Angioedema: manifestations and management.

Abstract:

:Angioedema is characterized by localized swelling of sudden onset affecting the skin and/or mucous membranes. It can be classified into hereditary and acquired forms. Hereditary angioedema is a rare disease inherited as an autosomal dominant trait and caused by a deficiency of C1-esterase inhibitor. Acute attacks are life threatening and cannot be managed by antihistamines, corticosteroids, or adrenergic drugs. Prophylactic therapy is possible with danazol or stanozolol. Acquired angioedema includes nonhereditary C1-esterase inhibitor deficiency; idiopathic, allergic, and drug-induced forms; angioedema associated with lupus erythematosus and hypereosinophilia; and angioedema caused by physical stimuli. Treatment of these forms of angioedema depends on identifying and avoiding the cause, induction of tolerance, or symptomatic treatment with systemic antihistamines.

journal_name

J Am Acad Dermatol

authors

Greaves M,Lawlor F

doi

10.1016/0190-9622(91)70183-3

subject

Has Abstract

pub_date

1991-07-01 00:00:00

pages

155-61; discussion 161-5

issue

1 Pt 2

eissn

0190-9622

issn

1097-6787

pii

0190-9622(91)70183-3

journal_volume

25

pub_type

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