Relief of the photosensitivity of erythropoietic protoporphyria by pyridoxine.

Abstract:

:Twenty-five years ago the use of pyridoxine was described for the treatment of photosensitivity eruptions. We report two cases of erythropoietic protoporphyria, which were only moderately responsive to beta-carotene and sunscreens, whereas the use of pyridoxine has been associated with a marked reduction in photosensitivity without evidence of adverse effects. Regarding the mechanism of action, we can only speculate that pyridoxine could be mediated by increased endogenous nicotinamide production. We believe that our results warrant therapeutic trial of oral pyridoxine in patients with unrelieved photosensitivity as a result of erythropoietic protoporphyria.

journal_name

J Am Acad Dermatol

authors

Ross JB,Moss MA

doi

10.1016/0190-9622(90)70043-h

subject

Has Abstract

pub_date

1990-02-01 00:00:00

pages

340-2

issue

2 Pt 2

eissn

0190-9622

issn

1097-6787

pii

0190-9622(90)70043-H

journal_volume

22

pub_type

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