sites and not be readily recognized. Delays in diagnosis and appropriate treatment may result in extensive ulcerations and scarring. We present two patients with pyoderma gangrenosum involving the breasts after breast operation. Delays in diagnosis resulted in extensive ulcera...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2006.02.066

    authors: Davis MD,Alexander JL,Prawer SE

    更新日期:2006-08-01 00:00:00