当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY期刊下所有文献 > Role of Demodex mite infestation in rosacea: A systematic review and meta-analysis.

Role of Demodex mite infestation in rosacea: A systematic review and meta-analysis.

Abstract：

BACKGROUND:The reported prevalence and degrees of Demodex mite infestation in rosacea vary widely. OBJECTIVE:We sought to conduct an evidence-based meta-analysis of the prevalence and degrees of Demodex mite infestation in patients with rosacea. METHODS:Systematic literature review and meta-analysis were conducted. Odds ratios for prevalence of infestation and standardized mean difference (SMD) for Demodex density in patients with rosacea were pooled. Subgroup analysis for type of rosacea, control group, and sampling and examination methods were also performed. RESULTS:Twenty-three case-control studies included 1513 patients with rosacea. Compared with the control patients, patients with rosacea were more likely to be infested by Demodex mites [odds ratio, 9.039; 95% confidence interval (CI), 4.827-16.925] and had significantly higher Demodex density (SMD, 1.617; 95% CI, 1.090-2.145). Both erythematotelangiectatic rosacea (SMD, 2.686; 95% CI, 1.256-4.116) and papulopustular rosacea (SMD, 2.804; 95% CI, 1.464-4.145) had significantly higher Demodex density than did healthy control patients. LIMITATIONS:Interstudy variability was high, and a causal relationship could not be established by case-control studies. CONCLUSIONS:Patients with rosacea had significantly higher prevalence and degrees of Demodex mite infestation than did control patients. Demodex mites may play a role in both erythematotelangiectatic rosacea and papulopustular rosacea.

journal_name

J Am Acad Dermatol

journal_title

Journal of the American Academy of Dermatology

authors

Chang YS,Huang YC

doi

10.1016/j.jaad.2017.03.040

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

441-447.e6

issue

3

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(17)30429-2

journal_volume

77

pub_type

杂志文章,meta分析,评审

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