Abstract：
BACKGROUND:Acral vascular syndromes associated with malignancy have rarely been reported. OBJECTIVE:Our purpose was to assess the clinical and evolving features of paraneoplastic acral vascular syndromes. PATIENTS AND METHODS:Two cases of paraneoplastic gangrene are described and analyzed together with previously reported cases identified by a MEDLINE search. RESULTS:Among the 68 patients identified, 40 had gangrene, 16 had acrocyanosis, and 12 had Raynaud's phenomenon. The male to female ratio was 0.89; median age was 59 years. Fingers were affected in 94%. Adenocarcinomas were the predominant associated malignancies (41%), and metastases were observed in 41%. The acral vascular syndromes in 48% of the patients definitively regressed after tumor treatment. Forty-four percent of the patients died within 2 years. A favorable cutaneous outcome was obtained with prostacyclin infusions in 6 patients. CONCLUSION:A neoplastic origin of acral vascular syndrome should be considered in elderly patients, especially men, in the absence of usual causative conditions.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Poszepczynska-Guigné E,Viguier M,Chosidow O,Orcel B,Emmerich J,Dubertret Ldoi
10.1067/mjd.2002.120474subject
Has Abstractpub_date
2002-07-01 00:00:00pages
47-52issue
1eissn
0190-9622issn
1097-6787pii
S0190962202000166journal_volume
47pub_type
杂志文章,评审abstract：:We report two cases in which dermatophytic infection developed almost entirely within a radiation field mimicking an acute radiation effect. Radiotherapists and dermatologists should be aware of this possibility and be able to differentiate it from radiation dermatitis. Topical antifungal agents are the recommended tr...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(88)70271-6
更新日期：1988-12-01 00:00:00
abstract：:The case of a 2-year-old Puerto Rican boy is presented. Clinical and histologic features are detailed because he showed peculiar jet black patches of pigmentation on the fingers of the right hand. This case, except for the lack of progression of the disease after a 2-year period of follow-up, shows many similarities t...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(80)80391-4
更新日期：1980-02-01 00:00:00
abstract：:Oral juvenile xanthogranuloma is a rare condition, with only 10 histologically proven cases previously described. A histologically unusual variant is reported here, diagnosis of which was aided by the use of immunohistochemical stains. Previously reported cases are reviewed, and their characteristics are tabulated and...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/0190-9622(95)91438-2
更新日期：1995-08-01 00:00:00
abstract：:Two children who had classic maple syrup urine disease developed an eruptive dermatitis when plasma isoleucine levels, leucine levels, or both fell below normal during periods of protein restriction. The dermatitis was resistant to topical corticosteroid therapy. Rapid resolution occurred after treatment with isoleuci...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/0190-9622(93)70036-s
更新日期：1993-02-01 00:00:00
abstract：BACKGROUND:Primary prevention of skin cancer must start early in life to reduce total life-time sun exposure and severe overexposure in childhood. Childhood is an excellent time to form life-long prevention habits. A school-based curriculum can be an effective prevention strategy. OBJECTIVE:Our purpose was to determin...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(96)90115-2
更新日期：1996-12-01 00:00:00
abstract：BACKGROUND:Early specialist evaluation during rapid proliferative growth of complicated infantile hemangiomas (IH) is crucial. Health disparities and barriers of access-to-care for children with IH have not been examined. OBJECTIVE:Investigate whether socioeconomic status (SES) is associated with age at subspecialist ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2018.09.041
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:Cutaneous polyarteritis nodosa (cPAN) is a skin medium vessel neutrophilic arteritis with livedo, nodules, and ulcerations. Macular lymphocytic arteritis (MLA) is a small arteritis with erythematous or pigmented macules and typical histologic features (a lymphocytic infiltrate, concentric fibrin ring, no dis...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2015.09.010
更新日期：2015-12-01 00:00:00
abstract：:Pyoderma gangrenosum is a neutrophilic dermatosis that may be associated with myeloid malignancies. Less information is available about the association of pyoderma gangrenosum with lymphoid malignancies. We present, to our knowledge, the first case of pyoderma gangrenosum associated with biphenotypic acute leukemia wh...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1067/mjd.2001.112377
更新日期：2001-03-01 00:00:00
abstract：:An association between HLA-DR1 and the development of multiple basal cell carcinomas was detected in southern Australia. A reduction in HLA-DR4 was found in patients with basal cell carcinoma compared with a local control group. The relative risk for HLA-DR1 was 2.1, which was lower than that for persons in farther co...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/0190-9622(91)70082-d
更新日期：1991-04-01 00:00:00
abstract：:With the introduction of the Medicare Access and Children's Health Insurance Program Reauthorization Act, clinicians who are not eligible for an exemption must choose to participate in 1 of 2 new reimbursement models: the Merit-based Incentive Payment System or Alternative Payment Models (APMs). Although most dermatol...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2017.01.031
更新日期：2017-06-01 00:00:00
abstract：:We discuss a metastatic dermatofibrosarcoma protuberans on the occiput of a 53-year-old man whose initial tumor appeared on his forehead 23 years previously. The pathology of the tumor that recurred at the initial site was fibrosarcomatous dermatofibrosarcoma protuberans, whereas the metastatic tumor was a pigmented d...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2008.10.053
更新日期：2009-07-01 00:00:00
abstract：:In recognition of continuing increases in the incidence of skin cancer, including malignant melanoma, the American Academy of Dermatology has encouraged dermatologic communities nationwide to offer free skin cancer screening to the public. Memorial Sloan-Kettering Cancer Center took part in one such effort last spring...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(86)70169-2
更新日期：1986-08-01 00:00:00
abstract：:Ochronosis is an uncommon condition characterized by yellow-brown pigment deposits in the dermis. It occurs in exogenous and endogenous forms. We report a case of exogenous ochronosis in a Hispanic woman and discuss the different forms of this condition. We treated the lesions with Q-switched ruby laser. ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(00)90257-3
更新日期：2000-05-01 00:00:00
abstract：BACKGROUND:Deep nasal defects of the dorsum, sidewall, and ala can be challenging to repair. OBJECTIVE:The article describes our experience with a muscle hinge transposition flap with overlying local full-thickness skin grafting for repair of deep nasal defects in a single-stage procedure. METHODS:A muscle hinge tran...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1067/mjd.2000.108374
更新日期：2000-11-01 00:00:00
abstract：BACKGROUND:There are subgroups of cutaneous squamous cell carcinoma (SCC) that have a higher risk for both regional and distant metastasis. When cutaneous SCC does metastasize, it typically spreads first to local nodal groups. Sentinel lymph node (SLN) localization has been successfully used to evaluate nodal metastasi...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1067/mjd.2000.106367
更新日期：2000-09-01 00:00:00
abstract：BACKGROUND:Although etanercept is used as a continuous therapy for moderate to severe plaque psoriasis, intermittent use may be necessary in some instances. OBJECTIVE:In this randomized, open-label study, we evaluated the effectiveness and safety of continuous versus interrupted etanercept therapy. METHODS:All patien...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jaad.2006.09.002
更新日期：2007-04-01 00:00:00
abstract：BACKGROUND:Tissue-destructive and more selective cytotoxic therapies are the main methods used to treat actinic cheilitis. A topical immune stimulant, 5% imiquimod cream, has recently been used for treatment of cutaneous epithelial malignancies including squamous cell carcinoma in situ and basal cell carcinoma. OBJECT...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1067/mjd.2002.126266
更新日期：2002-10-01 00:00:00
abstract：BACKGROUND:Lipodermatosclerosis is a sequela of deep venous insufficiency and a risk factor for the occurrence of venous leg ulceration. Medical compression stockings facilitate leg ulcer healing and prevent occurrence of ulcers resulting from removal of edema. Although the exact level of compression necessary for remo...
journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0190-9622(98)70271-3
更新日期：1998-12-01 00:00:00
abstract：:Pilomatrix carcinomas are rare neoplasms of the skin that may be locally aggressive or metastatic. The differentiation of these tumors from benign pilomatrixomas depends on a constellation of microscopic features, some of which may be equivocal or absent in individual biopsy specimens. We encountered a tumor with dist...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/0190-9622(90)70193-l
更新日期：1990-07-01 00:00:00
abstract：:We report a male infant with Down syndrome who had a transient myeloproliferative disorder associated with skin lesions. He was transferred to a neonatal intensive care unit because of low body weight, fetal edema, disseminated intravascular coagulation, and 10% blast cells in the peripheral blood. On postnatal day (P...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2008.09.029
更新日期：2009-05-01 00:00:00
abstract：BACKGROUND:In patients with malignancy-associated Sweet syndrome, a thorough evaluation for leukemia cutis should be considered. OBJECTIVE:We sought to describe the clinicopathologic characteristics of histiocytoid Sweet syndrome. METHODS:We retrospectively identified patients with histiocytoid Sweet syndrome at our ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2014.01.874
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:Sarcoidosis and granuloma annulare (GA) are cutaneous granulomatous disorders that can be difficult to treat. There is evidence of underlying Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway activation in sarcoidosis, suggesting that JAK inhibition might be effective. OBJEC...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2019.05.098
更新日期：2020-03-01 00:00:00
abstract：:A patient with sarcoidosis was treated with thalidomide for disfiguring and painful steroid unresponsive sarcoidal granulomas of the skin. The duration of the therapy was 14 months, during which time, the skin lesions resolved almost completely. The initial dosage was 200 mg a day, which was increased to 400 mg a day ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(98)70360-3
更新日期：1998-11-01 00:00:00
abstract：BACKGROUND:Eosinophilic myositis/perimyositis (EM/P) are a group of rare idiopathic muscle disorders associated with eosinophilia. OBJECTIVE:We describe the frequency and spectrum of cutaneous manifestations in EM/P and compare them with the idiopathic hypereosinophilic syndrome (HES). METHODS:We review the literatur...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(97)70136-1
更新日期：1997-09-01 00:00:00
abstract：:We describe a patient with clinical features of dermatitis herpetiformis (DH) and histopathologic features suggestive of both DH and bullous pemphigoid (BP). Immunofluorescent (IF) studies of skin biopsy revealed IgG and C3 deposits along the basement membrane zone (BMZ) in a linear pattern and circulating BMZ antibod...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(84)80441-7
更新日期：1984-05-01 00:00:00
abstract：BACKGROUND:Clinical and histopathologic features of childhood melanoma are poorly characterized. Atypical clinical presentations and ambiguous microscopic findings may contribute to diagnostic delays. OBJECTIVES:We sought to determine whether conventional ABCDE melanoma detection criteria (Asymmetry, Border irregulari...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2012.12.953
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND:Treatment guidelines are lacking for classic Kaposi sarcoma. OBJECTIVE:We sought to review the evidence on efficacy of treatments for classic Kaposi sarcoma. METHODS:Articles published in English or French in MEDLINE, Trip, Cochrane Library, and Pascal databases from 1980 to December 2010 were screened. St...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2012.04.018
更新日期：2013-02-01 00:00:00
abstract：:Five of seven patients with acquired immunodeficiency syndrome (AIDS) who had pruritus and a chronic, nonspecific-appearing skin eruption had increased antibody titers to antigens in the salivary glands of Aedes taeniorhynchus, a salt marsh mosquito common to South Florida. We hypothesize that the pruritus and skin le...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(89)80051-9
更新日期：1989-08-01 00:00:00
abstract：:Xeroderma pigmentosum is associated with severe actinic degeneration of the skin. Our patient with xeroderma pigmentosum showed increasing actinic damage in some areas covered by clothes. We therefore performed a complete evaluation of the patient's exposure to ultraviolet radiation. This included transmission measure...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/0190-9622(91)70054-6
更新日期：1991-02-01 00:00:00
abstract：:Patients with basal cell carcinoma and solar keratoses were treated with etretinate. Substantial and prolonged clinical improvement was seen. All patients with solar keratoses showed a decrease in the mean area and number of lesions and eight patients demonstrated complete healing clinically. Two patients experienced ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章
doi：10.1016/s0190-9622(88)70075-4
更新日期：1988-03-01 00:00:00
