Clinical, histopathologic, and immunophenotypic features of lymphomatoid papulosis with CD8 predominance in 14 pediatric patients.

Abstract:

BACKGROUND:Lymphomatoid papulosis (LyP) is a cyclic papulonodular eruption that is clinically benign and histologically malignant. Association with hematologic neoplasias has been reported in 5% to 20% of all cases. OBJECTIVE:We sought to review the clinical and histopathologic features of LyP in pediatric patients. METHODS:We searched for the records of all patients with a clinical and histopathologic diagnosis of LyP seen at our clinic from January 1991 through April 2008. The cases of pediatric patients (aged < 20 years) were reviewed in detail. RESULTS:Of 123 patients with LyP identified, 14 (11%) were in the pediatric age group. Most were male (64%); mean age of onset was 12 years. Type A LyP was identified in 12 patients, one patient had type B, and none had type C (type not determined in one case). Ten cases showed CD8 predominance by immunohistochemistry. T-cell intracytoplasmic antigen staining was positive in 3 cases of CD8(+) LyP type A and the one case of LyP type B. Lesional T-cell receptor gene rearrangement studies were negative in 9 of 10 patients with LyP type A. The average follow-up time was 5.5 years. Lesions improved with treatment in most cases, and none of the cases were associated with hematologic malignancies. LIMITATIONS:This was a retrospective review. CONCLUSIONS:Among our pediatric patients, we noted a predominance of CD8(+) LyP, which does not seem to have an aggressive course. Further longitudinal studies are necessary to evaluate prognostic differences between CD4(+) and CD8(+) LyP and their biological significance.

journal_name

J Am Acad Dermatol

authors

de Souza A,Camilleri MJ,Wada DA,Appert DL,Gibson LE,el-Azhary RA

doi

10.1016/j.jaad.2009.05.014

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

993-1000

issue

6

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(09)00616-1

journal_volume

61

pub_type

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