Epidermodysplasia verruciformis in the setting of graft-versus-host disease.

Abstract:

:We report a case of epidermodysplasia verruciformis (EV)-like lesions in a patient with graft-versus-host disease after peripheral blood stem cell transplantation from his HLA-matched brother. The patient presented with a diffuse papular eruption that was clinically consistent with graft-versus-host disease; however, histopathology demonstrated viral cytopathic changes and polymerase chain reaction confirmed EV human papillomavirus types 8 and 20. Repeated biopsy specimen showed both human papillomavirus cytopathic effect and graft-versus-host disease, and further workup revealed ocular and hepatic involvement. This progressed to a lupuslike syndrome with lichenoid, violaceous, flat-topped papules in a malar distribution and positive antinuclear autoantibodies. Although EV-like lesions have been reported in patients who are immunocompromised, the incidence is low, and may be linked to EV-related haplotypes.

journal_name

J Am Acad Dermatol

authors

Kunishige JH,Hymes SR,Madkan V,Wyatt AJ,Uptmore D,Lazar AJ,Giralt S,Rady P,Tyring S

doi

10.1016/j.jaad.2006.04.035

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

S78-80

issue

5 Suppl

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(06)01211-4

journal_volume

57

pub_type

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