Cutaneous wound healing: a model for cell-matrix interactions.

abstract：:A 58-year-old man presented with a 4-year history of a slowly enlarging, hyperkeratotic plaque on his glans penis that was compatible with a clinical diagnosis of pseudoepitheliomatous, keratotic, micaceous balanitis. The lesion had been treated unsuccessfully on three occasions with superficial shave excisional biops...

journal_title：Journal of the American Academy of Dermatology

authors： Jenkins D Jr,Jakubovic HR

更新日期：1988-02-01 00:00:00

abstract：:Vohwinkel's syndrome or keratoderma hereditaria mutilans is a diffuse, honeycombed, palmar, and plantar keratosis usually accompanied by pseudoainhum near the distal interphalangeal creases. The mutilating keratoderma associated with sensorineural hearing loss is thought to have an etiologic basis, resting on a mutati...

journal_title：Journal of the American Academy of Dermatology

authors： Solis RR,Diven DG,Trizna Z

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:Incomplete Mohs micrographic surgery (MMS) is the cessation of MMS while the tumor margins are known to be still positive. OBJECTIVE:Our purpose was to examine the factors behind unplanned incomplete MMS and to identify means of avoiding and managing this situation when it arises. METHODS:We performed a re...

journal_title：Journal of the American Academy of Dermatology

authors： Madani S,Huilgol SC,Carruthers A

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Renal allograft transplantation is associated with an increased incidence of malignant melanoma. The development of excess melanocytic nevi may be an indicator of this risk. OBJECTIVE:This study determines the prevalence of melanocytic nevi in children who have received renal allografts. METHODS:Total and ...

journal_title：Journal of the American Academy of Dermatology

authors： Smith CH,McGregor JM,Barker JN,Morris RW,Rigden SP,MacDonald DM

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Significant unmet need exists for long-term treatment of moderate to severe atopic dermatitis (AD). OBJECTIVE:To assess the long-term safety and efficacy of dupilumab in patients with AD. METHODS:This ongoing, multicenter, open-label extension study (NCT01949311) evaluated long-term dupilumab treatment in ...

journal_title：Journal of the American Academy of Dermatology

authors： Deleuran M,Thaçi D,Beck LA,de Bruin-Weller M,Blauvelt A,Forman S,Bissonnette R,Reich K,Soong W,Hussain I,Foley P,Hide M,Bouaziz JD,Gelfand JM,Sher L,Schuttelaar MLA,Wang C,Chen Z,Akinlade B,Gadkari A,Eckert L,Da

更新日期：2020-02-01 00:00:00

abstract：:Hyperkeratosis of the nipple and areola is a rare condition. We report two cases of hyperkeratosis of the nipple and areola occurring in men with no underlying endocrinopathy or synthetic estrogenic drug therapy. Both patients demonstrated prompt resolution of the hyperkeratosis of the nipples with a keratolytic gel. ...

journal_title：Journal of the American Academy of Dermatology

authors： Kuhlman DS,Hodge SJ,Owen LG

更新日期：1985-10-01 00:00:00

abstract：:We report 2 cases of relapsing nummular dermatitis according to mercury sensitivity, which was confirmed by patch testing. Removal of the amalgam from dental metal alloys markedly improved their skin eruptions. One of the patients, a dentist, experienced exacerbation of the eruptions on his lower legs after handling d...

journal_title：Journal of the American Academy of Dermatology

authors： Adachi A,Horikawa T,Takashima T,Ichihashi M

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND:Reports suggest that cigarette smoking might interfere with the effectiveness of antimalarial therapy as first-line treatment for cutaneous lupus erythematosus. Patients refractory to this treatment often must be treated with potentially more toxic regimens. OBJECTIVE:Our purpose was to examine the effects ...

journal_title：Journal of the American Academy of Dermatology

authors： Jewell ML,McCauliffe DP

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Cutaneous polyarteritis nodosa (cPAN) is a skin medium vessel neutrophilic arteritis with livedo, nodules, and ulcerations. Macular lymphocytic arteritis (MLA) is a small arteritis with erythematous or pigmented macules and typical histologic features (a lymphocytic infiltrate, concentric fibrin ring, no dis...

journal_title：Journal of the American Academy of Dermatology

authors： Buffiere-Morgado A,Battistella M,Vignon-Pennamen MD,de Masson A,Rybojad M,Petit A,Cordoliani F,Begon E,Flageul B,Mahr A,Bagot M,Bouaziz JD

更新日期：2015-12-01 00:00:00

abstract：:Striking results were obtained with oral itraconazole therapy in two opportunistic mycoses. Of 28 patients with cryptococcal meningitis, 18 achieved complete responses, including 16 of 24 patients with acquired immunodeficiency syndrome. Other manifestations of cryptococcosis were similarly responsive. In aspergillosi...

journal_title：Journal of the American Academy of Dermatology

authors： Denning DW,Tucker RM,Hanson LH,Stevens DA

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND:There is a lack of data on outcomes of management of pemphigus in children. OBJECTIVE:We sought to evaluate rituximab treatment in childhood and juvenile pemphigus. METHOD:All cases of pemphigus treated with rituximab in patients younger than 18 years were included. Clinical and epidemiologic data and deta...

journal_title：Journal of the American Academy of Dermatology

authors： Vinay K,Kanwar AJ,Sawatkar GU,Dogra S,Ishii N,Hashimoto T

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Epidermolysis bullosa (EB) is a genetic, heterogeneous, trauma-induced blistering disease. Patients with laminin-332-deficient non-Herlitz junctional EB (JEB-nH) can have impaired wound healing witnessed by persistent, small, deep ulcers on the hands and feet that adversely affect the quality of life. OBJEC...

journal_title：Journal of the American Academy of Dermatology

authors： Yuen WY,Huizinga J,Jonkman MF

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Malignant melanoma (MM) arising in a giant pigmented nevus (GPN) is a rare disease in adults with no large series published to our knowledge. OBJECTIVE:We sought to describe the characteristics, treatment, and survival of MM in GPN for adults. METHODS:Adults with invasive MM in GPN (n = 976) reported to th...

journal_title：Journal of the American Academy of Dermatology

authors： Turkeltaub AE,Pezzi TA,Pezzi CM,Dao H Jr

更新日期：2016-06-01 00:00:00

abstract：:Benign lymphangiomatous papules of the skin are benign lymphatic proliferations that may arise in the skin after operation or radiation therapy. We report a case of benign lymphangiomatous papules of the skin that occurred in a patient 4 years after undergoing radiation therapy to the chest for adenocarcinoma of the b...

journal_title：Journal of the American Academy of Dermatology

authors： Wagamon K,Ranchoff RE,Rosenberg AS,Jaworsky C

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Excess cathelicidin and kallikrein 5 (KLK5) have been hypothesized to play a role in the pathophysiology of rosacea. OBJECTIVE:We sought to evaluate the effects of azelaic acid (AzA) on these elements of the innate immune system. METHODS:Gene expression and protease activity were measured in laboratory mod...

journal_title：Journal of the American Academy of Dermatology

authors： Coda AB,Hata T,Miller J,Audish D,Kotol P,Two A,Shafiq F,Yamasaki K,Harper JC,Del Rosso JQ,Gallo RL

更新日期：2013-10-01 00:00:00

abstract：:The neutrophil function and plasma leukotactic activity of a patient with Sweet's syndrome and cystonodular acne were evaluated during a 2 1/2-year period. These studies demonstrated that chemotaxis was frequently slightly increased, especially during an exacerbation of Sweet's syndrome, but showed some decrease durin...

journal_title：Journal of the American Academy of Dermatology

authors： Kaplan SS,Wechsler HL,Basford RE,Zdziarski UE,Kuhns DB

更新日期：1985-06-01 00:00:00

abstract：:The clinical, electron microscopic, and freeze-fracture features of the skin of a harlequin fetus are described. Ultrastructural findings included large, concentric lamellar bodies, focal absence of intercellular stratum corneum lipid, and an increase in the size of desmosomes and the number of tight junctions. Althou...

journal_title：Journal of the American Academy of Dermatology

authors： Fleck RM,Barnadas M,Schulz WW,Roberts LJ,Freeman RG

更新日期：1989-11-01 00:00:00

abstract：:Pale cells that resemble those of Paget's disease have been found within apparently normal epidermis in a variety of benign papules. Although they have been considered an artifact, they show characteristic premature keratinization. In contrast to other dyskeratotic processes they mature into orthokeratotic squamae. Th...

journal_title：Journal of the American Academy of Dermatology

authors： Tschen JA,McGavran MH,Kettler AH

更新日期：1988-11-01 00:00:00

abstract：:Dialogues in Dermatology, a monthly audio program from the American Academy of Dermatology, contains discussions between dermatologists on timely topics. Commentaries from Dialogues Editor-in-Chief Jacqueline M. Junkins-Hopkins, MD, are provided after each discussion as a topic summary and are provided here as a speci...

journal_title：Journal of the American Academy of Dermatology

authors： Junkins-Hopkins JM

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Drug-specific T cells are involved in the pathogenesis of cutaneous adverse drug reactions (CADRs). OBJECTIVE:We sought to evaluate the diagnostic role of in vitro drug-induced release of interferon gamma in CADRs. METHODS:The study group consisted of 36 patients with CADRs after intake of 106 drugs that w...

journal_title：Journal of the American Academy of Dermatology

authors： Halevy S,Cohen AD,Grossman N

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Voriconazole, an antifungal agent, is associated with various cutaneous reactions, including phototoxicity, accelerated photoaging, and skin cancer. Incidence and risk factors for these reactions in children have not been well described. OBJECTIVE:We sought to determine the incidence of and factors associat...

journal_title：Journal of the American Academy of Dermatology

authors： Sheu J,Hawryluk EB,Guo D,London WB,Huang JT

更新日期：2015-02-01 00:00:00

abstract：:The tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA) causes a dose-dependent induction (up to 300-fold) of ornithine decarboxylase activity in the epidermis of intact mice within 5 hours after the application to the skin of from 1 to 10 nmoles of the ester in 0.2 ml of acetone. Enzyme activity...

journal_title：Journal of the American Academy of Dermatology

authors： Boutwell RK

更新日期：1982-04-01 00:00:00

abstract：:Angiolymphoid hyperplasia with eosinophilia developed in a 13-year-old boy. The immune phenotype of infiltrating cells and the distribution of adhesion molecules of the integrin, immunoglobulin, and selectin families were analyzed with monoclonal antibodies. The infiltrate consisted mainly of helper lymphocytes, monoc...

journal_title：Journal of the American Academy of Dermatology

authors： von den Driesch P,Gruschwitz M,Schell H,Sterry W

更新日期：1992-05-01 00:00:00

abstract：:A technique involving modification of the routine paraffin embedding procedure that allows immunohistochemical examination of extracellular antigens by light microscopy is described. The method is thus suitable for routine diagnostic immunofluorescence studies, permitting reliable, reproducible immunolabeling of immun...

journal_title：Journal of the American Academy of Dermatology

authors： Cerio R,MacDonald DM

更新日期：1988-10-01 00:00:00

abstract：BACKGROUND:In response to the increasing rate of skin cancer, particularly melanoma in the United States, the Environmental Protection Agency, the National Weather Service, the Centers for Disease Control and Prevention, National Association of Physicians for the Environment, and the American Academy of Dermatology, de...

journal_title：Journal of the American Academy of Dermatology

authors： Geller AC,Hufford D,Miller DR,Sun T,Wyatt SW,Reilley B,Bewerse B,Lisco J,Brooks D,Grupenhoff J,Weary P,Lew RA,Koh HK

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND:Bullous pemphigoid is an autoimmune blistering skin disease that predominantly affects the elderly. Conventional therapy using high-dose systemic corticosteroids and immunosuppressive agents can be ineffective in some patients and produce adverse events and relapses. Hence, alternate therapies are required. ...

journal_title：Journal of the American Academy of Dermatology

authors： Ahmed AR,Shetty S,Kaveri S,Spigelman ZS

更新日期：2016-04-01 00:00:00

abstract：:Several technics for immunofluorescent staining have been described in the literature and are presently used by laboratories performing direct and indirect tissue immunofluorescence. The purpose of this communication is to describe a simple immunofluorescent technic that uses a five-slide polypropylene slide mailer co...

journal_title：Journal of the American Academy of Dermatology

authors： Grimwood RE,Huff JC,Weston W

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND:Noninvoluting congenital hemangioma (NICH) is a distinct vascular tumor of infancy. OBJECTIVE:We describe the clinical characteristics, histopathology, imaging, and natural history of NICH and compare our findings with previous reports. METHODS:We conducted a retrospective review of charts and photographic...

journal_title：Journal of the American Academy of Dermatology

authors： Lee PW,Frieden IJ,Streicher JL,McCalmont T,Haggstrom AN

更新日期：2014-05-01 00:00:00

abstract：:Malignant myxoid melanoma (MMM) is a rarely reported variant of malignant melanoma, which can often be confused with other mucin-containing neoplasms. A retrospective study of 3 cases of MMM and a review of the English-language literature was performed. MMM affects an older population and is frequently misdiagnosed. T...

journal_title：Journal of the American Academy of Dermatology

authors： Patel P,Levin K,Waltz K,Helm KF

更新日期：2002-02-01 00:00:00

abstract：:Diabetic dermopathy (DD) is the most common cutaneous manifestation of diabetes mellitus. DD refers to atrophic, hyperpigmented macules characteristically located on the shins of patients with diabetes. They have an unfavorable association with the 3 most common microangiopathic complications of diabetes mellitus: neu...

journal_title：Journal of the American Academy of Dermatology

authors： Morgan AJ,Schwartz RA

更新日期：2008-03-01 00:00:00