Topical 5% imiquimod for the therapy of actinic cheilitis.

Abstract:

BACKGROUND:Tissue-destructive and more selective cytotoxic therapies are the main methods used to treat actinic cheilitis. A topical immune stimulant, 5% imiquimod cream, has recently been used for treatment of cutaneous epithelial malignancies including squamous cell carcinoma in situ and basal cell carcinoma. OBJECTIVE:Our aim was to review the results in patients who had been treated for actinic cheilitis with imiquimod cream. METHODS:A review identified 15 patients with biopsy-proven actinic cheilitis who had been treated with topical imiquimod 3 times weekly for 4 to 6 weeks. All patients with histories consistent with facial herpes simplex or documented prior facial herpes simplex eruptions were treated with oral valcyclovir, 1 g/d, during imiquimod therapy. RESULTS:All 15 patients showed clinical clearing of their actinic cheilitis at 4 weeks after discontinuation of the topical imiquimod. Sixty percent of the patients experienced a moderate to marked increased local reaction consisting of increased erythema, induration, and erosions or ulcerations, which in some cases continued through the period of therapy. CONCLUSION:Imiquimod appears to have a role in the treatment of actinic cheilitis. However, the dose and duration of therapy, as well as the long-term efficacy, need to be established; and local reactions are to be expected and may not improve during therapy.

journal_name

J Am Acad Dermatol

authors

Smith KJ,Germain M,Yeager J,Skelton H

doi

10.1067/mjd.2002.126266

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

497-501

issue

4

eissn

0190-9622

issn

1097-6787

pii

S0190962202000877

journal_volume

47

pub_type

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