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Giant angiofibromas in tuberous sclerosis complex: a possible role for localized lymphedema in their pathogenesis.

Abstract：

BACKGROUND:Giant angiofibromas in patients with tuberous sclerosis complex (TSC) are rare. OBJECTIVE:We sought to report two patients who had TSC with unusually large and disfiguring facial angiofibromas and to identify underlying histopathologic changes that may possibly explain the clinical features. METHODS:We performed a clinicopathologic, immunohistochemical, and molecular biologic study using 42 lesional specimens and peripheral blood from one of the two patients. The immunohistochemical investigations were mainly focused on the vascular moiety of the lesions. TSC1 and TSC2 alterations were studied using multiplex ligation-dependent probe amplification for large deletion/duplication mutations, whereas screening for small mutations was performed using polymerase chain reaction amplification of individual coding exons and exon-intron junctions of both genes followed by an analysis on denaturation gradient gel electrophoresis. RESULTS:Histopathologic examination revealed, in addition to findings typical of angiofibroma, several unusual features including multinucleated giant cells containing multiple intracytoplasmic vacuoles, Touton-like cells, emperipolesis, pagetoid dyskeratosis, vacuolar alteration at the dermoepidermal junction, Civatte bodies, and melanophages in the subjacent dermis. Numerous dilated lymphatic vessels were detected indicating localized lymphostasis, probably caused by secondary lymphedema. The lymphatic nature of the vessels was confirmed by immunohistochemical study. Genetic testing for TSC1 and TSC2 gene mutations revealed a substitution on position c.2251C>T resulting in a nonsense mutation R751X in fragment 20.2. LIMITATIONS:Histopathologic specimens and peripheral blood were available from only one patient. CONCLUSION:Localized lymphedema may contribute to the formation of large disfiguring angiofibromas in patients with TSC.

journal_name

J Am Acad Dermatol

journal_title

Journal of the American Academy of Dermatology

authors

Kacerovska D,Kerl K,Michal M,Filipova H,Vrtel R,Vanecek T,Zelenakova H,Kraus J,Kodet R,Kazakov DV

doi

10.1016/j.jaad.2012.03.021

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

1319-26

issue

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(12)00366-0

journal_volume

pub_type

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Giant angiofibromas in tuberous sclerosis complex: a possible role for localized lymphedema in their pathogenesis.