Abstract：
:Hirsutism in women is frequently associated with increased levels of androgens. Studies of biochemical changes, however, have yielded conflicting results. This study compares the findings in 30 hirsute women with normal menses and those of 30 hirsute women with abnormal cycles. Of the women with abnormal menstruation, 73% had oligoamenorrhea only and the others had dysfunctional uterine bleeding. The abnormally menstruating group had a similar mean age but tended to have heavier body weights than those with normal cycles. Free and total testosterone levels were significantly higher in the abnormal group (total testosterone, 54 +/- 35 ng/dl vs 35 +/- 12 ng/dl, p = 0.004; free testosterone, 7.8 +/- 4.9 pg/ml vs 4.2 +/- 1.4 pg/ml, p = 0.002). The abnormal group tended to have higher levels of androstenedione than the normal group (227 +/- 116 ng/dl vs 139 +/- 59 ng/dl) but dehydroepiandrosterone sulfate (DHEAS) levels were similar (320 +/- 142 mg/dl vs 298 +/- 169 pg/dl). Levels of thyroxin, thyrotropin, and prolactin were comparable in the two groups. Among hirsute women those with abnormal menses tended to be heavier and to have higher levels of total testosterone, free testosterone, and androstenedione. This is consistent with the clinical impression, not previously documented, that of hirsute women, those with abnormal menses have more severe endocrine abnormalities than those with normal cycles.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Redmond GP,Bergfeld W,Gupta M,Bedocs NM,Skibinski C,Gidwani Gdoi
10.1016/0190-9622(90)70011-6subject
Has Abstractpub_date
1990-01-01 00:00:00pages
76-8issue
1eissn
0190-9622issn
1097-6787pii
0190-9622(90)70011-6journal_volume
22pub_type
杂志文章abstract：BACKGROUND:Mohs micrographic surgery is thought to be a useful therapy for cutaneous melanoma. Controversy persists, however, because there are few published reports that document its safety and efficacy. OBJECTIVE:Our purpose was to determine the safety and efficacy of Mohs micrographic surgery for the treatment of c...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(97)80131-4
更新日期：1997-08-01 00:00:00
abstract：:Adult T-cell leukemia/lymphoma (ATLL) often involves the skin. Cases with skin lesions without either leukemic nor lymph node involvement have been categorized into a cutaneous type. While the clinical manifestations of the cutaneous-type ATLL are variable, including multiple papules, nodules, plaques, or erythroderma...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2006.12.031
更新日期：2007-11-01 00:00:00
abstract：:Metastasis to the skin from cervical carcinoma is relatively uncommon. Herein we present a 41-year-old woman with a history of cervical carcinoma with severe facial erythematous swelling and telangiectasia. She was initially treated for cellulitis without improvement. A skin biopsy specimen revealed widespread intrava...
journal_title：Journal of the American Academy of Dermatology
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doi：10.1016/j.jaad.2006.03.028
更新日期：2007-02-01 00:00:00
abstract：BACKGROUND:Noninvoluting congenital hemangioma (NICH) is a distinct vascular tumor of infancy. OBJECTIVE:We describe the clinical characteristics, histopathology, imaging, and natural history of NICH and compare our findings with previous reports. METHODS:We conducted a retrospective review of charts and photographic...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2014.01.860
更新日期：2014-05-01 00:00:00
abstract：:Significant progress has been made in skin replacement options in the past several decades. Although initially various materials have been used mainly for burn coverage, their application to dermatologic practice has increased significantly. We review the research, progress, and other aspects of wound coverage with sy...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/0190-9622(90)70279-q
更新日期：1990-10-01 00:00:00
abstract：:Fifty-four male and female patients with suspected colonic disease were examined for the presence of acrochordons prior to colonoscopy. Thirty-five of these patients (65%) had skin tags and twenty-six (48%) were found to have colonic polyps. In this study patients with acrochordons were significantly (p less than 0.00...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(86)70130-8
更新日期：1986-06-01 00:00:00
abstract：BACKGROUND:Psoriasis's effect on diabetes onset is well documented, but its effect on course of diabetes is poorly understood. OBJECTIVE:We sought to compare risks of developing microvascular and macrovascular complications between diabetic patients with and without psoriasis. METHODS:Adults with 2 or more diabetes d...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2015.02.1095
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND:Genetic and environmental components may contribute to acne causation. OBJECTIVE:We sought to assess the impact of family history, personal habits, dietary factors, and menstrual history on a new diagnosis of moderate to severe acne. METHODS:We conducted a case-control study in dermatologic outpatient clin...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jaad.2012.02.018
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:Darier disease (DD) is an autosomal dominant genodermatosis caused by mutations in the ATP2A2 gene. It has been reported that depletion of Ca(2+) stores within the endoplasmic reticulum of keratinocytes is associated with impaired cell cycle regulation and terminal differentiation. Mechanical stress, heat, o...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2009.07.031
更新日期：2010-05-01 00:00:00
abstract：BACKGROUND:Vulvo-cervico-vaginal involvement has rarely been reported in pemphigus vulgaris (PV) and has not been reported in pemphigus foliaceus (PF). OBJECTIVES:We sought to evaluate genital lesions and Papanicolaou (Pap) smears in female patients with PV and PF. METHODS:This prospective study includes all consecut...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2011.10.004
更新日期：2012-09-01 00:00:00
abstract：:We report two cases of congenital curvilinear palpable hyperpigmentation on the posterior aspect of bilateral legs in male infants. These lesions appeared shortly after birth and mimicked child abuse with looped cord or postinflammatory hyperpigmentation. Histopathologic features showed lentiginous melanocytic hyperpl...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2005.02.015
更新日期：2005-08-01 00:00:00
abstract：BACKGROUND:Few studies have examined patients initially presenting with clinical features of urticarial dermatitis (UD). OBJECTIVE:We sought to examine clinical and laboratory evaluations and final diagnoses of patients with clinical features of UD. METHODS:This was a retrospective review of patients with UD seen at ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2013.08.050
更新日期：2014-02-01 00:00:00
abstract：BACKGROUND:To prevent DNA damage caused by the ultraviolet (UV) radiation of sunlight, sunscreens are commonly used to protect human skin. Current analysis of sunscreens' effectiveness is done through complicated procedures, including human exposure. OBJECTIVE:We sought to design a simple system using thymidine-thymid...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2010.05.038
更新日期：2011-08-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/s0190-9622(80)80385-9
更新日期：1980-02-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2014.02.025
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:The association of nonparaneoplastic pemphigus with comorbid hematologic malignancies has yet to be established. OBJECTIVE:To estimate the association between pemphigus and the common types of hematologic malignancies. METHODS:A cross-sectional study was conducted comparing pemphigus patients with age-, se...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2017.11.039
更新日期：2018-06-01 00:00:00
abstract：:Oral juvenile xanthogranuloma is a rare condition, with only 10 histologically proven cases previously described. A histologically unusual variant is reported here, diagnosis of which was aided by the use of immunohistochemical stains. Previously reported cases are reviewed, and their characteristics are tabulated and...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/0190-9622(95)91438-2
更新日期：1995-08-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(89)70005-0
更新日期：1989-01-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
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doi：10.1016/j.jaad.2019.06.013
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(86)70104-7
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abstract：:Sunscreen preparations can reduce the erythemogenic ( sunburning ) effects of solar ultraviolet radiation (UVR). Less is known about the ability of sunscreens to protect against other forms of UVR-induced damage. This study was designed to yield data on epidermal cell damage at UVR doses sufficient to provoke vascular...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
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更新日期：1984-05-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2008.06.015
更新日期：2008-11-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2020.04.067
更新日期：2020-04-22 00:00:00
abstract：:This study compares the histopathologic characteristics of photodistributed and nonphotodistributed lichenoid drug eruptions in 13 patients. Both types have been said to be, in an unknown proportion, different from idiopathic lichen planus in that they can involve the deep as well as the superficial plexus, can contai...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/0190-9622(90)70275-m
更新日期：1990-10-01 00:00:00
abstract：UNLABELLED:Sentinel lymph node biopsy for melanoma was introduced in the early 1990s as a minimally invasive method of identifying and pathologically staging regional lymph node basins in patients with clinical stage I/II melanoma. Numerous large trials have demonstrated that sentinel lymph node evaluation has utility ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2009.11.695
更新日期：2010-05-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2008.10.049
更新日期：2009-06-01 00:00:00
abstract：:Pachyonychia congenita is a rare genetic disorder classified in clinical subtypes. Late onset of the disease has recently been described and designated as pachyonychia congenita tarda. A patient in whom typical manifestations of pachyonychia congenita appeared at the age of 39 years is described. This report substanti...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(96)90663-5
更新日期：1996-08-01 00:00:00
abstract：BACKGROUND:Onychomycosis is observed less frequently in children than adults. Until recently management of onychomycosis in children included topical formulations, oral griseofulvin, and in some cases deferral of treatment. OBJECTIVE:We attempted to determine the prevalence of onychomycosis in North American children ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,多中心研究
doi：10.1016/s0190-9622(97)80215-0
更新日期：1997-03-01 00:00:00
abstract：:Three clinicopathologic variants of lichen planopilaris are described. The first is characterized clinically by individual keratotic follicular papules and histologically by a lichenoid inflammatory cell infiltrate confined to the follicular epithelium. The second variant consists of erythematous to violaceous plaques...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/0190-9622(90)70078-v
更新日期：1990-04-01 00:00:00
abstract：BACKGROUND:Conventional therapy of severe bullous pemphigoid (BP) relies on the use of high-dose systemic corticosteroids with or without adjuvants, notably immunosuppressive agents. This approach can result in debilitating and potentially fatal side effects, hence the need to explore alternative therapies. Intravenous...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,meta分析
doi：10.1067/mjd.2000.112288
更新日期：2001-01-01 00:00:00
