Reduced skin irritation with tretinoin containing polyolprepolymer-2, a new topical tretinoin delivery system: a summary of preclinical and clinical investigations.

abstract：BACKGROUND:Finasteride, a type II 5alpha-reductase inhibitor, reduces scalp and serum dihydrotestosterone and has been shown to be effective in men with androgenetic alopecia (AGA). OBJECTIVE:The purpose of this study was to determine the effect of finasteride on scalp hair weight in men with AGA. METHODS:Sixty-six m...

journal_title：Journal of the American Academy of Dermatology

authors： Price VH,Menefee E,Sanchez M,Ruane P,Kaufman KD

更新日期：2002-04-01 00:00:00

abstract：:Melasma is an irregular brown or grayish-brown facial hypermelanosis, often affecting women, especially those living in areas of intense UV radiation. The precise cause of melasma remains unknown; however, there are many possible contributing factors. Because of its dermal component and tendency to relapse, melasma is...

journal_title：Journal of the American Academy of Dermatology

authors： Gupta AK,Gover MD,Nouri K,Taylor S

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Allergic contact dermatitis (ACD) to optical brighteners and enzymes in laundry detergents was the focus of numerous reports in the early 1970s. Subsequently, there has been little published on the incidence of allergic reactions to chemicals in laundry detergents. Nonetheless, consumers and physicians conti...

journal_title：Journal of the American Academy of Dermatology

authors： Belsito DV,Fransway AF,Fowler JF Jr,Sherertz EF,Maibach HI,Mark JG Jr,Mathias CG,Rietschel RL,Storrs FJ,Nethercott JR

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:The optimal long-term dosing strategy for adalimumab (ADA) in hidradenitis suppurativa/acne inversa (HS) was evaluated by pooling the results of the PIONEER phase 3 trials and an open-label extension (OLE) study. OBJECTIVE:To assess the response to and tolerability of long-term administration of ADA in HS. ...

journal_title：Journal of the American Academy of Dermatology

authors： Zouboulis CC,Okun MM,Prens EP,Gniadecki R,Foley PA,Lynde C,Weisman J,Gu Y,Williams DA,Jemec GBE

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Actinic keratosis is a skin lesion that can progress to squamous cell carcinoma but cannot always be clinically distinguished from a squamous cell carcinoma. OBJECTIVE:The purpose of this article is to describe the clinical presentation of actinic keratoses and squamous cell carcinoma. METHODS:The author's...

journal_title：Journal of the American Academy of Dermatology

authors： Moy RL

更新日期：2000-01-01 00:00:00

abstract：:Pruritus is a common symptom in patients with hepatobiliary disease. Numerous treatments have been attempted. We review published therapeutic trials for hepatobiliary pruritus and utilize statistical analysis to evaluate treatment results. Randomized placebo-controlled studies show cholestyramine, rifampin, naloxone, ...

journal_title：Journal of the American Academy of Dermatology

authors： Connolly CS,Kantor GR,Menduke H

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Most biopsy specimens of cicatricial (scarring) alopecia can be readily subclassified as lymphocytic versus neutrophilic, but specific diagnosis remains difficult, particularly when a late stage of the disease is sampled. OBJECTIVE:We sought to document patterns of scarring highlighted by elastic tissue sta...

journal_title：Journal of the American Academy of Dermatology

authors： Fung MA,Sharon VR,Ratnarathorn M,Konia TH,Barr KL,Mirmirani P

更新日期：2013-11-01 00:00:00

abstract：:Lipoid proteinosis (Urbach-Wiethe disease) is a rare, recessively inherited disorder that is characterized by the deposition of hyaline-like material in the skin, oral cavity, and other tissues. It usually appears in infancy with hoarseness. We report a case of lipoid proteinosis in a 10-year-old boy that demonstrates...

journal_title：Journal of the American Academy of Dermatology

authors： Konstantinov K,Kabakchiev P,Karchev T,Kobayasi T,Ullman S

更新日期：1992-08-01 00:00:00

abstract：:Multiple basal cell epitheliomas developed in two psoriatic patients during treatment with orally administered 8-methoxypsoralen and long-wave ultraviolet radiation (PUVA). Twenty-two basal cell epitheliomas (BCEs) were seen in the two patients, 80% occurring in non-sun-exposed areas. Since neither patient had any his...

journal_title：Journal of the American Academy of Dermatology

authors： Brown FS,Burnett JW,Robinson HM Jr

更新日期：1980-05-01 00:00:00

abstract：:The literature concerning the use and possible mode of action of thalidomide in reactional lepromatous leprosy and in various other conditions is reviewed. Although it has no action against the leprosy bacillus, its value in the treatment of the adverse reactions in this type of leprosy is well established, many lepro...

journal_title：Journal of the American Academy of Dermatology

authors： Barnhill RL,McDougall AC

更新日期：1982-09-01 00:00:00

abstract：BACKGROUND:Current knowledge of angiolymphoid hyperplasia with eosinophilia (ALHE) derives from retrospective reports and case series, leading to a nonevidence-based treatment approach. OBJECTIVE:We sought to systematically review the literature relating to cutaneous ALHE to estimate its epidemiology and treatment out...

journal_title：Journal of the American Academy of Dermatology

authors： Adler BL,Krausz AE,Minuti A,Silverberg JI,Lev-Tov H

更新日期：2016-03-01 00:00:00

abstract：:The main limitation for the use of direct immunofluorescence in skin biopsies was the necessity for frozen tissue. In 1973 Michel et al reported use of a liquid fixative, consisting of ammonium sulfate, N-ethyl-maleimide, magnesium sulfate, and potassium citrate, for handling skin biopsy specimens. The present study i...

journal_title：Journal of the American Academy of Dermatology

authors： Niedecken HW,Lange CE

更新日期：1985-05-01 00:00:00

abstract：BACKGROUND:Total body photography (TBP) can facilitate identification of new and changing lesions. By confirming that particular nevi are stable, TBP may reduce nevus biopsies. OBJECTIVES:We sought to determine the number and rate of nevus biopsies before and after TBP, and the factors associated with increased biopsy...

journal_title：Journal of the American Academy of Dermatology

authors： Truong A,Strazzulla L,March J,Boucher KM,Nelson KC,Kim CC,Grossman D

更新日期：2016-07-01 00:00:00

abstract：:A tumor is reported that had remarkable pathologic changes showing with light microscopy a pattern in some portions consistent with tubular apocrine adenoma, while other areas were suggestive of syringoid eccrine carcinoma. Perineural invasion, commonly seen in syringoid eccrine carcinoma and never before reported in ...

journal_title：Journal of the American Academy of Dermatology

authors： Burket JM,Zelickson AS

更新日期：1984-10-01 00:00:00

abstract：BACKGROUND:Vulvar lichen sclerosus is a chronic condition usually responsive to topical corticosteroids. OBJECTIVE:We sought to evaluate the efficacy (reduction of signs and symptoms) and safety of clobetasol propionate 0.05% and tacrolimus 0.1% in the treatment of vulvar lichen sclerosus. METHOD:This double-blind, r...

journal_title：Journal of the American Academy of Dermatology

authors： Funaro D,Lovett A,Leroux N,Powell J

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Bath-PUVA is used to treat a variety of dermatoses. However, the kinetics of 8-methoxypsoralen during treatment are not completely clarified. OBJECTIVE:The purpose of this study was to investigate the intensity of the phototoxic response and the persistence of phototoxicity after bath-PUVA. METHODS:Twelve ...

journal_title：Journal of the American Academy of Dermatology

authors： Gruss C,Behrens S,Reuther T,Husebo L,Neumann N,Altmeyer P,Lehmann P,Kerscher M

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:T-cell receptor (TCR) clonality may help establish a diagnosis of mycosis fungoides (MF). Routine clonality analysis is performed by using a polymerase chain reaction TCR- gamma assay, yet with this method, 10% to 50% of T-cell lymphomas escape detection. TCR- beta gene rearrangement is an additional assay. ...

journal_title：Journal of the American Academy of Dermatology

authors： Schachter O,Tabibian-Keissar H,Debby A,Segal O,Baum S,Barzilai A

更新日期：2020-11-01 00:00:00

abstract：:The occurrence of Langerhans cell histiocytosis (LCH) and malignancy in the same patient is rare. When LCH occurs concomitantly with acute leukemia, distinct temporal patterns often exist; acute myelogenous leukemia (AML) typically succeeds LCH, whereas acute lymphocytic leukemia (ALL) usually precedes it. We report a...

journal_title：Journal of the American Academy of Dermatology

authors： Chiles LR,Christian MM,McCoy DK,Hawkins HK,Yen AH,Raimer SS

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Small open studies of patients at high risk for squamous cell carcinoma (SCC) of the skin suggest that oral retinoid use reduces the risk of these tumors. Among patients at lower risk, randomized trials of low doses of retinoids did not demonstrate significant chemopreventive effects. Patients with psoriasis...

journal_title：Journal of the American Academy of Dermatology

authors： Nijsten TE,Stern RS

更新日期：2003-10-01 00:00:00

abstract：:We report a case of dermatomyositis presenting with cutaneous mucinosis as the sole manifestation. A malignancy screen revealed an underlying nasopharyngeal carcinoma. ...

journal_title：Journal of the American Academy of Dermatology

authors： Tan E,Tan SH,Ng SK

更新日期：2003-05-01 00:00:00

abstract：:Cultured epidermal sheets were examined before and at various times after grafting on skin ulcer beds. Before grafting, the sheet consisted of four to five layers of keratinocytes with incomplete differentiation. Ten days after grafting, graft recipient sites showed compact hyperkeratosis, a normal-appearing epidermis...

journal_title：Journal of the American Academy of Dermatology

authors： Phillips TJ,Bhawan J,Leigh IM,Baum HJ,Gilchrest BA

更新日期：1990-08-01 00:00:00

abstract：:A young woman developed minocycline-related lupus erythematosus with associated autoimmune hepatitis. All clinical and laboratory abnormalities returned to normal when the drug was stopped. The symptoms worsened dramatically upon rechallenge, strongly suggesting the reaction was related to the minocycline. ...

journal_title：Journal of the American Academy of Dermatology

authors： Crosson J,Stillman MT

更新日期：1997-05-01 00:00:00

abstract：:Primary cutaneous CD30 (Ki-1)-positive, large cell lymphomas (LCLs) represent a recently recognized group of cutaneous T-cell lymphomas with a favorable prognosis. The characteristic features of this cutaneous lymphoma are reviewed, differences with primary noncutaneous CD30+ LCLs emphasized, and its relation with oth...

journal_title：Journal of the American Academy of Dermatology

authors： Willemze R,Beljaards RC

更新日期：1993-06-01 00:00:00

abstract：:Six men suffering from acute dermatitis had positive patch tests to Larrea (creosote bush). The lesions preferentially involved sun-exposed sites, simulating a photodermatitis, but also were on the legs and scrotum. Our findings were more consistent with contact allergy than with a primary irritant or a phototoxic res...

journal_title：Journal of the American Academy of Dermatology

authors： Leonforte JF

更新日期：1986-02-01 00:00:00

abstract：:This article reports the cases of two patients in whom a widespread dermatophyte infection mimicked the cutaneous lesions of their underlying collagen vascular disease. Griseofulvin may be associated with an increased incidence of adverse cutaneous reactions in patients with systemic lupus erythematosus. One patient w...

journal_title：Journal of the American Academy of Dermatology

authors： Almeida L,Grossman M

更新日期：1990-11-01 00:00:00

abstract：:In this third and last part of our review of cutaneous vascular proliferations we include malignant vascular neoplasms and a group of heterogeneous cutaneous neoplasms characterized by a significant vascular component. We also review some disorders that, in our opinion, have been erroneously considered as vascular neo...

journal_title：Journal of the American Academy of Dermatology

authors： Requena L,Sangueza OP

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Inherited susceptibility genes have been associated with histopathologic characteristics of tumors. OBJECTIVE:We sought to identify associations between histology of melanomas and CDKN2A genotype. METHODS:This was a case-control study design comparing 28 histopathologic tumor features among individuals wit...

journal_title：Journal of the American Academy of Dermatology

authors： Sargen MR,Kanetsky PA,Newton-Bishop J,Hayward NK,Mann GJ,Gruis NA,Tucker MA,Goldstein AM,Bianchi-Scarra G,Puig S,Elder DE

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:It is unclear whether patients with atopic dermatitis (AD) have an altered prevalence or risk for contact sensitization. Increased exposure to chemicals in topical products together with impaired skin barrier function suggest a higher risk, whereas the immune profile suggests a lower risk. OBJECTIVE:To perf...

journal_title：Journal of the American Academy of Dermatology

authors： Hamann CR,Hamann D,Egeberg A,Johansen JD,Silverberg J,Thyssen JP

更新日期：2017-07-01 00:00:00

abstract：:The treatment of hidradenitis suppurativa (HS) has remained challenging because of the many knowledge gaps regarding etiology. However, recent studies into the pathogenesis of HS have enabled the investigation of newer therapies. The second article in this continuing medical education series reviews the evidence for e...

journal_title：Journal of the American Academy of Dermatology

authors： Goldburg SR,Strober BE,Payette MJ

更新日期：2020-05-01 00:00:00

abstract：:Bowenoid papulosis is an uncommon genital dysplasia induced by human papillomavirus infection. Clinically, it usually resembles persistent warts, but histologically it may be suggestive of squamous cell carcinoma in situ. This unusual disorder and recent advances in our understanding of it are reviewed. ...

journal_title：Journal of the American Academy of Dermatology

authors： Schwartz RA,Janniger CK

更新日期：1991-02-01 00:00:00