A simple and improved method for direct and indirect immunofluorescent staining.

abstract：BACKGROUND:Exposure to ultraviolet radiation (from solar and nonsolar sources) is a risk factor for skin cancer. OBJECTIVE:We sought to summarize recent estimates on sunburns, sun-protection behaviors, and indoor tanning available from national and selected statewide behavioral surveys. METHODS:Estimates of the preva...

journal_title：Journal of the American Academy of Dermatology

authors： Buller DB,Cokkinides V,Hall HI,Hartman AM,Saraiya M,Miller E,Paddock L,Glanz K

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:General practitioners/dermatologists may be aware of musculoskeletal symptoms in patients with psoriasis but may have difficulty accurately detecting psoriatic arthritis (PsA). OBJECTIVE:We sought to evaluate 3 PsA screening questionnaires-the Psoriasis and Arthritis Screening Questionnaire (PASQ), Psoriasi...

journal_title：Journal of the American Academy of Dermatology

authors： Mease PJ,Gladman DD,Helliwell P,Khraishi MM,Fuiman J,Bananis E,Alvarez D

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Rituximab has been increasingly used in autoimmune blistering dermatoses, mainly in pemphigus. However, only a few larger case series are available on this subject and information on the efficacy of retreatment with rituximab during relapses is lacking. OBJECTIVE:We sought to determine efficacy and adverse ...

journal_title：Journal of the American Academy of Dermatology

authors： Kasperkiewicz M,Shimanovich I,Ludwig RJ,Rose C,Zillikens D,Schmidt E

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Spironolactone is used off-label for androgenic alopecia because of its ability to arrest hair loss progression and long-term safety profile. However, little is known about the safety of spironolactone in breast cancer (BC) survivors. Because spironolactone has estrogenic effects, there is a theoretical risk...

journal_title：Journal of the American Academy of Dermatology

authors： Wei C,Bovonratwet P,Gu A,Moawad G,Silverberg JI,Friedman AJ

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Photodynamic therapy (PDT) and imiquimod are the treatments of choice for actinic keratosis (AK). As they have different mechanisms of action, it seems reasonable to assume that applying both treatments sequentially would be efficacious. OBJECTIVES:We sought to determine which of these therapeutic modalitie...

journal_title：Journal of the American Academy of Dermatology

authors： Serra-Guillén C,Nagore E,Hueso L,Traves V,Messeguer F,Sanmartín O,Llombart B,Requena C,Botella-Estrada R,Guillén C

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Some hereditary palmoplantar keratodermas (PPK) have been defined at the molecular level. OBJECTIVE:Our purpose was to establish the cause of a hereditary PPK with unique histopathologic findings in the epidermis. METHODS:Investigative studies included light and electron microscopy and determination of gen...

journal_title：Journal of the American Academy of Dermatology

authors： Magro CM,Baden LA,Crowson AN,Bowden PE,Baden HP

更新日期：1997-07-01 00:00:00

abstract：:In pyodermatitis-pyostomatitis vegetans annular pustular cutaneous lesions may precede, accompany, or follow the usually extensive vegetating oral disease. Sometimes only cutaneous or only oral lesions occur and previously have been described as separate entities. Clinical, histopathologic, and immunopathologic eviden...

journal_title：Journal of the American Academy of Dermatology

authors： Storwick GS,Prihoda MB,Fulton RJ,Wood WS

更新日期：1994-08-01 00:00:00

abstract：:Erythematous papulonodules that resembled a malignant lymphoma developed in a 62-year-old man. Further examination revealed that he had primary myelofibrosis with cutaneous extramedullary hematopoiesis. All three marrow elements (myeloid, erythroid, and megakaryocytic series) were present in the skin lesions. Although...

journal_title：Journal of the American Academy of Dermatology

authors： Mizoguchi M,Kawa Y,Minami T,Nakayama H,Mizoguchi H

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:Despite the prevalence of androgenetic alopecia among men, little is known about its psychological effects. OBJECTIVE:This investigation examined the psychosocial sequelae that balding men attribute to hair loss and compared balding and nonbalding men in personality functioning. METHODS:Subjects included 6...

journal_title：Journal of the American Academy of Dermatology

authors： Cash TF

更新日期：1992-06-01 00:00:00

abstract：:Skin biopsy specimens from 24 patients with different lichenoid skin diseases that had been proved histologically were studied immunohistologically. Marked differences were noted in the number of OKT6+/S100+ Langerhans cells within the epidermis and dermis in the lesional skin between lichen planus (and its related di...

journal_title：Journal of the American Academy of Dermatology

authors： Shiohara T,Moriya N,Tanaka Y,Arai Y,Hayakawa J,Chiba M,Nagashima M

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Segmental vitiligo (SV) is characterized by a unilateral and localized distribution, early onset, and stable disease after rapid progression. And SV is often associated with poor response to various treatment modalities. OBJECTIVE:We sought to evaluate the effectiveness of combination therapy with 308-nm ex...

journal_title：Journal of the American Academy of Dermatology

authors： Bae JM,Yoo HJ,Kim H,Lee JH,Kim GM

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:It was unclear whether an increased number of common nevi (moles) predicts melanoma death. OBJECTIVE:We prospectively examined the association between number of common nevi and risk of melanoma death. METHODS:Our study used data from the Nurses' Health Study (n = 77,288 women) and Health Professionals Foll...

journal_title：Journal of the American Academy of Dermatology

authors： Li WQ,Cho E,Weinstock MA,Li S,Stampfer MJ,Qureshi AA

更新日期：2019-05-01 00:00:00

abstract：:A woman with pemphigus vulgaris was treated by plasma exchange. Four separate exchanges of approximately 4,000 ml each were performed over a 2-week period. The patient's pemphigus antibody titer decreased from 1/320 before the first exchange to 1/20 after the final exchange, and no new lesions developed for 3 weeks fo...

journal_title：Journal of the American Academy of Dermatology

authors： Swanson DL,Dahl MV

更新日期：1981-03-01 00:00:00

abstract：:Infections with mycobacteria are of importance in the differential diagnosis of skin lesions in immunocompromised patients. We report the case of a human immunodeficency virus (HIV)-infected patient who presented with an annular plaque as cutaneous manifestation of Mycobacterium haemophilum. Improvement of the immunol...

journal_title：Journal of the American Academy of Dermatology

authors： Friedli A,Krischer J,Hirschel B,Saurat JH,Pechère M

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Several clinical studies have focused on the therapeutic effects of interferon gamma (IFN-gamma) in patients with severe atopic dermatitis (AD), although the dosage of recombinant IFN-gamma (rIFN-gamma), therapeutic schedule, and the degree of clinical improvement were different among studies. Although the e...

journal_title：Journal of the American Academy of Dermatology

authors： Jang IG,Yang JK,Lee HJ,Yi JY,Kim HO,Kim CW,Kim TY

更新日期：2000-06-01 00:00:00

abstract：:Eosinophilic spongiosis has a distinctive but not diagnostic histologic pattern of the epidermis. This pattern may be seen in a wide variety of clinical disorders. We have observed it most commonly in bullous pemphigoid, particularly the urticarial stage. In most biopsy specimens that show eosinophilic spongiosis, add...

journal_title：Journal of the American Academy of Dermatology

authors： Crotty C,Pittelkow M,Muller SA

更新日期：1983-03-01 00:00:00

abstract：:A unique, progressive syndrome of muscle weakness, ascending telangiectasia, and venous ectasia of the legs developed in a 55-year-old woman with autoimmune thyroiditis. Myopathy was documented by electromyography and electron microscopy. Her constellation of findings is considered to be of autoimmune origin. Treatmen...

journal_title：Journal of the American Academy of Dermatology

authors： Shelley WB,Shelley ED

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:Because of the relatively rare occurrence of malignant melanoma (MM) of the eyelid, prognostic factors in relation to survival in these patients have not been established. OBJECTIVE:Our purpose was to examine prognostic indicators in relation to survival in patients with MM of the eyelid. METHODS:All patie...

journal_title：Journal of the American Academy of Dermatology

authors： Tahery DP,Goldberg R,Moy RL

更新日期：1992-07-01 00:00:00

abstract：:The clinical and histologic spectrum of melanotic macule of the nail unit is examined and the differences in the clinical appearance of longitudinal melanochychia caused by melanotic macule and by other kinds of proliferations of melanocytes are assessed. We observed that the clinical appearance of the pigmented band ...

journal_title：Journal of the American Academy of Dermatology

authors： Husain S,Scher RK,Silvers DN,Ackerman AB

更新日期：2006-04-01 00:00:00

abstract：:The standard definition of itching (as "an unpleasant sensation that provokes the desire to scratch") takes no account of recent advances in knowledge about itch physiology. Always imprecise, this definition is also out-of-date. Its defects are discussed in this article, and some modifications are proposed. ...

journal_title：Journal of the American Academy of Dermatology

authors： Savin JA

更新日期：1998-08-01 00:00:00

abstract：:Novel tretinoin cream and gel formulations have been developed that incorporate polyolprepolymer-2, which is a material designed to help retain drug molecules in and on the skin when applied in topical vehicles. The results of preclinical and clinical investigations have confirmed the beneficial impact of such a vehic...

journal_title：Journal of the American Academy of Dermatology

authors： Quigley JW,Bucks DA

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:Epidemiology and patterns of antibiotic resistance for Staphylococcus aureus are changing in the United States. OBJECTIVE:We sought to determine the epidemiology and antibiotic susceptibility profiles in S aureus cutaneous infections in a pediatric dermatology tertiary health care facility in North Carolina...

journal_title：Journal of the American Academy of Dermatology

authors： Ortega-Loayza AG,Diamantis SA,Gilligan P,Morrell DS

更新日期：2010-05-01 00:00:00

abstract：:Hyperkeratinization is a primary or fundamental event in a majority of today's skin disorders. Hyperkeratinization is usually the result of decreased desquamation due to increased corneocyte cohesion. Strength of corneocyte cohesion is determined by strength of intercellular bonding. Intercellular bonding is weakened ...

journal_title：Journal of the American Academy of Dermatology

authors： Van Scott EJ,Yu RJ

更新日期：1984-11-01 00:00:00

abstract：:Keratosis follicularis spinulosa decalvans is a rare, X-linked disorder affecting both the skin and eyes. There are few reports about this entity. The aim of this report is to describe 2 brothers with progressive scarring alopecia of the scalp, hypotrichosis with follicular prominence of the eyelashes, and extensive k...

journal_title：Journal of the American Academy of Dermatology

authors： Alfadley A,Al Hawsawi K,Hainau B,Al Aboud K

更新日期：2002-11-01 00:00:00

abstract：:Five families with the dysplastic nevus syndrome, in each of which one member had ocular melanoma, are reported. These five families were examined within a 3-year period in one medical center. To date only five other families with such a combination have been reported. We suggest a causal relation between ocular melan...

journal_title：Journal of the American Academy of Dermatology

authors： Vink J,Crijns MB,Mooy CM,Bergman W,Oosterhuis JA,Went LN

更新日期：1990-11-01 00:00:00

abstract：:Pyoderma gangrenosum may occur in unusual sites and not be readily recognized. Delays in diagnosis and appropriate treatment may result in extensive ulcerations and scarring. We present two patients with pyoderma gangrenosum involving the breasts after breast operation. Delays in diagnosis resulted in extensive ulcera...

journal_title：Journal of the American Academy of Dermatology

authors： Davis MD,Alexander JL,Prawer SE

更新日期：2006-08-01 00:00:00

abstract：:Pathologic T-cell activation is implicated in psoriasis progression. CD80, a costimulatory molecule involved in T-cell activation, likely plays a key role. IDEC-114, an IgG(1) anti-CD80 antibody, was evaluated for safety, pharmacokinetics, and preliminary clinical activity in this open-label, single-dose, dose-escalat...

journal_title：Journal of the American Academy of Dermatology

authors： Gottlieb AB,Lebwohl M,Totoritis MC,Abdulghani AA,Shuey SR,Romano P,Chaudhari U,Allen RS,Lizambri RG

更新日期：2002-11-01 00:00:00

abstract：:The evaluation of skin findings is critical in identifying many types of injury, whether self- inflicted or accidentally or intentionally inflicted. Specific causes of injury include homicide, abuse, neglect, assault, self-inflicted injury, suicide, torture, poisoning, and bioterrorism. Forensic findings in hair and n...

journal_title：Journal of the American Academy of Dermatology

authors： Reddy K,Lowenstein EJ

更新日期：2011-05-01 00:00:00

abstract：:Keratoacanthomas infrequently are treated by radiotherapy. However, keratoacanthomas that are recurrent after surgical excision or whose resection would result in cosmetic deformity may benefit from radiotherapy. Between January 1970 and June 1988, 29 such keratoacanthomas in 18 patients were irradiated. Doses ranged ...

journal_title：Journal of the American Academy of Dermatology

authors： Donahue B,Cooper JS,Rush S

更新日期：1990-09-01 00:00:00

abstract：:Acrocyanosis is an uncommon condition characterized by symmetric coolness and violaceous discoloration of the hands and feet. The nose, ears, lips, and nipples are also often affected. The disease is temperature dependent and generally worsens with cold exposure. Acrocyanosis is often secondary to a variety of underly...

journal_title：Journal of the American Academy of Dermatology

authors： Nousari HC,Kimyai-Asadi A,Anhalt GJ

更新日期：2001-12-01 00:00:00