Monoclonal gammopathies and associated skin disorders.

Abstract:

:The monoclonal gammopathies are characterized by clonal proliferation of plasma cells and other clonally related cells in the B-cell lineage. These disorders include monoclonal gammopathy of undetermined significance, multiple myeloma, Waldenström macroglobulinemia, heavy chain diseases, plasmacytoma, and primary amyloidosis. Many skin disorders have been described in association with monoclonal gammopathies. This article provides an introduction to the definition, detection, natural course, and spectrum of monoclonal gammopathies and a brief discussion of pathogenesis. The article also reviews the skin disorders associated with monoclonal gammopathies, categorizes the association, and evaluates the strength of the association.

journal_name

J Am Acad Dermatol

authors

Daoud MS,Lust JA,Kyle RA,Pittelkow MR

doi

10.1016/s0190-9622(99)70434-2

subject

Has Abstract

pub_date

1999-04-01 00:00:00

pages

507-35; quiz 536-8

issue

4

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(99)70434-2

journal_volume

40

pub_type

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