Abstract:
BACKGROUND:Inherited susceptibility genes have been associated with histopathologic characteristics of tumors. OBJECTIVE:We sought to identify associations between histology of melanomas and CDKN2A genotype. METHODS:This was a case-control study design comparing 28 histopathologic tumor features among individuals with sporadic melanomas (N = 81) and cases from melanoma families with (N = 123) and without (N = 120) CDKN2A germline mutations. RESULTS:Compared with CDKN2A(-) cases, mutation carriers tended to have histologic features of superficial spreading melanoma subtype including higher pigmentation (Ptrend = .02) and increased pagetoid scatter (Ptrend = .07) after adjusting for age at diagnosis, sex, and American Joint Committee on Cancer thickness category. Similar associations were observed when comparing mutation carriers with a combined group of CDKN2A(-) (wild type) and sporadic melanomas. The presence of spindle cell morphology in the vertical growth phase was also an important predictor of genotype. Of the 15 cases with this phenotype, none were observed to harbor a CDKN2A mutation. LIMITATIONS:Our study examined rare mutations and may have been underpowered to detect small, but biologically significant associations between histology and genotype. CONCLUSION:Familial melanomas with CDKN2A mutations preferentially express a histologic phenotype of dense pigmentation, high pagetoid scatter, and a non-spindle cell morphology in the vertical growth phase.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Sargen MR,Kanetsky PA,Newton-Bishop J,Hayward NK,Mann GJ,Gruis NA,Tucker MA,Goldstein AM,Bianchi-Scarra G,Puig S,Elder DEdoi
10.1016/j.jaad.2014.11.014subject
Has Abstractpub_date
2015-03-01 00:00:00pages
496-507.e7issue
3eissn
0190-9622issn
1097-6787pii
S0190-9622(14)02198-7journal_volume
72pub_type
杂志文章abstract:BACKGROUND:Patients with melanoma are at increased risk for cutaneous squamous cell carcinomas (SCCs). OBJECTIVE:We sought to examine the incidence of subsequent SCC among melanoma survivors and the impact of patient and melanoma characteristics on SCC risk. METHODS:Kaiser Permanente Northern California members given...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2014.04.019
更新日期:2014-09-01 00:00:00
abstract::Primary hyperoxaluria encompasses 3 rare genetic disorders of glyoxylate metabolism characterized by excessive urinary excretion of oxalic acid, resulting in oxalosis. Patients typically have recurrent calcium oxalate nephrolithiasis and nephrocalcinosis, leading to chronic renal failure and death from uremia. Oxalate...
journal_title:Journal of the American Academy of Dermatology
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doi:10.1067/mjd.2002.105475
更新日期:2002-02-01 00:00:00
abstract::The retinoids have been investigated extensively as chemopreventive and therapeutic agents in a variety of neoplasms. They have been shown to inhibit the proliferation of transformed cell lines in vitro and transplanted tumors in vivo. In cultured murine melanoma cells, retinoids inhibit proliferation and induce diffe...
journal_title:Journal of the American Academy of Dermatology
pub_type: 临床试验,杂志文章
doi:10.1016/s0190-9622(86)70239-9
更新日期:1986-10-01 00:00:00
abstract::Five patients had kerion celsi on the glabrous skin. Four of these were farmers, and one was a veterinarian. The lesions occurred on the distal part of the forearm of four patients and in the breast area of one patient, most occurring during the spring months. Several of the lesions were misdiagnosed as bacterial infe...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(82)70130-6
更新日期:1982-10-01 00:00:00
abstract::Fifty-four male and female patients with suspected colonic disease were examined for the presence of acrochordons prior to colonoscopy. Thirty-five of these patients (65%) had skin tags and twenty-six (48%) were found to have colonic polyps. In this study patients with acrochordons were significantly (p less than 0.00...
journal_title:Journal of the American Academy of Dermatology
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doi:10.1016/s0190-9622(86)70130-8
更新日期:1986-06-01 00:00:00
abstract::A case of porphyria cutanea tarda in a human immunodeficiency virus-infected patient with hemophilia is reported. Onset of skin manifestations of porphyria cutanea tarda coincided with deterioration of immune function. However, acquired immunodeficiency syndrome has not yet developed with a follow-up interval of 39 mo...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1016/0190-9622(92)70122-v
更新日期:1992-05-01 00:00:00
abstract:BACKGROUND:An outbreak of tinea corporis occurred in members of a high school wrestling team during the 1992-1993 season. OBJECTIVE:To control the outbreak, we conducted an epidemiologic investigation. METHODS:We examined 28 team members and obtained skin scrapings from 16. To control the outbreak we recommended (1) ...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(94)70145-8
更新日期:1994-08-01 00:00:00
abstract::Capecitabine, an oral fluoropyrimidine and 5-fluorouracil (FU) prodrug recently approved for the treatment of metastatic colon and breast cancer, is currently under investigation in patients with gastric cancer. It has the advantage of oral administration, and good tolerability with its activity being comparable with ...
journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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更新日期:2014-02-01 00:00:00
abstract::Sixty-six confirmed cases of Bowen's disease (intraepidermal squamous cell carcinoma) were seen from 1965 through 1976: twenty-four cases were treated surgically-four by excision (two recurrences) and twenty by desiccation and curettage (four recurrences); one was treated with x-ray radiation; and forty-one were treat...
journal_title:Journal of the American Academy of Dermatology
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doi:10.1016/s0190-9622(79)80095-x
更新日期:1979-12-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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doi:10.1016/s0190-9622(86)70061-3
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1016/s0190-9622(89)70266-8
更新日期:1989-10-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(82)70160-4
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,多中心研究
doi:10.1067/mjd.2001.114576
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:The development of autoimmune sequelae is one of the characteristic features of drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome; however, the incidence of sequelae and prognosis of patients with DRESS are unknown. OBJECTIVE:We sought to investigate the...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2012.08.009
更新日期:2013-03-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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doi:10.1067/mjd.2003.180
更新日期:2003-04-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/0190-9622(95)90345-3
更新日期:1995-04-01 00:00:00
abstract::A 7-week-old male infant with a seizure disorder and an extensive sebaceous nevus of the scalp was examined. Computerized axial tomography (CAT) scan identified an intracerebral mass which proved to be a hamartomatous malofrmation fo the brain. The association of intracranial masses with sebaceous nevi should be recog...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(82)70093-3
更新日期:1982-06-01 00:00:00
abstract:BACKGROUND:Some studies have shown that switching patients from one tumor necrosis factor (TNF)-alfa inhibitor to another may be beneficial when they have an inadequate response or an adverse event. OBJECTIVE:We sought to assess the variables predicting the efficacy of the second TNF-alfa inhibitor in patients discont...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2013.10.019
更新日期:2014-02-01 00:00:00
abstract::Many patients with lipoprotein disorders are at increased risk for the development of premature atherosclerosis and, less commonly, other disorders that cause systemic morbidity. In some of these patients, xanthomas also develop and provide cutaneous markers for the lipoprotein disorder. As advances in molecular biolo...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1016/s0190-9622(88)70157-7
更新日期:1988-07-01 00:00:00