Abstract：
BACKGROUND:Methyldibromoglutaronitrile (MDGN) is a component of Euxyl K400, a preservative used in many skin care products in Europe. MDGN has been used in skin care products in the United States for the last 5 years. Contact allergy from MDGN has been reported from Europe. OBJECTIVE:The purpose of this study was to determine the frequency of MDGN as a sensitizer in patients undergoing routine patch testing. METHODS:We reviewed the results in 163 patients who underwent patch testing during a 4-month period to determine the number who had any reaction to MDGN at two different concentrations (0.2% and 0.5%). Tests were graded with the use of the North American Contact Dermatitis Group criteria (0 to 3+), and readings were performed at 48 and 96 hours (all positive reactions were evaluated at a follow-up visit or by telephone interview). RESULTS:In the 4-month period, 45 of the 163 patients showed some reaction (+/- to 3+) at one or more readings. Of these, the results for 23 patients were considered to be irritant false-positive reactions; for 3 patients, the results were classified as uncertain; and for 19 patients, the results were classified as allergic. Of these, the results for eight patients were of definite relevance; the results for five patients were of probable relevance, and the results for six patients were of doubtful relevance to the problem condition. Other positive patch tests to a variety of allergens were frequently seen in persons positive to MDGN. CONCLUSION:MDGN is a sensitizer in skin products and, with the increase of its use, should be considered in the patch test evaluation of patients with persistent dermatitis. Optimum patch test concentrations are yet to be determined.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Jackson JM,Fowler JFdoi
10.1016/s0190-9622(98)70589-4subject
Has Abstractpub_date
1998-06-01 00:00:00pages
934-7issue
6 Pt 1eissn
0190-9622issn
1097-6787pii
S0190-9622(98)70589-4journal_volume
38pub_type
杂志文章abstract：:A case of Staphylococcus aureus--induced bullous dermatosis limited to the sites of glucocorticosteroid-induced striae atrophicae is described. Skin with compromised mechanical integrity may be more susceptible to disruption by invasion of bacteria and/or by their exotoxin. The pathogenesis of striae atrophicae and th...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(84)70033-8
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abstract：:One hundred three patients with acne vulgaris were randomly designated to receive either a topical formulation of erythromycin plus zinc or a topical solution of 1% clindamycin phosphate (Cleocin-T). The patients treated themselves twice daily and were examined at 3, 6, 9, and 12 weeks after the start of therapy. By w...
journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0190-9622(90)70069-t
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abstract：:Fifty-four male and female patients with suspected colonic disease were examined for the presence of acrochordons prior to colonoscopy. Thirty-five of these patients (65%) had skin tags and twenty-six (48%) were found to have colonic polyps. In this study patients with acrochordons were significantly (p less than 0.00...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(86)70130-8
更新日期：1986-06-01 00:00:00
abstract：:Allergic contact dermatitis has been considered the most common of the many dermatologic conditions found with eyelid dermatitis. This is a retrospective study of 203 patients who presented with persistent or recurrent eyelid dermatitis with or without dermatitis elsewhere. Almost all underwent patch testing and, when...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1067/mjd.2002.122736
更新日期：2002-11-01 00:00:00
abstract：BACKGROUND:A task force of the National Psoriasis Foundation Medical Board was convened to evaluate treatment options for pustular psoriasis. Meetings were held by teleconference. Consensus on treatment of pustular psoriasis was achieved. Pustular psoriasis has been classified into localized and generalized forms. Ther...
journal_title：Journal of the American Academy of Dermatology
pub_type： 共识发展会议,杂志文章
doi：10.1016/j.jaad.2011.01.032
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abstract：BACKGROUND:The administration of a local anesthetic is often painful. OBJECTIVE:The purpose of this study was to determine whether rapidly shaking and pinching the skin during local anesthetic administration decreases pain perception. METHODS:The skin at the intended site of lidocaine injection was rapidly pinched be...
journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0190-9622(98)70404-9
更新日期：1998-07-01 00:00:00
abstract：BACKGROUND:In patients with malignancy-associated Sweet syndrome, a thorough evaluation for leukemia cutis should be considered. OBJECTIVE:We sought to describe the clinicopathologic characteristics of histiocytoid Sweet syndrome. METHODS:We retrospectively identified patients with histiocytoid Sweet syndrome at our ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2014.01.874
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:Photosensitivity (PS) in lupus erythematosus (LE) is frequently determined by patient report. OBJECTIVE:We sought to characterize self-reported PS in cutaneous LE (CLE). METHODS:The PS survey was used to classify subject responses into 5 phenotypes: direct sun-induced CLE flare (directCLE); general exacerb...
journal_title：Journal of the American Academy of Dermatology
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abstract：BACKGROUND:In primary melanomas, data on the degree of intratumoral heterogeneity to date have been lacking. OBJECTIVE:Our purpose was to investigate intratumoral DNA stem-line heterogeneity in superficial spreading melanoma (SSM). METHODS:Multiple measuring fields of 54 SSMs (tumor thickness median 1.60 mm) were stu...
journal_title：Journal of the American Academy of Dermatology
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abstract：BACKGROUND:Wide-ranging prevalence estimates of psoriatic arthritis (PsA) in patients with psoriasis have been reported. OBJECTIVES:To assess the prevalence and incidence of PsA in patients with psoriasis. METHODS:Two authors independently searched 3 databases for studies reporting on the prevalence or incidence of P...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,meta分析
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abstract：BACKGROUND:While scalp alopecia represents a distinctive feature of chronic graft-versus-host disease (cGVHD), little is known about the clinical and histologic presentation of hair loss. OBJECTIVES:We sought to classify the clinical presentations and histologic findings of chronic hair loss in patients with cutaneous...
journal_title：Journal of the American Academy of Dermatology
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doi：10.1016/j.jaad.2019.03.031
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2004.11.051
更新日期：2005-06-01 00:00:00
abstract：BACKGROUND:Reports suggest that cigarette smoking might interfere with the effectiveness of antimalarial therapy as first-line treatment for cutaneous lupus erythematosus. Patients refractory to this treatment often must be treated with potentially more toxic regimens. OBJECTIVE:Our purpose was to examine the effects ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章
doi：
更新日期：2000-06-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/0190-9622(91)70149-v
更新日期：1991-06-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2016.07.048
更新日期：2017-01-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(99)70203-3
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,多中心研究,随机对照试验
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
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journal_title：Journal of the American Academy of Dermatology
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doi：10.1016/j.jaad.2018.11.015
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:Biologic agents may predispose patients to skin and soft tissue infections (SSTIs). Guidelines recommend discontinuing the agent pre-operatively; the true risk of infection is unclear. OBJECTIVES:To assess the incidence of SSTIs in patients on biologic agents for all clinical indications. A secondary aim is...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(96)90081-x
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abstract：:Patch testing is a necessary tool to investigate contact dermatitis, which has developed alongside the increased knowledge of contact sensitivity in the past 100 years. The history of patch testing, the current state of the art with its problems, and future prospects are discussed. ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
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更新日期：1989-10-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2007.08.027
更新日期：2008-08-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
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更新日期：1991-11-01 00:00:00
abstract：UNLABELLED:Skin cancer is the most common cancer in human beings. The increased incidence of skin cancer has brought much attention to the process by which these tumors develop and how they can be prevented. Efforts have been made to educate the public about the importance of protecting skin from excessive ultraviolet ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2005.08.062
更新日期：2006-06-01 00:00:00
