Abstract:
:Kyrle's disease is a chronic, genetically determined, hyperkeratotic disorder occurring in the middle forties. We report fourteen cases of this disorder in a population of 1.5 million over a period of 15 years. We observed a female/male ratio of 6:1. Straw-colored keratotic plugs and flat scale show a marked predisposition for the calf, the tibial region, and the posterior part of the thigh. They vary in size from 1 to 4 mm, and there is occasional plaque formation. No koebnerization or pruritus was noted, and no statistically significant association with hepatic, renal, or diabetic disorders could be demonstrated. Microscopic features showed a consistent pattern of keratotic plug formation, with the plug sitting in an invaginated atrophic epidermis, and underlying dermal histiocyte and lymphocyte aggregation. All lesions contained orthokeratosis and parakeratosis, with some sections showing abnormal keratinization. Sodium dodecylsulfate gel electrophoresis did not demonstrate the presence of abnormal keratin bands.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Cunningham SR,Walsh M,Matthews R,Fulton R,Burrows Ddoi
10.1016/s0190-9622(87)70011-5subject
Has Abstractpub_date
1987-01-01 00:00:00pages
117-23issue
1 Pt 1eissn
0190-9622issn
1097-6787pii
S0190-9622(87)70011-5journal_volume
16pub_type
杂志文章abstract:BACKGROUND:There are limited data on the effectiveness of skin cancer prevention education and early detection programs at beaches. OBJECTIVES:We evaluate 4 strategies for addressing skin cancer prevention in beach settings. METHODS:This prospective study at 4 beaches included 4 intervention conditions: (1) education...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,随机对照试验
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更新日期:2011-02-01 00:00:00
abstract::Five patients had kerion celsi on the glabrous skin. Four of these were farmers, and one was a veterinarian. The lesions occurred on the distal part of the forearm of four patients and in the breast area of one patient, most occurring during the spring months. Several of the lesions were misdiagnosed as bacterial infe...
journal_title:Journal of the American Academy of Dermatology
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abstract:BACKGROUND:There are subgroups of cutaneous squamous cell carcinoma (SCC) that have a higher risk for both regional and distant metastasis. When cutaneous SCC does metastasize, it typically spreads first to local nodal groups. Sentinel lymph node (SLN) localization has been successfully used to evaluate nodal metastasi...
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
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更新日期:1998-11-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
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更新日期:2008-08-01 00:00:00