Abstract：
BACKGROUND:Spindle cell melanoma (SCM) including desmoplastic melanoma (DM) is a rare variant of malignant melanoma that may present diagnostic difficulties particularly when staining with S100 is negative, weak, focal, or a combination of these. Conventional melanocytic markers in SCM are usually negative. OBJECTIVE:We sought to compare the staining of p75 nerve growth factor receptor (NGF-R) and S100 in SCMs. METHODS:We evaluated the staining of p75 NGF-R and S100 in 13 cases of SCMs: 3 SCMs without desmoplasia, 5 pure DMs, and 5 combined DMs with a conventional component. RESULTS:Staining with p75 NGF-R was positive in 13 of 13 (100%) cases of SCMs. In 3 cases the intensity of staining and the percentage of cells staining with this marker were greater than those with S100. One case of SCM was negative for S100 but demonstrated strong expression of p75 NGF-R. One case was focally and weakly positive with S100 but expressed strong positive staining with p75 NGF-R. Absence of staining with p75 NGF-R was noted in the conventional round cell component of two of 5 (40%) combined DMs whereas the same areas were strongly positive for human melanoma black (HMB)-45 and Melan-A. In 5 of 5 (100%) cases of combined DMs the desmoplastic component stained positive with p75 NGF-R, demonstrating an inverse relationship with the staining of conventional melanocytic markers. LIMITATIONS:Small study size was a limitation. CONCLUSION:p75 NGF-R exhibits superior staining characteristics and greater sensitivity in identifying SCM and DMs than S100. P75 NGF-R may be a useful diagnostic and ancillary stain in addition to S100.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Lazova R,Tantcheva-Poor I,Sigal ACdoi
10.1016/j.jaad.2009.11.688subject
Has Abstractpub_date
2010-11-01 00:00:00pages
852-8issue
5eissn
0190-9622issn
1097-6787pii
S0190-9622(09)02296-8journal_volume
63pub_type
杂志文章abstract：:Onychomadesis is defined as spontaneous separation of the nail plate from the nail bed, beginning at its proximal end and resulting in the shedding of the nail. It has been associated with a variety of clinical settings, including systemic illnesses, generalized skin diseases, and drug therapies. There have been a sma...
journal_title：Journal of the American Academy of Dermatology
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doi：10.1067/mjd.2000.101588
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abstract：LEARNING OBJECTIVES:At the conclusion of this learning activity, physician participants should be able to assess their own diagnostic and patient management skills and use the results of this exercise to help determine personal learning needs. Instructions: In answering each question, refer to the specific directions p...
journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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abstract：BACKGROUND:The reported prevalence and degrees of Demodex mite infestation in rosacea vary widely. OBJECTIVE:We sought to conduct an evidence-based meta-analysis of the prevalence and degrees of Demodex mite infestation in patients with rosacea. METHODS:Systematic literature review and meta-analysis were conducted. O...
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abstract：:Diagnosis and classification of cutaneous lymphoid infiltrates are often hampered by lack of frozen tissue to allow detailed immunophenotyping. Therefore antibodies that recognize antigens resistant to routine tissue processing would be of value. In this study we present a detailed analysis of two such antibodies agai...
journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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abstract：:Papular mucinosis is a rare, idiopathic cutaneous mucinosis that is typically chronic and progressively severe. We present a case of a 59-year-old woman with a 6-month history of a dramatic papular eruption on her face and neck, with no associated internal organ involvement. A biopsy specimen demonstrated increased de...
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1067/mjd.2001.117736
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journal_title：Journal of the American Academy of Dermatology
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doi：10.1067/mjd.2001.116340
更新日期：2001-11-01 00:00:00
abstract：BACKGROUND:Psoriasis is a systemic inflammatory condition that is associated with a higher risk of cardiovascular (CV) disease. Tofacitinib is being investigated as a treatment for psoriasis. OBJECTIVE:We sought to evaluate the effects of tofacitinib on CV risk factors and major adverse CV events (MACEs) in patients w...
journal_title：Journal of the American Academy of Dermatology
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更新日期：2016-11-01 00:00:00
