Abstract：
:The etiology of mycosis fungoides (MF) is uncertain, although infectious agents and other environmental exposures have been implicated. We describe what appears to be the first case in which both a husband and his wife were diagnosed with large-cell transformation of MF. After 10 years of having stage I MF, the wife developed tumors that showed sheets of large transformed cells with dysplastic nuclei on skin biopsies, leading to a diagnosis of transformed MF. Her husband was diagnosed 14 months later with transformed MF following a biopsy of his right arm and leg after a 15-year history of presumed psoriasis. The fact that this rare occurrence happened in a couple who had been married for more than 25 years points to a common environmental exposure. Future studies should aim to clarify the potential role of infectious agents, such as human T-lymphotropic virus I and II, cytomegalovirus, Epstein-Barr virus, and other environmental exposures, in the development of MF.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Schmidt AN,Robbins JB,Greer JP,Zic JAdoi
10.1016/j.jaad.2005.09.013subject
Has Abstractpub_date
2006-05-01 00:00:00pages
S202-5issue
5 Suppleissn
0190-9622issn
1097-6787pii
S0190-9622(05)03004-5journal_volume
54pub_type
杂志文章abstract：BACKGROUND:Efalizumab inhibits multiple T-cell-mediated processes. OBJECTIVE:To evaluate 12- and 24-week efalizumab therapy for psoriasis. METHODS:In this phase III, randomized, double-blind trial, 498 patients received subcutaneous 1 or 2 mg/kg/wk efalizumab or placebo for 12 weeks. Efalizumab-treated patients who a...
journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jaad.2004.09.029
更新日期：2005-03-01 00:00:00
abstract：INTRODUCTION:Low-dose total skin electron beam therapy provides a durable treatment response for skin lesions caused by cutaneous T-cell lymphoma. We prospectively assessed the durability of response and quality of life for patients receiving low-dose total skin electron beam therapy using a novel rotational technique ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2020.12.023
更新日期：2020-12-14 00:00:00
abstract：:New and relatively old types of vascular (capillary) proliferations in the skin have been described or better categorized in the last few years. They include reactive angioendotheliomatosis, acroangiodermatitis (pseudo-Kaposi sarcoma), diffuse dermal angiomatosis, intravascular histocytosis, glomeruloid angioendotheli...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/s0190-9622(03)02100-5
更新日期：2003-11-01 00:00:00
abstract：:Recently, low-dose 5-fluorouracil/cisplatin induction concurrent with radiation (chemoradiation) has been reported to be effective for locally advanced squamous cell carcinoma of the otorhinolaryngologic and gynecologic regions. However, to date, this therapeutic option has not been evaluated for squamous cell carcino...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2005.12.035
更新日期：2006-11-01 00:00:00
abstract：:Our objective was to determine the percutaneous absorption of hydrocortisone in psoriatic skin. [14C]-Hydrocortisone formulated as a 0.5% cream was applied to sharply defined erythematous plaques with silvery scales on the dorsal forearm of four hospitalized psoriatic patients. An average 2.32 +/- 1.4 (SD) percent of ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(83)70072-1
更新日期：1983-05-01 00:00:00
abstract：:Acute febrile neutrophilic dermatosis, first described in 1964 by Robert Douglas Sweet, has been termed Sweet's syndrome. Classic Sweet's syndrome occurs in middle-aged women after a nonspecific infection of the respiratory or gastrointestinal tract. Raised erythematous plaques with pseudoblistering and occasionally p...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/s0190-9622(94)70215-2
更新日期：1994-10-01 00:00:00
abstract：BACKGROUND:Epidermolysis bullosa (EB) is a family of 23 genetic skin disorders for which treatments are mainly supportive. Graftskin is a bilayered living human skin construct characterized by a normal expression profile of all the genes reported as mutant in EB. OBJECTIVE:The objective of this study was to evaluate t...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1067/mjd.2003.502
更新日期：2003-06-01 00:00:00
abstract：:Metastatic Crohn's disease (CD) is a rare cutaneous manifestation of CD that was first described nearly 50 years ago. Many subsequent reports have defined its most common clinical and histopathologic features. The pathogenesis underlying metastatic CD is unknown but various hypotheses exist. An established standard th...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2014.04.002
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:Patients with epidermal nevi strongly demand cosmetic improvement. Laser treatment appears appealing and is frequently used in clinical practice. Nevertheless, large series with long-term follow-up are missing, preventing definitive conclusions about its real benefit. OBJECTIVE:To evaluate the long-term eff...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2019.06.013
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Vulvo-cervico-vaginal involvement has rarely been reported in pemphigus vulgaris (PV) and has not been reported in pemphigus foliaceus (PF). OBJECTIVES:We sought to evaluate genital lesions and Papanicolaou (Pap) smears in female patients with PV and PF. METHODS:This prospective study includes all consecut...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2011.10.004
更新日期：2012-09-01 00:00:00
abstract：BACKGROUND:Isotretinoin is a very effective drug for treating severe recalcitrant nodular acne. A new micronized formulation of isotretinoin has been shown to be clinically equivalent to standard isotretinoin with improved bioavailability and minimal food effect. The safety profile of the micronized formulation has not...
journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1067/mjd.2001.115966
更新日期：2001-08-01 00:00:00
abstract：BACKGROUND:Vulvar lichen sclerosus is a chronic condition usually responsive to topical corticosteroids. OBJECTIVE:We sought to evaluate the efficacy (reduction of signs and symptoms) and safety of clobetasol propionate 0.05% and tacrolimus 0.1% in the treatment of vulvar lichen sclerosus. METHOD:This double-blind, r...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jaad.2014.02.019
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:Oral methoxsalen (psoralen) and ultraviolet A radiation (PUVA) is a highly effective therapy for psoriasis and many other skin conditions. It is carcinogenic. Previously we reported an increased risk of melanoma that first emerged 15 years after first treatment. OBJECTIVE:Our purpose is to present additiona...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,多中心研究
doi：10.1067/mjd.2001.114576
更新日期：2001-05-01 00:00:00
abstract：:Renewed interest in experimental photocarcinogenesis was stimulated by the observation that skin cancers induced in mice by ultraviolet radiation are highly antigenic. Most of these cancers are rejected by the immune system on transplantation into a normal, genetically identical animal. This finding raised the questio...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/s0190-9622(86)70017-0
更新日期：1986-01-01 00:00:00
abstract：:Cutaneous extramedullary hemopoiesis (EMH) is a rare complication of chronic myeloproliferative and myelodysplastic disorders. Chronic idiopathic myelofibrosis (CIMF) is the most common underlying condition. To date, fewer than 30 cases have been reported in the literature and there has been significant confusion with...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2005.11.1038
更新日期：2006-08-01 00:00:00
abstract：:A 24-year-old woman with autoimmune thrombocytopenia and hypothyroidism had an inflammatory bullous eruption in the mouth, face, and trunk that left no milia or scars after healing. Histologic examination revealed a subepidermal bulla and a neutrophil infiltration. Direct immunofluorescence examination showed depositi...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(97)80408-2
更新日期：1997-02-01 00:00:00
abstract：BACKGROUND:Nephrogenic systemic fibrosis is a fibrosing disorder associated with gadolinium (Gd)-based contrast agents dosed during renal insufficiency. OBJECTIVE:In two patients, Gd deposition in tissue affected by nephrogenic systemic fibrosis was quantified using inductively coupled plasma mass spectrometry. The pr...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2009.07.018
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:There is growing evidence that Mohs micrographic surgery (MMS) is the treatment of choice for dermatofibrosarcoma protuberans (DFSP). OBJECTIVE:This study retrospectively compared the recurrence rates of DFSP after MMS with those after wide surgical excision; results at the Mayo Clinic and in the world lite...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：
更新日期：1996-07-01 00:00:00
abstract：BACKGROUND:Acral vascular syndromes associated with malignancy have rarely been reported. OBJECTIVE:Our purpose was to assess the clinical and evolving features of paraneoplastic acral vascular syndromes. PATIENTS AND METHODS:Two cases of paraneoplastic gangrene are described and analyzed together with previously rep...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1067/mjd.2002.120474
更新日期：2002-07-01 00:00:00
abstract：BACKGROUND:Secukinumab is a first-in-class interleukin 17A monoclonal antibody that has demonstrated an excellent safety and efficacy profile in phase 3 studies. OBJECTIVE:To evaluate the effectiveness of secukinumab in daily clinical practice and to understand the clinical and epidemiologic characteristics of patient...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jaad.2019.02.062
更新日期：2019-08-01 00:00:00
abstract：:An examination of 380 patients was accomplished in order to determine the frequency of occurrence of pigmentary demarcation lines in an unselected population. Both white and black patients were included in the study, and there was an equal sex distribution. Separation of data by age groups enabled us to determine that...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(87)70078-4
更新日期：1987-03-01 00:00:00
abstract：:The incidence of malignant melanoma is increasing faster than that of any other cancer. It is important to identify subsets of the population at high risk of its development so that they can be observed more closely to identify early melanomas when they are curable. It has been reported worldwide that persons with the...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/0190-9622(95)90073-x
更新日期：1995-03-01 00:00:00
abstract：:Dermatomyositis (DM) is an idiopathic inflammatory myopathy. The mainstay of treatment for DM is oral corticosteroids. However, the dose and length of treatment is debated. Adding to the confusion, there have been no randomized controlled studies comparing the use of various corticosteroid doses and taper rates, and n...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2008.02.043
更新日期：2008-07-01 00:00:00
abstract：BACKGROUND:After oral intake, 5-methoxypsoralen (5-MOP) is as effective as 8-MOP for PUVA therapy for psoriasis, with a lower incidence of acute cutaneous side effects. OBJECTIVE:We compared bath-water delivery of 5-MOP and 8-MOP for photochemotherapy of psoriasis. METHODS:Twenty-two patients underwent phototesting w...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(97)80278-2
更新日期：1997-06-01 00:00:00
abstract：:A 2 1/2-year-old white girl with citrullinemia accompanied by neurologic symptoms presented with 2- to 3-week loss of scalp hair. Examination of the scalp revealed 90% of the hairs to be broken off, leaving a stubble of hairs less than 1 mm in length. Microscopically, plucked hairs demonstrated flattening, twisting th...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(85)80018-9
更新日期：1985-01-01 00:00:00
abstract：:Three cases of allergic contact hypersensitivity to Sta-Lok and Loctite anaerobic sealants are reported. These two anaerobic sealants constitute a +100 million annual market in industrial sealants used to join metal surfaces together. To the best of my knowledge, these are the first reported cases of allergic contact ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(82)70160-4
更新日期：1982-12-01 00:00:00
abstract：BACKGROUND:The co-existence of hidradenitis suppurativa (HS) and atopic dermatitis (AD) had been reported but was not investigated in controlled studies. OBJECTIVE:To evaluate the bidirectional association between HS and AD. METHODS:A population-based retrospective cohort study was conducted to compare incidence rate...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2020.12.051
更新日期：2020-12-27 00:00:00
abstract：:With increasingly widespread use of cyclosporine for the treatment of psoriasis, it is imperative to identify reliable markers of cyclosporine-induced nephrotoxicity. Five patients with extensive psoriasis and no significant preexisting renal disease were treated with oral cyclosporine (average dosage, 5 mg/kg per day...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(89)70209-7
更新日期：1989-09-01 00:00:00
abstract：BACKGROUND:Only a few clinical trials have been performed on the treatment of generalized vitiligo in children. Recently, narrow-band UVB therapy has been reported to be an effective and safe therapeutic option in adult patients with vitiligo. OBJECTIVE:We studied the efficacy and safety of UVB (311 nm) therapy in chi...
journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章
doi：10.1016/S0190-9622(00)90133-6
更新日期：2000-02-01 00:00:00
abstract：:Parachlorometaxylenol is used as a germicide in many topical products. To our knowledge, this is the first case of dermatitis from parachlorometaxylenol in electrocardiograph electrodes used with cardiac monitors. The patient also had hand eczema from a germicidal soap containing parachlorometaxylenol. In addition, ou...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(86)70175-8
更新日期：1986-08-01 00:00:00
