当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY期刊下所有文献 > A prospective multicenter study assessing effectiveness and safety of secukinumab in a real-life setting in 158 patients.

A prospective multicenter study assessing effectiveness and safety of secukinumab in a real-life setting in 158 patients.

Abstract：

BACKGROUND:Secukinumab is a first-in-class interleukin 17A monoclonal antibody that has demonstrated an excellent safety and efficacy profile in phase 3 studies. OBJECTIVE:To evaluate the effectiveness of secukinumab in daily clinical practice and to understand the clinical and epidemiologic characteristics of patients treated with secukinumab in clinical settings. METHODS:In this multicenter prospective observational study, we recruited adult patients with moderate-to-severe plaque psoriasis from 12 hospitals in Spain during January-December 2016. These patients were treated with secukinumab and prospectively followed at 12-week intervals for 52 weeks. RESULTS:In total, 158 patients were recruited to the study. A Psoriasis Area and Severity Index (PASI) score improvement ≥75% over baseline (PASI-75) was achieved by 57%, 83.5%, 89%, and 78.5% of patients at weeks 4, 12, 24, and 52, respectively. PASI-90 was achieved in 27.8%, 62%, 64.6%, and 63.2% of patients at weeks 4, 12, 24, and 52, respectively; PASI-75 and PASI-90 responders were significantly more common among patients with a body mass index <30 kg/cm2 and patients without previous biologic therapy failures. LIMITATIONS:Observational study. Time from onset of psoriasis was not evaluated. CONCLUSION:Secukinumab is a safe treatment with effectiveness rates similar to those found in its phase 3 studies. These rates endure up to a year from start of treatment.

journal_name

J Am Acad Dermatol

journal_title

Journal of the American Academy of Dermatology

authors

Ortiz-Salvador JM,Saneleuterio-Temporal M,Magdaleno-Tapial J,Velasco-Pastor M,Pujol-Marco C,Sahuquillo-Torralba A,Mateu-Puchades A,Pitarch-Bort G,Marí-Ruiz JI,Mataix-Díaz J,Montesinos-Villaescusa E,Miralles-Botella J,García-Ferná

doi

10.1016/j.jaad.2019.02.062

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

427-432

issue

2

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(19)30360-3

journal_volume

81

pub_type

杂志文章,多中心研究

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