Measuring psoriatic arthritis symptoms: A core domain in psoriasis clinical trials.

Abstract:

BACKGROUND:The International Dermatology Outcome Measures established a set of core domains to be measured in all psoriasis trials. This set requires that symptoms of psoriatic arthritis (PsA) be measured in all psoriasis studies. OBJECTIVE:To identify the approach to PsA screening and the most appropriate outcome measure for capturing PsA symptoms. METHODS:Following guidelines (ie, the COnsensus-based Standards for the selection of health Measurement INstruments, Core Outcome Measures in Effectiveness Trials Initiative, and Outcome Measures in Rheumatology Handbook), we conducted a consensus-building study that included patients, physicians, industry partners, and patient association representatives. The process consisted of a literature review and quality appraisal of measures for PsA symptoms, a pre-Delphi exercise, a Delphi survey, and a consensus meeting. RESULTS:Among the 297 expert participants in the Delphi survey, 87.5% agreed that all patients in a psoriasis trial should be screened for PsA with a validated screening tool. Regarding the measurement of PsA symptoms, the preferred instrument was the Psoriatic Arthritis Impact of Disease-9 (PsAID9), with the Routine Assessment Patient Index Data-3 (RAPID3) representing an acceptable alternative. LIMITATIONS:Only International Dermatology Outcome Measures members participated in the consensus meeting. CONCLUSION:The overwhelming majority of expert stakeholders agreed that all psoriasis trial participants should be screened for PsA, with PsA symptoms measured by using PsAID9 (or alternatively with RAPID3).

journal_name

J Am Acad Dermatol

authors

Perez-Chada LM,Gottlieb AB,Cohen J,Mease P,Duffin KC,Garg A,Latella J,Armstrong AW,Ogdie A,Merola JF

doi

10.1016/j.jaad.2019.05.075

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

54-61

issue

1

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(19)30879-5

journal_volume

82

pub_type

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