Markedly elevated serum levels of calcium-binding S100A8/A9 proteins in psoriatic arthritis are due to activated monocytes/macrophages.


BACKGROUND:Serum levels of S100A8/A9 may correlate with disease activity in psoriasis. OBJECTIVE:We sought to elucidate the association of serum levels of S100A8/A9 heterodimers with the clinical subtypes of psoriasis and the major cell source. METHODS:Serum samples were collected from patients with psoriasis vulgaris (n = 30), psoriatic arthritis (PA) (n = 16), pustular psoriasis (n = 24), and atopic dermatitis (n = 14) and from healthy control subjects (n = 21). Serum concentrations of S100A8/A9 were measured, and the expression levels were examined in psoriatic lesions. The messenger RNA levels were quantified in circulating monocytes and neutrophils. RESULTS:Serum levels of S100A8/A9 were significantly increased in all subtypes of psoriasis as compared with healthy controls and atopic dermatitis. Among the psoriatic subtypes, PA and pustular psoriasis showed remarkably high concentrations of S100A8/A9 heterodimers. The higher serum levels were associated with the presence of articular symptoms, but not significantly correlated with body surface areas of psoriatic lesions. S100A8 was expressed by both keratinocytes and infiltrating mononuclear cells, whereas S100A9 was predominantly expressed by neutrophils. The expression levels of S100A8 and S100A9 messenger RNA in monocytes were increased by approximately 2.25- and 1.91-fold in PA, respectively, whereas no significant increase was observed in psoriasis vulgaris and pustular psoriasis. LIMITATIONS:Difficulty in acquisition of clinical and laboratory samples in untreated patients, and of a sufficient number of subjects, were limitations. CONCLUSIONS:Although serum levels of S100A8/A9 were increased in all types of psoriasis examined, patients with PA had higher levels of S100A8/A9, probably because of an activated monocyte/macrophage system.


J Am Acad Dermatol


Aochi S,Tsuji K,Sakaguchi M,Huh N,Tsuda T,Yamanishi K,Komine M,Iwatsuki K




Has Abstract


2011-05-01 00:00:00














  • Reduction in nevus biopsies in patients monitored by total body photography.

    abstract:BACKGROUND:Total body photography (TBP) can facilitate identification of new and changing lesions. By confirming that particular nevi are stable, TBP may reduce nevus biopsies. OBJECTIVES:We sought to determine the number and rate of nevus biopsies before and after TBP, and the factors associated with increased biopsy...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Truong A,Strazzulla L,March J,Boucher KM,Nelson KC,Kim CC,Grossman D

    更新日期:2016-07-01 00:00:00

  • In search of an optimum dose escalation for narrowband UVB phototherapy: is it time to quit 20% increments?

    abstract:OBJECTIVES:Our aim was to compare 20% with 10% to 5% incremental regimens in narrowband UVB phototherapy. STUDY PATIENTS:The study included patients with psoriasis (N = 191) with Fitzpatrick skin phototypes II and III. RESULTS:Occurrence of erythema as well as maximum and cumulative doses were higher with 20% escalat...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Boztepe G,Akinci H,Sahin S,Karaduman A,Evans SE,Erkin G,Atakan N,Akan T,Kölemen F

    更新日期:2006-08-01 00:00:00

  • Measuring psoriatic arthritis symptoms: A core domain in psoriasis clinical trials.

    abstract:BACKGROUND:The International Dermatology Outcome Measures established a set of core domains to be measured in all psoriasis trials. This set requires that symptoms of psoriatic arthritis (PsA) be measured in all psoriasis studies. OBJECTIVE:To identify the approach to PsA screening and the most appropriate outcome mea...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审


    authors: Perez-Chada LM,Gottlieb AB,Cohen J,Mease P,Duffin KC,Garg A,Latella J,Armstrong AW,Ogdie A,Merola JF

    更新日期:2020-01-01 00:00:00

  • Hepatonecrosis resulting from parenteral gold therapy in pemphigus vulgaris.

    abstract::A patient who had pemphigus vulgaris received therapy with gold thiomalate in addition to dexamethasone. Three weeks after the initiation of parenteral gold the patient developed acute hepatitis. Causes other than gold toxicity were ruled out, and the patient recovered completely after discontinuation of gold therapy....

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Rye B,Krusinski PA

    更新日期:1993-01-01 00:00:00

  • Epidermal expression of 65 and 72 kd heat shock proteins in psoriasis and AIDS-associated psoriasiform dermatitis.

    abstract:BACKGROUND:Psoriasiform dermatitis is common in patients with AIDS. The expression of heat shock proteins by keratinocytes has been postulated to be a significant factor in the physiopathology of psoriasis and might be subject to modulation in HIV-infected patients. OBJECTIVE:We sought to evaluate the epidermal expres...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Puig L,Fernández-Figueras MT,Ferrándiz C,Ribera M,de Moragas JM

    更新日期:1995-12-01 00:00:00

  • Cross-sectional study of blood biomarkers of patients with moderate to severe alopecia areata reveals systemic immune and cardiovascular biomarker dysregulation.

    abstract:BACKGROUND:Although there is increased understanding of the alopecia areata (AA) pathogenesis based on studies in scalp tissues, little is known about its systemic profile. OBJECTIVE:To evaluate the blood proteomic signature of AA and determine biomarkers associated with increased disease severity. METHODS:In a cross...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Glickman JW,Dubin C,Renert-Yuval Y,Dahabreh D,Kimmel GW,Auyeung K,Estrada YD,Singer G,Krueger JG,Pavel AB,Guttman-Yassky E

    更新日期:2021-02-01 00:00:00

  • Contact sensitivity to nickel and other metals in jewelry reactors.

    abstract:BACKGROUND:Many patients who give a history of a dermatitis reaction to jewelry or metal contact with skin are negative to metals on standard patch testing. Some may be showing false-negative reactions. OBJECTIVE:Our purpose was to determine whether patients with a history of jewelry reactions but whose standard patch...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Gawkrodger DJ,Lewis FM,Shah M

    更新日期:2000-07-01 00:00:00

  • Annular elastolytic giant cell granuloma in an infant: improvement after treatment with oral tranilast and topical pimecrolimus.

    abstract::Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin disease of unknown origin that is characterized clinically by annular patches with erythematous borders and hypopigmented centers and histologically by loss of elastic fibers and elastophagocytosis. We report a case of AEGCG in an 8-month-ol...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Lee HW,Lee MW,Choi JH,Moon KC,Koh JK

    更新日期:2005-11-01 00:00:00

  • Successful treatment of musk ketone-induced chronic actinic dermatitis with cyclosporine and PUVA.

    abstract::We describe a patient with chronic actinic dermatitis whose photopatch tests revealed reactions to musk ketone and musk ambrette, both of which were found in his aftershave lotion. Minimal erythema doses of UVA and UVB were decreased. After initial unsuccessful treatment with PUVA therapy the patient was successfully ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Gardeazábal J,Arregui MA,Gil N,Landa N,Ratón JA,Diáz-Pérez JL

    更新日期:1992-11-01 00:00:00

  • An analysis of health system reform for dermatologists: elements and implications of the Patient Protection and Affordable Care Act.

    abstract::The Patient Protection and Affordable Care Act will have substantial effects on the US health care system. Physicians hold varied opinions regarding the overall merits or drawbacks of the health system reform law, but it is critical that we understand its components and the implications for our practices and our patie...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Resneck JS Jr

    更新日期:2010-10-01 00:00:00

  • Characteristics, treatment, and survival of invasive malignant melanoma (MM) in giant pigmented nevi (GPN) in adults: 976 cases from the National Cancer Data Base (NCDB).

    abstract:BACKGROUND:Malignant melanoma (MM) arising in a giant pigmented nevus (GPN) is a rare disease in adults with no large series published to our knowledge. OBJECTIVE:We sought to describe the characteristics, treatment, and survival of MM in GPN for adults. METHODS:Adults with invasive MM in GPN (n = 976) reported to th...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Turkeltaub AE,Pezzi TA,Pezzi CM,Dao H Jr

    更新日期:2016-06-01 00:00:00

  • Graft-like plantar lesion secondary to possible dorsal-to-ventral cutaneous transposition.

    abstract::We describe a 3-year-old male patient with an unusual congenital lesion on the plantar surface of the left foot that had been asymptomatic until shortly before presentation. Histologic examination of the plaque revealed a thinner keratin layer, increased pigmentation, and a pilosebaceous unit with a visible vellus hai...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Dragan L,Lorincz AL,Medenica MM,Phillips SB

    更新日期:1999-05-01 00:00:00

  • Oral terbinafine in the treatment of toenail onychomycosis: North American multicenter trial.

    abstract:BACKGROUND:Onychomycosis is an increasing problem with limited therapeutic options. OBJECTIVE:We evaluated the safety and efficacy, of oral terbinafine, a new fungicidal antimycotic, in patients with toenail onychomycosis. METHODS:A North American multicenter, double-blind, placebo-controlled study evaluated the myco...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Drake LA,Shear NH,Arlette JP,Cloutier R,Danby FW,Elewski BE,Garnis-Jones S,Giroux JM,Gratton D,Gulliver W,Hull P,Jones HE,Journet M,Krol AL,Leyden JJ,Maddin SC,Ross JB,Savin RC,Scher RK,Sibbald GR,Tawfik NH,Zaia

    更新日期:1997-11-01 00:00:00

  • Angioma serpiginosum with extensive cutaneous involvement.

    abstract::Angioma serpiginosum is a rare condition that involves both the proliferation and dilatation of superficial blood vessels in the skin. It classically begins in childhood, is more common in females, and is asymptomatic. Typical lesions appear on the extremities and are often asymmetric. We report a case of angioma serp...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审


    authors: Katta R,Wagner A

    更新日期:2000-02-01 00:00:00

  • Granulomatous and suppurative dermatitis at interferon alfa injection sites: report of 2 cases.

    abstract::It has previously been reported that interferon alfa injection sites may develop pyoderma gangrenosum, interface dermatitis, vasculitis, or, more commonly, ulcers characterized by intravascular thrombi and a mixed inflammatory cell infiltrate. We describe 2 patients in whom granulomatous and suppurative dermatitis dev...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Sanders S,Busam K,Tahan SR,Johnson RA,Sachs D

    更新日期:2002-04-01 00:00:00

  • Dermoscopy of black skin: A cross-sectional study of clinical and dermoscopic features of melanocytic lesions in individuals with type V/VI skin compared to those with type I/II skin.

    abstract:BACKGROUND:The identification of "normal" dermoscopic patterns of acquired melanocytic nevi provides better diagnostic accuracy for melanoma in people with black skin. OBJECTIVE:We sought to describe melanocytic lesions (numbers and anatomic distributions) in skin types V and VI compared with skin types I and II, acco...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Tuma B,Yamada S,Atallah ÁN,Araujo FM,Hirata SH

    更新日期:2015-07-01 00:00:00

  • Etanercept improves the health-related quality of life of patients with psoriasis: results of a phase III randomized clinical trial.

    abstract::In this randomized, double-blind, phase III trial, patients with psoriasis received etanercept for 24 weeks or placebo for 12 weeks followed by etanercept for 12 weeks. At week 12, improvement in Dermatology Life Quality Index was 47% to 61% with etanercept compared with 11% with placebo (P < .0001). Etanercept rapidl...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,随机对照试验


    authors: Feldman SR,Kimball AB,Krueger GG,Woolley JM,Lalla D,Jahreis A

    更新日期:2005-11-01 00:00:00

  • Pili torti in association with citrullinemia.

    abstract::A 2 1/2-year-old white girl with citrullinemia accompanied by neurologic symptoms presented with 2- to 3-week loss of scalp hair. Examination of the scalp revealed 90% of the hairs to be broken off, leaving a stubble of hairs less than 1 mm in length. Microscopically, plucked hairs demonstrated flattening, twisting th...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Patel HP,Unis ME

    更新日期:1985-01-01 00:00:00

  • Cutaneous reactive angiomatoses: patterns and classification of reactive vascular proliferation.

    abstract::New and relatively old types of vascular (capillary) proliferations in the skin have been described or better categorized in the last few years. They include reactive angioendotheliomatosis, acroangiodermatitis (pseudo-Kaposi sarcoma), diffuse dermal angiomatosis, intravascular histocytosis, glomeruloid angioendotheli...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审


    authors: Rongioletti F,Rebora A

    更新日期:2003-11-01 00:00:00

  • Skin cancer awareness in suburban employees: a Hispanic perspective.

    abstract::Skin cancer is the most common form of cancer in the United States and accounts for an estimated 1 million new cases per year. In the white population, the rate of new melanomas diagnosed yearly has more than doubled from 5/100,000 in 1973 to 12/100,000 in 1990. The current lifetime risks for white persons are estimat...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Pipitone M,Robinson JK,Camara C,Chittineni B,Fisher SG

    更新日期:2002-07-01 00:00:00

  • Safety of dermatologic drugs used in pregnant patients with psoriasis and other inflammatory skin diseases.

    abstract::In patients with psoriasis, there is an increased availability of drugs for treatment. However, there are important questions about drug safety for mothers with psoriasis and their fetuses. Currently, there are limited safety data for many of the medications used. In this article, we review current pregnancy risk info...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审


    authors: Lam J,Polifka JE,Dohil MA

    更新日期:2008-08-01 00:00:00

  • Cost of atopic dermatitis and eczema in the United States.

    abstract:BACKGROUND:Atopic dermatitis/eczema (AD/E) is a common disease. Few studies have attempted to quantify the cost to third-party payers. OBJECTIVE:Our purpose was to identify the annual cost of medical services and prescription drugs for the treatment of AD/E to private insurance and Medicaid payers in the United States...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Ellis CN,Drake LA,Prendergast MM,Abramovits W,Boguniewicz M,Daniel CR,Lebwohl M,Stevens SR,Whitaker-Worth DL,Cheng JW,Tong KB

    更新日期:2002-03-01 00:00:00

  • Correlations of unique clinical, immunotypic, and histologic findings in cutaneous gamma/delta T-cell lymphoma.

    abstract::Cutaneous T-cell lymphoma is a malignancy of T cells that express a clone-specific heterodimer T-cell receptor for antigen. The second recognized case of an epidermotropic malignancy of T-cells expressing gamma/delta T-cell receptor-expressing cells is reported. The immunophenotype of the malignant T-cells was CD3+, C...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Heald P,Buckley P,Gilliam A,Perez M,Knobler R,Kacinski B,Edelson R

    更新日期:1992-05-01 00:00:00

  • Narrowband ultraviolet B and medium-dose ultraviolet A1 are equally effective in the treatment of moderate to severe atopic dermatitis.

    abstract:BACKGROUND:Phototherapy may be effective in atopic dermatitis (AD). Medium-dose (MD) ultraviolet (UV) A1 was introduced for the treatment of AD. Few immunohistochemical data are available pertaining to phototherapy in AD. Regulatory T cells may play a role in clearing AD. OBJECTIVES:We sought to compare the clinical a...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,随机对照试验


    authors: Majoie IM,Oldhoff JM,van Weelden H,Laaper-Ertmann M,Bousema MT,Sigurdsson V,Knol EF,Bruijnzeel-Koomen CA,de Bruin-Weller MS

    更新日期:2009-01-01 00:00:00

  • Bullous dermatosis caused by Staphylococcus aureus in locus minoris resistentiae.

    abstract::A case of Staphylococcus aureus--induced bullous dermatosis limited to the sites of glucocorticosteroid-induced striae atrophicae is described. Skin with compromised mechanical integrity may be more susceptible to disruption by invasion of bacteria and/or by their exotoxin. The pathogenesis of striae atrophicae and th...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Bronstein SW,Bickers DR,Lamkin BC

    更新日期:1984-02-01 00:00:00

  • Immunosuppression is an independent prognostic factor associated with aggressive tumor behavior in cutaneous melanoma.

    abstract:BACKGROUND:A number of factors other than those identified by the American Joint Committee on Cancer (AJCC) may have prognostic significance in the evaluation of melanoma. OBJECTIVE:We sought to evaluate commonly recorded clinical features potentially associated with aggressive melanoma. METHODS:We conducted a retros...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Donahue T,Lee CY,Sanghvi A,Obregon R,Sidiropoulos M,Cooper C,Merkel EA,Yélamos O,Ferris L,Gerami P

    更新日期:2015-09-01 00:00:00

  • Treatments of actinic cheilitis: A systematic review of the literature.

    abstract:BACKGROUND:No large studies have defined the best treatment of actinic cheilitis. METHODS:We conducted a systematic review to define the best therapies for actinic cheilitis in clinical response and recurrences. RESULTS:We first identified 444 papers, and 49 were finally considered, including 789 patients and 843 tre...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审


    authors: Lai M,Pampena R,Cornacchia L,Pellacani G,Peris K,Longo C

    更新日期:2020-09-01 00:00:00

  • Predictive value of HLA antigen for methotrexate-induced liver damage in patients with psoriasis.

    abstract::For an investigation of a possible association between HLA antigens and postmethotrexate liver damage, the A, B, C, and Dr loci of the HLA antigens were determined in thirty-two patients with severe psoriasis who had been treated with methotrexate. There was no association between HLA antigens and increasing severity ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Pestana A,Halprin KM,Taylor JR,Schiff ER,Esquenazi V,Comerford M,Gomez C

    更新日期:1985-01-01 00:00:00

  • UV-specific p53 and PTCH mutations in sporadic basal cell carcinoma of sun-exposed skin.

    abstract::UVB irradiation is known to produce DNA damage at mutation hotspots in the p53 tumor suppressor gene, leading to the development of skin cancers. Mutations in the PTCH tumor suppressor gene, which is known to be responsible for the development of nevoid basal cell carcinoma syndrome, have also been identified in spora...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Ratner D,Peacocke M,Zhang H,Ping XL,Tsou HC

    更新日期:2001-02-01 00:00:00

  • Antinuclear antibody-negative systemic lupus erythematosus. I. Anti-Ro(SSA) and anti-La(SSB) antibodies.

    abstract::Anti-Ro(SSA) and anti-La(SSB) antibodies are found in approximately 25% of systemic lupus erythematosus patients. These antibodies are also detected in lupus patients who fail to demonstrate a significant antinuclear antibody (ANA) titer when mouse liver is employed as the substrate. Approximately 5% to 10% of systemi...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Provost TT,Reichlin M

    更新日期:1981-01-01 00:00:00