Abstract：
BACKGROUND:Atopic dermatitis (AD), a chronic, highly pruritic skin disorder, impairs quality of life (QoL). Janus kinase inhibitors suppress inflammatory and pruritus-associated cytokine signaling in AD. OBJECTIVE:To report the effects of ruxolitinib (RUX) cream on itch and QoL in AD. METHODS:A total of 307 adult patients with an Investigator's Global Assessment (score of 2 or 3) and 3% to 20% affected body surface area were randomly assigned for 8 weeks to receive double-blind treatment with RUX (1.5% twice daily, 1.5% once daily, 0.5% once daily, or 0.15% once daily), vehicle twice daily, or triamcinolone cream (0.1% twice daily for 4 weeks then vehicle for 4 weeks). Itch was measured by using the numerical rating scale, and patient QoL was assessed with Skindex-16. RESULTS:Improvements in itch numerical rating scale and Skindex-16 were observed with RUX cream. Overall, 42.5% of patients who applied 1.5% RUX twice daily experienced minimal clinically important difference in itch within 36 hours of treatment (vehicle, 13.6%; P < .01); near-maximal improvement was observed by week 4. Itch reduction was associated with improved QoL burden (Pearson correlation, 0.67; P < .001). Significant improvements in Skindex-16 overall scores were noted at week 2. LIMITATIONS:Facial AD lesions were not treated. CONCLUSION:RUX cream provides a clinically meaningful reduction in itch and QoL burden.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Kim BS,Sun K,Papp K,Venturanza M,Nasir A,Kuligowski MEdoi
10.1016/j.jaad.2020.02.009subject
Has Abstractpub_date
2020-06-01 00:00:00pages
1305-1313issue
6eissn
0190-9622issn
1097-6787pii
S0190-9622(20)30213-9journal_volume
82pub_type
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