The risk of melanoma in association with long-term exposure to PUVA.

abstract：BACKGROUND:B-cell chronic lymphocytic leukemia (B-CLL) is a low-grade lymphoproliferative disorder with characteristic histomorphologic features and an identifiable immunophenotype. The skin can be involved in the context of known disease, but cutaneous signs are rarely the presenting findings. OBJECTIVE:Evaluation of...

journal_title：Journal of the American Academy of Dermatology

authors： Plaza JA,Comfere NI,Gibson LE,Colgan M,Davis DM,Pittelkow MR,Colgan JP

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Isotretinoin is a very effective drug for treating severe recalcitrant nodular acne. A new micronized formulation of isotretinoin has been shown to be clinically equivalent to standard isotretinoin with improved bioavailability and minimal food effect. The safety profile of the micronized formulation has not...

journal_title：Journal of the American Academy of Dermatology

authors： Strauss JS,Leyden JJ,Lucky AW,Lookingbill DP,Drake LA,Hanifin JM,Lowe NJ,Jones TM,Stewart DM,Jarratt MT,Katz I,Pariser DM,Pariser RJ,Tschen E,Chalker DK,Rafal ES,Savin RP,Roth HL,Chang LK,Baginski DJ,Kempers S,M

更新日期：2001-08-01 00:00:00

abstract：:Malignant melanoma is considered the most lethal skin cancer if it is not detected and treated during its early stages. About 10% of melanoma patients report a family history of melanoma; however, individuals with features of true hereditary melanoma (ie, unilateral lineage, multigenerational, multiple primary lesions...

journal_title：Journal of the American Academy of Dermatology

authors： Soura E,Eliades PJ,Shannon K,Stratigos AJ,Tsao H

更新日期：2016-03-01 00:00:00

abstract：:Malignant melanoma presenting as an inflammatory skin metastasis has been described but is an exceedingly rare phenomenon. We report an unusual case of a patient who developed right leg lesions that were initially thought to be infectious in origin. There was no resolution of these lesions with antibiotic therapy, and...

journal_title：Journal of the American Academy of Dermatology

authors： Cotton J,Armstrong DJ,Wedig R,Hood AF

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Surgical procedures used to remove genital warts (cryotherapy, electrodesiccation) are painful. Attempts to reduce the discomfort of surgery by prior lidocaine infiltration anesthesia are compromised by the pain of the infiltration. OBJECTIVE:Our purpose was to determine the efficacy of topically applied li...

journal_title：Journal of the American Academy of Dermatology

authors： Menter A,Black-Noller G,Riendeau LA,Monti KL

更新日期：1997-07-01 00:00:00

abstract：:Isotretinoin has demonstrated efficacy in a wide range of disorders. The beneficial effects of the drug, however, are limited by its adverse effects on the bone. Children exposed to high doses are at risk for premature epiphyseal closure, while adults on long-term therapy have an increased tendency to develop hypersto...

journal_title：Journal of the American Academy of Dermatology

authors： DiGiovanna JJ

更新日期：2001-11-01 00:00:00

abstract：:The Papillon-Lefèvre syndrome is characterized by palmoplantar hyperkeratosis and juvenile periodontitis that results in the precocious loss of both the deciduous and permanent teeth. We report a patient with Papillon-Lefèvre syndrome associated with acroosteolysis, an association that has not been previously describe...

journal_title：Journal of the American Academy of Dermatology

authors： Trattner A,David M,Sandbank M

更新日期：1991-05-01 00:00:00

abstract：:We describe the clinical and biochemical features of an infant with marked transient porphyrinemia in whom blistering developed while the infant was undergoing phototherapy for severe Rh isoimmunization. The cause of the transient porphyrinemia was likely to be multifactorial--abnormal porphyrin metabolism or accumula...

journal_title：Journal of the American Academy of Dermatology

authors： Mallon E,Wojnarowska F,Hope P,Elder G

更新日期：1995-08-01 00:00:00

abstract：:The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is a rare disorder caused by mutations of the FOXP3 gene. The FOXP3 gene encodes a DNA-binding protein of the forkhead/winged-helix family and is the central controller of the development of CD4+CD25+ regulatory T cells. CD4+CD25+ regu...

journal_title：Journal of the American Academy of Dermatology

authors： McGinness JL,Bivens MM,Greer KE,Patterson JW,Saulsbury FT

更新日期：2006-07-01 00:00:00

abstract：:Magnification of histologic and ultrastructural photoimages is frequently misrepresented in published reports. "Power," P, the usual mode of representation of magnification, is defined as the ratio of the distance between two points on the photoimage to that between the same two points on the original specimen, but is...

journal_title：Journal of the American Academy of Dermatology

authors： Lambert WC,Lambert MW

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND:We recently demonstrated that cultivation of Borrelia burgdorferi from skin biopsy specimens obtained from erythema migrans lesions was an efficacious procedure to confirm the diagnosis of Lyme disease. OBJECTIVE:Our purpose was to investigate the efficacy of our microbiologic technique on blood samples obt...

journal_title：Journal of the American Academy of Dermatology

authors： Berger BW,Johnson RC,Kodner C,Coleman L

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Guselkumab, an interleukin-23 blocker, was superior to adalimumab in treating moderate to severe psoriasis in a phase II trial. OBJECTIVES:We sought to compare efficacy and safety of guselkumab with adalimumab and placebo in patients with psoriasis treated for 1 year. METHODS:Patients were randomized to gu...

journal_title：Journal of the American Academy of Dermatology

authors： Blauvelt A,Papp KA,Griffiths CE,Randazzo B,Wasfi Y,Shen YK,Li S,Kimball AB

更新日期：2017-03-01 00:00:00

abstract：:Melasma is an irregular brown or grayish-brown facial hypermelanosis, often affecting women, especially those living in areas of intense UV radiation. The precise cause of melasma remains unknown; however, there are many possible contributing factors. Because of its dermal component and tendency to relapse, melasma is...

journal_title：Journal of the American Academy of Dermatology

authors： Gupta AK,Gover MD,Nouri K,Taylor S

更新日期：2006-12-01 00:00:00

abstract：:Retinoids, synthetic vitamin A analogs, stimulate mucous metaplasia and gap-junction proliferation in embryonic and neoplastic epidermis. Such effects demonstrate that vitamin A has potent effects on epidermal differentiation. Oddly, however, retinoid action in normal postnatal tissues, where these drugs are used clin...

journal_title：Journal of the American Academy of Dermatology

authors： Elias PM

更新日期：1986-10-01 00:00:00

abstract：BACKGROUND:Dermatophytic infections of the fingernail can be effectively treated with oral antifungal agents; however, a long duration of treatment, generally several months, is required for cure. OBJECTIVE:Our purpose was to compare the efficacies of short-duration treatment with terbinafine and griseofulvin in the m...

journal_title：Journal of the American Academy of Dermatology

authors： Haneke E,Tausch I,Bräutigam M,Weidinger G,Welzel D

更新日期：1995-01-01 00:00:00

abstract：:Punctate hyperkeratosis of the palms and soles is an uncommon autosomal dominant condition. We report a 65-year-old man with this condition and review the literature. With electron microscopy, we have examined both clinically affected and adjacent clinically unaffected palmar skin. The only ultrastructural differences...

journal_title：Journal of the American Academy of Dermatology

authors： Rubenstein DJ,Schwartz RA,Hansen RC,Payne CM

更新日期：1980-07-01 00:00:00

abstract：BACKGROUND:Ultraviolet (UV) photography has been used to motivate sun safety in behavioral interventions. The relationship between sun damage shown in UV photographs and melanoma risk has not been systematically investigated. OBJECTIVE:To examine the relationship between severity of sun damage in UV photographs and ph...

journal_title：Journal of the American Academy of Dermatology

authors： Gamble RG,Asdigian NL,Aalborg J,Gonzalez V,Box NF,Huff LS,Barón AE,Morelli JG,Mokrohisky ST,Crane LA,Dellavalle RP

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Psoriasis is a systemic inflammatory condition that is associated with a higher risk of cardiovascular (CV) disease. Tofacitinib is being investigated as a treatment for psoriasis. OBJECTIVE:We sought to evaluate the effects of tofacitinib on CV risk factors and major adverse CV events (MACEs) in patients w...

journal_title：Journal of the American Academy of Dermatology

authors： Wu JJ,Strober BE,Hansen PR,Ahlehoff O,Egeberg A,Qureshi AA,Robertson D,Valdez H,Tan H,Wolk R

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Psoralen plus ultraviolet A (PUVA) for the treatment of psoriasis has never been evaluated using the Psoriasis Area Severity Index (PASI) in a randomized, double-blind, placebo-controlled trial. The lack of such data limits our capacity to estimate PUVA's efficacy relative to other treatment options that are...

journal_title：Journal of the American Academy of Dermatology

authors： Sivanesan SP,Gattu S,Hong J,Chavez-Frazier A,Bandow GD,Malick F,Kricorian G,Koo J

更新日期：2009-11-01 00:00:00

abstract：:We describe a patient with clinical features of dermatitis herpetiformis (DH) and histopathologic features suggestive of both DH and bullous pemphigoid (BP). Immunofluorescent (IF) studies of skin biopsy revealed IgG and C3 deposits along the basement membrane zone (BMZ) in a linear pattern and circulating BMZ antibod...

journal_title：Journal of the American Academy of Dermatology

authors： Jawitz J,Kumar V,Nigra TP,Beutner EH

更新日期：1984-05-01 00:00:00

abstract：BACKGROUND:Chronic cutaneous lupus erythematosus (CCLE) often affects the scalp resulting in scarring alopecia. While histopathologic findings of CCLE have been well described, there is little written on the morphologic changes to the hair follicles in this condition. OBJECTIVE:We aim to determine the histopathologic ...

journal_title：Journal of the American Academy of Dermatology

authors： Chung HJ,Goldberg LJ

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:The lack of recommendations regarding dosing and administration, an undetermined risk of hypothalamic-pituitary-adrenal axis alteration, and the unknown effectiveness of intramuscular (IM) corticosteroid injection to treat dermatologic disease may be deterrents to use. OBJECTIVE:We sought to evaluate presen...

journal_title：Journal of the American Academy of Dermatology

authors： Reddy S,Ananthakrishnan S,Garg A

更新日期：2013-08-01 00:00:00

abstract：:The most common active ingredient in hair coloring is para-phenylenediamine (PPDA), which can produce contact dermatitis, particularly in persons who dye their scalp hair and in hairdressers. We have identified another group of patients also at risk, namely men from Arab countries, who commonly grow beards and dye the...

journal_title：Journal of the American Academy of Dermatology

authors： Hsu TS,Davis MD,el-Azhary R,Corbett JF,Gibson LE

更新日期：2001-05-01 00:00:00

abstract：:Kapos's varicelliform eruption usually occurs in persons with active skin disease of various types; however, in atopic dermatitis the condition may occur when the underlying disease is inactive. Two cases of widespread herpes simplex infection associated with Darier's disease are reported. In both cases, infection occ...

journal_title：Journal of the American Academy of Dermatology

authors： Toole JW,Hofstader SL,Ramsay CA

更新日期：1979-10-01 00:00:00

abstract：:The painful orogenital ulcerations of Behçet's disease are among the major symptoms of patients and are often intractable. We assessed the efficacy of granulocyte and monocyte adsorption apheresis therapy in two patients, a 21-year-old man with orogenital ulcerations and a 50-year-old woman with genital ulceration and...

journal_title：Journal of the American Academy of Dermatology

authors： Kanekura T,Gushi A,Iwata M,Fukumaru S,Sakamoto R,Kawahara K,Maruyama I,Kanzaki T

更新日期：2004-08-01 00:00:00

abstract：:There is no topical antiacne medication that acts against all four of the major pathophysiologic features of acne: hyperkeratinization, sebum production, bacterial proliferation, and inflammation. Topical azelaic acid cream helps both to normalize keratinization and to reduce the proliferation of Propionibacterium acn...

journal_title：Journal of the American Academy of Dermatology

authors： Webster G

更新日期：2000-08-01 00:00:00

abstract：:We report a case of epidermodysplasia verruciformis (EV)-like lesions in a patient with graft-versus-host disease after peripheral blood stem cell transplantation from his HLA-matched brother. The patient presented with a diffuse papular eruption that was clinically consistent with graft-versus-host disease; however, ...

journal_title：Journal of the American Academy of Dermatology

authors： Kunishige JH,Hymes SR,Madkan V,Wyatt AJ,Uptmore D,Lazar AJ,Giralt S,Rady P,Tyring S

更新日期：2007-11-01 00:00:00

abstract：:A father and his son were seen because of multiple wartlike lesions on their fingers and palms. On histologic examination, these lesions showed changes compatible with vascular fibromas, myxoid fibromas, and, in a few instances, verruca vulgaris. We are not aware of reports of similar cases in the dermatologic literat...

journal_title：Journal of the American Academy of Dermatology

authors： Coskey RJ,Mehregan AH,Lupulescu AP

更新日期：1980-05-01 00:00:00

abstract：:Malacoplakia, an inflammatory disease characterized by accumulations of phagocytic macrophages, occurs primarily in immunocompromised individuals. Cutaneous involvement is rare. Two men, each with a renal allograft, had expanding nodules on the temple and perianal area (case 1) and perianal, inguinal, and scrotal skin...

journal_title：Journal of the American Academy of Dermatology

authors： Lowitt MH,Kariniemi AL,Niemi KM,Kao GF

更新日期：1996-02-01 00:00:00

abstract：:Pressure ulcers are localized areas of tissue necrosis that result from unrelieved pressure. They are graded or staged according to the degree of tissue damage observed. The main etiologic factors include pressure, shearing forces, friction, and moisture. The clinical course may be complicated by several conditions in...

journal_title：Journal of the American Academy of Dermatology

authors： Kanj LF,Wilking SV,Phillips TJ

更新日期：1998-04-01 00:00:00