Abstract：
BACKGROUND:The increasing use of biologics is accompanied by a risk of hepatitis B (HBV) and C virus (HCV) reactivation. OBJECTIVE:To determine the predictors of HBV and HCV reactivation in psoriasis patients receiving biologics. METHODS:This study screened 2060 psoriasis patients (3562 treatment episodes) who were taking biologics from 2009 to 2018. There were 359 psoriasis patients with HBV (561 treatment episodes) and 61 with HCV infection (112 treatment episodes). RESULTS:During 8809 and 1522 person-months of follow-up, 88 treatment episodes for HBV involved HBV reactivation, and 14 episodes of HCV involved reactivation. The reactivation rate was significantly higher in treatment episodes of chronic HBV infection than that of occult HBV (34.3% vs. 3.2%, p=0.001) and resolved HBV (34.3% vs. 5.0%, p < 0.001). The multivariate analysis revealed that being HBsAg-seropositive, being HBeAg-seropositive, and TNF-α inhibitor therapy were risk factors for HBVr, while antiviral prophylaxis was effective in reducing the risk of HBV reactivation. No predictors were significantly associated with HCV reactivation. LIMITATIONS:Observational design and a lack of a comparison group. CONCLUSIONS:Psoriasis patients on biologics have a risk of HBV and HCV reactivations, particularly those who are HBsAg-seropositive, HBeAg-seropositive, and undergoing TNF-α inhibitor therapy.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Chiu HY,Chiu YM,Chang Liao NF,Chi CC,Tsai TF,Hsieh CY,Hsieh TY,Lai KL,Chiu TM,Wu NL,Hui RC,Lee CN,Wang TS,Chen PH,Yang CC,Huang YHdoi
10.1016/j.jaad.2019.12.001subject
Has Abstractpub_date
2019-12-07 00:00:00eissn
0190-9622issn
1097-6787pii
S0190-9622(19)33209-8pub_type
杂志文章abstract：:A woman with pemphigus vulgaris was treated by plasma exchange. Four separate exchanges of approximately 4,000 ml each were performed over a 2-week period. The patient's pemphigus antibody titer decreased from 1/320 before the first exchange to 1/20 after the final exchange, and no new lesions developed for 3 weeks fo...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(81)70033-1
更新日期：1981-03-01 00:00:00
abstract：:The standard definition of itching (as "an unpleasant sensation that provokes the desire to scratch") takes no account of recent advances in knowledge about itch physiology. Always imprecise, this definition is also out-of-date. Its defects are discussed in this article, and some modifications are proposed. ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(98)70087-8
更新日期：1998-08-01 00:00:00
abstract：:Lupus pernio has been associated with sarcoidosis of the upper respiratory tract. The semantic differences in the use of the designation "lupus pernio" are such that American dermatologists may not consider patients with nasal rim papules of sarcoidosis to have lupus pernio. During a 12-month period, we referred each ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/0190-9622(90)70061-l
更新日期：1990-03-01 00:00:00
abstract：BACKGROUND:Inherited susceptibility genes have been associated with histopathologic characteristics of tumors. OBJECTIVE:We sought to identify associations between histology of melanomas and CDKN2A genotype. METHODS:This was a case-control study design comparing 28 histopathologic tumor features among individuals wit...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2014.11.014
更新日期：2015-03-01 00:00:00
abstract：:Pruritus is a common symptom in patients with hepatobiliary disease. Numerous treatments have been attempted. We review published therapeutic trials for hepatobiliary pruritus and utilize statistical analysis to evaluate treatment results. Randomized placebo-controlled studies show cholestyramine, rifampin, naloxone, ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/0190-9622(95)91818-3
更新日期：1995-11-01 00:00:00
abstract：:Chronic mucocutaneous candidiasis is a complex disorder in which patients have chronic and recurrent Candida albicans infections of the skin, nails, and mucous membranes. There are several subgroups of patients with chronic mucocutaneous candidiasis, and these can be identified by associated disorders such as autoimmu...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/s0190-9622(08)81260-1
更新日期：1994-09-01 00:00:00
abstract：:Clofazimine has been in clinical use for almost 40 years, but little is known of its mechanism of action. The primary indication for clofazimine is multibacillary leprosy, but it is useful in several infectious and noninfectious diseases, such as typical myocobacterial infections, rhinoscleroma, pyoderma gangrenosum, ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/0190-9622(95)90134-5
更新日期：1995-02-01 00:00:00
abstract：:This review begins with a classification of adverse drug reactions and a summary of those features that distinguish allergic from toxic and idiosyncratic reactions. Factors that influence the risk of developing drug allergy are then reviewed, followed by a discussion of the known and suspected immunologic mechanisms r...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/s0190-9622(82)70073-8
更新日期：1982-05-01 00:00:00
abstract：:We observed the course of development of porokeratosis stimulated by benzylhydrochlorothiazide (BHCTh) in normal-appearing skin of a patient with long-standing stable porokeratosis of Mibelli. A 72-year-old Japanese man had had porokeratosis of Mibelli for more than 50 years. During administration of BHCTh for 1 year ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(84)70172-1
更新日期：1984-08-01 00:00:00
abstract：:The safety and efficacy of 0.1% tacrolimus ointment for the treatment of psoriasis on the face, intertriginous areas, or both were evaluated in an open-label, clinical trial of 21 patients with psoriasis. Patients applied 0.1% tacrolimus ointment twice daily for 8 weeks. Efficacy was assessed through the investigator'...
journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章
doi：10.1067/mjd.2003.169
更新日期：2003-04-01 00:00:00
abstract：:Infantile acropustulosis (IA) is a syndrome characterized by recurrent crops of 1- to 2-mm intensely pruritic vesicopustules that are found primarily on the distal extremities of infants. It is reportedly responsive to sulfones and unresponsive to other therapy, but if left untreated spontaneously resolves at about 2 ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(83)70187-8
更新日期：1983-11-01 00:00:00
abstract：:Cutaneous surgery has become critical to comprehensive dermatologic care, and dermatologists must therefore be equipped to manage the risks associated with surgical procedures. As complications may occur at any point along the continuum of care, assessing, managing and preventing risk from beginning to end becomes ess...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2020.10.099
更新日期：2021-01-23 00:00:00
abstract：:Three cases of allergic contact hypersensitivity to Sta-Lok and Loctite anaerobic sealants are reported. These two anaerobic sealants constitute a +100 million annual market in industrial sealants used to join metal surfaces together. To the best of my knowledge, these are the first reported cases of allergic contact ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(82)70160-4
更新日期：1982-12-01 00:00:00
abstract：:A patient who developed exfoliative erythroderma 11 days after the initiation of hydroxychloroquine treatment for psoriatic arthritis is presented. Our experience with her and the continued controversy regarding the incidence of adverse reactions in psoriatic patients to antimalarials prompted a detailed review of the...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(85)70108-9
更新日期：1985-05-01 00:00:00
abstract：:Skin cancer is less prevalent in people of color than in the white population. However, when skin cancer occurs in non-whites, it often presents at a more advanced stage, and thus the prognosis is worse compared with white patients. The increased morbidity and mortality associated with skin cancer in patients of color...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2013.11.038
更新日期：2014-04-01 00:00:00
abstract：:Four patients with severe psoriasis have been treated with oral cyclosporine for 6 months. Two had generalized erythroderma and two had extensive plaque-type psoriasis; all had either become unresponsive to or were unable to use other accepted treatments. All four patients responded rapidly and were completely clear o...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(87)70221-7
更新日期：1987-09-01 00:00:00
abstract：BACKGROUND:Some patients with pemphigus vulgaris (PV) have mucous membrane erosions with minimal skin involvement (mucosal dominant type), and others show extensive skin blisters and erosions in addition to mucous membrane involvement (mucocutaneous type). Patients with pemphigus foliaceus (PF) show only skin involveme...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(99)70183-0
更新日期：1999-02-01 00:00:00
abstract：BACKGROUND:Eczema is a common chronic inflammatory disease of the skin. Studies suggest differences in disease prevalence and severity by race/ethnicity. Our knowledge of health care utilization for eczema among different racial/ethnic groups remains limited. OBJECTIVE:To evaluate health care utilization for childhood...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2017.08.035
更新日期：2017-12-01 00:00:00
abstract：:We describe a 6-year-old boy with a granulomatous lesion on the upper aspect of his left arm. Fusarium solani infection was confirmed by biopsy studies and cultures. The biopsy specimen showed an unusually extensive dermal invasion with fungal hyphae. This is an uncommon clinical presentation for deep cutaneous infect...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2006.10.960
更新日期：2007-05-01 00:00:00
abstract：BACKGROUND:Drug cutaneous reaction and isolated cases of parotitis induced by terbinafine have been reported. OBSERVATION:We report a case of drug reaction with eosinophilia and systemic symptoms induced by terbinafine associated with a severe sialadenitis and a complete sicca syndrome. Evolution was protracted with a...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2004.06.023
更新日期：2004-11-01 00:00:00
abstract：BACKGROUND:The Patient-Reported Outcomes Measurement Information System (PROMIS) Itch Questionnaire (PIQ) was recently developed. OBJECTIVE:To validate PIQ short forms in adults with AD. METHODS:Self-administered questionnaires and skin examinations were performed in 239 adults with atopic dermatitis (AD) in a dermat...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2019.11.057
更新日期：2020-05-01 00:00:00
abstract：:To evaluate the sensitivity of histologic criteria 396 hematoxylin-eosin-stained step sections of 150 randomly sampled thin malignant melanomas (tumor thickness, less than or equal to 1.5 mm; level of invasion, I-III) were analyzed. The highest sensitivity was determined for nuclear atypia (84%), followed by the asymm...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(89)70143-2
更新日期：1989-06-01 00:00:00
abstract：BACKGROUND:The negative pigment network (NPN) is seen as a negative of the pigmented network and it is purported to be a melanoma-specific structure. OBJECTIVES:We sought to assess the frequency, sensitivity, specificity, and odds ratios (ORs) of NPN between melanoma cases and a group of control lesions. METHODS:Digi...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2012.08.012
更新日期：2013-04-01 00:00:00
abstract：:Myospherulosis is an uncommon subcutaneous disorder believed initially to be caused by an endosporulating fungus. Recently investigators have disproved an infectious cause and have shown that the disease represents an alteration in red blood cells, usually produced by petrolatum or lanolin, with an accompanying foreig...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/s0190-9622(89)80045-3
更新日期：1989-08-01 00:00:00
abstract：:Sweet's syndrome (SS) occurs most commonly in association with inflammatory or neoplastic disorders. Only rarely has it been associated with immunodeficiency disorders. We describe a child with a T-cell immunodeficiency who had a persistent neutrophilic dermatosis that was histologically and clinically consistent with...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1053/jd.1999.v40.a95650
更新日期：1999-05-01 00:00:00
abstract：BACKGROUND:An outbreak of tinea corporis occurred in members of a high school wrestling team during the 1992-1993 season. OBJECTIVE:To control the outbreak, we conducted an epidemiologic investigation. METHODS:We examined 28 team members and obtained skin scrapings from 16. To control the outbreak we recommended (1) ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(94)70145-8
更新日期：1994-08-01 00:00:00
abstract：:Lupus erythematosus (LE) is a multisystem disease. Genetic predisposition, altered immunity, hormones, drugs, viruses, and ultraviolet light all may play a role in etiology. A wide range of cutaneous lesions occur, and variants such as subacute cutaneous LE, complement-deficient LE, and neonatal LE have recently been ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/s0190-9622(81)70016-1
更新日期：1981-02-01 00:00:00
abstract：:Molecules of the extracellular matrix may influence the biologic behavior of basal cell keratinocytes. In the unwounded situation, basal cells are in contact with the basement membrane of the dermo-epidermal junction and eventually detach from this structure, move vertically, and differentiate. During wound healing th...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(85)80005-0
更新日期：1985-02-01 00:00:00
abstract：BACKGROUND:In several studies, delays in malignant melanoma (MM) diagnosis have been correlated with increased tumor thickness, increased morbidity, and increased mortality. OBJECTIVE:We sought to assess how MM is detected in British Columbia, Canada, and to understand the role of patient education and other factors o...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2004.04.031
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:Garment-related terms have been used to describe the pattern of distribution of giant congenital melanocytic nevi (GCMN). OBJECTIVE:We sought to describe patterns of distribution of GCMN and propose a classification scheme. METHODS:Photographic records of patients with GCMN from the Hospital Clinic of Barc...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2016.05.042
更新日期：2017-04-01 00:00:00
