Abstract：
:To evaluate the sensitivity of histologic criteria 396 hematoxylin-eosin-stained step sections of 150 randomly sampled thin malignant melanomas (tumor thickness, less than or equal to 1.5 mm; level of invasion, I-III) were analyzed. The highest sensitivity was determined for nuclear atypia (84%), followed by the asymmetry of the lesion (81.3%) and the presence of single cells in the upper layers of the epidermis (80.3%). The sensitivity was limited for the inflammatory reaction of the dermis (56%), poor demarcation of the lesion (49.3%), and infiltration of the adnexa (47.7%). For the mitotic activity a low sensitivity was found (33.3%). In only 7.6% of cases all criteria investigated (with the exception of the infiltration of adnexa) were simultaneously present. The three most sensitive criteria could be found in 46% of cases and two of these criteria in 88% of cases. In conclusion, this semiquantitative analysis of histologic criteria revealed that (1) thin malignant melanomas can be diagnosed with a few, but very sensitive, criteria and (2) the absence of criteria with minor sensitivity is not helpful for correct diagnosis.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Stolz W,Schmoeckel C,Welkovich B,Braun-Falco Odoi
10.1016/s0190-9622(89)70143-2subject
Has Abstractpub_date
1989-06-01 00:00:00pages
1115-20issue
6eissn
0190-9622issn
1097-6787pii
S0190-9622(89)70143-2journal_volume
20pub_type
杂志文章abstract：BACKGROUND:Methyldibromoglutaronitrile (MDGN) is a component of Euxyl K400, a preservative used in many skin care products in Europe. MDGN has been used in skin care products in the United States for the last 5 years. Contact allergy from MDGN has been reported from Europe. OBJECTIVE:The purpose of this study was to d...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(98)70589-4
更新日期：1998-06-01 00:00:00
abstract：BACKGROUND:Cutaneous disease is common in patients infected with HIV-1. OBJECTIVE:The aim of our study was to identify cutaneous markers associated with HIV-1 infection and disease progression as measured by Walter Reed (WR) stage. METHODS:For 42 months we have observed 912 HIV-1-positive patients in all WR stages. A...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(94)70236-5
更新日期：1994-11-01 00:00:00
abstract：BACKGROUND:The mature psoriatic lesion does not necessarily demonstrate changes relevant to early phases of the lesion. OBJECTIVE:In a model for relapsing psoriasis we examined the epidermal phenotype by means of a panel of immunohistochemical parameters: keratins 14 and 16, epidermal growth factor receptor (EGFR), Ki...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(99)70077-0
更新日期：1999-06-01 00:00:00
abstract：:As a prerequisite to standardization of dermatophyte susceptibility testing, conditions that support optimal growth of different dermatophyte species must be established. Eighteen isolates of Trichophyton spp. (T rubrum, T mentagrophytes, T tonsurans) were grown in 4 different media: RPMI 1640 with L-glutamine, withou...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(99)70392-0
更新日期：1999-06-01 00:00:00
abstract：:A case of malignant bronchial carcinoid with multiple cutaneous metastases is reported. Despite the extremely aggressive behavior of the disease and the presence of multiple hepatic metastases, the patient did not exhibit the usual clinical features of the carcinoid syndrome. The relevance of the finding of elevated 2...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(85)70175-2
更新日期：1985-08-01 00:00:00
abstract：:A single application (16 to 20 hours) of 1% gamma benzene hexachloride (GBH) lotion, when applied to a total island population of 178 persons in which seventy-four clinically had scabies, resulted in a cure rate of over 98%. Re-examination of the population at 10 and 21 weeks revealed only one remaining individual sti...
journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章
doi：10.1016/s0190-9622(83)70167-2
更新日期：1983-10-01 00:00:00
abstract：:A 7-week-old male infant with a seizure disorder and an extensive sebaceous nevus of the scalp was examined. Computerized axial tomography (CAT) scan identified an intracerebral mass which proved to be a hamartomatous malofrmation fo the brain. The association of intracranial masses with sebaceous nevi should be recog...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(82)70093-3
更新日期：1982-06-01 00:00:00
abstract：:Infantile acropustulosis (IA) is a syndrome characterized by recurrent crops of 1- to 2-mm intensely pruritic vesicopustules that are found primarily on the distal extremities of infants. It is reportedly responsive to sulfones and unresponsive to other therapy, but if left untreated spontaneously resolves at about 2 ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(83)70187-8
更新日期：1983-11-01 00:00:00
abstract：:Direct-to-consumer teledermatology is radically changing the way some patients obtain dermatologic care. Many direct-to-consumer teledermatology services offer care to patients younger than 18 years, but policies and standards are nonuniform. For pediatric patients, direct-to-consumer teledermatology is a substantial ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2016.08.002
更新日期：2016-11-01 00:00:00
abstract：:Most cutaneous squamous cell carcinomas (SCCs) of the trunk and extremities are small enough to be cured by simple surgical excision. Because the risk of metastasis of SCCs of the head and neck arising from mucosal surfaces is higher than the risk of metastasis of SCCs arising from cutaneous surfaces, it may be more a...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/s0190-9622(94)70073-7
更新日期：1994-04-01 00:00:00
abstract：BACKGROUND:The histopathological and clinical overlapping features between condyloma acuminata and bowenoid papulosis can present a diagnostic challenge and we sought to determine if immunochemistry can be helpful in this setting. OBJECTIVE:In this study, we evaluate the specificity and sensitivity of p16 immunohistoc...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2013.04.036
更新日期：2013-09-01 00:00:00
abstract：:Subungual Bowen's disease and squamous cell carcinoma are not as rare as has been implied by earlier literature. The course of the lesions is protracted. Clinically the diseases may mimic onychomycosis, chronic paronychia, eczema, verruca vulgaris, pyogenic granuloma, subungual exostosis, or malignant melanoma. Histol...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(84)70165-4
更新日期：1984-08-01 00:00:00
abstract：BACKGROUND:Many patients who give a history of a dermatitis reaction to jewelry or metal contact with skin are negative to metals on standard patch testing. Some may be showing false-negative reactions. OBJECTIVE:Our purpose was to determine whether patients with a history of jewelry reactions but whose standard patch...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1067/mjd.2000.107235
更新日期：2000-07-01 00:00:00
abstract：:Glyceryl monothioglycolate has recently been implicated as an allergen. A case of a hairdresser who used this material is presented. He appeared to have an irritant contact dermatitis on his fingertips. Patch testing the patient and extensive patch testing in a group of fifty-four volunteers showed a very high inciden...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(83)70188-x
更新日期：1983-11-01 00:00:00
abstract：:Pachyonychia congenita is a rare genetic disorder classified in clinical subtypes. Late onset of the disease has recently been described and designated as pachyonychia congenita tarda. A patient in whom typical manifestations of pachyonychia congenita appeared at the age of 39 years is described. This report substanti...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(96)90663-5
更新日期：1996-08-01 00:00:00
abstract：BACKGROUND:There is limited data on zoster recurrence. OBJECTIVE:To examine in detail zoster recurrence in a population-based cohort. METHODS:Using data from a large cohort (The 45 and Up Study) with linked medical data (2004-2015), the incidence of first and recurrent zoster was examined using survival analyses meth...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2020.06.1013
更新日期：2020-07-02 00:00:00
abstract：:Lymphomatoid papulosis is a chronic disease of cutaneous lymphoid infiltration characterized clinically by involuting and recurring papules, plaques, and nodules. The intriguing combination of a usually benign clinical course, a cytologically malignant lymphoid infiltrate on histologic examination, and a clear, but sp...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/s0190-9622(94)70045-1
更新日期：1994-03-01 00:00:00
abstract：:Zinc is a trace element essential to the gastrointestinal, immune, integumentary, reproductive, and central nervous systems. Zinc deficiency is prevalent in many areas of the world and is a diagnostically challenging condition. Cutaneous manifestations typically occur in moderate to severe zinc deficiency and present ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2013.04.028
更新日期：2013-10-01 00:00:00
abstract：:A cutaneous and soft tissue reaction that resulted from a broken thermometer inside the mouth of a 10-year-old boy is described. Metallic mercury globules and glass pieces were identified in the excised tissue. On histologic examination, a zone of necrosis, polymorphonuclear leukocytes, macrophages, and multinucleated...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/0190-9622(91)70283-8
更新日期：1991-11-01 00:00:00
abstract：BACKGROUND:Efficacy of oral antiviral therapies, ie, acyclovir, valacyclovir (VACV), and famciclovir, for suppression of recurrent genital herpes was studied at different doses and regimens. OBJECTIVE:We sought to compare the clinical efficacies of the different oral antiviral drugs prescribed prophylactically to supp...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,meta分析
doi：10.1016/j.jaad.2007.02.008
更新日期：2007-08-01 00:00:00
abstract：BACKGROUND:The cause of lichen sclerosus et atrophicus (LSA) is unknown, but on the penis it is associated with chronic occlusion, that is, phimosis. Microscopic changes of LSA were seen unexpectedly in two acrochordons. OBJECTIVE:Our purpose was to further characterize this phenomenon. METHODS:A total of 449 acrocho...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/0190-9622(93)70105-3
更新日期：1993-05-01 00:00:00
abstract：BACKGROUND:The negative pigment network (NPN) is seen as a negative of the pigmented network and it is purported to be a melanoma-specific structure. OBJECTIVES:We sought to assess the frequency, sensitivity, specificity, and odds ratios (ORs) of NPN between melanoma cases and a group of control lesions. METHODS:Digi...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2012.08.012
更新日期：2013-04-01 00:00:00
abstract：:Pigmented purpuric dermatosis can occasionally be caused by various medications. No reported cases of oral hypoglycemic agents causing pigmented purpuric dermatosis exist. We report a case of glipizide-induced pigmented dermatosis. ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(99)70335-x
更新日期：1999-11-01 00:00:00
abstract：BACKGROUND:Non-melanoma skin cancers (NMSCs) are increased in organ transplant recipients, but transplant and immunocompetent squamous and basal cell carcinomas (SCCs, BCCs) have not been compared previously in a single-center study. OBJECTIVE:To compare clinicopathologic features of transplant and immunocompetent NMS...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2005.10.049
更新日期：2006-02-01 00:00:00
abstract：BACKGROUND:Whole-body imaging is the current standard of care for staging all patients presenting with skin lesions of B-cell lymphomas (BCLs), regardless of skin disease extent; however, supporting data are lacking. OBJECTIVE:To determine the clinical utility of imaging in the detection of systemic involvement in low...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2019.01.037
更新日期：2019-10-01 00:00:00
abstract：:Cytokines are glycoproteins produced by many different cells. Via binding to specific receptors on target cells they regulate the activation, differentiation, and proliferation of immune and nonimmune cells. After injury keratinocytes synthesize and release cytokines such as interleukins, colony stimulating factors, a...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/0190-9622(91)70147-t
更新日期：1991-06-01 00:00:00
abstract：BACKGROUND:Hyperlipidemia has received little attention as a side effect of cyclosporine therapy for severe psoriasis. OBJECTIVE:We report changes in fasting serum lipids in patients treated with low-dose oral cyclosporine for psoriasis and discuss their significance. METHODS:Twenty-two patients with severe, recalcit...
journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/0190-9622(92)70213-y
更新日期：1992-09-01 00:00:00
abstract：:The PA Patch, a new multiple-antigen, predispensed patch testing device, was compared to the Finn Chamber in subjects with previous positive patch tests. After pressing the PA Patch well, the PA Patch performed as well as the Finn Chamber in nine subjects tested. ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0190-9622(87)70121-2
更新日期：1987-05-01 00:00:00
abstract：BACKGROUND:Vitamin D3 analogs have been found to be effective in treating psoriasis. OBJECTIVE:We attempted to identify the targets and actions of vitamin D3 in the skin and to explore the availability of synthetic vitamin D3 analogs with selective actions on particular cell types or cell functions. METHODS:A review ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：
更新日期：1997-09-01 00:00:00
abstract：BACKGROUND:The reported prevalence and degrees of Demodex mite infestation in rosacea vary widely. OBJECTIVE:We sought to conduct an evidence-based meta-analysis of the prevalence and degrees of Demodex mite infestation in patients with rosacea. METHODS:Systematic literature review and meta-analysis were conducted. O...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jaad.2017.03.040
更新日期：2017-09-01 00:00:00
