Abstract：
BACKGROUND:Paraneoplastic syndromes (PNS) are commonly associated with neuroendocrine cancers, such as small cell lung cancer. OBJECTIVES:We examined the association of PNS in Merkel cell carcinoma (MCC), a rare neuroendocrine skin cancer. METHODS:We identified PNS associated with MCC based on chart review of a Seattle-based repository and examined the incidence of MCC-associated hyponatremia in an independent cohort within Kaiser Permanente Northern California. RESULTS:Eight PNS cases were identified from the Seattle repository. Three distinct PNS types were observed: cerebellar degeneration (1 case), Lambert-Eaton myasthenic syndrome (2 cases), and malignancy-associated hyponatremia (5 cases). Moreover, the incidence of severe hyponatremia (serum sodium <125 mmol/L) coincident with MCC was identified among 4.3% (9 of 211) patients with MCC in the Kaiser Permanente Northern California cohort. LIMITATIONS:We did not have access to complete medical records on all patients so it was not possible to determine the prevalence of PNS in MCC. CONCLUSIONS:MCC can be associated with PNS similar to those found in other neuroendocrine cancers. Clinicians should be aware of these presentations as PNS often precede the identification of the underlying malignancy and usually resolve with appropriate treatment of the cancer.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Iyer JG,Parvathaneni K,Bhatia S,Tarabadkar ES,Blom A,Doumani R,McKenzie J,Asgari MM,Nghiem Pdoi
10.1016/j.jaad.2016.04.040subject
Has Abstractpub_date
2016-09-01 00:00:00pages
541-547issue
3eissn
0190-9622issn
1097-6787pii
S0190-9622(16)30145-1journal_volume
75pub_type
杂志文章abstract：:The case of a male diabetic patient with recurrent bullous lesions restricted to the hands is reported. Areas of spongiosis in the epidermis, as well as subepidermal blister formation, were observed in repeated biopsies. On electron microscopy, separation was seen at the level of the lamina lucida. No immunopathology ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：
更新日期：1985-11-01 00:00:00
abstract：:Sweet's syndrome (SS) occurs most commonly in association with inflammatory or neoplastic disorders. Only rarely has it been associated with immunodeficiency disorders. We describe a child with a T-cell immunodeficiency who had a persistent neutrophilic dermatosis that was histologically and clinically consistent with...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1053/jd.1999.v40.a95650
更新日期：1999-05-01 00:00:00
abstract：BACKGROUND:Guselkumab, an interleukin-23 blocker, was superior to adalimumab in treating moderate to severe psoriasis in a phase II trial. OBJECTIVES:We sought to compare efficacy and safety of guselkumab with adalimumab and placebo in patients with psoriasis treated for 1 year. METHODS:Patients were randomized to gu...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jaad.2016.11.041
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:Kaposi's varicelliform eruption (KVE), first described in 1887 by Moritz Kaposi, refers to a disseminated cutaneous infection with herpesvirus type 1 or 2, vaccinia virus, or coxsackievirus A16 in a patient with another underlying dermatosis. When herpesvirus type 1 or 2 is the pathogenic virus, the term "ec...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2005.01.140
更新日期：2005-07-01 00:00:00
abstract：:Removal of Norplant contraceptive implants may be rendered difficult by the size of the capsules and variations in insertion technique. In the standard removal technique, a single transverse incision is made close to and below the distal ends of the capsules, and a mosquito forceps is used for extraction. Described,...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(97)70116-6
更新日期：1997-11-01 00:00:00
abstract：:Melasma is an acquired brown hypermelanosis of the face. Although it is thought that melasma is associated with multiple etiologic factors (pregnancy, gastric, racial, and endocrine), one of the primary causes of its exacerbation appears to be exposure to sunlight. Three patterns of melasma are recognized clinically: ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(81)70071-9
更新日期：1981-06-01 00:00:00
abstract：:A locally invasive tumor developed in a 71-year-old woman on the right retroauricular skin, involving cartilage and parotid glands. Histologically, the tumor displayed characteristic features of basal cell epithelioma accompanied by stromal fibrosis. Histochemically, an apocrine pattern in enzyme reactions was detecte...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(85)70174-0
更新日期：1985-08-01 00:00:00
abstract：BACKGROUND:Glomangiomas are benign tumors arising from neuromyoarterial cells surrounding cutaneous arteriovenous anastomoses that serve as temperature regulators. They exist as solitary or multiple types, occurring sporadically or in a familial pattern, the latter of which is rare. OBJECTIVE:We describe a 4-generatio...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：
更新日期：2000-04-01 00:00:00
abstract：BACKGROUND:For treatment of localized scleroderma numerous treatments, including ones with potentially hazardous side effects, are currently used with only limited success. OBJECTIVE:We attempted to determine the efficacy of low-dose UVA1 irradiation in patients with severe localized scleroderma. METHODS:Patients wer...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(98)70533-x
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND:Only a few reports have been published on the long-term outcome of surgical excision of cutaneous squamous cell carcinoma (SCC). OBJECTIVE:Our purpose was to report the clinical findings and 5-year recurrence rate of all patients with cutaneous SCC treated with Mohs micrographic surgery (MMS) in Australia b...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jaad.2005.02.059
更新日期：2005-08-01 00:00:00
abstract：BACKGROUND:The current standard tool for diagnosing allergic contact dermatitis (ACD) in the United States is the T.R.U.E. test panels, which consist of 23 allergens. Previous studies have raised concern regarding the adequacy of these panels in fully assessing patients with possible ACD. OBJECTIVE:We sought to examin...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1067/mjd.2003.489
更新日期：2003-07-01 00:00:00
abstract：:Novel tretinoin cream and gel formulations have been developed that incorporate polyolprepolymer-2, which is a material designed to help retain drug molecules in and on the skin when applied in topical vehicles. The results of preclinical and clinical investigations have confirmed the beneficial impact of such a vehic...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/s0190-9622(98)70139-2
更新日期：1998-04-01 00:00:00
abstract：BACKGROUND:Recent studies have shown a higher prevalence of cardiovascular (CV) risk factors in patients with rosacea. However, it remains unknown whether rosacea represents an independent CV risk factor. OBJECTIVE:We evaluated the risk of myocardial infarction, stroke, CV death, major adverse CV events, and all-cause...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2016.02.1158
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:Confluent and reticulated papillomatosis (CRP) of Gougerot and Carteaud is an uncommon disorder of unknown cause for which a variety of treatments have been proposed. OBJECTIVE:We attempted to evaluate the effectiveness of oral minocycline. METHODS:Nine patients with CRP were treated with oral minocycline,...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(96)80120-4
更新日期：1996-02-01 00:00:00
abstract：:We report eight patients with ulcerative colitis who have subsequently developed pemphigoid. Four patients were investigated to determine the pattern of pemphigoid antibody staining on whole and chemically split skin and oral mucosa to distinguish between pemphigoid and epidermolysis bullosa acquisita. The findings we...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/s0190-9622(88)70176-0
更新日期：1988-08-01 00:00:00
abstract：BACKGROUND:The Patient-Reported Outcomes Measurement Information System (PROMIS) Itch Questionnaire (PIQ) was recently developed. OBJECTIVE:To validate PIQ short forms in adults with AD. METHODS:Self-administered questionnaires and skin examinations were performed in 239 adults with atopic dermatitis (AD) in a dermat...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2019.11.057
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:Several clinical studies have focused on the therapeutic effects of interferon gamma (IFN-gamma) in patients with severe atopic dermatitis (AD), although the dosage of recombinant IFN-gamma (rIFN-gamma), therapeutic schedule, and the degree of clinical improvement were different among studies. Although the e...
journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章
doi：
更新日期：2000-06-01 00:00:00
abstract：BACKGROUND:Little is known about how individuals with a predisposition for rosacea appear in childhood. This retrospective, matched control, longitudinal study examined the relationship between childhood stye and adult rosacea. METHODS:The records of the Rochester Epidemiology Project were examined to identify patient...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2006.03.023
更新日期：2006-12-01 00:00:00
abstract：:This is the second reported case of minocycline-induced Sweet's syndrome (and the first such case to appear in the American literature). The syndrome developed in a 32-year-old man 10 days after minocycline therapy for acne was begun and resolved rapidly after discontinuation of the medication and start of oral predni...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/0190-9622(92)70251-a
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abstract：:Tumid lupus erythematosus (LE) is a relatively rare and only recently recognized subset of chronic cutaneous lupus. We report a case occurring in a male with HIV infection whereby his rash was only unmasked by immune restoration following highly active antiretroviral therapy (HAART). The phenomenon of latent inflammat...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2004.04.020
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abstract：:Mycophenolate mofetil (MMF) has been widely used as an immunosuppressant in organ transplantation. MMF has recently been added to therapeutic regimens for skin disorders. Expanding the use of MMF in dermatology, we describe additional patients with autoimmune and inflammatory skin diseases, including 4 cases of pemphi...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(99)70203-3
更新日期：1999-02-01 00:00:00
abstract：:Six men suffering from acute dermatitis had positive patch tests to Larrea (creosote bush). The lesions preferentially involved sun-exposed sites, simulating a photodermatitis, but also were on the legs and scrotum. Our findings were more consistent with contact allergy than with a primary irritant or a phototoxic res...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(86)70022-4
更新日期：1986-02-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1067/mjd.2001.102669
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abstract：OBJECTIVES:Our aim was to compare 20% with 10% to 5% incremental regimens in narrowband UVB phototherapy. STUDY PATIENTS:The study included patients with psoriasis (N = 191) with Fitzpatrick skin phototypes II and III. RESULTS:Occurrence of erythema as well as maximum and cumulative doses were higher with 20% escalat...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2006.04.019
更新日期：2006-08-01 00:00:00
abstract：:Acute generalized exanthematous pustulosis is a severe cutaneous adverse reaction characterized by the rapid development of nonfollicular, sterile pustules on an erythematous base. It is attributed to drugs in the majority of cases. Antibiotics are the most common cause of acute generalized exanthematous pustulosis; h...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2015.07.017
更新日期：2015-11-01 00:00:00
abstract：:The advent of electron microscopy and immunohistochemical stains allowed for reclassification of the histiocytoses based on the predominant cell in the infiltrate. Although the current schema simplicity provides a good foundation, some patients display overlapping clinical and immunohistochemical features that defy cl...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2008.10.001
更新日期：2009-05-01 00:00:00
abstract：:Keratoacanthoma (KA) is currently considered a benign epithelial neoplasm. We report a patient with a lesion diagnosed as a KA that behaved aggressively like a squamous cell carcinoma (SCC). Similar reports are not uncommon in the literature. Because there are currently no criteria by which KA can be differentiated fr...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/s0190-9622(84)80010-9
更新日期：1984-02-01 00:00:00
abstract：:Cutaneous findings are not uncommonly a concomitant finding in patients afflicted with gastrointestinal (GI) diseases. The dermatologic manifestations may precede clinically evident GI disease. Part I of this 2-part CME review focuses on dermatologic findings as they relate to hereditary and nonhereditary polyposis di...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2012.10.037
更新日期：2013-02-01 00:00:00
abstract：:Infantile acropustulosis (IA) is a syndrome characterized by recurrent crops of 1- to 2-mm intensely pruritic vesicopustules that are found primarily on the distal extremities of infants. It is reportedly responsive to sulfones and unresponsive to other therapy, but if left untreated spontaneously resolves at about 2 ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(83)70187-8
更新日期：1983-11-01 00:00:00
abstract：BACKGROUND:Bullous pemphigoid is an autoimmune disease that typically presents with tense bullae and severe pruritus. However, bullae can be lacking, a subtype termed nonbullous pemphigoid. OBJECTIVE:To summarize the reported characteristics of nonbullous pemphigoid. METHODS:The EMBASE and MEDLINE databases were sear...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2017.10.035
更新日期：2018-05-01 00:00:00
