Superantigens in dermatology.

Abstract:

:Superantigens (SAgs) are virulent polypeptides that are produced by a variety of infectious organisms. They are capable of causing nonspecific T cell activation by circumventing normal antigen processing in the human host. The genetic makeup of the host plays a role in conferring susceptibility or protection against SAgs. They are linked to a variety of conditions, ranging from toxic shock syndrome to recurrent toxin-mediated perineal erythema. The early recognition of signs and symptoms of SAg-mediated illnesses is important to ensure prompt medical treatment.

journal_name

J Am Acad Dermatol

authors

Macias ES,Pereira FA,Rietkerk W,Safai B

doi

10.1016/j.jaad.2010.03.044

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

455-72; quiz 473-4

issue

3

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(10)00752-8

journal_volume

64

pub_type

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