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Sulfur revisited.

Abstract：

:Sulfur is a time-honored therapeutic agent useful in a variety of dermatologic disorders. Its keratolytic action is due to formation of hydrogen sulfide through a reaction that depends upon direct interaction between sulfur particles and keratinocytes. The smaller the particle size, the greater the degree of such interaction and the greater the therapeutic efficacy. When applied topically, sulfur induces various histologic changes, including hyperkeratosis, acanthosis, and dilatation of dermal vasculature. One study showed that sulfur was comedogenic when applied onto human and rabbit skin, findings that were not reproduced in other studies. About 1% of topically applied sulfur is systemically absorbed. Adverse effects from topically applied sulfur are uncommon and are mainly limited to the skin. In infants, however, fatal outcome after extensive application has been reported.

journal_name

J Am Acad Dermatol

journal_title

Journal of the American Academy of Dermatology

authors

Lin AN,Reimer RJ,Carter DM

doi

10.1016/s0190-9622(88)70079-1

subject

Has Abstract

pub_date

1988-03-01 00:00:00

pages

553-8

issue

3

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(88)70079-1

journal_volume

18

pub_type

杂志文章

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