Excess melanocytic nevi in children with renal allografts.

Abstract:

BACKGROUND:Renal allograft transplantation is associated with an increased incidence of malignant melanoma. The development of excess melanocytic nevi may be an indicator of this risk. OBJECTIVE:This study determines the prevalence of melanocytic nevi in children who have received renal allografts. METHODS:Total and regional melanocytic nevi counts were made in 38 children (27 boys, 11 girls) with a renal allograft and in 38 individually age- and sex-matched healthy controls; counts were related to age, sex, skin type, and duration of immunosuppression. RESULTS:There was a significant increase in the total number of nevi in the renal transplant group compared with the control group (p < 0.05), with most marked increases occurring on the back and at acral sites. A strong positive correlation between nevi count and duration of immunosuppression independent of age was observed (p < 0.005). CONCLUSION:Excess numbers of melanocytic nevi occur in children with renal allografts. These patients constitute a risk group for malignant melanoma and require continued assessment.

journal_name

J Am Acad Dermatol

authors

Smith CH,McGregor JM,Barker JN,Morris RW,Rigden SP,MacDonald DM

doi

10.1016/0190-9622(93)70008-h

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

51-5

issue

1

eissn

0190-9622

issn

1097-6787

pii

0190-9622(93)70008-H

journal_volume

28

pub_type

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