Abstract：
BACKGROUND:Cutaneous polyarteritis nodosa (cPAN) is a skin medium vessel neutrophilic arteritis with livedo, nodules, and ulcerations. Macular lymphocytic arteritis (MLA) is a small arteritis with erythematous or pigmented macules and typical histologic features (a lymphocytic infiltrate, concentric fibrin ring, no disruption of the internal elastic lamina). OBJECTIVE:We sought to assess the frequency of clinical and histologic features of MLA in patients with cPAN. METHODS:This was a monocentric retrospective analysis of patients given the diagnosis of cPAN with blinded assessment of skin biopsy specimens. RESULTS:All 35 patients included had an infiltrated livedo, nodules, or both. Ulceration was rare. Erythematous or pigmented lesions were present in 54% of patients. Predominantly lymphocytic arteritis, a paucity of neutrophils, concentric fibrin ring, and absence of internal lamina elastic disruption were present in 60%, 20%, 18%, and 23% of patients, respectively. Median follow-up was 11 years. None of the patients had systemic involvement, and 57% had a complete remission. The incidence of complete remission was not different between patients having a predominant lymphocyte infiltrate or few neutrophils. LIMITATIONS:This was a retrospective, monocentric study without a control group of patients with MLA. CONCLUSIONS:Our data do not favor the classification of cPAN and MLA as distinct entities.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Buffiere-Morgado A,Battistella M,Vignon-Pennamen MD,de Masson A,Rybojad M,Petit A,Cordoliani F,Begon E,Flageul B,Mahr A,Bagot M,Bouaziz JDdoi
10.1016/j.jaad.2015.09.010subject
Has Abstractpub_date
2015-12-01 00:00:00pages
1013-20issue
6eissn
0190-9622issn
1097-6787pii
S0190-9622(15)02181-7journal_volume
73pub_type
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