Cutaneous malacoplakia: a report of two cases and review of the literature.

Abstract:

:Malacoplakia, an inflammatory disease characterized by accumulations of phagocytic macrophages, occurs primarily in immunocompromised individuals. Cutaneous involvement is rare. Two men, each with a renal allograft, had expanding nodules on the temple and perianal area (case 1) and perianal, inguinal, and scrotal skin (case 2). Lesions resolved after combined surgical and antibiotic therapy. Histopathologic examination showed dense infiltration with large phagocytic macrophages containing round, concentric, laminar Von Kossa stain-positive inclusion bodies. Histiocytes had positive results for CD 68, lysozyme, and alpha 1-antitrypsin. Electron microscopic examination demonstrated rare intracytoplasmic inclusion bodies with concentric electron-dense laminations of calcium (Michaelis-Gutmann bodies.) Cutaneous malacoplakia should be considered in the differential diagnosis of nodules or draining ulcers, particularly in immunocompromised patients. Because Michaelis-Gutmann bodies are difficult to identify, specimens should be evaluated for cutaneous malacoplakia by immunohistochemical or electron microscopic means.

journal_name

J Am Acad Dermatol

authors

Lowitt MH,Kariniemi AL,Niemi KM,Kao GF

doi

10.1016/s0190-9622(07)80002-8

subject

Has Abstract

pub_date

1996-02-01 00:00:00

pages

325-32

issue

2 Pt 2

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(07)80002-8

journal_volume

34

pub_type

杂志文章,评审
  • Glipizide-induced pigmented purpuric dermatosis.

    abstract::Pigmented purpuric dermatosis can occasionally be caused by various medications. No reported cases of oral hypoglycemic agents causing pigmented purpuric dermatosis exist. We report a case of glipizide-induced pigmented dermatosis. ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(99)70335-x

    authors: Adams BB,Gadenne AS

    更新日期:1999-11-01 00:00:00

  • Familial anetoderma.

    abstract::Two families with anetoderma are described. Unlike previous reports of familial anetoderma, the disease process seemed to be limited to the skin, and there were no associated ocular, gastrointestinal, or orthopedic anomalies in the affected patients or in any other family members. Although infrequently reported, aneto...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(87)70047-4

    authors: Friedman SJ,Venencie PY,Bradley RR,Winkelmann RK

    更新日期:1987-02-01 00:00:00

  • P75 nerve growth factor receptor staining is superior to S100 in identifying spindle cell and desmoplastic melanoma.

    abstract:BACKGROUND:Spindle cell melanoma (SCM) including desmoplastic melanoma (DM) is a rare variant of malignant melanoma that may present diagnostic difficulties particularly when staining with S100 is negative, weak, focal, or a combination of these. Conventional melanocytic markers in SCM are usually negative. OBJECTIVE:...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2009.11.688

    authors: Lazova R,Tantcheva-Poor I,Sigal AC

    更新日期:2010-11-01 00:00:00

  • Late-onset Papillon-Lefèvre syndrome without alteration of the cathepsin C gene.

    abstract::Mutations in the cathepsin C gene have recently been detected in Papillon-Lefèvre syndrome (PLS). Until now, 5 cases with the late-onset variation of this disease have been reported in the literature. The genetic background of this type of PLS is still unknown. We describe a 46-year-old woman with late-onset transgred...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0190-9622(03)01558-5

    authors: Pilger U,Hennies HC,Truschnegg A,Aberer E

    更新日期:2003-11-01 00:00:00

  • Excess melanocytic nevi in children with renal allografts.

    abstract:BACKGROUND:Renal allograft transplantation is associated with an increased incidence of malignant melanoma. The development of excess melanocytic nevi may be an indicator of this risk. OBJECTIVE:This study determines the prevalence of melanocytic nevi in children who have received renal allografts. METHODS:Total and ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/0190-9622(93)70008-h

    authors: Smith CH,McGregor JM,Barker JN,Morris RW,Rigden SP,MacDonald DM

    更新日期:1993-01-01 00:00:00

  • A risk management program aimed at preventing fetal exposure to isotretinoin: retrospective cohort study.

    abstract:BACKGROUND:Preventing fetal exposure to isotretinoin is an important public health goal. Since approval of isotretinoin (1982), the Food and Drug Administration has implemented several unsuccessful risk management programs aimed at preventing fetal exposure. The Kaiser Permanente isotretinoin risk management program in...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2006.05.018

    authors: Cheetham TC,Wagner RA,Chiu G,Day JM,Yoshinaga MA,Wong L

    更新日期:2006-09-01 00:00:00

  • Hyperpigmentation, neutrophilic alveolitis, and erythema nodosum resulting from minocycline.

    abstract::Hyperpigmentation, pulmonary infiltration, and erythema nodosum occurred in a patient receiving long-term minocycline therapy. Bronchoalveolar lavage revealed both a neutrophilic and an eosinophilic alveolitis. The pulmonary and systemic symptoms promptly resolved after discontinuation of minocycline. ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/0190-9622(90)70135-5

    authors: Bridges AJ,Graziano FM,Calhoun W,Reizner GT

    更新日期:1990-05-01 00:00:00

  • Long-term use of psoralens and ultraviolet A for psoriasis: evidence for efficacy and cost savings.

    abstract::A 7.3-year prospective study of 1,380 patients with psoriasis who were treated with oral methoxsalen (8-methoxypsoralen) and ultraviolet A photochemotherapy (PUVA) revealed that patients who continued on PUVA therapy used inpatient hospital treatment less than one fourth as often as those who had discontinued treatmen...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(86)70066-2

    authors: Stern RS

    更新日期:1986-03-01 00:00:00

  • Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms severity score: A useful tool for assessing disease severity and predicting fatal cytomegalovirus disease.

    abstract:BACKGROUND:The prognosis of drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) is highly unpredictable. Severe complications, either related or unrelated to cytomegalovirus (CMV) reactivation, are a highly probable cause of death. OBJECTIVES:The aim was to estab...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2018.08.052

    authors: Mizukawa Y,Hirahara K,Kano Y,Shiohara T

    更新日期:2019-03-01 00:00:00

  • Update on the incidence and mortality from melanoma in the United States.

    abstract:BACKGROUND:Increases in the incidence of malignant melanoma have been among the largest of all cancers in the United States. OBJECTIVE:We report updated trends in melanoma rates among the US white population. METHODS:Incidence and mortality rates were calculated for 1973 to 1994. Trends were examined with stratificat...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(99)70562-1

    authors: Hall HI,Miller DR,Rogers JD,Bewerse B

    更新日期:1999-01-01 00:00:00

  • Propranolol treatment of infantile hemangioma is not associated with psychological problems at 7 years of age.

    abstract:BACKGROUND:Concern has been raised about the potential long-term effects of propranolol treatment for infantile hemangioma (IH). OBJECTIVES:We sought to assess psychologic (social, emotional, behavioral, and executive) functioning in children treated with propranolol for IH. METHODS:Twenty-seven patients with IH (6.1...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2017.01.025

    authors: Moyakine AV,Spillekom-van Koulil S,van der Vleuten CJM

    更新日期:2017-07-01 00:00:00

  • The clinical phenotype of pemphigus is defined by the anti-desmoglein autoantibody profile.

    abstract:BACKGROUND:Some patients with pemphigus vulgaris (PV) have mucous membrane erosions with minimal skin involvement (mucosal dominant type), and others show extensive skin blisters and erosions in addition to mucous membrane involvement (mucocutaneous type). Patients with pemphigus foliaceus (PF) show only skin involveme...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(99)70183-0

    authors: Amagai M,Tsunoda K,Zillikens D,Nagai T,Nishikawa T

    更新日期:1999-02-01 00:00:00

  • Pompholyx and eczematous reactions associated with intravenous immunoglobulin therapy.

    abstract:INTRODUCTION:Intravenous immunoglobulin (IVIG) is used to treat many inflammatory and autoimmune disorders and although generally well tolerated, cutaneous side effects occur. OBJECTIVE:We reviewed reports of pompholyx and eczematous reactions associated with IVIG. METHODS:A literature search was performed using the ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaad.2010.12.034

    authors: Gerstenblith MR,Antony AK,Junkins-Hopkins JM,Abuav R

    更新日期:2012-02-01 00:00:00

  • Alpha 1-antitrypsin deficiency genes: contributory defect in a subset of psoriatics?

    abstract::Since proteolytic processes are prominent in psoriasis, sera of forty-five psoriatics were examined for alpha 1-antitrypsin (alpha 1-AT) phenotype and eighteen sera, for alpha 1-AT content and function. Five sera (11.1%) had heterozygous phenotypes (2 MZ and 3 MS), a prevalence of Z and S variants similar to that repo...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(84)70216-7

    authors: Lipkin G,Galdston M,Kueppers F

    更新日期:1984-10-01 00:00:00

  • B-RAF and melanocytic neoplasia.

    abstract::High frequency of B-RAF gene mutations has recently been identified in benign melanocytic nevi and melanoma. This review focuses on clinical studies that evaluate the role of B-RAF in melanocytic neoplasia. ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaad.2005.04.013

    authors: Gill M,Celebi JT

    更新日期:2005-07-01 00:00:00

  • Multiple familial cutaneous glomangioma: a pedigree of 4 generations and critical analysis of histologic and genetic differences of glomus tumors.

    abstract:BACKGROUND:Glomangiomas are benign tumors arising from neuromyoarterial cells surrounding cutaneous arteriovenous anastomoses that serve as temperature regulators. They exist as solitary or multiple types, occurring sporadically or in a familial pattern, the latter of which is rare. OBJECTIVE:We describe a 4-generatio...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:

    authors: Blume-Peytavi U,Adler YD,Geilen CC,Ahmad W,Christiano A,Goerdt S,Orfanos CE

    更新日期:2000-04-01 00:00:00

  • Pigmentary demarcation lines associated with pregnancy.

    abstract::Pigmentary demarcation lines are borders of abrupt transition between more deeply pigmented skin and that of lighter pigmentation. Two patients developed these lines on the lower extremities during pregnancy. ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(84)70187-3

    authors: James WD,Meltzer MS,Guill MA,Berger TG,Rodman OG

    更新日期:1984-09-01 00:00:00

  • Connective tissue nevi: an entity revisited.

    abstract:BACKGROUND:Connective tissue nevi (CTN) may be isolated, either sporadic or hereditary, or syndromic as in the Buschke-Ollendorff syndrome. Few publications have addressed the variable clinical and histopathologic expression of these benign hamartomas. OBJECTIVE:We sought to characterize the clinical and histopatholog...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2011.08.008

    authors: Saussine A,Marrou K,Delanoé P,Bodak N,Hamel D,Picard A,Sassolas B,de Prost Y,Lemerrer M,Fraitag S,Bodemer C

    更新日期:2012-08-01 00:00:00

  • Isolated plantar collagenoma not associated with Proteus syndrome.

    abstract::Isolated plantar cerebriform collagenomas are a relatively rare type of connective tissue nevus. They have been suggested to be pathognomonic of Proteus syndrome. However, their presence is now considered to be a major criterion of Proteus syndrome, but the diagnosis of Proteus syndrome also requires the presence of o...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2007.03.016

    authors: Nelson AA,Ruben BS

    更新日期:2008-03-01 00:00:00

  • Diverse presentations of cutaneous mosaicism occur in CYLD cutaneous syndrome and may result in parent-to-child transmission.

    abstract:BACKGROUND:Clusters of rare cylindroma or spiradenoma tumors are a recurrent clinical presentation, yet conventional genetic testing results in individuals with these tumors are frequently normal. OBJECTIVE:To determine if genetic mosaicism accounts for such cases. METHODS:A study of 6 cases from a series of 55 patie...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2019.05.021

    authors: Arefi M,Wilson V,Muthiah S,Zwolinski S,Bajwa D,Brennan P,Blasdale K,Bourn D,Burn J,Santibanez-Koref M,Rajan N

    更新日期:2019-12-01 00:00:00

  • Efficacy and safety of antiscabietic agents: A systematic review and network meta-analysis of randomized controlled trials.

    abstract:BACKGROUND:Many drugs have been used to treat scabies, but it is unclear which of them is the most efficacious. OBJECTIVE:To evaluate the comparative efficacy and safety of antiscabietic agents. METHODS:A systematic review of randomized controlled trials was conducted. Direct and network meta-analyses were applied to...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.jaad.2019.01.004

    authors: Thadanipon K,Anothaisintawee T,Rattanasiri S,Thakkinstian A,Attia J

    更新日期:2019-05-01 00:00:00

  • A patient with lepromatous leprosy and anticytoskeletal antibodies.

    abstract::Sera from 34 patients with lepromatous leprosy were screened for the presence of autoantibodies by indirect immunofluorescence using two epithelial cell lines, PTK2 and HEp2, as substrates. Indirect immunofluorescence staining of both substrates with the serum of a patient with lepromatous leprosy revealed a cytoplasm...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(88)70120-6

    authors: Frey FL,Gottlieb AB,Levis WR

    更新日期:1988-05-01 00:00:00

  • The risk of melanoma in association with long-term exposure to PUVA.

    abstract:BACKGROUND:Oral methoxsalen (psoralen) and ultraviolet A radiation (PUVA) is a highly effective therapy for psoriasis and many other skin conditions. It is carcinogenic. Previously we reported an increased risk of melanoma that first emerged 15 years after first treatment. OBJECTIVE:Our purpose is to present additiona...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,多中心研究

    doi:10.1067/mjd.2001.114576

    authors: Stern RS,PUVA Follow up Study.

    更新日期:2001-05-01 00:00:00

  • Intermittent short courses of cyclosporine microemulsion for the long-term management of psoriasis: a 2-year cohort study.

    abstract:BACKGROUND:Cyclosporine is effective in psoriasis, but long-term continuous therapy may be limited by renal impairment and hypertension. Intermittent short courses of treatment should minimize side effects and improve the risk-benefit ratio. OBJECTIVE:Our purpose was to assess the long-term efficacy and safety of inte...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1067/mjd.2001.112400

    authors: Ho VC,Griffiths CE,Berth-Jones J,Papp KA,Vanaclocha F,Dauden E,Beard A,Puvanarajan L,Paul C

    更新日期:2001-04-01 00:00:00

  • Relief of the photosensitivity of erythropoietic protoporphyria by pyridoxine.

    abstract::Twenty-five years ago the use of pyridoxine was described for the treatment of photosensitivity eruptions. We report two cases of erythropoietic protoporphyria, which were only moderately responsive to beta-carotene and sunscreens, whereas the use of pyridoxine has been associated with a marked reduction in photosensi...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/0190-9622(90)70043-h

    authors: Ross JB,Moss MA

    更新日期:1990-02-01 00:00:00

  • A clinical and histologic comparison of electrosurgical and carbon dioxide laser peels.

    abstract:BACKGROUND:A radiofrequency-controlled electrosurgical device (ESD) has been adapted for skin peeling. A high-voltage, low-amperage current converts an irrigant into an ionized vapor, causing molecular dissociation and superficial damage in adjacent tissue. OBJECTIVE:We compared the clinical and histologic effects of ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1067/mjd.2001.109856

    authors: Acland KM,Calonje E,Seed PT,Stat C,Barlow RJ

    更新日期:2001-03-01 00:00:00

  • Hereditary melanoma: Update on syndromes and management: Genetics of familial atypical multiple mole melanoma syndrome.

    abstract::Malignant melanoma is considered the most lethal skin cancer if it is not detected and treated during its early stages. About 10% of melanoma patients report a family history of melanoma; however, individuals with features of true hereditary melanoma (ie, unilateral lineage, multigenerational, multiple primary lesions...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaad.2015.08.038

    authors: Soura E,Eliades PJ,Shannon K,Stratigos AJ,Tsao H

    更新日期:2016-03-01 00:00:00

  • Dermatopathology workforce in the United States: a survey.

    abstract:BACKGROUND:Although several studies have documented an undersupply of dermatologic services in the United States, little is known about the dermatopathology workforce. OBJECTIVE:Objectives included the following: (1) describe the dermatopathology workforce in the United States; (2) identify characteristics associated ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2010.09.733

    authors: Suwattee P,Cham PM,Abdollahi M,Warshaw EM

    更新日期:2011-12-01 00:00:00

  • An overlap of Cowden's disease and Bannayan-Riley-Ruvalcaba syndrome in the same family.

    abstract::We describe a family with the unusual association of Cowden's disease and Bannayan-Riley-Ruvalcaba syndrome. The father has characteristic mucocutaneous features that are palmoplantar keratoses, multiple facial papules, oral papillomatoses, lipomas, and vitiligo with involvement of the thyroid and digestive tract. The...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0190-9622(00)90109-9

    authors: Perriard J,Saurat JH,Harms M

    更新日期:2000-02-01 00:00:00

  • Erythema induratum (Bazin's disease).

    abstract::The clinical and histologic features of 26 cases of erythema induratum are reviewed. The characteristic cutaneous lesions on the legs of middle-aged women were violaceous, indurated nodules, 1 to 2 cm in diameter, which were painful, occasionally ulcerated, and could heal with scarring. The diagnosis was confirmed in ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(89)70248-6

    authors: Rademaker M,Lowe DG,Munro DD

    更新日期:1989-10-01 00:00:00