Abstract：
BACKGROUND:Hydroxychloroquine is widely used for the treatment of cutaneous lupus erythematosus (CLE). Although new recommendations exist for hydroxychloroquine dosing, there is still uncertainty about the dosage that will elicit a satisfactory response in CLE while limiting adverse effects, specifically retinopathy. OBJECTIVE:To summarize hydroxychloroquine dosages, outcomes, and adverse effects in the treatment of CLE, focusing on retinopathy. METHODS:A comprehensive literature search from inception to December 2018 was performed in Ovid MEDLINE, Ovid Embase, and The Cochrane Library (Wiley). Studies were screened against predefined inclusion and exclusion criteria. RESULTS:Twelve studies were selected and included 5 retrospective studies, 3 prospective studies, 2 case series, and 2 randomized controlled trials. These studies show that a hydroxychloroquine dosage up to 400 mg/d is effective for most CLE patients (range of effectiveness, 50%-97%), with few adverse effects. One incidence of retinopathy, after a very high cumulative dose, was reported across all 12 studies (852 total patients). LIMITATIONS:Because retinopathy and other serious adverse effects may not appear until much later, many of these studies are limited by short follow-up time. CONCLUSIONS:This evidence suggests that hydroxychloroquine for CLE is effective at 400 mg/d, with an exceedingly low incidence of retinopathy and other adverse effects.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Shipman WD,Vernice NA,Demetres M,Jorizzo JLdoi
10.1016/j.jaad.2019.07.027subject
Has Abstractpub_date
2020-03-01 00:00:00pages
709-722issue
3eissn
0190-9622issn
1097-6787pii
S0190-9622(19)32387-4journal_volume
82pub_type
杂志文章abstract：:We describe the clinical and biochemical features of an infant with marked transient porphyrinemia in whom blistering developed while the infant was undergoing phototherapy for severe Rh isoimmunization. The cause of the transient porphyrinemia was likely to be multifactorial--abnormal porphyrin metabolism or accumula...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/0190-9622(95)91428-5
更新日期：1995-08-01 00:00:00
abstract：BACKGROUND:Mohs micrographic surgery (MMS) has a low rate of surgical site infection (SSI) without the use of prophylactic antibiotics. In the studies to date, there has been variation in the steps taken by each surgeon to prevent SSIs but in all cases sterile technique was used during wound reconstruction. OBJECTIVE:...
journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章
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更新日期：2010-11-01 00:00:00
abstract：BACKGROUND:The cause of rosacea is unknown; among other factors a causative role has been postulated for the hair follicle mites Demodex folliculorum and Demodex brevis. OBJECTIVE:Our purpose was to compare the population density of Demodex mites in facial skin of defined categories of patients with rosacea with contr...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/0190-9622(93)70065-2
更新日期：1993-03-01 00:00:00
abstract：:Acute generalized exanthematous pustulosis is a severe cutaneous adverse reaction characterized by the rapid development of nonfollicular, sterile pustules on an erythematous base. It is attributed to drugs in the majority of cases. Antibiotics are the most common cause of acute generalized exanthematous pustulosis; h...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2015.07.017
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:Needle puncture and infiltrational anesthesia is generally required for minor cutaneous surgical procedures and may be associated with anxiety, fear, discomfort, and pain. The use of topical anesthetics such as eutectic lidocaine/prilocaine 5% cream may provide an alternative means of delivering anesthesia. ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0190-9622(96)90608-8
更新日期：1996-09-01 00:00:00
abstract：:Subacute myelomonocytic leukemia is typically preceded by a preleukemic phase lasting 1 to 10 years. We describe a case of subacute myelomonocytic leukemia preceded by pruritus for 7 years and by the intermittent appearance of nonspecific necrotic dermal nodules for 4 years. ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(80)80150-2
更新日期：1980-06-01 00:00:00
abstract：BACKGROUND:Keloids are a common lesion arising from sites of previous trauma and are a considerable source of morbidity because of continued growth of lesions, pruritus, and physical appearance. They consist of mesenchymal cells embedded in a stroma of disordered collagen matrix. Clinically, keloids are distinguished f...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1067/mjd.2001.117736
更新日期：2001-11-01 00:00:00
abstract：:Verruciform xanthoma is a rare lesion that occurs most commonly on the oral mucosa but is occasionally seen on the skin. We present a case of multiple verruciform xanthomas occurring on the hand and foot in which there were no preexisting lesions. The current literature on this rare condition is reviewed. The cause of...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/s0190-9622(89)70036-0
更新日期：1989-02-01 00:00:00
abstract：BACKGROUND:The International Dermatology Outcome Measures established a set of core domains to be measured in all psoriasis trials. This set requires that symptoms of psoriatic arthritis (PsA) be measured in all psoriasis studies. OBJECTIVE:To identify the approach to PsA screening and the most appropriate outcome mea...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2019.05.075
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abstract：:Three patients who had cardiac surgery developed a transient, noninflammatory subepidermal bullous eruption on the legs after epsilon-aminocaproic acid infusion. Fibrin thrombi were demonstrated in papillary dermal vessels. The use of epsilon-aminocaproic acid as an antifibrinolytic agent may predispose patients to cu...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/0190-9622(92)70272-h
更新日期：1992-11-01 00:00:00
abstract：BACKGROUND:Paraneoplastic syndromes (PNS) are commonly associated with neuroendocrine cancers, such as small cell lung cancer. OBJECTIVES:We examined the association of PNS in Merkel cell carcinoma (MCC), a rare neuroendocrine skin cancer. METHODS:We identified PNS associated with MCC based on chart review of a Seatt...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2016.04.040
更新日期：2016-09-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jaad.2006.03.025
更新日期：2006-07-01 00:00:00
abstract：:Sulfur is a time-honored therapeutic agent useful in a variety of dermatologic disorders. Its keratolytic action is due to formation of hydrogen sulfide through a reaction that depends upon direct interaction between sulfur particles and keratinocytes. The smaller the particle size, the greater the degree of such inte...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(88)70079-1
更新日期：1988-03-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2012.05.036
更新日期：2012-12-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2018.09.006
更新日期：2019-08-01 00:00:00
abstract：:Pigmented purpuric dermatosis can occasionally be caused by various medications. No reported cases of oral hypoglycemic agents causing pigmented purpuric dermatosis exist. We report a case of glipizide-induced pigmented dermatosis. ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(99)70335-x
更新日期：1999-11-01 00:00:00
abstract：:The Papillon-Lefèvre syndrome is characterized by palmoplantar hyperkeratosis and juvenile periodontitis that results in the precocious loss of both the deciduous and permanent teeth. We report a patient with Papillon-Lefèvre syndrome associated with acroosteolysis, an association that has not been previously describe...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/0190-9622(91)70127-n
更新日期：1991-05-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
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更新日期：1998-02-01 00:00:00
abstract：INTRODUCTION:Intravenous immunoglobulin (IVIG) is used to treat many inflammatory and autoimmune disorders and although generally well tolerated, cutaneous side effects occur. OBJECTIVE:We reviewed reports of pompholyx and eczematous reactions associated with IVIG. METHODS:A literature search was performed using the ...
journal_title：Journal of the American Academy of Dermatology
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abstract：:At the International Consensus Conference for Cutaneous T-Cell Lymphoma (CTCL) Treatment Recommendations (held in Boston, Massachusetts, Oct. 1 and 2, 1994), international experts were asked to assess where consensus existed and to identify areas that required clinical research. We review the epidemiology, pathology, ...
journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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更新日期：1985-02-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
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doi：10.1067/mjd.2001.104964
更新日期：2001-12-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
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doi：10.1016/j.jaad.2006.10.960
更新日期：2007-05-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
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doi：10.1016/s0190-9622(99)70405-6
更新日期：1999-07-01 00:00:00
abstract：:Scabies is an ectoparasitic dermatosis caused by Sarcoptes scabiei var. hominis and is a public health issue in all countries regardless of socioeconomic status. In high-income countries, delays in diagnosis can lead to institutional outbreaks; in low- and middle-income countries, poor access to health care contribute...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
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更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:Biologic agents may predispose patients to skin and soft tissue infections (SSTIs). Guidelines recommend discontinuing the agent pre-operatively; the true risk of infection is unclear. OBJECTIVES:To assess the incidence of SSTIs in patients on biologic agents for all clinical indications. A secondary aim is...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
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更新日期：2020-05-05 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(83)70046-0
更新日期：1983-03-01 00:00:00
abstract：BACKGROUND:Surgeons use absorbable and nonabsorbable sutures for epidermal wound closure. No large, randomized studies have compared the effect of these suture types on facial scar appearance. OBJECTIVE:To assess postsurgical facial scar appearance using either rapidly absorbable polyglactin 910 or nylon for epidermal...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2020.06.016
更新日期：2020-11-01 00:00:00
abstract：:We describe a 39-year-old man with a 3-year history of a recalcitrant psoriasiform eruption that was accentuated in the intertriginous areas. Hsitopathology was consistent with psoriasis. A glucagon level was 744 pg/mL with the upper limit of normal being 130 pg/mL. Computed tomographic scan of the abdomen revealed a ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1067/s0190-9622(02)61774-8
更新日期：2003-08-01 00:00:00
abstract：BACKGROUND:Adults are advised to wear sunscreen with a sun protection factor (SPF) of 15 or higher, apply it up to 30 minutes before sun exposure, and reapply it after 2 hours to reduce exposure to ultraviolet radiation in sunlight for the prevention of skin cancer. OBJECTIVE:This study investigated the extent to whic...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2010.11.044
更新日期：2012-01-01 00:00:00
